Home MAPK ERK inhibitor ERK5-IN-2

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ERK5-IN-2 ERK inhibitor

Cat.No.S6786

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50 of 0.82 μM and 3 μM for ERK5 and ERK5 MEF2D, respectively.
ERK5-IN-2 ERK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 388.19

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S678601 DMSO]78 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.44%
99.44

Chemical Information, Storage & Stability

Molecular Weight 388.19 Formula

C17H11BrFN3O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1888305-96-1 -- Storage of Stock Solutions

Synonyms N/A Smiles C1=CC(=C(C(=C1)Br)C(=O)C2=CNC(=C2)C(=O)NC3=CN=CC=C3)F

Solubility

In vitro
Batch:

DMSO : 78 mg/mL (200.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
ERK5 [1]
(Cell-free assay)
0.82 μM
ERK5 MEF2D [1]
(Cell-free assay)
3 μM
References

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