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PF-562271

For research use only.

Catalog No.S2890

89 publications

PF-562271 Chemical Structure

CAS No. 717907-75-0

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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Selleck's PF-562271 has been cited by 89 publications

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. [1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. [2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\SZmlEPTB;MD6yO|Y3KM7:TR?= Mn[4V2FPT0WU
SW982 NHnpeZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwM{K4NkDPxE1? MX\TRW5ITVJ?
KM12 NYnxcVhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTRO|hFUUN3ME2wMlM5PTV5IN88US=> MkGyV2FPT0WU
COLO-205 NHW4Nm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwNEi2OVgh|ryP MmrTV2FPT0WU
COLO-829 NYL3U2t[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwN{WxO|Yh|ryP MWLTRW5ITVJ?
MG-63 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjFWncxUUN3ME2wMlgxPjN5IN88US=> M{DjTHNCVkeHUh?=
IGROV-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL1T3RKSzVyPUCuPFExOzhizszN NVzIWpQ{W0GQR1XS
NCI-H650 NULWPWRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEftV5FKSzVyPUCuPFMyPTRizszN NXzQXo5jW0GQR1XS
RT-112 NH6xS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTrTWM2OD1yLkm4OFYh|ryP MUTTRW5ITVJ?
BCPAP MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:5TWM2OD1zLkCxNlg5KM7:TR?= M2XybnNCVkeHUh?=
ALL-PO MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrxRXY3UUN3ME2xMlAyPTh2IN88US=> MXvTRW5ITVJ?
KYSE-270 NVfRTW0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTFwMES3NVQh|ryP MXLTRW5ITVJ?
8305C NFGwe5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XKNGlEPTB;MT6wPVkxPCEQvF2= M4jWN3NCVkeHUh?=
NCI-H810 NWrTSoxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojhTWM2OD1zLkGwO|c3KM7:TR?= NIPu[YZUSU6JRWK=
CAL-33 M4Prb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\KfmlEPTB;MT6xNlk{QCEQvF2= NGnkPHpUSU6JRWK=
AN3-CA MoHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwMkG4Olch|ryP NXO1OWF4W0GQR1XS
NKM-1 NUjIXo55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2zcIRyUUN3ME2xMlI4PTB4IN88US=> NHjLeHFUSU6JRWK=
BPH-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnZVmpbUUN3ME2xMlI5PzZ4IN88US=> M3HC[nNCVkeHUh?=
MES-SA NVrlTXRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPSWmVmUUN3ME2xMlMxPjh{IN88US=> NHuz[|RUSU6JRWK=
CAL-62 M{XwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXXTWM2OD1zLkOxPVA6KM7:TR?= NUm3e21KW0GQR1XS
Detroit562 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj3eI5KSzVyPUGuN|UzOjJizszN MWPTRW5ITVJ?
KYSE-150 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PPRmlEPTB;MT6zOVI{PiEQvF2= Ml;HV2FPT0WU
SK-UT-1 M2WwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\MXYNKSzVyPUGuOFQ3PDdizszN NUTHV2pqW0GQR1XS
HUTU-80 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv4e4FKSzVyPUGuOFQ5QDZizszN M1rRWXNCVkeHUh?=
SIG-M5 M1fsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TZemlEPTB;MT60PFM5PyEQvF2= MV7TRW5ITVJ?
AGS NH;UXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfGV4JKSzVyPUGuOVIyOjRizszN M{DHNHNCVkeHUh?=
ST486 NHjIWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jucGlEPTB;MT61N|I4QCEQvF2= MWLTRW5ITVJ?
HSC-2 MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTFwNUO5OUDPxE1? M3jJZ3NCVkeHUh?=
LCLC-103H M{G3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TyXmlEPTB;MT61OVgyQCEQvF2= MnzlV2FPT0WU
BC-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\mfJJqUUN3ME2xMlYyPjZ2IN88US=> NHz3b5FUSU6JRWK=
