MCT
Inhibitory Selectivity
MCT Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8612 |
α-cyano-4-hydroxycinnamic acid(α-CHCA)4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs. |
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| S7339 |
AZD3965AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1. |
Lactate release by SiHa-WT cells treated with AR-C155858 (left; n = 8-9) or AZD3965 (right; n = 5-6) versus vehicle.
|
|
| S8747New |
BAY-8002BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S8612 |
α-cyano-4-hydroxycinnamic acid(α-CHCA)4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs. |
||
| S7339 |
AZD3965AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1. |
Lactate release by SiHa-WT cells treated with AR-C155858 (left; n = 8-9) or AZD3965 (right; n = 5-6) versus vehicle.
|
|
| S8747New |
BAY-8002BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels. |
