For research use only.

Catalog No.S5545

DL-Serine Chemical Structure

Molecular Weight(MW): 105.09

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

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Biological Activity

Description Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
In vitro

The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence[2]. Serine activates recombinant PKM2 with a half maximal activation concentration (AC50) of 1.3 mM. Isothermal titration calorimetry was used to determine the dissociation constant (Kd) of the PKM2-serine interaction as 0.20 mM. Serine can bind to and activate human PKM2 and that following serine deprivation, PKM2 activity in cells is reduced. This reduction in PKM2 activity shifts cells to a fuel-efficient mode where more pyruvate is diverted to the mitochondria and more glucose derived carbon is channelled into serine biosynthesis to support cell proliferation[1].


Solubility (25°C)

In vitro Water 8 mg/mL (76.12 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 105.09


CAS No. 302-84-1
Storage powder
in solvent
Synonyms N/A
Smiles NC(CO)C(O)=O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04367792 Recruiting -- COVID-19 A.O. Ospedale Papa Giovanni XXIII|CVPath Institute Inc. Renu Virmani Aloke Finn|A.O. Ospedale Papa Giovanni XXIII Anatomia Patologica Dr Andrea Gianatti co-PI April 2020 --
NCT04224064 Not yet recruiting Diagnostic Test: Blood sampling Liposarcoma|Atypical Lipomatous Tumor Institut du Cancer de Montpellier - Val d''Aurelle January 2020 Not Applicable
NCT03979482 Recruiting -- Pulmonary Artery Hypertension Laval University June 1 2019 --
NCT04257877 Recruiting Procedure: Blood sampling Diabetes Type 1|Proteomics|Diabetic Peripheral Neuropathy Aristotle University Of Thessaloniki November 20 2018 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID