MCT

All (5) MCT Inhibitors (5) New MCT Products

Catalog No.	Information	Product Use Citations	Product Validations
S8612	α-cyano-4-hydroxycinnamic acid(α-CHCA) 4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.
S7919^New	AR-C155858 AR-C155858 is a potent inhibitor of MCT1 and MCT2 with Ki of 2.3 nM and 10 nM, respectively.
S7339	AZD3965 AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.	Nature, 2020, 577(7788):115-120 Biochem Biophys Res Commun, 2018, 503(2):737-743 Cancer Res, 2017, 77(20):5591-5601	Lactate release by SiHa-WT cells treated with AR-C155858 (left; n = 8-9) or AZD3965 (right; n = 5-6) versus vehicle.
S8747^New	BAY-8002 BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.	Cancer Discov, 2017, 7(9):1018-1029
S6732^New	7ACC2 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.

Catalog No.	Information	Product Use Citations	Product Validations
S8612	α-cyano-4-hydroxycinnamic acid(α-CHCA) 4-Chloro-α-cyanocinnamic acid (α-CHCA) is a classic monocarboxylate transporters (MCT) inhibitor. α-cyano-4-hydroxycinnamate (CHC) has a 10-fold selectivity for MCT1 compared to other MCTs.
S7919^New	AR-C155858 AR-C155858 is a potent inhibitor of MCT1 and MCT2 with Ki of 2.3 nM and 10 nM, respectively.
S7339	AZD3965 AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.	Nature, 2020, 577(7788):115-120 Biochem Biophys Res Commun, 2018, 503(2):737-743 Cancer Res, 2017, 77(20):5591-5601	Lactate release by SiHa-WT cells treated with AR-C155858 (left; n = 8-9) or AZD3965 (right; n = 5-6) versus vehicle.
S8747^New	BAY-8002 BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.	Cancer Discov, 2017, 7(9):1018-1029
S6732^New	7ACC2 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.