Terbinafine

Catalog No.S1725 Synonyms: SF 86-327

Terbinafine  Chemical Structure

Molecular Weight(MW): 291.43

Terbinafine is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Terbinafine is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
Targets
squalene epoxidase [1]
In vitro

Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5]

Protocol

Solubility (25°C)

In vitro DMSO 58 mg/mL (199.01 mM)
Ethanol 58 mg/mL (199.01 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 291.43
Formula

C21H25N

CAS No. 91161-71-6
Storage powder
in solvent
Synonyms SF 86-327

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02019446 Not yet recruiting Diabetes Mellitus Type 2|Onychomycosis BCDiabetes.Ca|BritaMed Inc. July 2018 Not Applicable
NCT02019446 Not yet recruiting Diabetes Mellitus Type 2|Onychomycosis BCDiabetes.Ca|BritaMed Inc. July 2018 Not Applicable
NCT03471455 Not yet recruiting Tinea Postgraduate Institute of Medical Education and Research April 2018 Phase 2
NCT03471455 Not yet recruiting Tinea Postgraduate Institute of Medical Education and Research April 2018 Phase 2
NCT03171584 Not yet recruiting Antifungal Drugs in Onychomycosis Assiut University July 1 2017 Phase 3
NCT03171584 Not yet recruiting Antifungal Drugs in Onychomycosis Assiut University July 1 2017 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID