PKM

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PKM Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S8279 Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
J Cancer, 2021, 12(1):76-88
Cancer Sci, 2021, 112(9):3507-3519
J Cell Mol Med, 2021, 10.1111/jcmm.17007
S8616 PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Front Immunol, 2021, 12:680068
Int J Biol Sci, 2021, 17(8):1895-1908
Exp Eye Res, 2021, 213:108823
S5545 DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
S6508 Mitapivat Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
S7302 TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.
Fitoterapia, 2021, 152:104922
S7928 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
PLoS Pathog, 2021, 17(3):e1008866
Exp Eye Res, 2021, 213:108823
Cell Rep, 2020, 26;31(8):107690
S8279 Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
J Cancer, 2021, 12(1):76-88
Cancer Sci, 2021, 112(9):3507-3519
J Cell Mol Med, 2021, 10.1111/jcmm.17007
S8616 PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Front Immunol, 2021, 12:680068
Int J Biol Sci, 2021, 17(8):1895-1908
Exp Eye Res, 2021, 213:108823
S5545 DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
S6508 Mitapivat Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
S7302 TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.
Fitoterapia, 2021, 152:104922
S7928 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
PLoS Pathog, 2021, 17(3):e1008866
Exp Eye Res, 2021, 213:108823
Cell Rep, 2020, 26;31(8):107690
Tags: PKM activator | PKM inhibitor | PKM modulator |PKM activity