CGTH-W-1 NXPyU2RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTqUJlKSzVyPUGuOlE3PzlizszN MlfJV2FPT0WU
MZ1-PC NGTufZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFwNkKzNVIh|ryP MnyyV2FPT0WU
SW1710 NGfEN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfNflR5UUN3ME2xMlYzPjJ6IN88US=> Mnz4V2FPT0WU
EW-13 M37WOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[zbGlEPTB;MT62N|Q3PiEQvF2= NWHHeYZyW0GQR1XS
TE-11 Ml\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULzfo1uUUN3ME2xMlY{PTJ{IN88US=> M3OxZnNCVkeHUh?=
BHY NVe2OWlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r6[mlEPTB;MT62OVY3OyEQvF2= NXrxS3ZYW0GQR1XS
ML-2 NIexPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1GxN2lEPTB;MT62OlgxOiEQvF2= NVHmVZpHW0GQR1XS
MEL-JUSO NV[zS|JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXTTWM2OD1zLkeyPFkyKM7:TR?= M2fIR3NCVkeHUh?=
U251 NVjWd|lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XCV2lEPTB;MT63OFA{OSEQvF2= M1fuNXNCVkeHUh?=
MHH-ES-1 NXzFeWdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTFwN{m1Olgh|ryP M2j4RXNCVkeHUh?=
CAL-85-1 NWH2eXdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\0Z4RKSzVyPUGuPFA1QSEQvF2= MmnIV2FPT0WU
D-336MG NWnwXpluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTFwOEW2NVQh|ryP NHuwWoRUSU6JRWK=
VA-ES-BJ M1;VZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFwOUCzNVUh|ryP MlzMV2FPT0WU
MDA-MB-468 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjlOpBKSzVyPUGuPVEzPzJizszN M1fsVXNCVkeHUh?=
MEL-HO NX\ZXFdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHlOGRKSzVyPUGuPVc6QTNizszN NXjsV3lDW0GQR1XS
SW954 NFnyUGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG2XolKSzVyPUKuNFAyPTFizszN M4K2WnNCVkeHUh?=
LB831-BLC NHvXeJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJwMEC5PFgh|ryP NUfZdHg2W0GQR1XS
EW-16 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwMEO5PFMh|ryP NWWwPWJRW0GQR1XS
NCI-H460 NYO0e3JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofZTWM2OD1{LkC0PFM6KM7:TR?= NYC4fnpZW0GQR1XS
CHP-212 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXpNJhIUUN3ME2yMlA6PTN7IN88US=> M3u4SnNCVkeHUh?=
MHH-NB-11 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW2eZVKSzVyPUKuNVI5OThizszN MmjwV2FPT0WU
DU-4475 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwMUS3OVkh|ryP NFfSNVNUSU6JRWK=
ABC-1 MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDwd2pKSzVyPUKuNlUyQTZizszN NHvrSoZUSU6JRWK=
LOUCY MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHabpBKSzVyPUKuNlYyOjhizszN NH:4SFVUSU6JRWK=
LC-2-ad NYj1bm1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjOXmR4UUN3ME2yMlI3QTZ4IN88US=> M{fwVnNCVkeHUh?=
ETK-1 NHjsXItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PicWlEPTB;Mj6yPFQ3KM7:TR?= MlP2V2FPT0WU
KYSE-180 NW\3ZZNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIqzS3BKSzVyPUKuNlg5PzRizszN Ml7OV2FPT0WU
HOP-92 M1TCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W0SmlEPTB;Mj6zNFY4OyEQvF2= NULiOpNwW0GQR1XS
RCC10RGB M37LW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jmPWlEPTB;Mj6zNlUxPyEQvF2= M3qyb3NCVkeHUh?=
KASUMI-1 M2TtTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[5VHJEUUN3ME2yMlMzQDhizszN M{i5TnNCVkeHUh?=
ACN M{D2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\KSWVYUUN3ME2yMlM1PzR3IN88US=> NF3lN2tUSU6JRWK=
BxPC-3 NYDX[pU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwM{W0N|Yh|ryP MULTRW5ITVJ?
MONO-MAC-6 M{\zcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHjVnBnUUN3ME2yMlQyOjR6IN88US=> NILPOJFUSU6JRWK=
CAL-39 M4L0Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn5fWhKSzVyPUKuOFE3OjhizszN MoC1V2FPT0WU
