Tetramisole HCl

For research use only.

Catalog No.S4094

Tetramisole HCl Chemical Structure

CAS No. 5086-74-8

Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.

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Biological Activity

Description Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.
In vitro

Tetramisole is active at low, atoxic oral and parenteral dose levels against all adult and immature gastrointestinal and pulmonary nematodes tested in 14 different hosts. [1] Tetramisole (10 μg/mL) causes a sustained contraction of the isolated somatic muscles of the worm. Tetramisole reduces the resting potential of Ascaris muscle from 34 mV to 10 mV. Tetramisole causes contraction of Ascaris muscle previously depolarized with high K+ solutions. [2] Tetramisole (0.1 mM) augmentes the twitch responses of both the directly and indirectly stimulated muscle in cats. Tetramisole (0.1 mM) increases the twitch response of the preparation and reverses the blocking action of tubocurarine in chickens. Tetramisole (0.1 mM) produces reversible neuromuscular block and contracture of the muscle in chickens. [3]

In vivo Tetramisole (2 mg/kg, i.v.) after a delay of 20 s, produces a strong contraction of the nictitating membrane in the cat which is accompanied by a small brief fall in blood pressure followed by a sustained rise that persisted for up to 20 min. Tetramisole (2 mg/kg) elicites a greater contractile response in the membrane than in non-reserpinized cats. Tetramisole (5-10 mg/kg, i.v.) causes a sharp transient fall in blood pressure in rabbits which is partially antagonized by atropine. [3] Tetramisole (15 mg/kg) rises the mean faecal egg count from 3 weeks after treatment and remaines continuously higher up to 12 weeks in sheeps. [4]


Solubility (25°C)

In vitro Water 41 mg/mL (170.3 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 240.75


CAS No. 5086-74-8
Storage powder
in solvent
Synonyms N/A
Smiles C1CSC2=NC(CN21)C3=CC=CC=C3.Cl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID