For research use only.
Catalog No.S1725 Synonyms: SF 86-327
CAS No. 91161-71-6
Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
Purity & Quality Control
Choose Selective Fungal Inhibitors
|Description||Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.|
Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively.  Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL).  Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes.  Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L.  Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. 
-  Vickers AE, et al. Drug Metab Dispos, 1999, 27(9), 1029-1038.
-  Ryder NS, et al. Med Mycol, 2001, 39(1), 91-95.
-  Abdel-Rahman SM, et al. Drug Metab Dispos, 1999, 27(7), 770-775.
|In vitro||DMSO||58 mg/mL (199.01 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04880980||Recruiting||Drug: Terbinafine Pill|Drug: Itraconazole capsule||Dermatophyte Infection|Terbinafine Adverse Reaction|Itraconazole Adverse Reaction||Pak Emirates Military Hospital||March 1 2021||Phase 3|
|NCT01484145||Completed||Drug: Terbinafine HCl||Onychomycosis||Nitric BioTherapeutics Inc||December 2011||Phase 2|
|NCT01772212||Completed||Drug: Terbinafine 250 mg||Mycoses||GlaxoSmithKline||February 24 2011||Phase 1|
|NCT00117767||Completed||Drug: Terbinafine hydrochloride (HCl)|Drug: Griseofulvin||Tinea Capitis||Novartis Pharmaceuticals|Novartis||June 2004||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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