• ERK1
  • ERK2
  • ERK5

ERK5 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1531 BIX 02189 BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. Selective ERK5, IC50: 59 nM
S7525 XMD8-92 XMD8-92 is a potent and selective dual inhibitor of big map kinase (BMK1, ERK5) and bromodomain-containing proteins (BRDs, BET) with Kd of 80 nM and 170 nM for ERK5 and BRD4(1), respectively. Selective BMK1, Kd: 80 nM
S7334 ERK5-IN-1 ERK5-IN-1 (XMD17-109) is a potent, and selective ERK5 inhibitor with IC50 of 162 nM. Selective ERK5, IC50: 162 nM
S6786 ERK5-IN-2 ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50 of 0.82 μM and 3 μM for ERK5 and ERK5 MEF2D, respectively. Selective ERK5 MEF2D, IC50: 3 μM; ERK5, IC50: 0.82 μM
S8896 BAY-885 BAY-885 is a highly potent and selective ERK5 inhibitor. Selective
S0726 XMD8-85 (ERK5-IN-1) XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. Selective