For research use only.
CAS No. 5086-74-8
Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.
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|Description||Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.|
Tetramisole is active at low, atoxic oral and parenteral dose levels against all adult and immature gastrointestinal and pulmonary nematodes tested in 14 different hosts.  Tetramisole (10 μg/mL) causes a sustained contraction of the isolated somatic muscles of the worm. Tetramisole reduces the resting potential of Ascaris muscle from 34 mV to 10 mV. Tetramisole causes contraction of Ascaris muscle previously depolarized with high K+ solutions.  Tetramisole (0.1 mM) augmentes the twitch responses of both the directly and indirectly stimulated muscle in cats. Tetramisole (0.1 mM) increases the twitch response of the preparation and reverses the blocking action of tubocurarine in chickens. Tetramisole (0.1 mM) produces reversible neuromuscular block and contracture of the muscle in chickens. 
|In vivo||Tetramisole (2 mg/kg, i.v.) after a delay of 20 s, produces a strong contraction of the nictitating membrane in the cat which is accompanied by a small brief fall in blood pressure followed by a sustained rise that persisted for up to 20 min. Tetramisole (2 mg/kg) elicites a greater contractile response in the membrane than in non-reserpinized cats. Tetramisole (5-10 mg/kg, i.v.) causes a sharp transient fall in blood pressure in rabbits which is partially antagonized by atropine.  Tetramisole (15 mg/kg) rises the mean faecal egg count from 3 weeks after treatment and remaines continuously higher up to 12 weeks in sheeps. |
|In vitro||Water||41 mg/mL (170.3 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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