Dibutyryl cAMP sodium (Bucladesine)

Catalog No.S7858 Batch:S785808

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Technical Data

Formula

C18H23N5NaO8P
Molecular Weight 491.37 CAS No. 16980-89-5
Solubility (25°C)* In vitro DMSO 98 mg/mL (199.44 mM)
Water 98 mg/mL (199.44 mM)
Ethanol 25 mg/mL (50.87 mM)
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Bucladesine sodium is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor.
Targets
PDE [5] PKA [1]
In vitro

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. [1]

In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. [2]

Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. [3]
In vivo

In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments. [4]

Protocol (from reference)

Cell Assay:

[6]
  • Cell lines

    PC12 cells

  • Concentrations

    1 mM

  • Incubation Time

    24 h

  • Method

    Cells were incubated with 1 mM of db-cAMP.
Animal Study:

[4]
  • Animal Models

    Mice

  • Dosages

    600 nM/mouse

  • Administration

    i.p.

References

  • https://pubmed.ncbi.nlm.nih.gov/11161593/
  • https://pubmed.ncbi.nlm.nih.gov/11469895/
  • https://pubmed.ncbi.nlm.nih.gov/16538385/
  • https://pubmed.ncbi.nlm.nih.gov/26066527/
  • https://pubmed.ncbi.nlm.nih.gov/22302126/
  • https://pubmed.ncbi.nlm.nih.gov/9721736/

Selleck's Dibutyryl cAMP sodium (Bucladesine) has been cited by 53 publications

Regulation of inflammatory responses by pH-dependent transcriptional condensates [ Cell, 2025, S0092-8674(25)00735-4] PubMed: 40680734
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress [ Nat Neurosci, 2025, 28(6):1174-1184] PubMed: 40456907
Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression [ Nat Commun, 2025, 16(1):6151] PubMed: 40610440
α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons [ Redox Biol, 2025, 86:103817] PubMed: 40812158
Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition [ PLoS Pathog, 2025, 21(2):e1012367] PubMed: 39928684
Establishment of reproducible method for production of cultured epidermal sheets with controlled melanocyte density [ Regen Ther, 2025, 29:499-505] PubMed: 40395371
Control of Inflammatory Response by Tissue Microenvironment [ bioRxiv, 2025, 2024.05.10.592432] PubMed: 38798655
RNA triggers chronic stress during neuronal aging [ bioRxiv, 2025, 2025.08.04.668575] PubMed: 40799579
Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation [ Cell Rep Med, 2024, 5(3):101477] PubMed: 38508143
In Situ Functionalization of Polar Polythiophene-Based Organic Electrochemical Transistor to Interface In Vitro Models [ ACS Appl Mater Interfaces, 2024, 16(40):54292-54303] PubMed: 39327895

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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