PKM

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PKM Products

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  • New PKM Products
Catalog No. Product Name Information Product Use Citations Product Validations
E2829New Alkannin Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).
S8279 Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
Adv Sci (Weinh), 2022, 10.1002/advs.202104055
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Mil Med Res, 2022, 9(1):22
S8616 PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Exp Cell Res, 2022, S0014-4827(22)00045-3
Eur J Pharmacol, 2022, S0014-2999(22)00105-4
Cell Biol Int, 2022, 10.1002/cbin.11780
S5545 DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
S6508 Mitapivat Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
S7302 TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.
Fitoterapia, 2021, 152:104922
S7928 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
Int J Mol Sci, 2022, 23(2)775
Cell Biol Int, 2022, 10.1002/cbin.11780
PLoS Pathog, 2021, 17(3):e1008866
E2829New Alkannin Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).
S8279 Shikonin (C.I. 75535) Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
Adv Sci (Weinh), 2022, 10.1002/advs.202104055
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Mil Med Res, 2022, 9(1):22
S8616 PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Exp Cell Res, 2022, S0014-4827(22)00045-3
Eur J Pharmacol, 2022, S0014-2999(22)00105-4
Cell Biol Int, 2022, 10.1002/cbin.11780
S5545 DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
S6508 Mitapivat Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
S7302 TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.
Fitoterapia, 2021, 152:104922
S7928 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
Int J Mol Sci, 2022, 23(2)775
Cell Biol Int, 2022, 10.1002/cbin.11780
PLoS Pathog, 2021, 17(3):e1008866
E2829New Alkannin Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).
Tags: PKM activator | PKM inhibitor | PKM modulator |PKM activity