PF-562271

Catalog No.S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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In DMSO USD 350 In stock
USD 170 In stock
USD 270 In stock
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6 Customer Reviews

  • Effect of matrix stiffness on the susceptibility of primary HDFs to apoptosis induced by inhibition of mechanotransduction pathways. HDFs (primary human dermal fibroblasts) were cultured on collagen-coated polyacrylamide hydrogels that recapitulated the stiffness of normal (4 kPa) or densely fibrotic (50 kPa) skin for 24 hours and treated with or without the agents indicated for an additional 48 hours. Apoptosis was assessed by annexin V staining. Data are means ± SD from three independent experiments. P value was determined by Student’s t test.

    Science, 2017, 9(420), doi: 10.1126/scitranslmed.aal3765. PF-562271 purchased from Selleck.

    (F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

    Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.

  • D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

    Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

    Acta Pharmacol Sin, 2018, doi:10.1038/aps.2017.189. PF-562271 purchased from Selleck.

  • VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

    Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

    OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

    PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. [1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. [2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rqXmlEPTB;MD6yO|Y3KM7:TR?= NFr3PHpUSU6JRWK=
SW982 NIPmUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\kTWM2OD1yLkOyPFIh|ryP M2LEXnNCVkeHUh?=
KM12 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwM{i1OVch|ryP NFu5XJJUSU6JRWK=
COLO-205 NEHofopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PONWlEPTB;MD60PFY2QCEQvF2= M3XmPHNCVkeHUh?=
COLO-829 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH73THZKSzVyPUCuO|UyPzZizszN M17XWXNCVkeHUh?=
MG-63 M3f4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwOEC2N|ch|ryP NES4bpBUSU6JRWK=
IGROV-1 NVrH[|NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTOXVRKSzVyPUCuPFExOzhizszN NYLCXZVzW0GQR1XS
NCI-H650 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Ww[GlEPTB;MD64N|E2PCEQvF2= NYjYS5ROW0GQR1XS
RT-112 NX7mSVRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwOUi0OkDPxE1? MmrIV2FPT0WU
BCPAP M4\XUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zvemlEPTB;MT6wNVI5QCEQvF2= NVP0Om84W0GQR1XS
ALL-PO M1Hqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfz[HZKSzVyPUGuNFE2QDRizszN NYXsSlV5W0GQR1XS
KYSE-270 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTFwMES3NVQh|ryP MkO3V2FPT0WU
8305C NVXUUVA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoWzTWM2OD1zLkC5PVA1KM7:TR?= M4HvOXNCVkeHUh?=
NCI-H810 MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITmZVdKSzVyPUGuNVA4PzZizszN MWLTRW5ITVJ?
CAL-33 M2DOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrCO5BiUUN3ME2xMlEzQTN6IN88US=> NWXKPYZRW0GQR1XS
AN3-CA MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTFwMkG4Olch|ryP NEXsSFNUSU6JRWK=
NKM-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzZTHJKSzVyPUGuNlc2ODZizszN NV;CeGQ4W0GQR1XS
BPH-1 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn1NJRkUUN3ME2xMlI5PzZ4IN88US=> MmXKV2FPT0WU
MES-SA Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH3XnA6UUN3ME2xMlMxPjh{IN88US=> MUHTRW5ITVJ?
CAL-62 NGXr[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHGOJJKSzVyPUGuN|E6ODlizszN NF\kfGNUSU6JRWK=
Detroit562 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v2dmlEPTB;MT6zOVIzOiEQvF2= MkHuV2FPT0WU
KYSE-150 M3TzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwM{WyN|Yh|ryP NYjmW411W0GQR1XS
SK-UT-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrVTWM2OD1zLkS0OlQ4KM7:TR?= NGGzN2dUSU6JRWK=
HUTU-80 MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwNES4PFYh|ryP NVi0N2JbW0GQR1XS
SIG-M5 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFwNEizPFch|ryP M3XLT3NCVkeHUh?=
AGS NIWwco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT6PGlRUUN3ME2xMlUzOTJ2IN88US=> NWXaSXU4W0GQR1XS
ST486 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjQUopLUUN3ME2xMlU{Ojd6IN88US=> MUPTRW5ITVJ?
HSC-2 NEHBTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTFwNUO5OUDPxE1? M3;JdXNCVkeHUh?=
LCLC-103H MkX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTTTWM2OD1zLkW1PFE5KM7:TR?= NYH0ZlkxW0GQR1XS
BC-1 M17ZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrZR|BKSzVyPUGuOlE3PjRizszN NIf4Zo5USU6JRWK=
CGTH-W-1 NXzzbXhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTFwNkG2O|kh|ryP MnvBV2FPT0WU
MZ1-PC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFwNkKzNVIh|ryP M17L[HNCVkeHUh?=
SW1710 MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTuWVZKSzVyPUGuOlI3OjhizszN NF6zXGtUSU6JRWK=
EW-13 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjNV4dKSzVyPUGuOlM1PjZizszN MWfTRW5ITVJ?
TE-11 M3S4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfxN4RKSzVyPUGuOlM2OjJizszN MnfVV2FPT0WU
BHY MnGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\RTWM2OD1zLk[1OlY{KM7:TR?= M1fTb3NCVkeHUh?=
ML-2 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PMeWlEPTB;MT62OlgxOiEQvF2= MmflV2FPT0WU
MEL-JUSO MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;xeGlEPTB;MT63Nlg6OSEQvF2= MUTTRW5ITVJ?
U251 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXLTWM2OD1zLke0NFMyKM7:TR?= MoWwV2FPT0WU
MHH-ES-1 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;qTWM2OD1zLke5OVY5KM7:TR?= NYrGNmVbW0GQR1XS
CAL-85-1 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTFwOEC0PUDPxE1? NXe0VGxzW0GQR1XS
D-336MG NWG3cWVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3sTWM2OD1zLki1OlE1KM7:TR?= MknDV2FPT0WU
VA-ES-BJ NYX6VFlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTFwOUCzNVUh|ryP NFKxNIRUSU6JRWK=
MDA-MB-468 MmjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFwOUGyO|Ih|ryP MnPIV2FPT0WU
MEL-HO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHZTWM2OD1zLkm3PVk{KM7:TR?= MVXTRW5ITVJ?
SW954 NXnkZXZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf3RVZKSzVyPUKuNFAyPTFizszN NGXLbIlUSU6JRWK=
LB831-BLC NETOOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULpeIdGUUN3ME2yMlAxQTh6IN88US=> MVvTRW5ITVJ?
EW-16 NUG0cm03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHETWM2OD1{LkCzPVg{KM7:TR?= MmXiV2FPT0WU
NCI-H460 M4Xwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWr3foZzUUN3ME2yMlA1QDN7IN88US=> Ml;HV2FPT0WU
CHP-212 MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJwMEm1N|kh|ryP NHLF[21USU6JRWK=
MHH-NB-11 MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXLeVRKSzVyPUKuNVI5OThizszN NUD2OYVCW0GQR1XS
DU-4475 M3XITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJwMUS3OVkh|ryP NYjOUos2W0GQR1XS
ABC-1 NWraU5RuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7YW|NKSzVyPUKuNlUyQTZizszN NF3FfolUSU6JRWK=
LOUCY NHjMVmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTPTWM2OD1{LkK2NVI5KM7:TR?= MoT1V2FPT0WU
LC-2-ad NHfpdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrIWFZKSzVyPUKuNlY6PjZizszN MnfDV2FPT0WU
ETK-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDxTWM2OD1{LkK4OFYh|ryP NHn2O|lUSU6JRWK=
KYSE-180 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrqfFJwUUN3ME2yMlI5QDd2IN88US=> NF:zUpVUSU6JRWK=
HOP-92 M2DPW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;6TWM2OD1{LkOwOlc{KM7:TR?= MmTHV2FPT0WU
RCC10RGB MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofqTWM2OD1{LkOyOVA4KM7:TR?= NUnjc21KW0GQR1XS
KASUMI-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJwM{K4PEDPxE1? MkP0V2FPT0WU
ACN M3XJTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJwM{S3OFUh|ryP M37J[3NCVkeHUh?=
BxPC-3 NWLib2dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;nNGlEPTB;Mj6zOVQ{PiEQvF2= MnLtV2FPT0WU
MONO-MAC-6 NXH2bVNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfOTWM2OD1{LkSxNlQ5KM7:TR?= MlvhV2FPT0WU
CAL-39 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJwNEG2Nlgh|ryP MlK5V2FPT0WU
CMK MnPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJwNEG3PVUh|ryP NH60fm9USU6JRWK=
MFE-296 NYLyb5FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ZTWM2OD1{LkS3O|kzKM7:TR?= NUfqNmtHW0GQR1XS
DU-145 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\5SHhrUUN3ME2yMlQ6OTF6IN88US=> M3G2ZXNCVkeHUh?=
MDA-MB-231 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjMfJlvUUN3ME2yMlQ6PTd{IN88US=> MUHTRW5ITVJ?
EFO-27 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnznTWM2OD1{LkWxPFg5KM7:TR?= MUHTRW5ITVJ?
SNU-387 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXHVJpJUUN3ME2yMlUzQDJizszN NUjP[IluW0GQR1XS
KYSE-410 M4jsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrU[|N2UUN3ME2yMlU3PTF5IN88US=> M2XzeXNCVkeHUh?=
NCCIT NFj5VXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJwNUeyOEDPxE1? NFjjUWtUSU6JRWK=
LXF-289 MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJwNUiyO|Mh|ryP Mk\oV2FPT0WU
HMV-II MmPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1yyOWlEPTB;Mj61PFk6PyEQvF2= M2XrXnNCVkeHUh?=
MOLT-4 M4XUS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVGwPVFbUUN3ME2yMlYxPzF{IN88US=> MUHTRW5ITVJ?
KOSC-2 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJwNkO4O|kh|ryP MkXEV2FPT0WU
TUR NHfINGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXLPIppUUN3ME2yMlY2OzZ7IN88US=> MkPQV2FPT0WU
NCI-H2087 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwN{G2OFYh|ryP M2TLeXNCVkeHUh?=
SCC-15 NGTJUYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJwN{WyOVIh|ryP MoHUV2FPT0WU
HSC-4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LBXGlEPTB;Mj63PFM5QSEQvF2= MUPTRW5ITVJ?
G-402 NUPrbXM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzVTWM2OD1{LkixOFQ4KM7:TR?= MYfTRW5ITVJ?
GP5d NYLnPZpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJwOEO4Nlch|ryP MUXTRW5ITVJ?
IGR-1 NFzlN3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwOEO5PFch|ryP M17neXNCVkeHUh?=
SK-PN-DW NXj1NYo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTqUpluUUN3ME2yMlg3OjB2IN88US=> MX7TRW5ITVJ?
OPM-2 MnfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmxVWZbUUN3ME2yMlg6QTd6IN88US=> Mo\KV2FPT0WU
5637 M1i4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Tt[2lEPTB;Mj65NlQ{QSEQvF2= NFXQNZhUSU6JRWK=
NCI-H2030 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJwOUiwNlkh|ryP NGDZUIVUSU6JRWK=
SK-LU-1 MmPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT0VGlDUUN3ME2yMlk5OzN2IN88US=> MVnTRW5ITVJ?
EW-18 NYX0S3R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTNwMEWzNkDPxE1? MYHTRW5ITVJ?
786-0 NWrHXZBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TYRmlEPTB;Mz6wOVc5PCEQvF2= MV\TRW5ITVJ?
NCI-H1963 M4q3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTUN2hKSzVyPUOuNFg5OjVizszN NXLrenFMW0GQR1XS
A2780 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH1WlBKSzVyPUOuNVA{PDFizszN M2PKNnNCVkeHUh?=
NCI-H526 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TjZmlEPTB;Mz6xN|k3OSEQvF2= MVHTRW5ITVJ?
BHT-101 NH;PWG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTNwMUW3PVgh|ryP NET0NZBUSU6JRWK=
RPMI-7951 M4LUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3radGlEPTB;Mz6yNFE{PyEQvF2= M17pPXNCVkeHUh?=
HL-60 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnRTWM2OD1|LkKxNVQh|ryP MnjwV2FPT0WU
CTV-1 Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNwMkWzO|ch|ryP MVfTRW5ITVJ?
IST-SL1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHU[XJKSzVyPUOuNlk1PjVizszN NWXDV|NIW0GQR1XS
G-401 MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNwMkm4NFgh|ryP MmDEV2FPT0WU
OVCAR-5 MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{njOmlEPTB;Mz6zOlM2OiEQvF2= NIP2SFRUSU6JRWK=
EW-1 NIX1OHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP1UmZKSzVyPUOuOFA2PDRizszN NG\ITVFUSU6JRWK=
H4 NUHLe3pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrlTZduUUN3ME2zMlQ4PTZ7IN88US=> Mn7GV2FPT0WU
EM-2 NX;vOnllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;M[WlEPTB;Mz60PFY4PCEQvF2= M{jaUnNCVkeHUh?=
RS4-11 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqzTWM2OD1|LkS4O|E2KM7:TR?= MXfTRW5ITVJ?
NOMO-1 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNwNEmyNFQh|ryP NF\qSZlUSU6JRWK=
HCT-116 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTNwNUC3NVEh|ryP NXPLZWlIW0GQR1XS
CAL-120 M1jQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfYenNKSzVyPUOuOVc{PSEQvF2= M{HCVHNCVkeHUh?=
CAL-51 NHLsUIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LDRWlEPTB;Mz61O|YyOiEQvF2= NF23d|BUSU6JRWK=
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IPC-298 NFHFflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4OxTGlEPTB;OD6yO|cxQSEQvF2= NIjmRYxUSU6JRWK=
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CAMA-1 NGTueJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLFVo16UUN3ME25MlA3ODF{IN88US=> MlzJV2FPT0WU
HT-29 NIjpUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGwPYtYUUN3ME25MlEzOzd|IN88US=> NVnr[Y42W0GQR1XS
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SK-CO-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnXTWM2OD17Lke2NlM2KM7:TR?= MVPTRW5ITVJ?
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NCI-H716 NHzxXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjxSow4UUN3ME25Mlk{OzJ{IN88US=> NUTmdVhqW0GQR1XS
U-698-M NGrrZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfWPHV{UUN3ME25Mlk6PyEQvF2= M2jFVHNCVkeHUh?=
EFO-21 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;KTWM2OD1zMD6wNFk{KM7:TR?= Mo\2V2FPT0WU
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OS-RC-2 NF[wcVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfMRW1sUUN3ME2xNE4{OjJ5IN88US=> MUnTRW5ITVJ?
YT M{i3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTCTZM5UUN3ME2xNE41ODBzIN88US=> NHTBcYRUSU6JRWK=
COLO-679 M4e4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTFyLkSyPFUh|ryP NV\0PVBjW0GQR1XS
CAS-1 NGfiR5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTFyLkS2NFgh|ryP M1eyO3NCVkeHUh?=
NCI-H2052 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jpXmlEPTB;MUCuOVExPSEQvF2= MkDjV2FPT0WU
NCI-H2452 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17oN2lEPTB;MUCuOlE5OSEQvF2= MkTNV2FPT0WU
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HuP-T4 M4riSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPxcI1uUUN3ME2xNE44ODZ6IN88US=> MmfuV2FPT0WU
UMC-11 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFyLkmzO|Mh|ryP MmjIV2FPT0WU
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DoTc2-4510 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYixXFV4UUN3ME2xNU4yOzh7IN88US=> NUi0doNvW0GQR1XS
HLE NFfGOpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHFUGd2UUN3ME2xNU4zOTF7IN88US=> NEe0Xo9USU6JRWK=
SW626 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFzLkK4PFkh|ryP NHXmR25USU6JRWK=
COR-L105 NX3LR2FGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHZW|Y3UUN3ME2xNU4{OjN5IN88US=> Mle4V2FPT0WU
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GR-ST MmXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLqUmpNUUN3ME2xNU43OThzIN88US=> MVnTRW5ITVJ?
BL-41 Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XDXGlEPTB;MUGuO|E4OyEQvF2= NFjhOIxUSU6JRWK=
GB-1 M2W5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D6[WlEPTB;MUGuO|YyQSEQvF2= M{HuVnNCVkeHUh?=
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L-540 NX3DSVl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTFzLki5PUDPxE1? NULzU3dGW0GQR1XS
NCI-H69 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHveotKSzVyPUGyMlAyOzlizszN M13E[3NCVkeHUh?=
769-P NV7ISIlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTF{LkCxPUDPxE1? NY\yd2VNW0GQR1XS
A172 NEPQPG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml75TWM2OD1zMj6xNlA4KM7:TR?= M4riVXNCVkeHUh?=
CAL-27 NYe3bHp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX2OFE4UUN3ME2xNk4yOzZ7IN88US=> MWHTRW5ITVJ?
NCI-H1437 M4TY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe2[IZKSzVyPUGyMlE1PDdizszN NUXGfWJZW0GQR1XS
REH MlLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTGTWM2OD1zMj6xOVc{KM7:TR?= MkPEV2FPT0WU
KINGS-1 NHXWVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLJb4FFUUN3ME2xNk4{PDJzIN88US=> NVflT3BRW0GQR1XS
NCI-H1792 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF{LkO4OVEh|ryP NX7we3M{W0GQR1XS
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HAL-01 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF{Lk[xO|Qh|ryP M1XZbnNCVkeHUh?=
NCI-H2141 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3DSZZKSzVyPUGyMlY2QCEQvF2= M{nKOnNCVkeHUh?=
HCC1806 NGD3UppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TzSmlEPTB;MUKuOlk2OiEQvF2= NIfaOIRUSU6JRWK=
LU-134-A NUHqcGp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTub|VKSzVyPUGyMlk{KM7:TR?= MljmV2FPT0WU
HT NHv5T5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT6TWM2OD1zMj65OFM4KM7:TR?= NYPDfGNJW0GQR1XS
OE33 NVPEVXlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nqVGlEPTB;MUKuPVQ2PiEQvF2= M4DBb3NCVkeHUh?=
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SW948 NGjsbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnyTWM2OD1zMz6wNVMh|ryP NIGwbWlUSU6JRWK=
LB2241-RCC NXXrXlFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D1U2lEPTB;MUOuNVQ3QSEQvF2= Moe0V2FPT0WU
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RPMI-8402 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTF|LkWwN|Eh|ryP MXrTRW5ITVJ?
DEL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;Vd4V7UUN3ME2xN{42PTB|IN88US=> M1[xOXNCVkeHUh?=
NB5 NWfido5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[yZmlEPTB;MUOuOVUxOyEQvF2= NWDzT4FNW0GQR1XS
NUGC-3 NX\DeGNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnVTWM2OD1zMz63OFU{KM7:TR?= MYHTRW5ITVJ?
CAL-72 M3HmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF2LkG5NFYh|ryP NHLnS|ZUSU6JRWK=
VMRC-RCZ MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn74TWM2OD1zND6yN|Yh|ryP MUDTRW5ITVJ?
YAPC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXQSmtKSzVyPUG0MlI1ODdizszN MlO2V2FPT0WU
ES5 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH3VY9xUUN3ME2xOE4zPTl7IN88US=> NV3Se4pvW0GQR1XS
CAL-12T M2DhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXntUpBHUUN3ME2xOE41OzN4IN88US=> MV\TRW5ITVJ?
GAMG NIPnfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorYTWM2OD1zND61OVc4KM7:TR?= M{C5VXNCVkeHUh?=
BT-20 M1jhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nMdGlEPTB;MUSuPVM5PCEQvF2= MX7TRW5ITVJ?
KALS-1 M1[xVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn5TWM2OD1zNT6wNVU5KM7:TR?= NFGz[Y1USU6JRWK=
LS-123 MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXWelRKSzVyPUG1MlAyPjVizszN MV7TRW5ITVJ?
LK-2 NGHtTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknkTWM2OD1zNT6wPFYzKM7:TR?= Ml21V2FPT0WU
NCI-H1770 MmraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zXU2lEPTB;MUWuNlg3QCEQvF2= M1\DfXNCVkeHUh?=
MIA-PaCa-2 M1jIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\1TWM2OD1zNT60NVY{KM7:TR?= M4K5XHNCVkeHUh?=
DB MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;JTWM2OD1zNT62PVQyKM7:TR?= NGi0VY1USU6JRWK=
Becker MknoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rmTGlEPTB;MUWuPFkzPiEQvF2= M4fOcHNCVkeHUh?=
HT-144 NY\nVot2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2KybWlEPTB;MUWuPVQ6PyEQvF2= MVTTRW5ITVJ?
NCI-H2405 M4L5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHwN|VOUUN3ME2xOk4zOjF6IN88US=> NGH5NoxUSU6JRWK=
TK10 MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DFXmlEPTB;MU[uN|c1OiEQvF2= M4TKRXNCVkeHUh?=
THP-1 MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojaTWM2OD1zNj60OlY2KM7:TR?= M4THeXNCVkeHUh?=
LB373-MEL-D NV;KbIRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7aN3o5UUN3ME2xOk43OTN6IN88US=> MVrTRW5ITVJ?
SJSA-1 M4TxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXsR4pKSzVyPUG2MlkzOTlizszN NFPWc3pUSU6JRWK=
EB2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rXbmlEPTB;MUeuO|QzPiEQvF2= M3vVeHNCVkeHUh?=
MN-60 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PSfGlEPTB;MUeuO|k{PiEQvF2= MlLNV2FPT0WU
A253 M1vTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TSZmlEPTB;MUeuPFI2KM7:TR?= M{TFUXNCVkeHUh?=
CESS NWnsO5NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLG[ZE{UUN3ME2xO{46OzJ4IN88US=> NGfae5NUSU6JRWK=
EW-11 NYjRfYxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fEe2lEPTB;MUeuPVk2QCEQvF2= MlPHV2FPT0WU
TE-8 MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LpXmlEPTB;MUiuNFY3QSEQvF2= MlvyV2FPT0WU
UACC-257 Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF6LkKwOlIh|ryP MkHUV2FPT0WU
NCI-H226 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe4d3dOUUN3ME2xPE45Ojl7IN88US=> MXnTRW5ITVJ?
NCI-H748 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPyTWM2OD1zOD64OVg2KM7:TR?= MVzTRW5ITVJ?
NCI-H1299 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL1TWM2OD1zOD64PVE5KM7:TR?= NWP4d4MzW0GQR1XS
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COLO-678 M1vmT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PU[WlEPTB;NECuOVk2KM7:TR?= M2PIeHNCVkeHUh?=
PF-382 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlezTWM2OD12MD63OFg4KM7:TR?= M1XKcHNCVkeHUh?=
OAW-42 NXf1dZpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfSTWM2OD12Mj6yPVQzKM7:TR?= M2C4ZXNCVkeHUh?=
LB996-RCC NVTGPFV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrHXIJKSzVyPUSyMlgxODhizszN NIjYbGdUSU6JRWK=
SAS NGHJToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHRRllKSzVyPUSzMlQzQDhizszN MVPTRW5ITVJ?
MRK-nu-1 M{fqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHvfYtKSzVyPUS0Mlc1OTRizszN MnS4V2FPT0WU
EoL-1-cell NHKzNmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PPeWlEPTB;NESuPVE{PiEQvF2= MljGV2FPT0WU
NCI-H2342 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rZO2lEPTB;NEWuNVEyPyEQvF2= MlXXV2FPT0WU
NCI-H1703 NFu2OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3PTGN1UUN3ME20Ok4xPTl{IN88US=> NFLSN3lUSU6JRWK=
NCI-H187 NXLrVlBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG4Wm5KSzVyPUS2MlE5PjlizszN NF7Yc4dUSU6JRWK=
CP66-MEL MmSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTR4LkK3PFkh|ryP NHKzNFlUSU6JRWK=
HCC1569 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M136T2lEPTB;NE[uOVkyPyEQvF2= NXjGdo51W0GQR1XS
BL-70 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jObmlEPTB;NE[uO|c{PyEQvF2= M2XuWnNCVkeHUh?=
Saos-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vM[WlEPTB;NEeuN|EzOyEQvF2= NELhWIJUSU6JRWK=
LC-1F M4HLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTR5Lk[xNFUh|ryP MXTTRW5ITVJ?
KY821 M4fnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TjcmlEPTB;NEeuOlQ{PCEQvF2= NWrhd2hjW0GQR1XS
PSN1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLoTWM2OD12OD6xOFAyKM7:TR?= MVPTRW5ITVJ?
RT4 NGDGRnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;FbY5KSzVyPUS4Mlg{PzdizszN MonnV2FPT0WU
LS-1034 NVi0TIpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH5Wot7UUN3ME20PE45QTV2IN88US=> MXHTRW5ITVJ?
NCI-H1395 NUSzR|A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnhUXg2UUN3ME20PU4xPDl{IN88US=> Mmj4V2FPT0WU
EKVX NV65cFMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfIOm8yUUN3ME20PU43PzNzIN88US=> MlyzV2FPT0WU
IST-MES1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR7Lki5OFQh|ryP NEW0TZBUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. [1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. [3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. [4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. [5]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts.
  • Formulation: 5% Gelucire
  • Dosages: 50 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 507.49
Formula

C21H20F3N7O3S

CAS No. 717907-75-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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FAK Signaling Pathway Map

Related FAK Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID