XIAP Selective Inhibitors | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7025 Embelin

Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM.

Selective XIAP, IC50: 4.1 μM
S7010 GDC-0152

GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.

Pan XIAP-BIR2, Ki: 112 nM; XIAP-BIR3, Ki: 28 nM
S7015 Birinapant

Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. Phase 2.

Pan XIAP, Kd: 45 nM
S7009 LCL161

LCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2.

Pan
S7597 BV-6

BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.

Pan