U-104

For research use only.

Catalog No.S2866 Synonyms: MST-104, NSC 213841, SLC-0111, WBI-5111

6 publications

U-104 Chemical Structure

CAS No. 178606-66-1

U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 77 In stock
EUR 77 In stock
EUR 97 In stock
EUR 147 In stock
EUR 265 In stock
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Selleck's U-104 has been cited by 6 publications

3 Customer Reviews

  • (c-f) Effects of the CAIX inhibitor U-104 (75 μM) on cell proliferation by Pt45.P1/asTF+ cells (c, e) or Pt45.P1 cells (d, f) under advanced-stage (c, d) or early-stage conditions (e, f). At the indicated times, WST-1 uptake was measured by colorimetry. The error bars are s.e.m. * Indicates significance at P<0.05.

    Lab Invest, 2016, 96(12):1234-1245. U-104 purchased from Selleck.

    Regression coefficients from the second-order stepwise linear regression model are provided based on the data obtained from Search 2.1 (B) The results allow the least effective compounds to be eliminated. Red is used to highlighted drug contributions that do not help to inhibit cell viability, orange bars are used to indicate minimal contributions and green highlights synergistic drug interactions. The inset in B shows the linear fit of modelled data with theoretical quartiles versus standardized residuals and the corresponding R2-values for each model. Significance is indicated by asterisks, **p < 0.01 and *p < 0.05.

    Sci Rep, 2015, 5:14508. U-104 purchased from Selleck.

  • Synchronous with the decrease in CA9 expression, the TMZ + U‑104 combination substantially decreased the expression of SOX9, p-AKT and BCL‑2 in glioma cells, and increased the expression of BAX, compared to the TMZ alone group.

    Int J Oncol, 2018, 53(1):189-202. U-104 purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.
Targets
CAXII [1]
(Cell-free assay)
CAIX [1]
(Cell-free assay)
4.5 nM(Ki) 45.1 nM(Ki)
In vitro

U-104 (50  μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50  μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells. [2] U-104 possesses aromatic groups at the second nitrogen ureido group. [3]

In vivo U-104 (38 mg/kg) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg) inhibits metastases formation in the 4T1 experimental metastasis mice model. [1] U-104 (38 mg/kg) significantly delay primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (5 mg/mL, oral gavage) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells. [2]

Protocol

Animal Research:[2]
- Collapse
  • Animal Models: Balb/c mice orthotopically implanted with 4T1 cells.
  • Dosages: 5 mg/mL
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 62 mg/mL (200.43 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 309.32
Formula

C13H12FN3O3S

CAS No. 178606-66-1
Storage powder
in solvent
Synonyms MST-104, NSC 213841, SLC-0111, WBI-5111
Smiles C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03450018 Recruiting Drug: SLC-0111|Drug: Gemcitabine Injection Metastatic Pancreatic Ductal Adenocarcinoma British Columbia Cancer Agency|Welichem Biotech Inc.|Canadian Cancer Society (CCS) January 10 2019 Phase 1|Phase 2
NCT02215850 Completed Drug: SLC-0111 Solid Tumours Welichem Biotech Inc.|Ozmosis Research Inc. October 2014 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Carbonic Anhydrase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID