Tetramisole HCl

For research use only.

Catalog No.S4094

Tetramisole HCl Chemical Structure

CAS No. 5086-74-8

Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.

Purity & Quality Control

Choose Selective Parasite Inhibitors

Biological Activity

Description Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.
In vitro

Tetramisole is active at low, atoxic oral and parenteral dose levels against all adult and immature gastrointestinal and pulmonary nematodes tested in 14 different hosts. [1] Tetramisole (10 μg/mL) causes a sustained contraction of the isolated somatic muscles of the worm. Tetramisole reduces the resting potential of Ascaris muscle from 34 mV to 10 mV. Tetramisole causes contraction of Ascaris muscle previously depolarized with high K+ solutions. [2] Tetramisole (0.1 mM) augmentes the twitch responses of both the directly and indirectly stimulated muscle in cats. Tetramisole (0.1 mM) increases the twitch response of the preparation and reverses the blocking action of tubocurarine in chickens. Tetramisole (0.1 mM) produces reversible neuromuscular block and contracture of the muscle in chickens. [3]

In vivo Tetramisole (2 mg/kg, i.v.) after a delay of 20 s, produces a strong contraction of the nictitating membrane in the cat which is accompanied by a small brief fall in blood pressure followed by a sustained rise that persisted for up to 20 min. Tetramisole (2 mg/kg) elicites a greater contractile response in the membrane than in non-reserpinized cats. Tetramisole (5-10 mg/kg, i.v.) causes a sharp transient fall in blood pressure in rabbits which is partially antagonized by atropine. [3] Tetramisole (15 mg/kg) rises the mean faecal egg count from 3 weeks after treatment and remaines continuously higher up to 12 weeks in sheeps. [4]

Protocol

Solubility (25°C)

In vitro Water 41 mg/mL (170.3 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 240.75
Formula

C11H12N2S.HCl

CAS No. 5086-74-8
Storage powder
in solvent
Synonyms N/A
Smiles C1CSC2=NC(CN21)C3=CC=CC=C3.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Tetramisole HCl | Tetramisole HCl ic50 | Tetramisole HCl price | Tetramisole HCl cost | Tetramisole HCl solubility dmso | Tetramisole HCl purchase | Tetramisole HCl manufacturer | Tetramisole HCl research buy | Tetramisole HCl order | Tetramisole HCl mouse | Tetramisole HCl chemical structure | Tetramisole HCl mw | Tetramisole HCl molecular weight | Tetramisole HCl datasheet | Tetramisole HCl supplier | Tetramisole HCl in vitro | Tetramisole HCl cell line | Tetramisole HCl concentration | Tetramisole HCl nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID