PF-562271

Catalog No.S2890

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

6 Customer Reviews

Effect of matrix stiffness on the susceptibility of primary HDFs to apoptosis induced by inhibition of mechanotransduction pathways. HDFs (primary human dermal fibroblasts) were cultured on collagen-coated polyacrylamide hydrogels that recapitulated the stiffness of normal (4 kPa) or densely fibrotic (50 kPa) skin for 24 hours and treated with or without the agents indicated for an additional 48 hours. Apoptosis was assessed by annexin V staining. Data are means ± SD from three independent experiments. P value was determined by Student’s t test.

Science, 2017, 9(420), doi: 10.1126/scitranslmed.aal3765. PF-562271 purchased from Selleck.

(F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.
D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

Acta Pharmacol Sin, 2018, doi:10.1038/aps.2017.189. PF-562271 purchased from Selleck.
VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description

Targets

FAK ^[1] (Cell-free assay)	PYK2 ^[1] (Cell-free assay)	CDK2/CyclinE ^[1] (Cell-free assay)	CDK3/CyclinE ^[1] (Cell-free assay)	CDK1/CyclinB ^[1] (Cell-free assay)	View More
1.5 nM	13 nM	30 nM	47 nM	58 nM	View More

In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. ^[1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. ^[2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
MV-4-11	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVP0e4NiUUN3ME2wMlI4PjZizszN	NGTic5BUSU6JRWK=
SW982	NXzpbZRvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYLJR\|UxRTBwM{K4NkDPxE1?	NFuxN4RUSU6JRWK=
KM12	NIT2N2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHHCPZRKSzVyPUCuN\|g2PTdizszN	M2riPXNCVkeHUh?=
COLO-205	NEnqe21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUnsVFY2UUN3ME2wMlQ5PjV6IN88US=>	NV7XS3FyW0GQR1XS
COLO-829	NGm3[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUnZRpdSUUN3ME2wMlc2OTd4IN88US=>	NIXCb3RUSU6JRWK=
MG-63	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDaTWM2OD1yLkiwOlM4KM7:TR?=	M4XvUHNCVkeHUh?=
IGROV-1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXPzPWJFUUN3ME2wMlgyODN6IN88US=>	M{\wTHNCVkeHUh?=
NCI-H650	NYPkOmo6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWe3Z5FKUUN3ME2wMlg{OTV2IN88US=>	M1nMOHNCVkeHUh?=
RT-112	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHTMcm9KSzVyPUCuPVg1PiEQvF2=	NXfBfoZJW0GQR1XS
BCPAP	NGLsS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml3tTWM2OD1zLkCxNlg5KM7:TR?=	NX\ZS2h3W0GQR1XS
ALL-PO	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX22U3Q1UUN3ME2xMlAyPTh2IN88US=>	NI\ST\|NUSU6JRWK=
KYSE-270	NUWzZWJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml\MTWM2OD1zLkC0O\|E1KM7:TR?=	NH;vVHRUSU6JRWK=
8305C	M1e4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUTSfpV7UUN3ME2xMlA6QTB2IN88US=>	NXy0TlFSW0GQR1XS
NCI-H810	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnfxTWM2OD1zLkGwO\|c3KM7:TR?=	MknvV2FPT0WU
CAL-33	MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4H3d2lEPTB;MT6xNlk{QCEQvF2=	MWXTRW5ITVJ?
AN3-CA	MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2LR[WlEPTB;MT6yNVg3PyEQvF2=	Ml3PV2FPT0WU
NKM-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;zTWM2OD1zLkK3OVA3KM7:TR?=	MlfmV2FPT0WU
BPH-1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVPJR\|UxRTFwMki3OlYh\|ryP	M{THenNCVkeHUh?=
MES-SA	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVHJR\|UxRTFwM{C2PFIh\|ryP	NEnZSXJUSU6JRWK=
CAL-62	MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIfPeZlKSzVyPUGuN\|E6ODlizszN	MXTTRW5ITVJ?
Detroit562	NX64bJRbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTFwM{WyNlIh\|ryP	NXzVd3F7W0GQR1XS
KYSE-150	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M37jPWlEPTB;MT6zOVI{PiEQvF2=	NV;4XnpKW0GQR1XS
SK-UT-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDRfHZKSzVyPUGuOFQ3PDdizszN	NIHlSllUSU6JRWK=
HUTU-80	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEjBelNKSzVyPUGuOFQ5QDZizszN	NVfv[VZEW0GQR1XS
SIG-M5	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DPTWlEPTB;MT60PFM5PyEQvF2=	NIjob29USU6JRWK=
AGS	NXXMeYtrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUezcFlPUUN3ME2xMlUzOTJ2IN88US=>	NXXCVWhDW0GQR1XS
ST486	NXfDeG0zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzQd2FKSzVyPUGuOVMzPzhizszN	M4rzenNCVkeHUh?=
