Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S4002 Sitagliptin phosphate monohydrate 41 mg/mL 100 mg/mL <1 mg/mL
S3031 Linagliptin <1 mg/mL 17 mg/mL 1 mg/mL
S3033 Vildagliptin (LAF-237) 60 mg/mL 60 mg/mL 60 mg/mL
S1540 Saxagliptin 63 mg/mL 63 mg/mL 24 mg/mL
S2868 Alogliptin(SYR-322)benzoate 2 mg/mL 68 mg/mL <1 mg/mL
S5909 Anagliptin 20 mg/mL 77 mg/mL 77 mg/mL
S5365 Alogliptin 18 mg/mL 67 mg/mL 67 mg/mL
S5079 Sitagliptin -1 mg/mL 81 mg/mL -1 mg/mL
S5063 Trelagliptin succinate 95 mg/mL 95 mg/mL 5 mg/mL
S8565 Omarigliptin (MK-3102) <1 mg/mL 79 mg/mL <1 mg/mL
S7513 Trelagliptin <1 mg/mL 71 mg/mL 3 mg/mL
S4697 Saxagliptin hydrate 1 mg/mL 66 mg/mL 66 mg/mL
S4636 Teneligliptin hydrobromide 100 mg/mL 100 mg/mL 17 mg/mL
Catalog No. Information Product Use Citations Product Validations

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.



Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9.


Vildagliptin (LAF-237)

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.



Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.



Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.



Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.



Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.



Sitagliptin is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.


Trelagliptin succinate

Trelagliptin succinate is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).


Omarigliptin (MK-3102)

Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).



Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Phase 3.


Saxagliptin hydrate

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.


Teneligliptin hydrobromide

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Tags: DPP-4 inhibition | DPP-4 inhibitor diabetes | DPP-4 enzyme | DPP-4 inhibitors mechanism | DPP-4 drugs | DPP-4 cancer | DPP-4 inhibitors list | DPP-4 activity | DPP-4 inhibitors drugs | DPP-4 inhibitors review | new DPP-4 inhibitor | DPP-4 assay | DPP-4 inhibitors cancer | FDA approved DPP-4 inhibitors