Home Metabolism -Proteases Acyltransferase DGAT1 Selective Inhibitors

DGAT1 Selective Inhibitors

  • ACAT
  • ACAT1
  • ACAT2
  • DGAT
  • DGAT1
  • DGAT2
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2674 A922500 A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. Selective human DGAT1, IC50: 7 nM; mouse DGAT1, IC50: 24 nM
S7192 PF-04620110 PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. Pan DGAT1, IC50: 19 nM
s7889 Xanthohumol Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1. Pan DGAT1, IC50: 40 μM