PF-562271

Name: PF-562271
Brand: Selleck Chemicals
SKU: S2890
Rating: 5 (67 reviews)

For research use only. Not for use in humans.

Catalog No.S2890

67 publications

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

Selleck's PF-562271 has been cited by 67 publications

Cancer Cell, 2019, 36(2):179-193

PubMed: 31378681 ( click the link to review the publication )

Cell, 2019, 36(2):179-193

PubMed: 28162770 ( click the link to review the publication )

Clin Cancer Res, 2019, 25(14):4552-4566

PubMed: 30979745 ( click the link to review the publication )

Sci Signal, 2019, 12(565)

PubMed: 30670633 ( click the link to review the publication )

Cell Death Dis, 2019, 10(10):738

PubMed: 31570694 ( click the link to review the publication )

J Biol Chem, 2019, 294(18):7221-7230

PubMed: 30846565 ( click the link to review the publication )

J Tissue Eng Regen Med, 2019, 13(4):625-636

PubMed: 30770650 ( click the link to review the publication )

J Cancer Res Clin Oncol, 2019, 145(6):1461-1469

PubMed: 31006845 ( click the link to review the publication )

Molecules, 2019, 24(10)

PubMed: 31109130 ( click the link to review the publication )

J Pharm Biomed Anal, 2019, 168:163-173

PubMed: 30807921 ( click the link to review the publication )

Mol Med Rep, 2019, 19(6):4753-4760

PubMed: 31059085 ( click the link to review the publication )

Zygote, 2019, 27(3):173-179

PubMed: 31171046 ( click the link to review the publication )

Cell Rep, 2018, 22(10):2784-2796

PubMed: 29514104 ( click the link to review the publication )

Oncogene, 2018, 37(22):2953-2966

PubMed: 29515233 ( click the link to review the publication )

Oncogene, 2018, 37(23):3166-3182

PubMed: 29545604 ( click the link to review the publication )

Cell Death Dis, 2018, 9(9):848

PubMed: 30154481 ( click the link to review the publication )

Cancer Sci, 2018, 109(12):3783-3793

PubMed: 30281878 ( click the link to review the publication )

J Am Heart Assoc, 2018, 7(18):e008604

PubMed: 30371220 ( click the link to review the publication )

J Cell Sci, 2018, 131(10)

PubMed: 29678906 ( click the link to review the publication )

Stem Cells Int, 2018, 2018:2190657

PubMed: 30275837 ( click the link to review the publication )

Int J Oncol, 2018, 53(4):1544-1556

PubMed: 30066854 ( click the link to review the publication )

Acta Pharmacol Sin, 2018, 10.1038/aps

PubMed: 29417941 ( click the link to review the publication )

Cell Cycle, 2018, 17(23):2577-2592

PubMed: 30488756 ( click the link to review the publication )

Oncol Rep, 2018, 40(4):2325-2333

PubMed: 30106432 ( click the link to review the publication )
Cancer Epidemiol Biomarkers Prev, 2018, 27(7):805-813

PubMed: 29654156 ( click the link to review the publication )

Sci Transl Med, 2017, 9(420)

PubMed: 29237758 ( click the link to review the publication )

Nat Commun, 2017, 8:14122

PubMed: 28098159 ( click the link to review the publication )

Mol Syst Biol, 2017, 13(1):905

PubMed: 28069687 ( click the link to review the publication )

Cancer Sci, 2017, 108(7):1347-1356

PubMed: 28406574 ( click the link to review the publication )

FEBS J, 2017, 284(17):2856-2869

PubMed: 28665039 ( click the link to review the publication )

Sci Rep, 2017, 7(1):4032

PubMed: 28642549 ( click the link to review the publication )

Mol Carcinog, 2017, 56(12):2558-2565

PubMed: 28667800 ( click the link to review the publication )

Cancer Manag Res, 2017, 9:879-889

PubMed: 29276408 ( click the link to review the publication )

Cell Signal, 2017, 38:1-9

PubMed: 28647573 ( click the link to review the publication )

Oncol Rep, 2017, 38(1):63-70

PubMed: 28560386 ( click the link to review the publication )

Onco Targets Ther, 2017, 10:5817-5826

PubMed: 29263678 ( click the link to review the publication )

Evid Based Complement Alternat Med, 2017, 2017:4535326

PubMed: 29234400 ( click the link to review the publication )

Mol Med Rep, 2017, 16(6):8937-8943

PubMed: 28990104 ( click the link to review the publication )

Oncotarget, 2017, 8(43):75102-75113

PubMed: 29088849 ( click the link to review the publication )

Biophys J, 2017, 113(7):1585-1598

PubMed: 28844472 ( click the link to review the publication )

Nat Cell Biol, 2016, 18(2):168-80

PubMed: 26689676 ( click the link to review the publication )

Nat Commun, 2016, 7:10354

PubMed: 26838601 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(23):5851-5863

PubMed: 27220963 ( click the link to review the publication )

Cancer Lett, 2016, 376(1):188-96

PubMed: 26996299 ( click the link to review the publication )

Breast Cancer Res, 2016, 18(1):81

PubMed: 27495308 ( click the link to review the publication )

Oral Oncology, 2016, 10.1016/j.oraloncology.2016.05.010

PubMed: ( click the link to review the publication )

Sci Rep, 2016, 6:36214

PubMed: 27796369 ( click the link to review the publication )

J Biol Chem, 2016, 291(15):8140-9

PubMed: 26865633 ( click the link to review the publication )
Mol Pharmacol, 2016, 89(5):521-40

PubMed: 26895766 ( click the link to review the publication )

J Proteome Res, 2016, 15(12):4369-4386

PubMed: 27762562 ( click the link to review the publication )

Int J Biochem Cell Biol, 2016, 71:62-71

PubMed: 26693891 ( click the link to review the publication )

Oncotarget, 2016, 7(30):48093-48106

PubMed: 27344177 ( click the link to review the publication )

Sci Rep, 2016, 6:19261

PubMed: 26763933 ( click the link to review the publication )

Oncotarget, 2016, 7(29):45186-45198

PubMed: 27286256 ( click the link to review the publication )

Nat Cell Biol, 2015, 17(11):1412-21

PubMed: 26436690 ( click the link to review the publication )

Elife, 2015, 4

PubMed: 26274564 ( click the link to review the publication )

Oncogene, 2015, 34(40):5114-27

PubMed: 25639872 ( click the link to review the publication )

Cell Physiol Biochem, 2015, 37(2):515-26

PubMed: 26330161 ( click the link to review the publication )

J Biol Chem, 2015, 290(14):8677-92

PubMed: 25713079 ( click the link to review the publication )

Environ Toxicol Pharmacol, 2015, 39(1):114-24

PubMed: 25481308 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2015, 112(20):E2595-601

PubMed: 25941386 ( click the link to review the publication )

Oncotarget, 2015, 6(28):25755-69

PubMed: 26342198 ( click the link to review the publication )

Oncotarget, 2015, 6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Environ Toxicol Pharm, 2014, 39(1):114-124

PubMed: 25481308 ( click the link to review the publication )

PLoS One, 2014, 9(2):e88587

PubMed: 24523919 ( click the link to review the publication )

Cancer Sci, 2013, 104(12):1618-25

PubMed: 24112719 ( click the link to review the publication )

Int J Clin Exp Pathol, 2013, 6(10):2082-91

PubMed: 24133586 ( click the link to review the publication )

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description

Targets

FAK ^[1] (Cell-free assay)	PYK2 ^[1] (Cell-free assay)	CDK2/CyclinE ^[1] (Cell-free assay)	CDK3/CyclinE ^[1] (Cell-free assay)	CDK1/CyclinB ^[1] (Cell-free assay)	View More
1.5 nM	13 nM	30 nM	47 nM	58 nM	View More

In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. ^[1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. ^[2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
MV-4-11	NEDiS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mki3TWM2OD1yLkK3OlYh\|ryP	MVHTRW5ITVJ?
SW982	M2fXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1\zcmlEPTB;MD6zNlgzKM7:TR?=	NETWTGxUSU6JRWK=
KM12	NEG3NINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH7VSnBKSzVyPUCuN\|g2PTdizszN	MXLTRW5ITVJ?
COLO-205	M17nXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmK2TWM2OD1yLkS4OlU5KM7:TR?=	NYnYOmZGW0GQR1XS
COLO-829	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mm\HTWM2OD1yLke1NVc3KM7:TR?=	NWrTV4ttW0GQR1XS
MG-63	NVXS[Is4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnX2TWM2OD1yLkiwOlM4KM7:TR?=	NVnhNnVkW0GQR1XS
IGROV-1	M{HuPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTBwOEGwN\|gh\|ryP	MojaV2FPT0WU
NCI-H650	NHm4TGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTBwOEOxOVQh\|ryP	Mm\3V2FPT0WU
RT-112	NYfHVYUzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fUfWlEPTB;MD65PFQ3KM7:TR?=	Mn7RV2FPT0WU
BCPAP	NUnSbYx2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEf0eJpKSzVyPUGuNFEzQDhizszN	MUDTRW5ITVJ?
ALL-PO	MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkDlTWM2OD1zLkCxOVg1KM7:TR?=	Mn\yV2FPT0WU
KYSE-270	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1L5W2lEPTB;MT6wOFcyPCEQvF2=	MXfTRW5ITVJ?
8305C	NFvO[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmjvTWM2OD1zLkC5PVA1KM7:TR?=	NGHrW4NUSU6JRWK=
NCI-H810	NXzGTJRIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGfHcmtKSzVyPUGuNVA4PzZizszN	Mn7wV2FPT0WU
CAL-33	M2nGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTFwMUK5N\|gh\|ryP	M2rUPHNCVkeHUh?=
AN3-CA	MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M176SWlEPTB;MT6yNVg3PyEQvF2=	NXPwZ\|BzW0GQR1XS
NKM-1	NXuxVGk{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4H2VGlEPTB;MT6yO\|UxPiEQvF2=	M2nIb3NCVkeHUh?=
BPH-1	M3jUWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlmwTWM2OD1zLkK4O\|Y3KM7:TR?=	NVP2RZR2W0GQR1XS
MES-SA	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVT0S5E2UUN3ME2xMlMxPjh{IN88US=>	Ml;TV2FPT0WU
CAL-62	NXSxOmxlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUf3XoZzUUN3ME2xMlMyQTB7IN88US=>	NVnacWtIW0GQR1XS
Detroit562	NHvlelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmXGTWM2OD1zLkO1NlIzKM7:TR?=	MYrTRW5ITVJ?
KYSE-150	NWH6b5JzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTFwM{WyN\|Yh\|ryP	MWTTRW5ITVJ?
SK-UT-1	M1Hyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTFwNES2OFch\|ryP	Ml7nV2FPT0WU
HUTU-80	M4Lofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYTpc\|NMUUN3ME2xMlQ1QDh4IN88US=>	NGTk[VFUSU6JRWK=
SIG-M5	NVjySndXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3zBb2lEPTB;MT60PFM5PyEQvF2=	NXPoeWd[W0GQR1XS
AGS	NGjPO29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHK1WZJKSzVyPUGuOVIyOjRizszN	MmLsV2FPT0WU
ST486	Mo\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XnNWlEPTB;MT61N\|I4QCEQvF2=	M3i1cnNCVkeHUh?=
HSC-2	MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVL6PXBkUUN3ME2xMlU{QTVizszN	NXPyOpd4W0GQR1XS
LCLC-103H	M1i5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkS0TWM2OD1zLkW1PFE5KM7:TR?=	M1XBT3NCVkeHUh?=
BC-1	NHTYO\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTFwNkG2OlQh\|ryP	NH:5eo5USU6JRWK=
CGTH-W-1	Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHITWM2OD1zLk[xOlc6KM7:TR?=	M33wN3NCVkeHUh?=
MZ1-PC	NVr6XHFzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4fWTmlEPTB;MT62NlMyOiEQvF2=	MmTSV2FPT0WU
SW1710	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF31VpBKSzVyPUGuOlI3OjhizszN	MUHTRW5ITVJ?
EW-13	Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYKxSFZ1UUN3ME2xMlY{PDZ4IN88US=>	MmDoV2FPT0WU
TE-11	M3LmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MY\JR\|UxRTFwNkO1NlIh\|ryP	MYTTRW5ITVJ?
BHY	Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXrcIlKSzVyPUGuOlU3PjNizszN	NEDDPFZUSU6JRWK=
ML-2	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NInmR\|FKSzVyPUGuOlY5ODJizszN	Mlm4V2FPT0WU
MEL-JUSO	NHmxRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWPvNlYzUUN3ME2xMlczQDlzIN88US=>	NXLRXGxkW0GQR1XS
U251	MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHnDV2dKSzVyPUGuO\|QxOzFizszN	NGjueXNUSU6JRWK=
MHH-ES-1	NXjhb\|NiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTFwN{m1Olgh\|ryP	NXP2TGJ3W0GQR1XS
CAL-85-1	NGPqeWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUPIT4l1UUN3ME2xMlgxPDlizszN	MV;TRW5ITVJ?
D-336MG	MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmXUTWM2OD1zLki1OlE1KM7:TR?=	NXrpeINEW0GQR1XS
VA-ES-BJ	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVfpNItHUUN3ME2xMlkxOzF3IN88US=>	MoP3V2FPT0WU
MDA-MB-468	M33wO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jUNWlEPTB;MT65NVI4OiEQvF2=	Mkj6V2FPT0WU
MEL-HO	NYi4fIpiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1uzV2lEPTB;MT65O\|k6OyEQvF2=	MVLTRW5ITVJ?
SW954	MmHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEfQOW9KSzVyPUKuNFAyPTFizszN	MXfTRW5ITVJ?
LB831-BLC	M2X4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLKTFlrUUN3ME2yMlAxQTh6IN88US=>	NHfxWmZUSU6JRWK=
EW-16	NVzpe5lDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3TGW2lEPTB;Mj6wN\|k5OyEQvF2=	NF7wTnpUSU6JRWK=
NCI-H460	NYrvfZljT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzQdHdKSzVyPUKuNFQ5OzlizszN	MU\TRW5ITVJ?
CHP-212	NGTUd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGPoVGhKSzVyPUKuNFk2OzlizszN	MVHTRW5ITVJ?
MHH-NB-11	NV7CTG83T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLVW2tRUUN3ME2yMlEzQDF6IN88US=>	NV25OHZ4W0GQR1XS
DU-4475	MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml3RTWM2OD1{LkG0O\|U6KM7:TR?=	MUPTRW5ITVJ?
ABC-1	M3LUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3zacGlEPTB;Mj6yOVE6PiEQvF2=	MWfTRW5ITVJ?
LOUCY	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH;oVIVKSzVyPUKuNlYyOjhizszN	NICyTXpUSU6JRWK=
LC-2-ad	Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmjsTWM2OD1{LkK2PVY3KM7:TR?=	M1\GXHNCVkeHUh?=
ETK-1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTJwMki0OkDPxE1?	NGruUpZUSU6JRWK=
KYSE-180	NGX0UW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;NVVBLUUN3ME2yMlI5QDd2IN88US=>	M2TTWnNCVkeHUh?=
HOP-92	NWKyT282T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWPJR\|UxRTJwM{C2O\|Mh\|ryP	Mn\OV2FPT0WU
RCC10RGB	MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3jvNGlEPTB;Mj6zNlUxPyEQvF2=	NUn0PWtuW0GQR1XS
KASUMI-1	M2\0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV3vN2d6UUN3ME2yMlMzQDhizszN	MWLTRW5ITVJ?
ACN	NWTJd5oyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1Hke2lEPTB;Mj6zOFc1PSEQvF2=	MW\TRW5ITVJ?
BxPC-3	M{[xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYS2d4RbUUN3ME2yMlM2PDN4IN88US=>	MULTRW5ITVJ?
MONO-MAC-6	MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1vIT2lEPTB;Mj60NVI1QCEQvF2=	M{\4RnNCVkeHUh?=
CAL-39	NXH1U3E{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{D4VmlEPTB;Mj60NVYzQCEQvF2=	NF62NlBUSU6JRWK=
CMK	NFHYNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3LaXWlEPTB;Mj60NVc6PSEQvF2=	MoraV2FPT0WU
MFE-296	NU[zOZY2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LuXGlEPTB;Mj60O\|c6OiEQvF2=	NE\zbYNUSU6JRWK=
DU-145	NYXXTHE2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIjiOZBKSzVyPUKuOFkyOThizszN	MXvTRW5ITVJ?
MDA-MB-231	MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVrXe4pZUUN3ME2yMlQ6PTd{IN88US=>	MV3TRW5ITVJ?
EFO-27	NXfDc3d{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mm\PTWM2OD1{LkWxPFg5KM7:TR?=	NH[0TFBUSU6JRWK=
SNU-387	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWfoWZhkUUN3ME2yMlUzQDJizszN	MmfNV2FPT0WU
KYSE-410	NH\KXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{jFNWlEPTB;Mj61OlUyPyEQvF2=	NH3VdZdUSU6JRWK=
NCCIT	M3LkTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1nQSGlEPTB;Mj61O\|I1KM7:TR?=	MnjxV2FPT0WU
LXF-289	M4LQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoTETWM2OD1{LkW4Nlc{KM7:TR?=	MW\TRW5ITVJ?
HMV-II	M1TqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFTCWWxKSzVyPUKuOVg6QTdizszN	MlzlV2FPT0WU
MOLT-4	M2DBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYjPd2lKUUN3ME2yMlYxPzF{IN88US=>	Ml3DV2FPT0WU
KOSC-2	NVfkPXg6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHPnXoZKSzVyPUKuOlM5PzlizszN	MUTTRW5ITVJ?
TUR	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlfrTWM2OD1{Lk[1N\|Y6KM7:TR?=	MmHoV2FPT0WU
NCI-H2087	NFznd5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUTRV3B3UUN3ME2yMlcyPjR4IN88US=>	NYLvTVVQW0GQR1XS
SCC-15	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF3LUnJKSzVyPUKuO\|UzPTJizszN	MVrTRW5ITVJ?
HSC-4	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUjDPHBxUUN3ME2yMlc5Ozh7IN88US=>	Mn[3V2FPT0WU
G-402	MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MojETWM2OD1{LkixOFQ4KM7:TR?=	Mn7yV2FPT0WU
GP5d	M1jRSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWnufW5NUUN3ME2yMlg{QDJ5IN88US=>	NYHz[5hzW0GQR1XS
IGR-1	NEDCfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NW\hfFI4UUN3ME2yMlg{QTh5IN88US=>	MYfTRW5ITVJ?
SK-PN-DW	M4rxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkPMTWM2OD1{Lki2NlA1KM7:TR?=	NIfyZZlUSU6JRWK=
OPM-2	MkfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmO0TWM2OD1{Lki5PVc5KM7:TR?=	M4rTWXNCVkeHUh?=
5637	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGHrTHFKSzVyPUKuPVI1OzlizszN	NX7VXlJ6W0GQR1XS
NCI-H2030	NHjwS2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkSzTWM2OD1{Lkm4NFI6KM7:TR?=	NWToWVBVW0GQR1XS
SK-LU-1	Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXjRfWt1UUN3ME2yMlk5OzN2IN88US=>	MlL4V2FPT0WU
EW-18	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWfjVmtvUUN3ME2zMlA2OzJizszN	M3y3W3NCVkeHUh?=
786-0	NUfWNYpRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWDiN5ZXUUN3ME2zMlA2Pzh2IN88US=>	MnHuV2FPT0WU
NCI-H1963	NFzYUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MULJR\|UxRTNwMEi4NlUh\|ryP	MXHTRW5ITVJ?
A2780	NX71RZdUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DJOGlEPTB;Mz6xNFM1OSEQvF2=	NYDodZZLW0GQR1XS
NCI-H526	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NG\CcnlKSzVyPUOuNVM6PjFizszN	NHn5fHFUSU6JRWK=
BHT-101	NIfRZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUTvVpRRUUN3ME2zMlE2Pzl6IN88US=>	MYnTRW5ITVJ?
RPMI-7951	NXHPbFRiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlXGTWM2OD1\|LkKwNVM4KM7:TR?=	NUTMRplFW0GQR1XS
HL-60	Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTNwMkGxOEDPxE1?	M3L1OnNCVkeHUh?=
CTV-1	MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mlv4TWM2OD1\|LkK1N\|c4KM7:TR?=	NWP0cWZNW0GQR1XS
IST-SL1	NIXzT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnHiTWM2OD1\|LkK5OFY2KM7:TR?=	NX7Db5dIW0GQR1XS
G-401	NVOzSIdrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHziOodKSzVyPUOuNlk5ODhizszN	NVrVcYN7W0GQR1XS
OVCAR-5	M1zMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoK4TWM2OD1\|LkO2N\|UzKM7:TR?=	Mk\YV2FPT0WU
EW-1	Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnPhTWM2OD1\|LkSwOVQ1KM7:TR?=	MnnwV2FPT0WU
H4	NXLRcHNVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTNwNEe1Olkh\|ryP	MVTTRW5ITVJ?
EM-2	NIrLUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHzrNY9KSzVyPUOuOFg3PzRizszN	NILZXYpUSU6JRWK=
RS4-11	NIj6[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWXhZpl3UUN3ME2zMlQ5PzF3IN88US=>	NHPDS2VUSU6JRWK=
NOMO-1	NFHESWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1zQNmlEPTB;Mz60PVIxPCEQvF2=	NVr5WJlNW0GQR1XS
HCT-116	NFvV[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7MTWM2OD1\|LkWwO\|EyKM7:TR?=	Mk\kV2FPT0WU
CAL-120	NUPz[YpYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo[5TWM2OD1\|LkW3N\|Uh\|ryP	NWPLbow5W0GQR1XS
CAL-51	M2j4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXyxTnB3UUN3ME2zMlU4PjF{IN88US=>	NXTPfZQ4W0GQR1XS
RVH-421	MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYrJR\|UxRTNwNkCzNVEh\|ryP	M3n5W3NCVkeHUh?=
NCI-H2081	MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTNwNkWyPFgh\|ryP	NFn0dXJUSU6JRWK=
SBC-5	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVrRWZNCUUN3ME2zMlY4QDh{IN88US=>	NH\6TYFUSU6JRWK=
RL95-2	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWXmUIZmUUN3ME2zMlcyQDZ2IN88US=>	MkDvV2FPT0WU
SW872	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1nuc2lEPTB;Mz63Olk2QCEQvF2=	M{L5SHNCVkeHUh?=
VM-CUB-1	NX;QTYp5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3LaNWlEPTB;Mz63O\|UyKM7:TR?=	M4LmOXNCVkeHUh?=
SUP-T1	NUKxb4g3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUDJR\|UxRTNwN{izNkDPxE1?	NHS4WG5USU6JRWK=
697	NU\HTXRDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmrOTWM2OD1\|LkixOlU4KM7:TR?=	MkK3V2FPT0WU
DBTRG-05MG	MoP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYDMN4w2UUN3ME2zMlgyPjd4IN88US=>	NInGPFhUSU6JRWK=
TE-441-T	NV3Bb3RoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MY\JR\|UxRTNwOEK5N{DPxE1?	M4TUfnNCVkeHUh?=
A204	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2i3NmlEPTB;Mz65NFk2PiEQvF2=	MlnGV2FPT0WU
HCC2998	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3fI[GlEPTB;Mz65OFg1OyEQvF2=	NGXWNGlUSU6JRWK=
SCC-4	NWrM[mpyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoDHTWM2OD1\|Lkm1O\|gzKM7:TR?=	M{D1c3NCVkeHUh?=
ACHN	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVXw[\|JPUUN3ME20MlAzOzdizszN	MWXTRW5ITVJ?
NB1	M332fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX7JR\|UxRTRwME[2OFQh\|ryP	NG\jVVVUSU6JRWK=
PANC-08-13	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDJTWM2OD12LkC3O\|Mh\|ryP	NEnUfmRUSU6JRWK=
A4-Fuk	M2q4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWLrRWZXUUN3ME20MlA4QDZzIN88US=>	NVj5PW1zW0GQR1XS
NCI-H747	MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1rtXWlEPTB;ND6wPFY4PCEQvF2=	NFjVRnhUSU6JRWK=
G-361	NVzvV4tXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{TpVmlEPTB;ND6wPVA3KM7:TR?=	M2PPfnNCVkeHUh?=
NCI-H292	NXvmPZk{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYO2VnRjUUN3ME20MlA6PDJ7IN88US=>	NYLsc21mW0GQR1XS
HGC-27	NXOyTWo4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NE\qWFFKSzVyPUSuNFk2PDlizszN	MX;TRW5ITVJ?
ATN-1	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVzWUnNxUUN3ME20MlExPzd5IN88US=>	M2DsSnNCVkeHUh?=
RPMI-2650	M4XKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWDJR\|UxRTRwMUK5O\|Uh\|ryP	MnK0V2FPT0WU
SIMA	M3ewWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkKzTWM2OD12LkG0OEDPxE1?	Mk\zV2FPT0WU
CA46	M3roRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{K4emlEPTB;ND6xOlExPCEQvF2=	NYHR[o5qW0GQR1XS
CHL-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYrJR\|UxRTRwMUi5OlEh\|ryP	NEPrVJhUSU6JRWK=
TE-10	NHTNWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7QTWM2OD12LkKyPFg4KM7:TR?=	NUjQfXBPW0GQR1XS
NCI-H1734	M2TN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLGbWh{UUN3ME20MlI3Pjl3IN88US=>	NIT4dm9USU6JRWK=
DV-90	NEP3Zo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXXJR\|UxRTRwMkmzPVch\|ryP	M1r4RnNCVkeHUh?=
MOLT-16	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml7jTWM2OD12LkOxNFE3KM7:TR?=	NHvXfHVUSU6JRWK=
HuCCT1	NGnsW3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX\HRYx[UUN3ME20MlM{PzJ\|IN88US=>	NV62PWZZW0GQR1XS
A3-KAW	NFrTZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTOTWM2OD12LkO1OVUzKM7:TR?=	M1\z[XNCVkeHUh?=
HOS	NFHBfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkPoTWM2OD12LkO4OVY4KM7:TR?=	NFLoTWFUSU6JRWK=
KS-1	M3fvfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUCzcW1lUUN3ME20MlQzPDV7IN88US=>	M2fGOnNCVkeHUh?=
SNU-423	NETmbHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV\QbJVoUUN3ME20MlQzPjh3IN88US=>	MnLHV2FPT0WU
BC-3	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWjQRo1nUUN3ME20MlQ{PDd5IN88US=>	NULR[lNmW0GQR1XS
SCC-9	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYXUO3B7UUN3ME20MlQ1Ojl7IN88US=>	MX;TRW5ITVJ?
C8166	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M13tOGlEPTB;ND60O\|c2OyEQvF2=	M2PRdnNCVkeHUh?=
NCI-H358	Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2r2VWlEPTB;ND60PFU{OiEQvF2=	NVfMWWN6W0GQR1XS
GT3TKB	NIjybFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIW3fZBKSzVyPUSuOFg5OjJizszN	NUHibotQW0GQR1XS
NCI-SNU-1	NXnXUmlUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXHJR\|UxRTRwNEm3NFEh\|ryP	NVzkbXNZW0GQR1XS
Ca9-22	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1LyPWlEPTB;ND61OVUyPiEQvF2=	M1KzN3NCVkeHUh?=
L-363	NIXHVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHjjUZJKSzVyPUSuOVU6QTZizszN	NGPJO3dUSU6JRWK=
Calu-1	NWnLPIFUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4W3XWlEPTB;ND61PFcxPyEQvF2=	NHfFcY9USU6JRWK=
OE19	NIPkT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXezXpI5UUN3ME20MlY{OTR3IN88US=>	Mm\DV2FPT0WU
COR-L23	NVrxUlN1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{PubmlEPTB;ND62O\|I5KM7:TR?=	M{LpVXNCVkeHUh?=
A431	NWXzSGtLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnfUTWM2OD12Lk[4NlI5KM7:TR?=	MWrTRW5ITVJ?
MKN1	M{fiN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2GxU2lEPTB;ND63NFY3PSEQvF2=	MVrTRW5ITVJ?
SH-4	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTRwN{K2N\|Mh\|ryP	NVTEVWt5W0GQR1XS
SNB75	MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEXNSmlKSzVyPUSuO\|Q3PiEQvF2=	MXjTRW5ITVJ?
SW780	NFH4cIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWPBR4RKUUN3ME20Mlc3QDR7IN88US=>	NX3P[mQyW0GQR1XS
GOTO	NEjjUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUjvS4lJUUN3ME20Mlc6Ojl\|IN88US=>	MYjTRW5ITVJ?
U-266	NWi5c5RjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3:yfWlEPTB;ND65OFkyQSEQvF2=	MmfCV2FPT0WU
KURAMOCHI	Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTVwMEK4N\|Qh\|ryP	MmTqV2FPT0WU
NMC-G1	M3\Qfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIfOOYhKSzVyPUWuNFkyOzlizszN	NYDScIdCW0GQR1XS
COLO-684	NVPDSWh[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlXYTWM2OD13LkK1N\|cyKM7:TR?=	Moi5V2FPT0WU
NTERA-S-cl-D1	M1rPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoLxTWM2OD13LkK5NlE5KM7:TR?=	NIHCWmZUSU6JRWK=
RD	NXfNcWI6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmK0TWM2OD13LkK5O\|cyKM7:TR?=	NHnQN\|dUSU6JRWK=
A2058	M4DT[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlzyTWM2OD13LkOwOFM5KM7:TR?=	NF7DTIpUSU6JRWK=
NCI-H2009	MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFS1PZJKSzVyPUWuN\|A2OzhizszN	MkDNV2FPT0WU
8-MG-BA	Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVPJSmRvUUN3ME21MlM4ODd5IN88US=>	NGTZSFdUSU6JRWK=
LC4-1	NE\2d25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTVwM{mzNFMh\|ryP	NIHo[WJUSU6JRWK=
A101D	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVT4Rm9pUUN3ME21MlM6Pjh7IN88US=>	MnTUV2FPT0WU
ES8	NUPjTI5qT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFzvZ3RKSzVyPUWuOFE1ODlizszN	M33NXXNCVkeHUh?=
SF126	M3zrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofITWM2OD13LkSxOFY2KM7:TR?=	NGSw[FFUSU6JRWK=
GDM-1	NV\0UXp6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2fGOGlEPTB;NT60NVc5OSEQvF2=	MmfyV2FPT0WU
TE-6	NGr1cINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn;ETWM2OD13LkS0OVY6KM7:TR?=	MWrTRW5ITVJ?
SR	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn7pTWM2OD13LkWzOlQ2KM7:TR?=	NVjndYJqW0GQR1XS
HOP-62	M3O4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1W5eGlEPTB;NT61Olg5PyEQvF2=	NHyzNmlUSU6JRWK=
HCC2157	M{jjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlXZTWM2OD13LkW2PFk3KM7:TR?=	NIXMbIlUSU6JRWK=
TE-15	NEfWN\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGLzd3dKSzVyPUWuOVc4PzlizszN	MnjlV2FPT0WU
BFTC-905	NXnDUpdCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIXSPVJKSzVyPUWuOlA1OjFizszN	NVP3NlhXW0GQR1XS
TE-9	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH65S3dKSzVyPUWuOlE4QDhizszN	NHPifohUSU6JRWK=
647-V	M4LKW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1fT[WlEPTB;NT62NlA1OiEQvF2=	M4rhcHNCVkeHUh?=
KG-1	NHXU[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1fKN2lEPTB;NT63OFAxPSEQvF2=	MXTTRW5ITVJ?
KYSE-510	MmjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlfqTWM2OD13Lke5OVgyKM7:TR?=	NWj5Top1W0GQR1XS
SK-MES-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTVwOEW4PVEh\|ryP	NEPjNJFUSU6JRWK=
OVCAR-3	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTVwOEiyNFYh\|ryP	MX;TRW5ITVJ?
LB1047-RCC	NH7sZ3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUm5clBFUUN3ME21MlkxOTR6IN88US=>	MkfRV2FPT0WU
HEL	M1rKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFjONoJKSzVyPU[uNFIyQDhizszN	NGTZVJlUSU6JRWK=
KARPAS-45	NX7lOFlFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4f5bWlEPTB;Nj6wN\|c5PyEQvF2=	M4\sfnNCVkeHUh?=
NCI-H1304	Mn;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYjJR\|UxRTZwMUK0PVch\|ryP	MVPTRW5ITVJ?
PC-3	MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTZwMUOwO\|Ih\|ryP	NV\FZoVSW0GQR1XS
Calu-3	MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFvxfopKSzVyPU[uNVQ3QDlizszN	Mnv5V2FPT0WU
NCI-H1648	MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV3JR\|UxRTZwMUWxOkDPxE1?	MmXzV2FPT0WU
HSC-3	NWDiXlJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHPOb2pKSzVyPU[uNVc{QTZizszN	M3HGdHNCVkeHUh?=
COLO-824	MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTZwMke4Olgh\|ryP	M{DCUnNCVkeHUh?=
COLO-680N	NXf2Xnd4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlLDTWM2OD14LkO3OlM5KM7:TR?=	MmTQV2FPT0WU
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LU-134-A	NX2yVYtST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{TsSmlEPTB;MUKuPVMh\|ryP	NEXGfm1USU6JRWK=
HT	NYTI[5dLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXzJR\|UxRTF{Lkm0N\|ch\|ryP	NH\4ZmtUSU6JRWK=
OE33	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmPwTWM2OD1zMj65OFU3KM7:TR?=	M3vrT3NCVkeHUh?=
ES4	NVTMZmE6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWrFR3dJUUN3ME2xNk46PDh5IN88US=>	NEnpSW1USU6JRWK=
SW948	MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVPJR\|UxRTF\|LkCxN{DPxE1?	MoTyV2FPT0WU
LB2241-RCC	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MW\JR\|UxRTF\|LkG0Olkh\|ryP	NYjoRZE3W0GQR1XS
CCF-STTG1	NGLRS\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn[wTWM2OD1zMz60NFM6KM7:TR?=	M{nUXHNCVkeHUh?=
RPMI-8402	NHeyN2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIK4VWxKSzVyPUGzMlUxOzFizszN	NYDZZWN6W0GQR1XS
DEL	NIXGfJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUGz[otyUUN3ME2xN{42PTB\|IN88US=>	NWjNd5J1W0GQR1XS
NB5	M2mydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU\JR\|UxRTF\|LkW1NFMh\|ryP	M4DiPXNCVkeHUh?=
NUGC-3	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH\rVJBKSzVyPUGzMlc1PTNizszN	M2PYN3NCVkeHUh?=
CAL-72	M2TlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2LmPWlEPTB;MUSuNVkxPiEQvF2=	M3rSbnNCVkeHUh?=
VMRC-RCZ	NHi0NY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlX0TWM2OD1zND6yN\|Yh\|ryP	NHTYSo5USU6JRWK=
YAPC	M3fNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWLLXI12UUN3ME2xOE4zPDB5IN88US=>	M1X3W3NCVkeHUh?=
ES5	NX\IT4RJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXLJR\|UxRTF2LkK1PVkh\|ryP	MXnTRW5ITVJ?
CAL-12T	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFq1fW5KSzVyPUG0MlQ{OzZizszN	NGe5TppUSU6JRWK=
GAMG	NXru[odGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUTJR\|UxRTF2LkW1O\|ch\|ryP	MkDLV2FPT0WU
BT-20	NYW3VWRkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1XXTmlEPTB;MUSuPVM5PCEQvF2=	NITNdZNUSU6JRWK=
KALS-1	NGi5Zm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmXwTWM2OD1zNT6wNVU5KM7:TR?=	NYnvcFJPW0GQR1XS
LS-123	MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4fuTmlEPTB;MUWuNFE3PSEQvF2=	NXHHcGtNW0GQR1XS
LK-2	NWXwOlZQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlK0TWM2OD1zNT6wPFYzKM7:TR?=	MXjTRW5ITVJ?
NCI-H1770	NI\uT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUDwcIZzUUN3ME2xOU4zQDZ6IN88US=>	NYPEeXpbW0GQR1XS
MIA-PaCa-2	Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUjHbYY2UUN3ME2xOU41OTZ\|IN88US=>	NFLmclVUSU6JRWK=
DB	NWnl[45ZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2X4OGlEPTB;MUWuOlk1OSEQvF2=	NHTUTGZUSU6JRWK=
Becker	Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH:4SHRKSzVyPUG1Mlg6OjZizszN	MUTTRW5ITVJ?
HT-144	MlnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTF3Lkm0PVch\|ryP	NGTCXlNUSU6JRWK=
NCI-H2405	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXfJR\|UxRTF4LkKyNVgh\|ryP	M1;N[HNCVkeHUh?=
TK10	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mkm0TWM2OD1zNj6zO\|QzKM7:TR?=	M3nQXHNCVkeHUh?=
THP-1	M4fpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXruRXBWUUN3ME2xOk41PjZ3IN88US=>	MnfjV2FPT0WU
LB373-MEL-D	NFvHOlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHHSTYlKSzVyPUG2MlYyOzhizszN	MljPV2FPT0WU
SJSA-1	NEDaOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHn5Zo1KSzVyPUG2MlkzOTlizszN	NV3tcphRW0GQR1XS
EB2	NWS3fVB5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHTXWm5KSzVyPUG3Mlc1OjZizszN	NEHQXIhUSU6JRWK=
MN-60	NFjKOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVTJR\|UxRTF5Lke5N\|Yh\|ryP	NHvmZohUSU6JRWK=
A253	MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUTT[VY5UUN3ME2xO{45OjVizszN	Ml7hV2FPT0WU
CESS	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn3jTWM2OD1zNz65N\|I3KM7:TR?=	NIPaWYdUSU6JRWK=
EW-11	M3vQUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVHJR\|UxRTF5Lkm5OVgh\|ryP	NWCyU45MW0GQR1XS
TE-8	M37ub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVfJR\|UxRTF6LkC2Olkh\|ryP	MVfTRW5ITVJ?
UACC-257	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF7EV5hKSzVyPUG4MlIxPjJizszN	NFexZ4pUSU6JRWK=
NCI-H226	M1fLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmL0TWM2OD1zOD64Nlk6KM7:TR?=	NU[0OG8xW0GQR1XS
NCI-H748	NFvBfVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXzJR\|UxRTF6Lki1PFUh\|ryP	NIPmT4pUSU6JRWK=
NCI-H1299	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoHmTWM2OD1zOD64PVE5KM7:TR?=	MY\TRW5ITVJ?
IST-MEL1	M{PqTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjGTYlKSzVyPUG5MlE4PTRizszN	M3;1TXNCVkeHUh?=
HCC1187	NEHjTJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHTUV4pKSzVyPUG5MlE4QTZizszN	M3;hUHNCVkeHUh?=
HT-1376	NGfsOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXhTWM2OD1zOT6yNFI6KM7:TR?=	MnzBV2FPT0WU
SK-MEL-2	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\p[JJGUUN3ME2xPU4zOTV3IN88US=>	MnXFV2FPT0WU
U031	M1\4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3HxZmlEPTB;MUmuNlIyQSEQvF2=	MmT3V2FPT0WU
NCI-H524	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4rZdmlEPTB;MUmuOVczPSEQvF2=	NXn6[GoxW0GQR1XS
KU812	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVjWVW54UUN3ME2xPU42QTR2IN88US=>	NVO2Om8{W0GQR1XS
NB10	NEnVb4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3r5b2lEPTB;MUmuOlI3QCEQvF2=	NXHyO\|FkW0GQR1XS
NOS-1	MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmLRTWM2OD1{MD6xOVc4KM7:TR?=	MYXTRW5ITVJ?
EW-7	MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFrVcIxKSzVyPUKwMlE3OjhizszN	M{\lS3NCVkeHUh?=
Raji	M3\QPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHrGNXFKSzVyPUKwMlI2PjhizszN	Ml63V2FPT0WU
LB2518-MEL	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fkOmlEPTB;MkCuN\|k2OyEQvF2=	M1jvd3NCVkeHUh?=
PANC-10-05	MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXrJR\|UxRTJyLkS2NVMh\|ryP	MlvCV2FPT0WU
MZ2-MEL	NEfoWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYLJR\|UxRTJyLkW4NVQh\|ryP	NXHZU5oxW0GQR1XS
MFE-280	M3TGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mmn5TWM2OD1{MT6zNVg5KM7:TR?=	NUfsRll4W0GQR1XS
RKO	NWjlOnIyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4LHSWlEPTB;MkGuN\|IxOiEQvF2=	MnfsV2FPT0WU
KMOE-2	NGHSU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1m5emlEPTB;MkGuN\|I5QCEQvF2=	NFjwSpNUSU6JRWK=
K5	NWjhfHkyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXn4[ndUUUN3ME2yNU4{QDl\|IN88US=>	M1;aPHNCVkeHUh?=
NCI-H64	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlG1TWM2OD1{MT60O\|U3KM7:TR?=	NWfWZ45lW0GQR1XS
K-562	NFzUR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7oTWM2OD1{MT60PVcyKM7:TR?=	M{PROnNCVkeHUh?=
HCE-T	Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnvW3dKSzVyPUKxMlUxQTRizszN	MmHSV2FPT0WU
COLO-792	NXjueJB1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHXBXW9KSzVyPUKxMlU5OjdizszN	NEi1V5pUSU6JRWK=
PFSK-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVvJR\|UxRTJzLk[4N\|ch\|ryP	Mk\ZV2FPT0WU
DOK	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUnNd5BlUUN3ME2yNU44Pjh5IN88US=>	MoLTV2FPT0WU
NCI-H1882	MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF3aNZpKSzVyPUKxMlg2QTZizszN	MnHIV2FPT0WU
KNS-81-FD	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHjXb5ZKSzVyPUKxMlg3OzFizszN	Mm\UV2FPT0WU
OCUB-M	NWfBU2VOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX3SNVNiUUN3ME2yNU46Pjh6IN88US=>	MWXTRW5ITVJ?
NCI-H1694	NXLBVHRTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIXxWnVKSzVyPUKxMlk5PjNizszN	MVfTRW5ITVJ?
LS-513	M4KxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFHjbHJKSzVyPUKyMlA{PjdizszN	M2PSd3NCVkeHUh?=
NCI-H2122	NEDSXmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYXJR\|UxRTJ{LkG2O\|ch\|ryP	M2XqXHNCVkeHUh?=
IMR-5	MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEjORpRKSzVyPUKyMlI5PyEQvF2=	M3P4SHNCVkeHUh?=
SNU-C2B	NX31fmRjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4frZWlEPTB;MkKuOlc1PiEQvF2=	MWPTRW5ITVJ?
A498	MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIH5bo9KSzVyPUKyMlgyPzdizszN	M2rtdnNCVkeHUh?=
NCI-H727	NVnHdYZzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1XGUWlEPTB;MkKuPFg{PiEQvF2=	MX3TRW5ITVJ?
SW1573	NFPx[ZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4Wx[2lEPTB;MkOuNFY1PiEQvF2=	M4TWWnNCVkeHUh?=
RO82-W-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF3ocFVKSzVyPUKzMlI2OTFizszN	NYi5emFRW0GQR1XS
SKG-IIIa	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3\ZbGlEPTB;MkOuN\|U1PiEQvF2=	NIPMOlZUSU6JRWK=
MC-CAR	NGHvZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWPJR\|UxRTJ\|LkWxPFMh\|ryP	NFO4cpZUSU6JRWK=
NCI-H446	M4HX[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml\DTWM2OD1{Mz62NFk{KM7:TR?=	MoDJV2FPT0WU
PC-14	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV6zeGpzUUN3ME2yN{43PjJ\|IN88US=>	MlnCV2FPT0WU
TGBC1TKB	NGX6SGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYPubGdbUUN3ME2yN{44PDZzIN88US=>	M1r5cHNCVkeHUh?=
EFM-19	NX7Cb3pbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MU\JR\|UxRTJ2LkG4OFQh\|ryP	NVjUNnBnW0GQR1XS
SK-N-DZ	NXWwVFZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXPJR\|UxRTJ2LkS5O\|ch\|ryP	MVjTRW5ITVJ?
NCI-H661	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHfZSHZKSzVyPUK0MlUzOTdizszN	M3jLPHNCVkeHUh?=
SW1990	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4XkPGlEPTB;MkSuOVg5OyEQvF2=	MlLwV2FPT0WU
SW684	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnnvTWM2OD1{ND63OlI1KM7:TR?=	NIXDS3FUSU6JRWK=
Ca-Ski	NYGxVnFxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUfNOIx6UUN3ME2yOE46OjN5IN88US=>	Ml[4V2FPT0WU
TGW	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4nqe2lEPTB;MkWuNlM{PyEQvF2=	NWjscXBbW0GQR1XS
CaR-1	MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2XITWlEPTB;MkWuN\|U4KM7:TR?=	MULTRW5ITVJ?
D-247MG	M4nYXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUnycm1uUUN3ME2yOU41PzR\|IN88US=>	MlHMV2FPT0WU
CCRF-CEM	NH7nV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF;0Z2pKSzVyPUK1Mlc1PTlizszN	NH;IOnVUSU6JRWK=
CAPAN-1	MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUfSVpRtUUN3ME2yOU44PTBzIN88US=>	M3rFPHNCVkeHUh?=
CP50-MEL-B	Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUjJR\|UxRTJ3Lkm5NFEh\|ryP	NIq5TlNUSU6JRWK=
FADU	Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2L5TWlEPTB;Mk[uOVE2OiEQvF2=	NIrERlNUSU6JRWK=
Daudi	NFvxcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWqyU3lvUUN3ME2yOk42OTV6IN88US=>	MkfRV2FPT0WU
U-87-MG	NIfFbJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFKxd3JKSzVyPUK2MlU{ODVizszN	MkP1V2FPT0WU
DSH1	MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHvSXlQUUN3ME2yOk42PDB4IN88US=>	NGnoTW1USU6JRWK=
KYSE-520	M{HIdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3TsbWlEPTB;Mk[uOVU2OyEQvF2=	MnfVV2FPT0WU
HuH-7	NWnMTnRWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHDe5pZUUN3ME2yOk46ODh4IN88US=>	NIi5[WlUSU6JRWK=
U-2-OS	M12wcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTJ5LkCyO\|Eh\|ryP	NFz1PXVUSU6JRWK=
LU-99A	NHvCR4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXrFTG4yUUN3ME2yO{4yPzV2IN88US=>	NFfPbWpUSU6JRWK=
T98G	NWn2VYhkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NE\sOXpKSzVyPUK3MlE6PzNizszN	NHfTV2hUSU6JRWK=
MZ7-mel	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnLCTWM2OD1{Nz61OVQ5KM7:TR?=	M4jXb3NCVkeHUh?=
SNU-C1	NGTSSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUDQdlFjUUN3ME2yO{43PDlzIN88US=>	NFz3O\|hUSU6JRWK=
MDA-MB-175-VII	NXnJdGZGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4jvVmlEPTB;MkeuOlk4PSEQvF2=	NXu3OndtW0GQR1XS
HuP-T3	Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3LBfmlEPTB;MkiuNFQ6PSEQvF2=	MXTTRW5ITVJ?
T-24	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFXQb3NKSzVyPUK4MlE6OjVizszN	MnjMV2FPT0WU
HDLM-2	M{ex[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn63TWM2OD1{OD6yOFU6KM7:TR?=	NVTD[FY6W0GQR1XS
NCI-H1651	MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXrJR\|UxRTJ6LkK1PVIh\|ryP	MkPaV2FPT0WU
SK-N-AS	M{C5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlX0TWM2OD1{OD6zNVcyKM7:TR?=	MYrTRW5ITVJ?
NY	MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3HzNmlEPTB;MkiuOlU4QSEQvF2=	NYX1XIx{W0GQR1XS
D-283MED	M2LmXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLkPIlrUUN3ME2yPE45PzB6IN88US=>	M4fnNnNCVkeHUh?=
KLE	NFL0OHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYjJR\|UxRTJ6Lkm5NFYh\|ryP	MX7TRW5ITVJ?
NCI-H28	NGWxWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LK[WlEPTB;MkmuNFEzKM7:TR?=	NIDjTFlUSU6JRWK=
TE-1	NGDRT5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIXH[YZKSzVyPUK5MlIyPjdizszN	MYfTRW5ITVJ?
SK-MEL-24	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYrXblU1UUN3ME2yPU42PDZ4IN88US=>	MmW1V2FPT0WU
CAL-54	NFn3R3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmHmTWM2OD1{OT62NFQ3KM7:TR?=	MXTTRW5ITVJ?
A673	NYPUbG1HT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmraTWM2OD1{OT63N\|Ih\|ryP	NX:0UY1qW0GQR1XS
HEC-1	NWjUb\|hwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGfYUHdKSzVyPUOwMlAxPTNizszN	M1HqbXNCVkeHUh?=
LS-411N	M363cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXHJR\|UxRTNyLkG0O\|Uh\|ryP	M{ji[nNCVkeHUh?=
SW962	NFjXS4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGj3W2FKSzVyPUOwMlI1PzdizszN	NFPaephUSU6JRWK=
OVCAR-8	NXy5WVJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYjFZXB6UUN3ME2zNE43Pzl2IN88US=>	NXXsSWFKW0GQR1XS
NCI-H630	M2rDVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTNyLki5OVMh\|ryP	MmjOV2FPT0WU
D-263MG	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHwTWM2OD1\|MT6wOFI1KM7:TR?=	M362b3NCVkeHUh?=
NCI-H596	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGnmNVVKSzVyPUOxMlA3OjFizszN	NVLafHcyW0GQR1XS
BB49-HNC	NUPpPGlJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{\2e2lEPTB;M{GuNVEzKM7:TR?=	NETlTXVUSU6JRWK=
KYSE-70	MmDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTNzLkOwNFgh\|ryP	MknCV2FPT0WU
LAN-6	NHLYOpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTNzLkS5PVIh\|ryP	M{HHT3NCVkeHUh?=
NCI-H2228	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{XGO2lEPTB;M{GuOVYzPSEQvF2=	Mk\QV2FPT0WU
SW620	NV3sdWcyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH\5dYtKSzVyPUOxMlYzQDNizszN	MV\TRW5ITVJ?
KM-H2	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\4SHpKSzVyPUOxMlc{ODZizszN	M1vV[3NCVkeHUh?=
DJM-1	M{XpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NE[1bpRKSzVyPUOyMlE{QDZizszN	NEDpVnRUSU6JRWK=
SW48	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4ewfGlEPTB;M{KuN\|gzPSEQvF2=	NXzNWVJ2W0GQR1XS
NCI-H1793	Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYj2XXk{UUN3ME2zNk43OTZ\|IN88US=>	MX3TRW5ITVJ?
LU-165	M3fkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWXRZVVrUUN3ME2zN{4xODhizszN	MlHpV2FPT0WU
EHEB	NVy5[3JCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPzO4lKSzVyPUOzMlA1QTRizszN	NEjKZ5FUSU6JRWK=
NCI-H441	MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH7NbINKSzVyPUOzMlIzOzVizszN	NFTPcHNUSU6JRWK=
LOXIMVI	NW[1cZh7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fiZ2lEPTB;M{OuN\|Y4QSEQvF2=	NX;iPFBDW0GQR1XS
MC-IXC	NGrPdIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1;SXmlEPTB;M{OuOVY2PSEQvF2=	MXXTRW5ITVJ?
NCI-H522	MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlzITWM2OD1\|Mz62OVQh\|ryP	NWHtWlE4W0GQR1XS
IA-LM	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3\JN2lEPTB;M{OuOlc1PiEQvF2=	M2PoU3NCVkeHUh?=
NCI-H1417	NYLQfVV4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{L5TmlEPTB;M{OuPVU5PSEQvF2=	MofmV2FPT0WU
HCC2218	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXzJR\|UxRTN3LkKxPFUh\|ryP	MlrIV2FPT0WU
HC-1	M3zFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUX2T3FSUUN3ME2zOU41ODJ2IN88US=>	NEWzcWFUSU6JRWK=
