Terbinafine

Catalog No.S1725 Synonyms: SF 86-327

For research use only.

Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.

Terbinafine  Chemical Structure

CAS No. 91161-71-6

Selleck's Terbinafine has been cited by 4 Publications

Purity & Quality Control

Choose Selective Fungal Inhibitors

Biological Activity

Description Terbinafine (SF 86-327) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
Targets
squalene epoxidase [1]
In vitro

Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 58 mg/mL
(199.01 mM)
Water Insoluble
Ethanol '58 mg/mL

Chemical Information

Molecular Weight 291.43
Formula

C21H25N

CAS No. 91161-71-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04880980 Recruiting Drug: Terbinafine Pill|Drug: Itraconazole capsule Dermatophyte Infection|Terbinafine Adverse Reaction|Itraconazole Adverse Reaction Pak Emirates Military Hospital March 1 2021 Phase 3
NCT04188574 Recruiting Drug: BB2603-1|Drug: BB2603-3|Drug: BB2603-10|Drug: Vehicle Distal Subungual Onychomycosis|Fungal Infection|Fungus Nail Blueberry Therapeutics|IQVIA Biotech March 22 2021 Phase 2
NCT01484145 Completed Drug: Terbinafine HCl Onychomycosis Nitric BioTherapeutics Inc December 2011 Phase 2
NCT01772212 Completed Drug: Terbinafine 250 mg Mycoses GlaxoSmithKline February 24 2011 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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