Catalog No.S2603

For research use only.

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.

Tioxolone Chemical Structure

CAS No. 4991-65-5

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Biological Activity

Description Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.
CAI [1]
91 nM(Ki)
In vitro

Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties. The three-dimensional framework of Tioxolone is further stabilized by π-π interactions between the oxathiolone and benzene rings in partially overlapping molecules. [1]

In vivo Tioxolone, a Benzoxathiol derivatives, has been used in the local therapy of psoriasis vulgaris and acne, and also reported to have anti-bacterial, anti-mycotic, and cytostatic properties. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 168.17


CAS No. 4991-65-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC2=C(C=C1O)OC(=O)S2

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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