Aromatase

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Aromatase Products

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  • Aromatase Inhibitors (9)
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Catalog No. Product Name Information Product Use Citations Product Validations
S1188 Anastrozole (ZD-1033) Anastrozole (ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00579-z
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1196 Exemestane (FCE 24304) Exemestane (FCE24304, PNU155971) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.
J Steroid Biochem Mol Biol, 2022, S0960-0760(22)00072-3
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cancers (Basel), 2021, 13(14)3586
S1235 Letrozole (CGS 20267) Letrozole (CGS 20267) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.
Horm Behav, 2022, 140:105122
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Mol Hum Reprod, 2021, 27(4)gaab013
S1672 Aminoglutethimide Aminoglutethimide (BA-16038, NSC-330915) is an aromatase inhibitor with IC50 of 10 μM.
Drug Test Anal, 2020, 10.1002/dta.2917
S2208 Formestane Formestane (CGP-32349, NSC 282175) is a second generation selective aromatase inhibitor with an IC50 of 80 nM.
S3784 Obacunone (AI3-37934) Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.
Cell Mol Biol Lett, 2022, 27(1):29
S5158 alpha-Naphthoflavone Alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
S7867 Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.
J Med Virol, 2019, 91(8):1440-1447
S9519 Fadrozole (CGS16949A) Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.
Drug Test Anal, 2020, 10.1002/dta.2917
S1188 Anastrozole (ZD-1033) Anastrozole (ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Hum Cell, 2021, 10.1007/s13577-021-00579-z
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1196 Exemestane (FCE 24304) Exemestane (FCE24304, PNU155971) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.
J Steroid Biochem Mol Biol, 2022, S0960-0760(22)00072-3
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Cancers (Basel), 2021, 13(14)3586
S1235 Letrozole (CGS 20267) Letrozole (CGS 20267) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.
Horm Behav, 2022, 140:105122
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Mol Hum Reprod, 2021, 27(4)gaab013
S1672 Aminoglutethimide Aminoglutethimide (BA-16038, NSC-330915) is an aromatase inhibitor with IC50 of 10 μM.
Drug Test Anal, 2020, 10.1002/dta.2917
S2208 Formestane Formestane (CGP-32349, NSC 282175) is a second generation selective aromatase inhibitor with an IC50 of 80 nM.
S3784 Obacunone (AI3-37934) Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.
Cell Mol Biol Lett, 2022, 27(1):29
S5158 alpha-Naphthoflavone Alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
S7867 Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.
J Med Virol, 2019, 91(8):1440-1447
S9519 Fadrozole (CGS16949A) Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes.
Drug Test Anal, 2020, 10.1002/dta.2917
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