CMK NVz3WIY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v1V2lEPTB;Mj60NVc6PSEQvF2= M4TldHNCVkeHUh?=
MFE-296 NFPWWGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnSbFJKSzVyPUKuOFc4QTJizszN MoPwV2FPT0WU
DU-145 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKxTWM2OD1{LkS5NVE5KM7:TR?= NILHS5NUSU6JRWK=
MDA-MB-231 MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XQeGlEPTB;Mj60PVU4OiEQvF2= NWDPeIU1W0GQR1XS
EFO-27 M4LXNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHTS2VGUUN3ME2yMlUyQDh6IN88US=> MYnTRW5ITVJ?
SNU-387 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrxb|VKSzVyPUKuOVI5OiEQvF2= M1XVXHNCVkeHUh?=
KYSE-410 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HiNGlEPTB;Mj61OlUyPyEQvF2= NGnUXGNUSU6JRWK=
NCCIT MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli4TWM2OD1{LkW3NlQh|ryP M2TLU3NCVkeHUh?=
LXF-289 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDMTWM2OD1{LkW4Nlc{KM7:TR?= MVnTRW5ITVJ?
HMV-II MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nvR2lEPTB;Mj61PFk6PyEQvF2= Mn\EV2FPT0WU
MOLT-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrXTWM2OD1{Lk[wO|EzKM7:TR?= NW\MfmVrW0GQR1XS
KOSC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzDTWM2OD1{Lk[zPFc6KM7:TR?= NGHNbppUSU6JRWK=
TUR MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[0Xmt[UUN3ME2yMlY2OzZ7IN88US=> MofoV2FPT0WU
NCI-H2087 NYjIV4xmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HqSGlEPTB;Mj63NVY1PiEQvF2= M361SHNCVkeHUh?=
SCC-15 NXL4R5FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;LS2lEPTB;Mj63OVI2OiEQvF2= NFmydJJUSU6JRWK=
HSC-4 NWnRVVdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXSbW9KSzVyPUKuO|g{QDlizszN NVHtOmM{W0GQR1XS
G-402 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwOEG0OFch|ryP NIC1dlJUSU6JRWK=
GP5d MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LBNWlEPTB;Mj64N|gzPyEQvF2= NIXtPGZUSU6JRWK=
IGR-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NECzUmpKSzVyPUKuPFM6QDdizszN Mn\sV2FPT0WU
SK-PN-DW MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHkPW03UUN3ME2yMlg3OjB2IN88US=> NFe5RYhUSU6JRWK=
OPM-2 NILQRpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJwOEm5O|gh|ryP MnrGV2FPT0WU
5637 NF3MOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO1TWM2OD1{LkmyOFM6KM7:TR?= NVPtdnY1W0GQR1XS
NCI-H2030 NI[wSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\QNGlEPTB;Mj65PFAzQSEQvF2= Mo\3V2FPT0WU
SK-LU-1 MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJwOUizN|Qh|ryP NV\XWokxW0GQR1XS
EW-18 NXvCZ4xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX31d2ZoUUN3ME2zMlA2OzJizszN NY\CXmd7W0GQR1XS
786-0 NULXdXFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj3TWM2OD1|LkC1O|g1KM7:TR?= NUiyOGt7W0GQR1XS
NCI-H1963 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PKWWlEPTB;Mz6wPFgzPSEQvF2= NYDUN3lnW0GQR1XS
A2780 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjrTWM2OD1|LkGwN|QyKM7:TR?= MlTkV2FPT0WU
NCI-H526 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rzRWlEPTB;Mz6xN|k3OSEQvF2= M4jQTXNCVkeHUh?=
BHT-101 NWTHdIZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTNwMUW3PVgh|ryP M1:1OHNCVkeHUh?=
RPMI-7951 NHW5T4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP1bWVKSzVyPUOuNlAyOzdizszN NH;2e2hUSU6JRWK=
HL-60 NYnjeWhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r3UmlEPTB;Mz6yNVE1KM7:TR?= NYm3cFFqW0GQR1XS
CTV-1 NEj4TmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHtToI{UUN3ME2zMlI2Ozd5IN88US=> NFj5O|ZUSU6JRWK=
IST-SL1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEftVJZKSzVyPUOuNlk1PjVizszN M2naU3NCVkeHUh?=
