DPP-4

Signaling Pathway Map

Research Area

Inhibitory Selectivity

DPP-4 Products

New DPP-4 Products
Catalog No. Information Product Use Citations Product Validations
S4002

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

S3031

Linagliptin

Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9.

S3033

Vildagliptin (LAF-237)

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

S1540

Saxagliptin

Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S2868

Alogliptin(SYR-322)benzoate

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

S8455New

Talabostat (Val-boroPro, PT-100)

Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.

S5909New

Anagliptin

Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

S5365

Alogliptin

Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.

S8565

Omarigliptin (MK-3102)

Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).

S7513

Trelagliptin

Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Phase 3.

S4697

Saxagliptin hydrate

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S4636

Teneligliptin hydrobromide

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

S5063

Trelagliptin succinate

Trelagliptin succinate is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).

S5079

Sitagliptin

Sitagliptin is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

Catalog No. Information Product Use Citations Product Validations
S4002

Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

S3031

Linagliptin

Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9.

S3033

Vildagliptin (LAF-237)

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

S1540

Saxagliptin

Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S2868

Alogliptin(SYR-322)benzoate

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

S8455New

Talabostat (Val-boroPro, PT-100)

Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.

S5909New

Anagliptin

Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

S5365

Alogliptin

Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.

S8565

Omarigliptin (MK-3102)

Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).

S7513

Trelagliptin

Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Phase 3.

S4697

Saxagliptin hydrate

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

S4636

Teneligliptin hydrobromide

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

S5063

Trelagliptin succinate

Trelagliptin succinate is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).

S5079

Sitagliptin

Sitagliptin is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

Tags: DPP-4 inhibition | DPP-4 inhibitor diabetes | DPP-4 enzyme | DPP-4 inhibitors mechanism | DPP-4 drugs | DPP-4 cancer | DPP-4 inhibitors list | DPP-4 activity | DPP-4 inhibitors drugs | DPP-4 inhibitors review | new DPP-4 inhibitor | DPP-4 assay | DPP-4 inhibitors cancer | FDA approved DPP-4 inhibitors