Dibutyryl-cAMP (Bucladesine)

Catalog No.S7858 Synonyms: dbcAMP

For research use only.

Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.

Dibutyryl-cAMP (Bucladesine) Chemical Structure

CAS No. 16980-89-5

Selleck's Dibutyryl-cAMP (Bucladesine) has been cited by 18 publications

Purity & Quality Control

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Biological Activity

Description Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.
PDE [5]
PKA [1]
In vitro

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. [1] In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. [2] Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells NIjl[5lHfW6ldHnvckBie3OjeR?= NWjCc5JZPCCq NH64SJlCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCWTl\hcJBp[SCycn;keYN1cW:wIHHmeIVzKDRiaILzJIJ6KEWOSWPBMEBKSzVyPUK4Mlkh|ryP MmrEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMECwNlAoRjFzMECwNFIxRC:jPh?=
mouse S49 cells NEDnRndEgXSxdH;4bYNqfHliYYPzZZk> Ml;HOVAxKM7:TR?= MXSyNE01QSCq NUjKUHZSS3m2b4TvfIlkcXS7IHHnZYlve3RiSFfQVnRie2VvZHXmbYNq\W62IH3veZNmKFN2OTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDheEA2ODBidV2gZYZ1\XJiMkCgeI8hPDliaILzJIJ6KHSrbXWtZ492enOnIIP0eYR6 MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4NUinQlIzOTZ3OEyvZV4>
Methods Test Index PMID
Immunofluorescence α-SMAD 2/3 19858184
In vivo

In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments. [4]

Protocol (from reference)

Animal Research:


  • Animal Models: Mice
  • Dosages: 600 nM/mouse
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 98 mg/mL warmed
(199.44 mM)
Water 98 mg/mL warmed
(199.44 mM)
Ethanol ''19 mg/mL warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.37


CAS No. 16980-89-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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