G-401 NGjvUpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\wTWM2OD1|LkK5PFA5KM7:TR?= Mn2yV2FPT0WU
OVCAR-5 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXtR3BKSzVyPUOuN|Y{PTJizszN M1XMfnNCVkeHUh?=
EW-1 M3LhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTESYplUUN3ME2zMlQxPTR2IN88US=> M1WxTHNCVkeHUh?=
H4 NW\pS2pPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;w[WlEPTB;Mz60O|U3QSEQvF2= NH3ue2lUSU6JRWK=
EM-2 Mlq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnZb3lNUUN3ME2zMlQ5Pjd2IN88US=> M2m5bnNCVkeHUh?=
RS4-11 M3v6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HBcmlEPTB;Mz60PFcyPSEQvF2= MnLrV2FPT0WU
NOMO-1 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;HVolKSzVyPUOuOFkzODRizszN NVLLUVNoW0GQR1XS
HCT-116 NXXPUJE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;LepNKSzVyPUOuOVA4OTFizszN MmHuV2FPT0WU
CAL-120 NV7wW5RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\3ZWlEPTB;Mz61O|M2KM7:TR?= MmjYV2FPT0WU
CAL-51 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrlZ4JKSzVyPUOuOVc3OTJizszN NWn1TZp2W0GQR1XS
RVH-421 M2X3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXlWVhrUUN3ME2zMlYxOzFzIN88US=> MnjyV2FPT0WU
NCI-H2081 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzU[lBKSzVyPUOuOlUzQDhizszN MmXwV2FPT0WU
SBC-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULJRopPUUN3ME2zMlY4QDh{IN88US=> NVHkW|lTW0GQR1XS
RL95-2 NGK3cXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvRTYZuUUN3ME2zMlcyQDZ2IN88US=> NYexfolwW0GQR1XS
SW872 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\X[WlKSzVyPUOuO|Y6PThizszN NYDKfWlsW0GQR1XS
VM-CUB-1 NXr4Om9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jQRWlEPTB;Mz63O|UyKM7:TR?= NX3ZOIk6W0GQR1XS
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SK-HEP-1 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRThwM{W3NlMh|ryP Mm\JV2FPT0WU
PANC-03-27 NW[ydmZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jNOWlEPTB;OD6zOlkzKM7:TR?= NELGSIlUSU6JRWK=
KP-4 M2DnbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLQTWM2OD16LkSxPFU{KM7:TR?= NFn5e3RUSU6JRWK=
RERF-LC-MS MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRThwNEi1PVUh|ryP M1Lac3NCVkeHUh?=
C-33-A MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG5boJnUUN3ME24MlYyPTJ7IN88US=> MnXMV2FPT0WU
PA-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrCbVRRUUN3ME24MlY3Pjl2IN88US=> MoPhV2FPT0WU
TE-5 NWrFZVk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qzPGlEPTB;OD63NFI6PiEQvF2= Mle5V2FPT0WU
MHH-PREB-1 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRThwN{OxNFch|ryP NWLF[415W0GQR1XS
C3A Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fQc2lEPTB;OD63OlU3OSEQvF2= NUjReldiW0GQR1XS
SK-OV-3 NVnDWFhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRThwN{m3O|Ih|ryP MUPTRW5ITVJ?
AM-38 NGDRVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLxTWM2OD16LkiwOFM6KM7:TR?= NWjYSHZVW0GQR1XS
LoVo NXLnN45JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3JXXVsUUN3ME24Mlk2PTZ4IN88US=> Mk[5V2FPT0WU
MKN45 MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfuTWM2OD16Lkm2NFY{KM7:TR?= M2\yfnNCVkeHUh?=
NH-12 M2\aVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV63WYxLUUN3ME25MlAzPTR{IN88US=> NWq2TJV6W0GQR1XS
CAMA-1 NXTZUFZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vMOWlEPTB;OT6wOlAyOiEQvF2= Mny4V2FPT0WU
HT-29 NED1e5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jtfWlEPTB;OT6xNlM4OyEQvF2= NY\LcJg{W0GQR1XS
DMS-273 NEPJepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTlwMUK1JO69VQ>? MUDTRW5ITVJ?
NCI-H719 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXFTWM2OD17LkG4N|kyKM7:TR?= NVHuO45wW0GQR1XS
SF539 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nTcWlEPTB;OT6yNVA6QCEQvF2= MXPTRW5ITVJ?
Daoy Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu1TWM2OD17LkK0NVQ{KM7:TR?= MXvTRW5ITVJ?
HCC70 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni1TWM2OD17LkK3N|A6KM7:TR?= MVLTRW5ITVJ?
MFH-ino MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1KySGlEPTB;OT6yPVAxPyEQvF2= NH;ycnpUSU6JRWK=
UACC-62 MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLoSIpKSzVyPUmuN|czQTdizszN MoX3V2FPT0WU
C2BBe1 NIXKSmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK4XWhTUUN3ME25MlM6PjV{IN88US=> MlTxV2FPT0WU
KNS-42 M{nCSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHIeI1tUUN3ME25MlQ{PDB5IN88US=> MnraV2FPT0WU
SK-LMS-1 NFPpWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy4fY1KSzVyPUmuO|U2OzVizszN NW\rdpptW0GQR1XS
SK-CO-1 NWPzUZpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTlwN{[yN|Uh|ryP NYDOVXdxW0GQR1XS
SN12C MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nUbWlEPTB;OT63OlgxPiEQvF2= NVnHbZlZW0GQR1XS
HTC-C3 NFrUNnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\QTWM2OD17Lke3PVg1KM7:TR?= NYPNPYp3W0GQR1XS
OVCAR-4 NH3n[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXvPZVKSzVyPUmuPFQ5OjhizszN MYnTRW5ITVJ?
CHP-126 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTlwOUOyPUDPxE1? MkLZV2FPT0WU
NCI-H716 M{[wOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrMTWM2OD17LkmzN|IzKM7:TR?= MojyV2FPT0WU
U-698-M NWj2OnFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPjbJdKSzVyPUmuPVk4KM7:TR?= M{OxT3NCVkeHUh?=
EFO-21 NGeweIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnZUVJKSzVyPUGwMlAxQTNizszN MUTTRW5ITVJ?
RXF393 NXjxXoVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j1W2lEPTB;MUCuNVM6OiEQvF2= M1HMeXNCVkeHUh?=
ChaGo-K-1 Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3FTG1pUUN3ME2xNE4yPzd4IN88US=> M2rCN3NCVkeHUh?=
SJRH30 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzueoFKSzVyPUGwMlE5PDRizszN NGXwd3pUSU6JRWK=
LU-65 MmH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFyLkK5OFMh|ryP NXLnfIRXW0GQR1XS
OS-RC-2 NHXhRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\oTWM2OD1zMD6zNlI4KM7:TR?= NInubXFUSU6JRWK=
YT NWe4[3E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13aOGlEPTB;MUCuOFAxOSEQvF2= M4TORXNCVkeHUh?=
COLO-679 M4HvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTFyLkSyPFUh|ryP NUnnN5cxW0GQR1XS
CAS-1 NX;kSm81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfLTWM2OD1zMD60OlA5KM7:TR?= Mlz5V2FPT0WU
NCI-H2052 NWHR[3JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;JTWM2OD1zMD61NVA2KM7:TR?= NEDNW|BUSU6JRWK=
NCI-H2452 MnTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jGXGlEPTB;MUCuOlE5OSEQvF2= MnWyV2FPT0WU
SW13 NVHSNW92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TsbWlEPTB;MUCuOlM4PCEQvF2= MX\TRW5ITVJ?
HuP-T4 MlLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoWxTWM2OD1zMD63NFY5KM7:TR?= MkjxV2FPT0WU
UMC-11 NFPLdYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e2dmlEPTB;MUCuPVM4OyEQvF2= Ml7lV2FPT0WU
EGI-1 M1POb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PzdmlEPTB;MUCuPVQ2PSEQvF2= MVHTRW5ITVJ?
JiyoyeP-2003 NIT4XFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvtTWM2OD1zMT6wPFkzKM7:TR?= MojBV2FPT0WU
J-RT3-T3-5 NYPIN4pbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXPPYlKSzVyPUGxMlEzODlizszN NVHlOWRPW0GQR1XS
DoTc2-4510 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTDNGhKSzVyPUGxMlE{QDlizszN MU\TRW5ITVJ?
HLE MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfaWI5KSzVyPUGxMlIyOTlizszN NU\YO5hWW0GQR1XS
SW626 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFzLkK4PFkh|ryP NFfWO2NUSU6JRWK=
COR-L105 NWruU5hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3y1dGlEPTB;MUGuN|I{PyEQvF2= MVjTRW5ITVJ?
ES6 NGrDUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFzLkW3OkDPxE1? NVTUNmI2W0GQR1XS
SNU-449 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr2TWM2OD1zMT62NFczKM7:TR?= MYnTRW5ITVJ?
GR-ST MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFzLk[xPFEh|ryP MlzTV2FPT0WU
BL-41 M4LPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXkeY9KSzVyPUGxMlcyPzNizszN NWS1[4ZzW0GQR1XS
GB-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3FOGlKSzVyPUGxMlc3OTlizszN NHSxbo1USU6JRWK=
COLO-320-HSR MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTFzLki1NVkh|ryP NVXacIpPW0GQR1XS
L-540 M3TPTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFzLki5PUDPxE1? NWO1XIM5W0GQR1XS
NCI-H69 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH0TWM2OD1zMj6wNVM6KM7:TR?= NFr6blJUSU6JRWK=
769-P NH\tNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF{LkCxPUDPxE1? NX7BXpBzW0GQR1XS
A172 MorPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TSOWlEPTB;MUKuNVIxPyEQvF2= Moi3V2FPT0WU
CAL-27 M4PMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr6TWM2OD1zMj6xN|Y6KM7:TR?= NHT4WJdUSU6JRWK=
NCI-H1437 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInBW45KSzVyPUGyMlE1PDdizszN MljUV2FPT0WU
REH NFzJeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfx[mhWUUN3ME2xNk4yPTd|IN88US=> MmTIV2FPT0WU
KINGS-1 M2DJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XqOGlEPTB;MUKuN|QzOSEQvF2= NFW3ZopUSU6JRWK=
NCI-H1792 NV;NZZp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nxbWlEPTB;MUKuN|g2OSEQvF2= NIHqZ|NUSU6JRWK=
SK-MM-2 MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTu[ppkUUN3ME2xNk41ODh5IN88US=> MVfTRW5ITVJ?
8505C M4XzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF{Lk[xNkDPxE1? NHLEe3RUSU6JRWK=
HAL-01 NVrOb5M2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF{Lk[xO|Qh|ryP MXfTRW5ITVJ?
NCI-H2141 NXyxNmhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTF{Lk[1PEDPxE1? NXvEPFJwW0GQR1XS
HCC1806 M{LheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnNWWFKSzVyPUGyMlY6PTJizszN NUD5fGVxW0GQR1XS
LU-134-A NEntd4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H0SGlEPTB;MUKuPVMh|ryP NV\uXFhiW0GQR1XS
HT MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF{Lkm0N|ch|ryP M3f3S3NCVkeHUh?=
OE33 M4DXcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF{Lkm0OVYh|ryP M4XxfXNCVkeHUh?=
ES4 Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3OclhoUUN3ME2xNk46PDh5IN88US=> NITmU4pUSU6JRWK=
SW948 NFjzO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTF|LkCxN{DPxE1? NWDzO3Z6W0GQR1XS
LB2241-RCC NV3FUG5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljPTWM2OD1zMz6xOFY6KM7:TR?= MX\TRW5ITVJ?
CCF-STTG1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXlcWNKSzVyPUGzMlQxOzlizszN Mo\0V2FPT0WU
RPMI-8402 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL4R4RqUUN3ME2xN{42ODNzIN88US=> MWDTRW5ITVJ?
DEL M{TKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rYcGlEPTB;MUOuOVUxOyEQvF2= NYfReohUW0GQR1XS
NB5 NXryXIhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TQXmlEPTB;MUOuOVUxOyEQvF2= Mn3SV2FPT0WU
NUGC-3 NH35dXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX5TWM2OD1zMz63OFU{KM7:TR?= M1raenNCVkeHUh?=
CAL-72 M1XXWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHZco9KSzVyPUG0MlE6ODZizszN MVrTRW5ITVJ?
