Pamidronate Disodium

Catalog No.S1311 Synonyms: CGP 23339AE

Pamidronate Disodium Chemical Structure

Molecular Weight(MW): 279.03

Pamidronate Disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.

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Biological Activity

Description Pamidronate Disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.
In vitro

Pamidronate increases OPG mRNA levels and protein secretion by hOB by up to 2- to 3-fold in a dose-dependent fashion with a maximum effect at 1 µM after 72 hours. Artemisinin prevents the inhibitory effects of the glucocorticoid dexamethasone on OPG mRNA and protein production. Pamidronate induces type I collagen secretion and alkaline phosphatase activity by 2-fold. [1] Pamidronate has a more pronounced calcium-lowering action than etidronate (etidronic acid) and clodronate (clodronic acid) and provides a longer period of normocalcaemic remission. [2] Pamidronate (APD) dose-dependently inhibits resorption of calcium phosphate films by equine OCLs with an IC(50) of 0.58 μM in one horse. Pamidronate also dose-dependently inhibits the number of OCLs present in BM cultures after 7 days. [3]

In vivo Pamidronate administration significantly suppresses this increase below the control level in the tibia and distal femur of oophorectomized rats. Pamidronate significantly increases bone density and ash weight in both sham-operated and oophorectomized rats. [4] Pamidronate inhibits all significant effects of growth hormone (GH) and it also decreases the IGF-I levels in rats treated with growth hormone (GH). Pamidronate itself results in increased the bone density and ash weight of the tibia and decreased urinary DPD excretion. [5]

Protocol

Solubility (25°C)

In vitro Water 56 mg/mL (200.69 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 279.03
Formula

C3H9NNa2O7P2

CAS No. 57248-88-1
Storage powder
in solvent
Synonyms CGP 23339AE

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID