Catalog No.S1725 Synonyms: SF 86-327
Molecular Weight(MW): 291.43
Terbinafine is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
Purity & Quality Control
Choose Selective Anti-infection Inhibitors
|Description||Terbinafine is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.|
Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively.  Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL).  Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes.  Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L.  Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. 
-  Vickers AE, et al. Drug Metab Dispos, 1999, 27(9), 1029-1038.
-  Ryder NS, et al. Med Mycol, 2001, 39(1), 91-95.
-  Abdel-Rahman SM, et al. Drug Metab Dispos, 1999, 27(7), 770-775.
|In vitro||DMSO||58 mg/mL (199.01 mM)|
|Ethanol||58 mg/mL (199.01 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02019446||Not yet recruiting||Diabetes Mellitus Type 2|Onychomycosis||BCDiabetes.Ca|BritaMed Inc.||July 2018||Not Applicable|
|NCT03471455||Not yet recruiting||Tinea||Postgraduate Institute of Medical Education and Research||April 2018||Phase 2|
|NCT03171584||Not yet recruiting||Antifungal Drugs in Onychomycosis||Assiut University||July 1 2017||Phase 3|
|NCT03094468||Withdrawn||Onychomycosis of Toenail||Polichem S.A.|Almirall S.A.||May 2017||Phase 3|
|NCT03135912||Completed||Tinea Pedis||South End Skin Care||January 3 2017||Phase 2|
|NCT02606032||Recruiting||Ulcerative Colitis||Hamilton Health Sciences Corporation|Hamilton Academic Health Sciences Organization||May 2016||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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