DASA-58

DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.

DASA-58 Chemical Structure

DASA-58 Chemical Structure

CAS: 1203494-49-8

Selleck's DASA-58 has been cited by 12 Publications

1 Customer Review

Purity & Quality Control

Batch: S792801 DMSO] 91 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.76%
99.76

DASA-58 Related Products

Choose Selective PKM Inhibitors

Biological Activity

Description DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
Targets
PKM2 [1]
In vitro
In vitro DASA-58 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes in primary BMDMs, and also inhibits glycolysis and the accumulation of succinate in LPS-activated macrophages. [1] In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1α. DASA-58 also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells. [2]
In Vivo
In vivo DASA-58 (40 μM) affects EMT of prostate cancers and tumor dissemination in SCID mice. [2]
Animal Research Animal Models Male SCID-bg/bg mice bearing PC3 tumors
Dosages 40 μM
Administration Drug-treated cells are injected into mice by i.v.

Chemical Information & Solubility

Molecular Weight 453.53 Formula

C19H23N3O6S2

CAS No. 1203494-49-8 SDF Download DASA-58 SDF
Smiles C1CN(CCN(C1)S(=O)(=O)C2=CC=CC(=C2)N)S(=O)(=O)C3=CC4=C(C=C3)OCCO4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 91 mg/mL ( (200.64 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy DASA-58 | DASA-58 supplier | purchase DASA-58 | DASA-58 cost | DASA-58 manufacturer | order DASA-58 | DASA-58 distributor