HSC-2	NYDj[IFTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYDJR\|UxRTFwNUO5OUDPxE1?	M{Tzc3NCVkeHUh?=
LCLC-103H	NVHrXW5kT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HSRWlEPTB;MT61OVgyQCEQvF2=	Mlv0V2FPT0WU
BC-1	NGOyS2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHvTWM2OD1zLk[xOlY1KM7:TR?=	MVrTRW5ITVJ?
CGTH-W-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH;lRW9KSzVyPUGuOlE3PzlizszN	MmX0V2FPT0WU
MZ1-PC	MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPDXZJKSzVyPUGuOlI{OTJizszN	MoTZV2FPT0WU
SW1710	MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2qwPGlEPTB;MT62NlYzQCEQvF2=	MULTRW5ITVJ?
EW-13	NVPjT4wzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTFwNkO0OlYh\|ryP	NYq5bYd3W0GQR1XS
TE-11	NEnpeVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M362V2lEPTB;MT62N\|UzOiEQvF2=	MmDRV2FPT0WU
BHY	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHWx[GRKSzVyPUGuOlU3PjNizszN	M3zTcHNCVkeHUh?=
ML-2	NEnFZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MofITWM2OD1zLk[2PFAzKM7:TR?=	Mon6V2FPT0WU
MEL-JUSO	NWXue5N6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HoVGlEPTB;MT63Nlg6OSEQvF2=	Ml:zV2FPT0WU
U251	Ml[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTzTWM2OD1zLke0NFMyKM7:TR?=	NHPyeGFUSU6JRWK=
MHH-ES-1	NHjC[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYHJR\|UxRTFwN{m1Olgh\|ryP	M2nTVnNCVkeHUh?=
CAL-85-1	M1;oZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVrXRm9WUUN3ME2xMlgxPDlizszN	NG\LVoZUSU6JRWK=
D-336MG	M3y1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2X0NmlEPTB;MT64OVYyPCEQvF2=	MXzTRW5ITVJ?
VA-ES-BJ	NEXoTFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYHlTY1TUUN3ME2xMlkxOzF3IN88US=>	M3noOHNCVkeHUh?=
MDA-MB-468	NFfUVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NY[3[lA4UUN3ME2xMlkyOjd{IN88US=>	NUXTWJI{W0GQR1XS
MEL-HO	NVHvT4JbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVPJR\|UxRTFwOUe5PVMh\|ryP	M1Hvc3NCVkeHUh?=
SW954	NVvFZopHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEXUOYNKSzVyPUKuNFAyPTFizszN	MWfTRW5ITVJ?
LB831-BLC	MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLNTWM2OD1{LkCwPVg5KM7:TR?=	MUjTRW5ITVJ?
EW-16	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2\VcWlEPTB;Mj6wN\|k5OyEQvF2=	MYXTRW5ITVJ?
NCI-H460	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYLJR\|UxRTJwMES4N\|kh\|ryP	NXvNSoJFW0GQR1XS
CHP-212	NFzxXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUi2eYd1UUN3ME2yMlA6PTN7IN88US=>	NFu4UlZUSU6JRWK=
MHH-NB-11	M2WzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mk\xTWM2OD1{LkGyPFE5KM7:TR?=	MoTrV2FPT0WU
DU-4475	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnETWM2OD1{LkG0O\|U6KM7:TR?=	M2fjTnNCVkeHUh?=
ABC-1	NW\QXWZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHjySm1KSzVyPUKuNlUyQTZizszN	MoiwV2FPT0WU
LOUCY	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHrRdnhKSzVyPUKuNlYyOjhizszN	Mlf0V2FPT0WU
LC-2-ad	M2TJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIrRXJVKSzVyPUKuNlY6PjZizszN	MmjCV2FPT0WU
ETK-1	NYXQRWpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NETyXI5KSzVyPUKuNlg1PiEQvF2=	NVu0Rm9qW0GQR1XS
KYSE-180	M4PuNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NImxdG5KSzVyPUKuNlg5PzRizszN	NH75OWxUSU6JRWK=
HOP-92	NVvOc\|huT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV;SRnVXUUN3ME2yMlMxPjd\|IN88US=>	MoTqV2FPT0WU
RCC10RGB	NIDpdItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MonaTWM2OD1{LkOyOVA4KM7:TR?=	NXz4VXVCW0GQR1XS
KASUMI-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NITDW3pKSzVyPUKuN\|I5QCEQvF2=	M2XzdnNCVkeHUh?=
ACN	NWHCW\|FtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M131ZmlEPTB;Mj6zOFc1PSEQvF2=	NEXxUopUSU6JRWK=
BxPC-3	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmPsTWM2OD1{LkO1OFM3KM7:TR?=	NEj5XGlUSU6JRWK=
MONO-MAC-6	NILSNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIjnTXBKSzVyPUKuOFEzPDhizszN	Ml3jV2FPT0WU
CAL-39	MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M17zZmlEPTB;Mj60NVYzQCEQvF2=	M{TuSnNCVkeHUh?=
CMK	NWfFNnlHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHPFfnBKSzVyPUKuOFE4QTVizszN	Mn;ZV2FPT0WU
MFE-296	M2TnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{HTNGlEPTB;Mj60O\|c6OiEQvF2=	NIHIXYJUSU6JRWK=
DU-145	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFfvV4dKSzVyPUKuOFkyOThizszN	MXXTRW5ITVJ?
MDA-MB-231	MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHz3cJJKSzVyPUKuOFk2PzJizszN	NUL3SotyW0GQR1XS
EFO-27	MmnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3\sSmlEPTB;Mj61NVg5QCEQvF2=	M{fq[XNCVkeHUh?=
SNU-387	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGKxc3JKSzVyPUKuOVI5OiEQvF2=	NWXCXplrW0GQR1XS
KYSE-410	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4PxbWlEPTB;Mj61OlUyPyEQvF2=	MX7TRW5ITVJ?
NCCIT	NH2yN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn3GTWM2OD1{LkW3NlQh\|ryP	MkLoV2FPT0WU
LXF-289	M{TW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYLJR\|UxRTJwNUiyO\|Mh\|ryP	M3zFVnNCVkeHUh?=
HMV-II	NIOwV5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGTpfIlKSzVyPUKuOVg6QTdizszN	NWnuUZZ1W0GQR1XS
MOLT-4	NGHY[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MY\JR\|UxRTJwNkC3NVIh\|ryP	NUXzRVZjW0GQR1XS
KOSC-2	Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIPjZ5pKSzVyPUKuOlM5PzlizszN	MlXzV2FPT0WU
TUR	NWXUeZhoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzUUFBKSzVyPUKuOlU{PjlizszN	MnPvV2FPT0WU
NCI-H2087	M1jlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTJwN{G2OFYh\|ryP	MXTTRW5ITVJ?
SCC-15	MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4rW[2lEPTB;Mj63OVI2OiEQvF2=	MXLTRW5ITVJ?
HSC-4	NWrFWFl4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUXJR\|UxRTJwN{izPFkh\|ryP	NIXwU5hUSU6JRWK=
G-402	MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIjIbopKSzVyPUKuPFE1PDdizszN	MkCyV2FPT0WU
GP5d	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGHWW2hKSzVyPUKuPFM5OjdizszN	NVG0NIVvW0GQR1XS
IGR-1	NYfmZndnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYXJclVDUUN3ME2yMlg{QTh5IN88US=>	M1rzOnNCVkeHUh?=
SK-PN-DW	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYDYR2p2UUN3ME2yMlg3OjB2IN88US=>	NETNclBUSU6JRWK=
OPM-2	MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jwN2lEPTB;Mj64PVk4QCEQvF2=	NGPm[4VUSU6JRWK=
5637	NWrubHhlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVfMbFh[UUN3ME2yMlkzPDN7IN88US=>	MVLTRW5ITVJ?
NCI-H2030	NHvr[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXjJR\|UxRTJwOUiwNlkh\|ryP	NUPrXZdZW0GQR1XS
SK-LU-1	MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUG3cGpCUUN3ME2yMlk5OzN2IN88US=>	NYnCPGlDW0GQR1XS
EW-18	NFHjWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoHITWM2OD1\|LkC1N\|Ih\|ryP	M{ntdnNCVkeHUh?=
786-0	M1r2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmX3TWM2OD1\|LkC1O\|g1KM7:TR?=	Mk\yV2FPT0WU
NCI-H1963	M2\ES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1zuRWlEPTB;Mz6wPFgzPSEQvF2=	MnfzV2FPT0WU
A2780	MoTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVToNXdIUUN3ME2zMlExOzRzIN88US=>	M{jsPHNCVkeHUh?=
NCI-H526	M{[0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYnkZXlbUUN3ME2zMlE{QTZzIN88US=>	NVezRW86W0GQR1XS
BHT-101	Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\sVGlEPTB;Mz6xOVc6QCEQvF2=	Mk[0V2FPT0WU
RPMI-7951	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYjJR\|UxRTNwMkCxN\|ch\|ryP	MVrTRW5ITVJ?
HL-60	MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHzSW4ZKSzVyPUOuNlEyPCEQvF2=	M2HDcXNCVkeHUh?=
CTV-1	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHLWVZdKSzVyPUOuNlU{PzdizszN	MoLqV2FPT0WU
IST-SL1	M13lXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{L1R2lEPTB;Mz6yPVQ3PSEQvF2=	NEDhU3lUSU6JRWK=
G-401	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUjiWndnUUN3ME2zMlI6QDB6IN88US=>	MkniV2FPT0WU
OVCAR-5	NWD5RnlLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFTJdGNKSzVyPUOuN\|Y{PTJizszN	M3\p[XNCVkeHUh?=
EW-1	NIHpSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHv4SYVKSzVyPUOuOFA2PDRizszN	NUnOfYx5W0GQR1XS
H4	MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFOz[pRKSzVyPUOuOFc2PjlizszN	M2rnZXNCVkeHUh?=
EM-2	NWjOXWhiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFLuVnhKSzVyPUOuOFg3PzRizszN	MXrTRW5ITVJ?
RS4-11	NWfvS2Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGTWXGFKSzVyPUOuOFg4OTVizszN	NWizd\|FUW0GQR1XS
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CAL-120	MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DrR2lEPTB;Mz61O\|M2KM7:TR?=	MofmV2FPT0WU
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NCI-H747	NFrOPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFLlOZJKSzVyPUSuNFg3PzRizszN	M4nmcXNCVkeHUh?=
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NCI-H358	NHqzb4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWTJR\|UxRTRwNEi1N\|Ih\|ryP	MXHTRW5ITVJ?
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NCI-SNU-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoXrTWM2OD12LkS5O\|AyKM7:TR?=	NGPZO\|hUSU6JRWK=
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NCI-H2009	NWm5cHNOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXL6PYRRUUN3ME21MlMxPTN6IN88US=>	NV[1d2hnW0GQR1XS
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A101D	NHHvT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWfJR\|UxRTVwM{m2PFkh\|ryP	MonaV2FPT0WU
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TE-6	MlnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHvZ4NKSzVyPUWuOFQ2PjlizszN	NUiycI5CW0GQR1XS
SR	NFuzeXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVrnXoJkUUN3ME21MlU{PjR3IN88US=>	NGP0foJUSU6JRWK=
HOP-62	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;zeXltUUN3ME21MlU3QDh5IN88US=>	MnPqV2FPT0WU
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TE-9	NXzvVHdMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUniW5R4UUN3ME21MlYyPzh6IN88US=>	MX7TRW5ITVJ?
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KYSE-510	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MonXTWM2OD13Lke5OVgyKM7:TR?=	M{PmTnNCVkeHUh?=
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OVCAR-3	NGfMWnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXLJeYZjUUN3ME21Mlg5OjB4IN88US=>	MlfpV2FPT0WU
LB1047-RCC	NXnDOYxTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUfJR\|UxRTVwOUCxOFgh\|ryP	MWjTRW5ITVJ?
HEL	NUjtb2sxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEjXeVdKSzVyPU[uNFIyQDhizszN	M1H4PHNCVkeHUh?=
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NCI-H1304	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHjTU2xKSzVyPU[uNVI1QTdizszN	MVLTRW5ITVJ?
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NCI-H838	NYnHXWk1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NILIfFdKSzVyPU[uOVE4ODNizszN	NYrE[Fc6W0GQR1XS
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639-V	MkLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MorHTWM2OD14Lke1NVI4KM7:TR?=	Mo[yV2FPT0WU
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C-4-II	MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGrTZZZKSzVyPU[uPFMyOTdizszN	M{\LNnNCVkeHUh?=
23132-87	NIfQ[ohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVrRZnJvUUN3ME22MlkxQTBzIN88US=>	MYfTRW5ITVJ?
MEG-01	NYLtVIVtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHW0e4RKSzVyPU[uPVM2PDZizszN	M4HFWXNCVkeHUh?=
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NCI-H2347	MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUf3cFRRUUN3ME22Mlk1PzF3IN88US=>	MYrTRW5ITVJ?
MS-1	NEO4VotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYflRpZrUUN3ME22Mlk2OTl{IN88US=>	NWHNWFY6W0GQR1XS
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LB771-HNC	M4Ht[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWWxOmMxUUN3ME23MlE5ODN6IN88US=>	MlzCV2FPT0WU
LCLC-97TM1	NWDEWoFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFvUUnpKSzVyPUeuNlEzPzNizszN	NHTMbW1USU6JRWK=
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IST-SL2	NH\RTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTdwNUKyO\|Ih\|ryP	NVTCUI16W0GQR1XS
MLMA	MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkHQTWM2OD15LkW0Olg6KM7:TR?=	MWrTRW5ITVJ?
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HT-1080	NHPHSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1Hk[GlEPTB;Nz63PFU2PSEQvF2=	M3;SOXNCVkeHUh?=
SF268	M1XKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWXJR\|UxRTdwOEO1OkDPxE1?	MWPTRW5ITVJ?
COLO-800	M2q2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmnKTWM2OD15LkmwOlg2KM7:TR?=	NF[w[m1USU6JRWK=
BB30-HNC	MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTdwOUS1OVMh\|ryP	NEPJN\|JUSU6JRWK=
CAKI-1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHznN4xKSzVyPUiuNFY2OjFizszN	M4rWWXNCVkeHUh?=
GCIY	NHj4OZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXSxNm5PUUN3ME24MlI{PzF\|IN88US=>	NVHvdW1MW0GQR1XS
MKN28	NXzlc\|h4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX;JR\|UxRThwMkS1PVgh\|ryP	M2LjNnNCVkeHUh?=
IPC-298	NXGxR294T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVewTGExUUN3ME24MlI4PzB7IN88US=>	NIPvU2xUSU6JRWK=
NCI-H1650	NXrNUmJIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{DDXGlEPTB;OD6yPVE5PSEQvF2=	MlexV2FPT0WU
