Vildagliptin (LAF-237)

For research use only.

Catalog No.S3033

6 publications

Vildagliptin (LAF-237) Chemical Structure

CAS No. 274901-16-5

Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

Selleck's Vildagliptin (LAF-237) has been cited by 6 publications

Purity & Quality Control

Choose Selective DPP-4 Inhibitors

Biological Activity

Description Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.
DPP-4 [1]
(Cell-free assay)
2.3 nM
In vitro

Vildagliptin is the most stable DPP-IV inhibitor, binding in the S1- and S2-catalytic sites of DPP-IV, possessing a P-1 site transition-state mimetic. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Caco-2 cells NIrzdW9HfW6ldHnvckBie3OjeR?= NYT0V3dLUW6qaXLpeIlwdiCxZjDoeY1idiCGUGC0JIV5eHKnc4Pl[EBqdiCFYXPvMVIh[2WubIOsJGtqRTBwMEC0JO69VQ>? MWSxO|A{PDF2OB?=
insect cells M{LmWWZ2dmO2aX;uJIF{e2G7 NFnWRW1KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjpd{11[WepZXSgSHBRPCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{NCCLQ{WwQVAvODV4IN88US=> NEDxWo0zODdzOESyNC=>

... Click to View More Cell Line Experimental Data

In vivo Vildagliptin(orally dosed with 10 μmol/kg) is a potent, orally active inhibitor of plasma DPP-IV activity that provides increased levels of GLP-1 in an oral glucose tolerance test (OGTT) with Obese male Zucker rats. Vildagliptin orally dosed with 10 μmol/kg both significantly decreases glucose excursions and stimulates insulin secretion in Obese male Zucker rats. Maximum inhibition of plasma DPP-IV activity (95%) is observed approximately 2 hours postdose of Vildagliptin (1 μmol/kg, po) while >50% inhibition of DPP-IV is observed within 30 min postdose and persisted for >10 hours in normal Cynomolgus monkeys. [1] Vildagliptin(60 mg/kg) increases pancreatic beta cell mass through enhanced beta cell replication and reduced apoptosis, and the increased beta cell mass is sustained for 12 days after vildagliptin washout. [2] Vildagliptin administrated at doses of 10 mg/kg for 32 weeks protects nerve fiber loss in streptozotocin (STZ)-induced diabetic adult male Sprague Dawley rats. [3]


Animal Research:[1]
- Collapse
  • Animal Models: Obese male Zucker rats
  • Dosages: 10 μmol/kg
  • Administration: Orally administrated at a single dose
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 60 mg/mL (197.75 mM)
Water 60 mg/mL (197.75 mM)
Ethanol 60 mg/mL (197.75 mM)
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 303.4


CAS No. 274901-16-5
Storage powder
in solvent
Synonyms N/A
Smiles C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04081857 Completed Drug: HGP1810|Drug: HCP1704 Health Subjective Hanmi Pharmaceutical Company Limited June 3 2019 Phase 1
NCT04087525 Completed Drug: HIP1701|Drug: HGP1809 Health Subjective Hanmi Pharmaceutical Company Limited October 23 2018 Phase 1
NCT03577184 Withdrawn Drug: Metformin/Vildagliptin Diabetes Mellitus Type 2 Clinision July 2018 --
NCT02145611 Completed Drug: Glibenclamide|Drug: Vildagliptin Type 2 Diabetes Mellitus|Hypertension|Endothelial Dysfunction Dr. José Fernando Vilela-Martin MD PhD|Novartis|Hospital de Base July 2013 Phase 4
NCT01862263 Terminated Drug: Vildagliptin|Drug: Insulin|Drug: Placebo Type 2 Diabetes Mellitus Novartis Pharmaceuticals|Novartis May 2013 Phase 4
NCT01686932 Completed Drug: Vildagliptin|Drug: Sitagliptin Diabetes Mellitus Type 2 Novartis Pharmaceuticals|Novartis November 2012 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

DPP-4 Signaling Pathway Map

Related DPP-4 Products

Tags: buy Vildagliptin (LAF-237) | Vildagliptin (LAF-237) supplier | purchase Vildagliptin (LAF-237) | Vildagliptin (LAF-237) cost | Vildagliptin (LAF-237) manufacturer | order Vildagliptin (LAF-237) | Vildagliptin (LAF-237) distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID