Home Metabolism Carbonic Anhydrase inhibitor Tioxolone

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Tioxolone Carbonic Anhydrase inhibitor

Cat.No.S2603

Tioxolone(Thioxolone) is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
Tioxolone Carbonic Anhydrase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 168.17

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Chemical Information, Storage & Stability

Molecular Weight 168.17 Formula

C7H4O3S

 Storage (From the date of receipt)
CAS No. 4991-65-5 Download SDF Storage of Stock Solutions

Synonyms Thioxolone Smiles C1=CC2=C(C=C1O)OC(=O)S2

Solubility

In vitro
Batch:

DMSO : 34 mg/mL (202.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 34 mg/mL

Ethanol : 34 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
CAI [1]
91 nM(Ki)
In vitro

Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. This compound is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties. The three-dimensional framework of this chemical is further stabilized by π-π interactions between the oxathiolone and benzene rings in partially overlapping molecules. [1]
In vivo

Tioxolone, a Benzoxathiol derivatives, has been used in the local therapy of psoriasis vulgaris and acne, and this compound is also reported to have anti-bacterial, anti-mycotic, and cytostatic properties. [2]
References

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