Name: Terbinafine
Brand: Selleck Chemicals
SKU: S1725
Availability: InStock
Rating: 5 (8 reviews)

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Quality Control

Batch: Purity: 99.96%

99.96

Related Targets	Integrase Bacterial Antibiotics Anti-infection Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Fungal Inhibitors	Cycloheximide Tolnaftate Manogepix (E1210) Amorolfine HCl Isavuconazole Juglone Bifonazole Thimerosal Pseudolaric Acid B Butylparaben

Solubility

In vitro
Batch:

DMSO : 58 mg/mL (199.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 58 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.000mg/ml (10.29mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.000mg/ml (10.29mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	291.43	Formula	C₂₁H₂₅N	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	91161-71-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SF 86-327,TDT 067			SMILES	CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	squalene epoxidase
In vitro	Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), HLS 831(CYP2C9), or ethynylestradiol, CsA, and cortisol. This compound proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. It is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). This chemical inhibits dextromethorphan O-demethylation with an apparent K_i ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. It shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. This compound decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). It might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest.
References	[1] https://pubmed.ncbi.nlm.nih.gov/10460803/ [2] https://pubmed.ncbi.nlm.nih.gov/11270414/ [3] https://pubmed.ncbi.nlm.nih.gov/10383919/ [4] https://pubmed.ncbi.nlm.nih.gov/15102749/ [5] https://pubmed.ncbi.nlm.nih.gov/18272192/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-31)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07738328	NOT_YET_RECRUITING	Acute Kidney Injury; Cardiac Surgical Procedures	Guangdong Provincial People's Hospital	2026-09-01	PHASE2
NCT07738328	NOT_YET_RECRUITING	Acute Kidney Injury; Cardiac Surgical Procedures	Guangdong Provincial People's Hospital	2026-09-01	PHASE2
NCT07365423	RECRUITING	Recurrent Prostate Cancer	Swiss Cancer Institute	2026-04-24	PHASE2
NCT07365423	RECRUITING	Recurrent Prostate Cancer	Swiss Cancer Institute	2026-04-24	PHASE2
NCT07382427	NOT_YET_RECRUITING	Onychomycosis of Toenail	Onyx Axiom	2026-03	PHASE2
NCT07382427	NOT_YET_RECRUITING	Onychomycosis of Toenail	Onyx Axiom	2026-03	PHASE2

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Terbinafine Fungal inhibitor

Chemical Structure

Molecular Weight: 291.43