Catalog No.S1725 Synonyms: SF 86-327
Molecular Weight(MW): 291.43
Terbinafine is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
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Choose Selective Anti-infection Inhibitors
|Description||Terbinafine is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.|
Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively.  Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL).  Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes.  Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L.  Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. 
-  Vickers AE, et al. Drug Metab Dispos, 1999, 27(9), 1029-1038.
-  Ryder NS, et al. Med Mycol, 2001, 39(1), 91-95.
-  Abdel-Rahman SM, et al. Drug Metab Dispos, 1999, 27(7), 770-775.
|In vitro||DMSO||58 mg/mL (199.01 mM)|
|Ethanol||58 mg/mL (199.01 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01484145||Completed||Drug: Terbinafine HCl||Onychomycosis||Nitric BioTherapeutics Inc||December 2011||Phase 2|
|NCT01772212||Completed||Drug: Terbinafine 250 mg||Mycoses||GlaxoSmithKline||February 24 2011||Phase 1|
|NCT00386802||Completed||Drug: Antifungal drug. VORICONAZOL. (VFEND®)||Invader Fungal Infection||PETHEMA Foundation||August 2006||Phase 4|
|NCT00117754||Completed||Drug: Terbinafine hydrochloride||Tinea Capitis||Novartis||July 2004||Phase 3|
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