VMRC-RCZ M3\Jemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\WXWJKSzVyPUG0MlI{PiEQvF2= NXfOO3dHW0GQR1XS
YAPC M{LNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF2LkK0NFch|ryP NXnKR5FbW0GQR1XS
ES5 NUH2d493T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXQTWM2OD1zND6yOVk6KM7:TR?= Mlv2V2FPT0WU
CAL-12T M1LzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL6TWM2OD1zND60N|M3KM7:TR?= NF3QSFhUSU6JRWK=
GAMG M3nHOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF2LkW1O|ch|ryP NIq1VVdUSU6JRWK=
BT-20 M{TofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK1RXBNUUN3ME2xOE46Ozh2IN88US=> NXfEVoVtW0GQR1XS
KALS-1 NIjrXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly3TWM2OD1zNT6wNVU5KM7:TR?= NHzuZpBUSU6JRWK=
LS-123 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjaVWNKSzVyPUG1MlAyPjVizszN M2rncHNCVkeHUh?=
LK-2 MorsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWzb2xKSzVyPUG1MlA5PjJizszN MWHTRW5ITVJ?
NCI-H1770 NF;sclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX4TWM2OD1zNT6yPFY5KM7:TR?= NH3XNmhUSU6JRWK=
MIA-PaCa-2 M{[zdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXnfm9nUUN3ME2xOU41OTZ|IN88US=> MorhV2FPT0WU
DB M1vUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTF3Lk[5OFEh|ryP M4[1fHNCVkeHUh?=
Becker NEfa[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mwZ2lEPTB;MUWuPFkzPiEQvF2= MVLTRW5ITVJ?
HT-144 NXPFT3BwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO2TWM2OD1zNT65OFk4KM7:TR?= Mnu3V2FPT0WU
NCI-H2405 NGTuRldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:5TWM2OD1zNj6yNlE5KM7:TR?= MYLTRW5ITVJ?
TK10 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTF4LkO3OFIh|ryP NWjFT5pSW0GQR1XS
THP-1 NH;SbGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LRXWlEPTB;MU[uOFY3PSEQvF2= MVvTRW5ITVJ?
LB373-MEL-D NF\ve21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTF4Lk[xN|gh|ryP MYPTRW5ITVJ?
SJSA-1 MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q3dWlEPTB;MU[uPVIyQSEQvF2= NWm1RYdNW0GQR1XS
EB2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nTXmlEPTB;MUeuO|QzPiEQvF2= NXjx[4dFW0GQR1XS
MN-60 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X2RWlEPTB;MUeuO|k{PiEQvF2= M1rBTnNCVkeHUh?=
A253 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn2TWM2OD1zNz64NlUh|ryP MkXvV2FPT0WU
CESS MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF5LkmzNlYh|ryP NX3jb3R{W0GQR1XS
EW-11 M3rYfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXDTWM2OD1zNz65PVU5KM7:TR?= NVi0fow{W0GQR1XS
TE-8 NFP0U|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF6LkC2Olkh|ryP NY\sc2xLW0GQR1XS
UACC-257 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPjTWM2OD1zOD6yNFYzKM7:TR?= MlHVV2FPT0WU
NCI-H226 NGnqRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLCTWM2OD1zOD64Nlk6KM7:TR?= MojQV2FPT0WU
NCI-H748 NHH0WXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rWPWlEPTB;MUiuPFU5PSEQvF2= M3PoOXNCVkeHUh?=
NCI-H1299 NGfSXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\kdGlEPTB;MUiuPFkyQCEQvF2= Ml36V2FPT0WU
IST-MEL1 NWGxS49DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTxPJYyUUN3ME2xPU4yPzV2IN88US=> NILpNHJUSU6JRWK=
HCC1187 NYO2dVVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLWNIdzUUN3ME2xPU4yPzl4IN88US=> NHHGZ4lUSU6JRWK=
HT-1376 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC5VYhKSzVyPUG5MlIxOjlizszN NIfUblVUSU6JRWK=
SK-MEL-2 NInSVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTF7LkKxOVUh|ryP M{Lq[nNCVkeHUh?=
U031 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPwbWFKSzVyPUG5MlIzOTlizszN MnTkV2FPT0WU
NCI-H524 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDGR5BKSzVyPUG5MlU4OjVizszN MYrTRW5ITVJ?
KU812 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF7LkW5OFQh|ryP NYLlfZY4W0GQR1XS
NB10 NFzXOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOzTWM2OD1zOT62NlY5KM7:TR?= NIDrSWtUSU6JRWK=
NOS-1 M4PuNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK1NVFyUUN3ME2yNE4yPTd5IN88US=> MkDnV2FPT0WU
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MRK-nu-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f2bGlEPTB;NESuO|QyPCEQvF2= NWfsd|ZUW0GQR1XS
EoL-1-cell NUL5e|hiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj5TWM2OD12ND65NVM3KM7:TR?= NELZTJNUSU6JRWK=
NCI-H2342 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LWTGlEPTB;NEWuNVEyPyEQvF2= MWLTRW5ITVJ?
NCI-H1703 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37xWGlEPTB;NE[uNFU6OiEQvF2= M33WUXNCVkeHUh?=
NCI-H187 NHrKd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S3bmlEPTB;NE[uNVg3QSEQvF2= Mn\DV2FPT0WU
CP66-MEL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PBfGlEPTB;NE[uNlc5QSEQvF2= M2nHTnNCVkeHUh?=
HCC1569 M1PWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTtXJZjUUN3ME20Ok42QTF5IN88US=> NYDTPYR5W0GQR1XS
BL-70 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW0cmRKSzVyPUS2Mlc4OzdizszN NYHhe|J3W0GQR1XS
Saos-2 NWDwToxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P5[GlEPTB;NEeuN|EzOyEQvF2= MWLTRW5ITVJ?
LC-1F NFnFSpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrVT2ZKSzVyPUS3MlYyODVizszN M2jJZXNCVkeHUh?=
KY821 MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[3TWM2OD12Nz62OFM1KM7:TR?= NFvkZ5JUSU6JRWK=
PSN1 NX\jZlVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTHTWM2OD12OD6xOFAyKM7:TR?= M37RV3NCVkeHUh?=
RT4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfhTWM2OD12OD64N|c4KM7:TR?= MkSyV2FPT0WU
LS-1034 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjBTWM2OD12OD64PVU1KM7:TR?= NITwUnpUSU6JRWK=
NCI-H1395 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTR7LkC0PVIh|ryP NYjYVIRpW0GQR1XS
EKVX NFLTNoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\4VGlEPTB;NEmuOlc{OSEQvF2= Mm\TV2FPT0WU
IST-MES1 M3jRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3njfmlEPTB;NEmuPFk1PCEQvF2= MVzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-FAK / FAK / p-Talin / Talin ; 

PubMed: 26530902     


Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells.

p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; 

PubMed: 29417941     


MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.

26530902 29417941
Immunofluorescence
p-FAK; 

PubMed: 26530902     


Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).

26530902
Growth inhibition assay
Cell viability; 

PubMed: 28953264     


MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk (*) and p < 0.01 are designated by two asterisks (**).

28953264
In vivo PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. [1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. [3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. [4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. [5]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts.
  • Dosages: 50 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
For best results, use promptly after mixing.
5 mg/ml

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 507.49
Formula

C21H20F3N7O3S

CAS No. 717907-75-0
Storage powder
in solvent
Synonyms N/A
Smiles CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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FAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID