ACAT Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S0820 RP-64477

RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.

Selective ACAT, IC50: 180 nM; ACAT, IC50: 503 nM; ACAT, IC50: 113 nM
S2187 Avasimibe (CI-1011)

Avasimibe (CI-1011, PD-148515) inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.

Selective ACAT, IC50: 3.3 μM
S4189 Cyclandelate

Cyclandelate (BS 572) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

Selective ACAT, IC50: 80 μM