DL-Serine

Catalog No.S5545

DL-Serine Chemical Structure

Molecular Weight(MW): 105.09

Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

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Biological Activity

Description Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
In vitro

The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence[2]. Serine activates recombinant PKM2 with a half maximal activation concentration (AC50) of 1.3 mM. Isothermal titration calorimetry was used to determine the dissociation constant (Kd) of the PKM2-serine interaction as 0.20 mM. Serine can bind to and activate human PKM2 and that following serine deprivation, PKM2 activity in cells is reduced. This reduction in PKM2 activity shifts cells to a fuel-efficient mode where more pyruvate is diverted to the mitochondria and more glucose derived carbon is channelled into serine biosynthesis to support cell proliferation[1].

Protocol

Solubility (25°C)

In vitro Water 8 mg/mL (76.12 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 105.09
Formula

C3H7NO3

CAS No. 302-84-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03711500 Not yet recruiting Schizophrenia|Schizo Affective Disorder New York State Psychiatric Institute|Nathan Kline Institute for Psychiatric Research March 2019 Phase 1|Phase 2
NCT03711500 Not yet recruiting Schizophrenia|Schizo Affective Disorder New York State Psychiatric Institute|Nathan Kline Institute for Psychiatric Research March 2019 Phase 1|Phase 2
NCT03778320 Completed Healthy Volunteers Concert Pharmaceuticals December 14 2018 Phase 1
NCT03778320 Completed Healthy Volunteers Concert Pharmaceuticals December 14 2018 Phase 1
NCT03711903 Not yet recruiting Intracerebral Hemorrhage National Neuroscience Institute|Aegis CN LLC funding and Singapore Clinical research institute for study monitoring November 15 2018 Phase 2
NCT03711903 Not yet recruiting Intracerebral Hemorrhage National Neuroscience Institute|Aegis CN LLC funding and Singapore Clinical research institute for study monitoring November 15 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID