- Inhibitory Selectivity
- PKM Inhibitors (4)
- New PKM Products
|Catalog No.||Information||Product Use Citations||Product Validations|
PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
ML265 is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
Surface staining of total thymocytes from LckCre/Sin1fl/fl mice treated with vehicle or the PKM2 activator DASA-58. Upper panels are CD4 and CD8 staining. Lower panels are gated on the CD4 and CD8 DN subset for further CD44 and CD25 expression analyses. Numbers in the panels show the relative percentage of cells in that area.
Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.