KP-N-YS	M4PpdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRThwMkmzNFgh\|ryP	NXi4TFJSW0GQR1XS
J82	Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVj0b3hTUUN3ME24MlM1OTJ2IN88US=>	MoD3V2FPT0WU
SK-HEP-1	NVLD[Xc1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYiwSFlxUUN3ME24MlM2PzJ\|IN88US=>	Mmr3V2FPT0WU
PANC-03-27	NXP0W5BnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV7KVoVvUUN3ME24MlM3QTJizszN	NWfMR5cyW0GQR1XS
KP-4	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWrUUos{UUN3ME24MlQyQDV\|IN88US=>	M4nI[nNCVkeHUh?=
RERF-LC-MS	NVHsfJc1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIjtflhKSzVyPUiuOFg2QTVizszN	NW[5fpk6W0GQR1XS
C-33-A	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXLsUoNbUUN3ME24MlYyPTJ7IN88US=>	MULTRW5ITVJ?
PA-1	NVS3XFhQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVnJR\|UxRThwNk[2PVQh\|ryP	MkT3V2FPT0WU
TE-5	M1exbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUfJR\|UxRThwN{CyPVYh\|ryP	Ml7uV2FPT0WU
MHH-PREB-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkjiTWM2OD16LkezNVA4KM7:TR?=	MmDBV2FPT0WU
C3A	NH\F[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWe3eY1sUUN3ME24Mlc3PTZzIN88US=>	M2rZSXNCVkeHUh?=
SK-OV-3	MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2\6eGlEPTB;OD63PVc4OiEQvF2=	NELUTWlUSU6JRWK=
AM-38	Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkD5TWM2OD16LkiwOFM6KM7:TR?=	MWLTRW5ITVJ?
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MKN45	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkG0TWM2OD16Lkm2NFY{KM7:TR?=	NU[zTmRYW0GQR1XS
NH-12	NFrVeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV\6enNkUUN3ME25MlAzPTR{IN88US=>	NUfPSHl[W0GQR1XS
CAMA-1	Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MULJR\|UxRTlwME[wNVIh\|ryP	MYDTRW5ITVJ?
HT-29	MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUjibnNoUUN3ME25MlEzOzd\|IN88US=>	NYHFTIVWW0GQR1XS
DMS-273	M4HlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnXTTWM2OD17LkGyOUDPxE1?	NV;ZT5p5W0GQR1XS
NCI-H719	M3LzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoDCTWM2OD17LkG4N\|kyKM7:TR?=	MnzTV2FPT0WU
SF539	NFTHTlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NETmW4pKSzVyPUmuNlExQThizszN	MmG0V2FPT0WU
Daoy	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkXmTWM2OD17LkK0NVQ{KM7:TR?=	M{ewbHNCVkeHUh?=
HCC70	NGPDeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTlwMkezNFkh\|ryP	MYXTRW5ITVJ?
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UACC-62	M1PsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{jDemlEPTB;OT6zO\|I6PyEQvF2=	Ml\HV2FPT0WU
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KNS-42	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUS0SpAxUUN3ME25MlQ{PDB5IN88US=>	MVrTRW5ITVJ?
SK-LMS-1	MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYLlUVRYUUN3ME25Mlc2PTN3IN88US=>	NGn2bldUSU6JRWK=
SK-CO-1	NYTL[3FGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3PRUGlEPTB;OT63OlI{PSEQvF2=	MmDUV2FPT0WU
SN12C	NWTTVWdQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXjIXpNvUUN3ME25Mlc3QDB4IN88US=>	MYDTRW5ITVJ?
HTC-C3	NWXGeJd{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MojFTWM2OD17Lke3PVg1KM7:TR?=	M3HueXNCVkeHUh?=
OVCAR-4	M2r3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoP6TWM2OD17Lki0PFI5KM7:TR?=	NV74ZXJYW0GQR1XS
CHP-126	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDmTWM2OD17LkmzNlkh\|ryP	MVHTRW5ITVJ?
NCI-H716	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTlwOUOzNlIh\|ryP	M321XHNCVkeHUh?=
U-698-M	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M33Q[mlEPTB;OT65PVch\|ryP	NVzYS202W0GQR1XS
EFO-21	NGDxTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoLNTWM2OD1zMD6wNFk{KM7:TR?=	M1vq[nNCVkeHUh?=
RXF393	NFnINpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnnJTWM2OD1zMD6xN\|kzKM7:TR?=	NFjLfYpUSU6JRWK=
ChaGo-K-1	NWrNVIN6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWnhcVdXUUN3ME2xNE4yPzd4IN88US=>	M3\kSnNCVkeHUh?=
SJRH30	NELUSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTFyLkG4OFQh\|ryP	NU\V[HJjW0GQR1XS
LU-65	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlfBTWM2OD1zMD6yPVQ{KM7:TR?=	MVLTRW5ITVJ?
OS-RC-2	NX34dVE5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\sZ4lKSzVyPUGwMlMzOjdizszN	MnTQV2FPT0WU
YT	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1P6e2lEPTB;MUCuOFAxOSEQvF2=	MlnlV2FPT0WU
COLO-679	M4[3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2jPdmlEPTB;MUCuOFI5PSEQvF2=	MkC0V2FPT0WU
CAS-1	M1L4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4D3XmlEPTB;MUCuOFYxQCEQvF2=	Mk\0V2FPT0WU
NCI-H2052	NETpdZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4rjRmlEPTB;MUCuOVExPSEQvF2=	NUHIWms4W0GQR1XS
NCI-H2452	NVjUNVY2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUfJR\|UxRTFyLk[xPFEh\|ryP	NVjrNHIyW0GQR1XS
SW13	Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInqW3NKSzVyPUGwMlY{PzRizszN	NV;KXnVrW0GQR1XS
HuP-T4	NHL0R\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUfkfmFEUUN3ME2xNE44ODZ6IN88US=>	MmfnV2FPT0WU
UMC-11	NIni[nNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYDJR\|UxRTFyLkmzO\|Mh\|ryP	MYrTRW5ITVJ?
EGI-1	NHnkXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4HaRWlEPTB;MUCuPVQ2PSEQvF2=	MY\TRW5ITVJ?
JiyoyeP-2003	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFrkOJRKSzVyPUGxMlA5QTJizszN	MojEV2FPT0WU
J-RT3-T3-5	NELoUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MY\JR\|UxRTFzLkGyNFkh\|ryP	Mkn0V2FPT0WU
DoTc2-4510	NYr3[4FoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnXvTWM2OD1zMT6xN\|g6KM7:TR?=	NG\DWWtUSU6JRWK=
HLE	NGTlenRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnLuTWM2OD1zMT6yNVE6KM7:TR?=	NHXkOlVUSU6JRWK=
SW626	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWXJR\|UxRTFzLkK4PFkh\|ryP	NELCUlJUSU6JRWK=
COR-L105	NXPCXFdZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEDXTFRKSzVyPUGxMlMzOzdizszN	MkHuV2FPT0WU
ES6	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjaNYViUUN3ME2xNU42PzZizszN	NFj4c3BUSU6JRWK=
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GR-ST	NFTsfFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWTp[VZ3UUN3ME2xNU43OThzIN88US=>	NHLWdFVUSU6JRWK=
BL-41	M17aT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoraTWM2OD1zMT63NVc{KM7:TR?=	MYnTRW5ITVJ?
GB-1	NGrmfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUKw[5VOUUN3ME2xNU44PjF7IN88US=>	MlTOV2FPT0WU
COLO-320-HSR	NIG3[GRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTFzLki1NVkh\|ryP	NVzkXmVIW0GQR1XS
L-540	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUfJR\|UxRTFzLki5PUDPxE1?	NFPMd3ZUSU6JRWK=
NCI-H69	Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFTWTmxKSzVyPUGyMlAyOzlizszN	NIXie4RUSU6JRWK=
769-P	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{PacGlEPTB;MUKuNFE6KM7:TR?=	MUnTRW5ITVJ?
A172	M2HE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX3JR\|UxRTF{LkGyNFch\|ryP	M4SzcHNCVkeHUh?=
CAL-27	M{\1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTF{LkGzOlkh\|ryP	NU[4WGFqW0GQR1XS
NCI-H1437	NWXBXGRlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3mb2E4UUN3ME2xNk4yPDR5IN88US=>	M1e1NnNCVkeHUh?=
REH	NHHSPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGeze2lKSzVyPUGyMlE2PzNizszN	NHzIVGpUSU6JRWK=
KINGS-1	NYrzUXlkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HFR2lEPTB;MUKuN\|QzOSEQvF2=	M3PwfXNCVkeHUh?=
NCI-H1792	NYDmZZQzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4XzcGlEPTB;MUKuN\|g2OSEQvF2=	M2fZdnNCVkeHUh?=
SK-MM-2	M4jUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlG3TWM2OD1zMj60NFg4KM7:TR?=	Mk\XV2FPT0WU
8505C	M2LmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1;qbmlEPTB;MUKuOlEzKM7:TR?=	M2e2RnNCVkeHUh?=
HAL-01	NEL3XY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXr5SGx{UUN3ME2xNk43OTd2IN88US=>	Ml;GV2FPT0WU
NCI-H2141	NGP3NYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUDJR\|UxRTF{Lk[1PEDPxE1?	MWXTRW5ITVJ?
HCC1806	NITvcJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1zVWGlEPTB;MUKuOlk2OiEQvF2=	MVfTRW5ITVJ?
LU-134-A	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTF{LkmzJO69VQ>?	NF;zeHlUSU6JRWK=
HT	NFThfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnPvTWM2OD1zMj65OFM4KM7:TR?=	M4jaeXNCVkeHUh?=
OE33	M4njUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGK2V29KSzVyPUGyMlk1PTZizszN	NEHpWmlUSU6JRWK=
ES4	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2izZ2lEPTB;MUKuPVQ5PyEQvF2=	Ml\XV2FPT0WU
SW948	NGLzbnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MW\JR\|UxRTF\|LkCxN{DPxE1?	MnH0V2FPT0WU
LB2241-RCC	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGSzXWJKSzVyPUGzMlE1PjlizszN	MUjTRW5ITVJ?
CCF-STTG1	MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGixTG1KSzVyPUGzMlQxOzlizszN	NHy0OHlUSU6JRWK=
RPMI-8402	MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVnUenBwUUN3ME2xN{42ODNzIN88US=>	Ml;hV2FPT0WU
DEL	NFz4WW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml:2TWM2OD1zMz61OVA{KM7:TR?=	MX3TRW5ITVJ?
NB5	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml7wTWM2OD1zMz61OVA{KM7:TR?=	NFy2SJJUSU6JRWK=
NUGC-3	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGG5[YxKSzVyPUGzMlc1PTNizszN	NHe2TXRUSU6JRWK=
CAL-72	Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnTKTWM2OD1zND6xPVA3KM7:TR?=	NWTEb2VmW0GQR1XS
VMRC-RCZ	NYLhSoVZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\q[ZQ2UUN3ME2xOE4zOzZizszN	NVvQfW1OW0GQR1XS
YAPC	NV\jbnNCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml\WTWM2OD1zND6yOFA4KM7:TR?=	MYHTRW5ITVJ?
ES5	NVm3TGI2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2DEe2lEPTB;MUSuNlU6QSEQvF2=	M1fOT3NCVkeHUh?=
CAL-12T	MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfGPI4xUUN3ME2xOE41OzN4IN88US=>	NGPJPHZUSU6JRWK=
GAMG	Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUHJR\|UxRTF2LkW1O\|ch\|ryP	M1PUXHNCVkeHUh?=
BT-20	M4\6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjRVFlKSzVyPUG0Mlk{QDRizszN	NHjUN\|NUSU6JRWK=
KALS-1	Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmLsTWM2OD1zNT6wNVU5KM7:TR?=	M2Xk[nNCVkeHUh?=
LS-123	M17MV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPB[2tKSzVyPUG1MlAyPjVizszN	MoX5V2FPT0WU
LK-2	MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnnzTWM2OD1zNT6wPFYzKM7:TR?=	M332XHNCVkeHUh?=
NCI-H1770	NUjoR2RWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3rBPGlEPTB;MUWuNlg3QCEQvF2=	NIrVXHdUSU6JRWK=
MIA-PaCa-2	M4jhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTF3LkSxOlMh\|ryP	MXrTRW5ITVJ?
DB	MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUDJR\|UxRTF3Lk[5OFEh\|ryP	NYK1PYxVW0GQR1XS
Becker	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUf3OmlzUUN3ME2xOU45QTJ4IN88US=>	MXPTRW5ITVJ?
HT-144	M2XqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmH1TWM2OD1zNT65OFk4KM7:TR?=	NXTKTG0xW0GQR1XS
NCI-H2405	NETjTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NILnUWlKSzVyPUG2MlIzOThizszN	NWLHO3R7W0GQR1XS
TK10	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnjwTWM2OD1zNj6zO\|QzKM7:TR?=	NXzWZYJGW0GQR1XS
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NCI-H661	M4ewd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX;JR\|UxRTJ2LkWyNVch\|ryP	NXjO[\|ZZW0GQR1XS
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NCI-H1651	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnfDTWM2OD1{OD6yOVkzKM7:TR?=	MoXLV2FPT0WU
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HH	NY\XRoNHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlLkTWM2OD1\|NT60NVQyKM7:TR?=	NELnRXVUSU6JRWK=
EFE-184	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkjPTWM2OD1\|NT62PFI6KM7:TR?=	MlfJV2FPT0WU
NCI-H1355	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{LadGlEPTB;M{WuO\|cyQCEQvF2=	NHzaZVFUSU6JRWK=
BV-173	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGPNbHhKSzVyPUO1MlgzPjRizszN	NViyV4t{W0GQR1XS
NEC8	M{Kze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXv6NlJOUUN3ME2zOk41QTJ2IN88US=>	MWTTRW5ITVJ?
SW1463	NY\XfGZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmS4TWM2OD1\|Nj62OVY3KM7:TR?=	NV\rNIFTW0GQR1XS
KYSE-140	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVzJR\|UxRTN4LkeyPVgh\|ryP	M4C0XnNCVkeHUh?=
no-11	NXzXZnVIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEDVUmVKSzVyPUO2Mlg2OzZizszN	Mn7MV2FPT0WU
HCC1937	MmTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWT2XIFZUUN3ME2zO{4xOTV2IN88US=>	Mn7iV2FPT0WU
LNCaP-Clone-FGC	NF;zTmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnS0TWM2OD1\|Nz6xPVA{KM7:TR?=	MVzTRW5ITVJ?
KARPAS-422	MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYXJR\|UxRTN5LkS0N\|Eh\|ryP	NUnS[Ws3W0GQR1XS
RCM-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGPhOXlKSzVyPUO3MlU{PThizszN	NGjtZlVUSU6JRWK=
A375	MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUDkUIFwUUN3ME2zO{44PjR5IN88US=>	MkfGV2FPT0WU
TGBC24TKB	Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXrJR\|UxRTN6LkCyN\|kh\|ryP	NV3mRlRnW0GQR1XS
MDA-MB-453	NFrvZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHjvfFlKSzVyPUO5MlAzOThizszN	MmLHV2FPT0WU
Capan-2	M4HJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVS1c4FMUUN3ME2zPU4xPTB7IN88US=>	NX\POWRtW0GQR1XS
SW756	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWHJR\|UxRTN7LkWwPVEh\|ryP	NXzxV21NW0GQR1XS
KU-19-19	MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTN7Lk[yPFIh\|ryP	M2j5UXNCVkeHUh?=
NCI-H2170	NYHtfYtsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mk\ZTWM2OD1\|OT65PVc4KM7:TR?=	M1LLbnNCVkeHUh?=
COLO-678	M4rLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUD5OGtHUUN3ME20NE42QTVizszN	M2DEbXNCVkeHUh?=
PF-382	NIXnZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHSwTHVKSzVyPUSwMlc1QDdizszN	MnnDV2FPT0WU
OAW-42	NXnRWoxiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2rFRmlEPTB;NEKuNlk1OiEQvF2=	M2HrZXNCVkeHUh?=
LB996-RCC	M3rEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NG[xZ4JKSzVyPUSyMlgxODhizszN	NITRUIdUSU6JRWK=
SAS	M{jsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTR\|LkSyPFgh\|ryP	NUHFfpVCW0GQR1XS
MRK-nu-1	M3KzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLNVYNJUUN3ME20OE44PDF2IN88US=>	NVHrOoNGW0GQR1XS
EoL-1-cell	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4q5eGlEPTB;NESuPVE{PiEQvF2=	M1X3UHNCVkeHUh?=
NCI-H2342	NF7nW5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEL1e5VKSzVyPUS1MlEyOTdizszN	MnrwV2FPT0WU
NCI-H1703	MmPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWXKTmtRUUN3ME20Ok4xPTl{IN88US=>	NVTMWYtSW0GQR1XS
NCI-H187	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTR4LkG4Olkh\|ryP	MXjTRW5ITVJ?
CP66-MEL	NYniUVZVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPyWZZKSzVyPUS2MlI4QDlizszN	NFWwUnNUSU6JRWK=
HCC1569	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zOSWlEPTB;NE[uOVkyPyEQvF2=	MUXTRW5ITVJ?
BL-70	M4Tm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MonZTWM2OD12Nj63O\|M4KM7:TR?=	M1rQWXNCVkeHUh?=
Saos-2	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWfJR\|UxRTR5LkOxNlMh\|ryP	NYP3RZJJW0GQR1XS
LC-1F	NYC4cI9VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{PPPGlEPTB;NEeuOlExPSEQvF2=	MnTKV2FPT0WU
KY821	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlX6TWM2OD12Nz62OFM1KM7:TR?=	MXXTRW5ITVJ?
PSN1	NIjPOpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYXJR\|UxRTR6LkG0NFEh\|ryP	Ml7zV2FPT0WU
RT4	NEfXZ5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVvoZmZ7UUN3ME20PE45Ozd5IN88US=>	MofDV2FPT0WU
LS-1034	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{TuV2lEPTB;NEiuPFk2PCEQvF2=	MXPTRW5ITVJ?
NCI-H1395	NGDVWHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXXJR\|UxRTR7LkC0PVIh\|ryP	M2m0SXNCVkeHUh?=
EKVX	NIGx[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnT0TWM2OD12OT62O\|MyKM7:TR?=	Mn7HV2FPT0WU
IST-MES1	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnezTWM2OD12OT64PVQ1KM7:TR?=	NILSZ3lUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo

PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. ^[1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. ^[3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. ^[4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. ^[5]

Protocol

Animal Research:^[1]	+ Expand Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts. Formulation: 5% Gelucire Dosages: 50 mg/kg Administration: Oral gavage (Only for Reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	100 mg/mL warmed (197.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download PF-562271 SDF

Molecular Weight	507.49
Formula	C₂₁H₂₀F₃N₇O₃S
CAS No.	717907-75-0
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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FAK Signaling Pathway Map

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Defactinib (VS-6063, PF-04554878) ^New

Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
PF-00562271 Besylate

PF-00562271 Besylate is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
PF-573228

PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.
PF-562271 HCl

PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Ibrutinib (PCI-32765)

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
Dasatinib

Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.
Saracatinib (AZD0530)

Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Phase 2/3.

Features:The 1st Src inhibitor to show inhibition of the Src pathway in human tumor tissue.

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PF-562271