Home Endocrinology & Hormones Aromatase

Aromatase

Aromatase, also called (estrogen synthase) belongs to a subfamily of Cytochrome P450 (CYP450). Aromatase is an enzyme which can transform androgens into estrogens in the central nervous system (CNS) so that aromatase can influence physiological and behavioral processes. Aromatase inhibitors can be potential drugs for breast cancer and ovarian cancer. The growth of some cancer cells depend on estrogen while aromatase inhibitors can block the synthesis of estrogen from the androgens.

Other Endocrinology & Hormones Related Inhibitors

Adrenergic Receptor Androgen Receptor Estrogen/progestogen Receptor 5-alpha Reductase RAAS Glucocorticoid Receptor ACE Mineralocorticoid Receptor PGDS Progesterone Receptor
Cat.No. Product Name Information Product Use Citations Product Validations
S1235 Letrozole Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays. It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. This compound induces autophagy.
Mol Syst Biol, 2025, 10.1038/s44320-025-00104-6
Exp Neurol, 2025, 392:115365
eNeuro, 2024, 11(8)ENEURO.0332-24.2024
Verified customer review of Letrozole
S1188 Anastrozole Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.
Mol Oncol, 2023, 10.1002/1878-0261.13541
Commun Biol, 2023, 6(1):695
Cell Discov, 2022, 8(1):40
Verified customer review of Anastrozole
S1196 Exemestane Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.
Commun Biol, 2023, 6(1):695
Front Mol Biosci, 2022, 9:981962
J Pers Med, 2022, 12(2)258
Verified customer review of Exemestane
S3784 Obacunone (AI3-37934) Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. This compound significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; it is also a novel activator of Nrf2.
Int J Mol Sci, 2023, 24(14)11484
University of Valencia, 2023,
Cell Mol Biol Lett, 2022, 27(1):29
S9519 Fadrozole (CGS16949A) Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.
iScience, 2024, 27(10):110862
Epigenetics Chromatin, 2023, 16(1):2
Drug Test Anal, 2020, 10.1002/dta.2917
S5158 alpha-Naphthoflavone Alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
S7867 Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. It exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. This compound inhibits PPARγ activity. It exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. This chemical also inhibits aromatase. It induces apoptosis. Phase 2.
Front Endocrinol (Lausanne), 2024, 15:1354435
J Med Virol, 2019, 91(8):1440-1447

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