Diminazene Aceturate

Catalog No.S4104

Diminazene Aceturate Chemical Structure

Molecular Weight(MW): 515.52

Diminazene is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.

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Biological Activity

Description Diminazene is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent.
In vitro

Diminazene is capable of inhibiting the P2 transporter activity and this activity is lost in one diminazene-adapted trypanosome line, this does not formally prove that TbAT1 transports diminazene, nor does it establish whether transporter in addition to P2 could be involved in diminazene uptake. Diminazene is rapidly accumulated through a single transporter in T. brucei brucei 427 with Km value of 0.45 μM. [3H]Diminazene transport is also potently inhibited by pentamidine and adenosine, with Ki values of 0.21 μM and 0.25 μM, respectively. [3H]diminazene (2.5 μM) is clearly accumulated by yeast cells expressing TbAT1, with a rate of 0.0083 pmol/107 cell/s, and this process is completely inhibited by the presence of 1 mM unlabeled diminazene aceturate. [1]

In vivo Diminazene aceturate (3.5 mg/kg) appeares to be effective in the first treatment of horses and mules infected with T. evansi, parasites are cleared from the peripheral blood of horses on days 1 and 7 and mules on days 1 and 14. [2] Diminazene aceturate (DA) (7 mg/kg, i.m.) effectively clears the parasites from the blood of the infected treated dogs. [3]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (193.97 mM)
DMSO 19 mg/mL (36.85 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 515.52
Formula

C14H15N7.2C4H7NO3

CAS No. 908-54-3
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID