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Catalog No. Product Name Information Product Use Citations Product Validations
S6732 7ACC2 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.
S7339 AZD3965 AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.
Cell Rep, 2022, 39(6):110792
Cells, 2022, 11(7)1177
Cell Rep, 2021, 35(9):109202
S8612 α-cyano-4-hydroxycinnamic acid(α-CHCA) 4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.
Cancer Cell, 2021, S1535-6108(21)00659-0
S8747 BAY-8002 BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.
Cancers (Basel), 2021, 13(14)3635
Cancer Discov, 2017, 7(9):1018-1029
S9907 Syrosingopine (Su-3118) Syrosingopine (Su-3118) is a dual MCT1 and MCT4 inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.
Blood, 2021, 2649
S9929New VB124 VB124, a potent and selective MCT4 inhibitor, specifically inhibits lactate efflux/import in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism. 
S6732 7ACC2 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.
S7339 AZD3965 AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.
Cell Rep, 2022, 39(6):110792
Cells, 2022, 11(7)1177
Cell Rep, 2021, 35(9):109202
S8612 α-cyano-4-hydroxycinnamic acid(α-CHCA) 4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.
Cancer Cell, 2021, S1535-6108(21)00659-0
S8747 BAY-8002 BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.
Cancers (Basel), 2021, 13(14)3635
Cancer Discov, 2017, 7(9):1018-1029
S9907 Syrosingopine (Su-3118) Syrosingopine (Su-3118) is a dual MCT1 and MCT4 inhibitor with IC50 values of 2500nM and 40 nM in HAP1 cells, respectively.
Blood, 2021, 2649
S9929New VB124 VB124, a potent and selective MCT4 inhibitor, specifically inhibits lactate efflux/import in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism. 
S9929New VB124 VB124, a potent and selective MCT4 inhibitor, specifically inhibits lactate efflux/import in MDA-MB-231 cells expressing MCT4, and is used for the research of cardiac hypertrophy, heart failure, and metabolism. 
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