PKM

Inhibitory Selectivity

PKM Products

Catalog No. Information Product Use Citations Product Validations
S8279

Shikonin

Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.

S6508

Mitapivat

Mitapivat is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.

S8616

PKM2 inhibitor(compound 3k)

PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.

S7302

TEPP-46 (ML265)

ML265 is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.

S7928

DASA-58

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

S5545

DL-Serine

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

Catalog No. Information Product Use Citations Product Validations
S8279

Shikonin

Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.

S6508

Mitapivat

Mitapivat is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.

S8616

PKM2 inhibitor(compound 3k)

PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.

Catalog No. Information Product Use Citations Product Validations
S7302

TEPP-46 (ML265)

ML265 is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.

S7928

DASA-58

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

S5545

DL-Serine

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

Tags: PKM activator | PKM inhibitor | PKM modulator |PKM activity