HH	MlfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MknDTWM2OD1\|NT60NVQyKM7:TR?=	NIjwW3FUSU6JRWK=
EFE-184	NEX4UmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3PyVWlEPTB;M{WuOlgzQSEQvF2=	NGTZeppUSU6JRWK=
NCI-H1355	M1TXRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M37wbWlEPTB;M{WuO\|cyQCEQvF2=	NFvlRYxUSU6JRWK=
BV-173	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHzNV2FKSzVyPUO1MlgzPjRizszN	NXnyOYFiW0GQR1XS
NEC8	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;mV2lEPTB;M{[uOFkzPCEQvF2=	NUPSVllvW0GQR1XS
SW1463	M3nwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnzjTWM2OD1\|Nj62OVY3KM7:TR?=	MXfTRW5ITVJ?
KYSE-140	MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXna[IdQUUN3ME2zOk44Ojl6IN88US=>	M4nacHNCVkeHUh?=
no-11	MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHXHUYJKSzVyPUO2Mlg2OzZizszN	MnTlV2FPT0WU
HCC1937	NXTFW\|lmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTN5LkCxOVQh\|ryP	NWrMXohSW0GQR1XS
LNCaP-Clone-FGC	NYjybZROT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml;ETWM2OD1\|Nz6xPVA{KM7:TR?=	Mo\MV2FPT0WU
KARPAS-422	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHXlV\|FKSzVyPUO3MlQ1OzFizszN	MXnTRW5ITVJ?
RCM-1	MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLHTWM2OD1\|Nz61N\|U5KM7:TR?=	M2OwUnNCVkeHUh?=
A375	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M33JN2lEPTB;M{euO\|Y1PyEQvF2=	NHLKUZZUSU6JRWK=
TGBC24TKB	M4HYXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTZ[oVKSzVyPUO4MlAzOzlizszN	MYHTRW5ITVJ?
MDA-MB-453	M2\GVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGLC[3RKSzVyPUO5MlAzOThizszN	MmjtV2FPT0WU
Capan-2	NV24bJZyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEDmZ2NKSzVyPUO5MlA2ODlizszN	MXXTRW5ITVJ?
SW756	MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3fJUGlEPTB;M{muOVA6OSEQvF2=	NG\yd4lUSU6JRWK=
KU-19-19	MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlT1TWM2OD1\|OT62NlgzKM7:TR?=	NHW1eINUSU6JRWK=
NCI-H2170	NF3T[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4[ze2lEPTB;M{muPVk4PyEQvF2=	NWGyWolUW0GQR1XS
COLO-678	NXi1cmpOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUm5cXByUUN3ME20NE42QTVizszN	MnPIV2FPT0WU
PF-382	Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTRyLke0PFch\|ryP	MnTQV2FPT0WU
OAW-42	MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUT0ZWU5UUN3ME20Nk4zQTR{IN88US=>	NF7aeJJUSU6JRWK=
LB996-RCC	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnTJTWM2OD12Mj64NFA5KM7:TR?=	MYHTRW5ITVJ?
SAS	NYfTUJV5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEjYT2NKSzVyPUSzMlQzQDhizszN	MWfTRW5ITVJ?
MRK-nu-1	M4\ZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfr[GRKSzVyPUS0Mlc1OTRizszN	NELlVXpUSU6JRWK=
EoL-1-cell	NXXCRWlDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mnn4TWM2OD12ND65NVM3KM7:TR?=	NVLlUFRIW0GQR1XS
NCI-H2342	MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTR3LkGxNVch\|ryP	Ml7oV2FPT0WU
NCI-H1703	NETod\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTR4LkC1PVIh\|ryP	NGK4TGxUSU6JRWK=
NCI-H187	NWOwRoVzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmjJTWM2OD12Nj6xPFY6KM7:TR?=	MY\TRW5ITVJ?
CP66-MEL	MnPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFq2WJhKSzVyPUS2MlI4QDlizszN	NHLHUFBUSU6JRWK=
HCC1569	M4DWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2Prb2lEPTB;NE[uOVkyPyEQvF2=	M4HzOHNCVkeHUh?=
BL-70	NFjzPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfRRmR2UUN3ME20Ok44PzN5IN88US=>	M3vtUHNCVkeHUh?=
Saos-2	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\qTmZKSzVyPUS3MlMyOjNizszN	MkLsV2FPT0WU
LC-1F	M{nCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIDDcYlKSzVyPUS3MlYyODVizszN	NX32e5pVW0GQR1XS
KY821	M2rV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIG5TWlKSzVyPUS3MlY1OzRizszN	NUfFcWhNW0GQR1XS
PSN1	NIjiPYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NED0OXZKSzVyPUS4MlE1ODFizszN	NXHFZXZUW0GQR1XS
RT4	M3PQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoTETWM2OD12OD64N\|c4KM7:TR?=	NV20XoE{W0GQR1XS
LS-1034	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3rN[GlEPTB;NEiuPFk2PCEQvF2=	MljSV2FPT0WU
NCI-H1395	NVP5bHpTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlTpTWM2OD12OT6wOFkzKM7:TR?=	NFfoWYlUSU6JRWK=
EKVX	NIXy[\|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn7WTWM2OD12OT62O\|MyKM7:TR?=	NVfySJJnW0GQR1XS
IST-MES1	MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1TJPWlEPTB;NEmuPFk1PCEQvF2=	MmTuV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-FAK / FAK / p-Talin / Talin ; PubMed: 26530902 Cancer Res Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells. p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; PubMed: 29417941 Acta Pharmacol Sin MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.	26530902 29417941
Immunofluorescence	p-FAK; PubMed: 26530902 Cancer Res Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).	26530902
Growth inhibition assay	Cell viability; PubMed: 28953264 Nutrients MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk () and p < 0.01 are designated by two asterisks (*).	28953264

In vivo

PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. ^[1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. ^[3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. ^[4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. ^[5]

Protocol

Animal Research:^[1]	- Collapse Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts. Formulation: 5% Gelucire Dosages: 50 mg/kg Administration: Oral gavage (Only for Reference)

References

- Collapse

Solubility (25°C)

In vitro	DMSO	100 mg/mL warmed (197.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O For best results, use promptly after mixing.	5 mg/ml

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download PF-562271 SDF

Molecular Weight	507.49
Formula	C₂₁H₂₀F₃N₇O₃S
CAS No.	717907-75-0
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A
Smiles	CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O

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Computed Result

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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FAK Signaling Pathway Map

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PF-562271