SZL P1-41

Catalog No.S9724 Batch:S972401

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Technical Data

Formula

C24H24N2O3S

Molecular Weight 420.52 CAS No. 222716-34-9
Solubility (25°C)* In vitro DMSO 5 mg/mL (11.89 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells.
Targets
Skp2 [1]
In vitro

SZL P1-41 indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells.[1]

In vivo

SZL P1-41 also exhibits potent anti-tumor activity in animal studies.[1]

Protocol (from reference)

Cell Assay:

[1]

  • Cell lines

    PC3 cells

  • Concentrations

    10 μM, 20 μM

  • Incubation Time

    4 days

  • Method

    For Skp2 inhibitor administration, 5~10 × 103 of cells are seeded in 12 wells in triplicate for 24 h and then treated with various doses of SZL P1-41 (refreshed every two days). After four days, cells are harvested, stained with 0.4% blue solution, and viable cells are counted using hemocytometer under microscope by blue dye exclusion method. For treatment, 8× 103 of PC3 cells with were seeded in 12 wells in triplicate for 24 h and then treated with various doses of SZL P1-41 for four and three days, respectively (refreshed every two days).

Animal Study:

[1]

  • Animal Models

    nude mice bearing A549 xenograft tumors, nude mice bearing PC3 xenograft tumors

  • Dosages

    80 mg/kg, 40 mg/kg

  • Administration

    IP

Selleck's SZL P1-41 has been cited by 2 publications

Gastrodin overcomes chemoresistance via inhibiting Skp2-mediated glycolysis [ Cell Death Discov, 2023, 9(1):364] PubMed: 37779163
Gastrodin overcomes chemoresistance via inhibiting Skp2-mediated glycolysis [ Cell Death Discov, 2023, 9(1):364] PubMed: 37779163

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.