PF-562271

For research use only.

Catalog No.S2890

78 publications

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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Selleck's PF-562271 has been cited by 78 publications

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. [1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. [2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 NWPOdW13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMke2OkDPxE1? M3racXNCVkeHUh?=
SW982 M2fHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr5eJhKSzVyPUCuN|I5OiEQvF2= MX7TRW5ITVJ?
KM12 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXQOI93UUN3ME2wMlM5PTV5IN88US=> NYXycmZCW0GQR1XS
COLO-205 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TWSmlEPTB;MD60PFY2QCEQvF2= NGXJfpdUSU6JRWK=
COLO-829 MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXITWM2OD1yLke1NVc3KM7:TR?= NUnveoUyW0GQR1XS
MG-63 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW0fIhMUUN3ME2wMlgxPjN5IN88US=> NYXsSFVnW0GQR1XS
IGROV-1 NUTKdZRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoeyTWM2OD1yLkixNFM5KM7:TR?= M3faenNCVkeHUh?=
NCI-H650 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13KVWlEPTB;MD64N|E2PCEQvF2= NUPLPYx[W0GQR1XS
RT-112 NVHRTWYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn6WnZKSzVyPUCuPVg1PiEQvF2= NF75fJBUSU6JRWK=
BCPAP Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHmTWM2OD1zLkCxNlg5KM7:TR?= NVL4TmNMW0GQR1XS
ALL-PO M13Q[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fxPWlEPTB;MT6wNVU5PCEQvF2= NEHMNWZUSU6JRWK=
KYSE-270 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH0TWM2OD1zLkC0O|E1KM7:TR?= NXzJUVhCW0GQR1XS
8305C NVjIXFgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\EW2lEPTB;MT6wPVkxPCEQvF2= NILMVlNUSU6JRWK=
NCI-H810 MnO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXoTWM2OD1zLkGwO|c3KM7:TR?= NXK4WnFwW0GQR1XS
CAL-33 MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfHXXk5UUN3ME2xMlEzQTN6IN88US=> M3\xd3NCVkeHUh?=
AN3-CA M3Tw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofjTWM2OD1zLkKxPFY4KM7:TR?= M3jnb3NCVkeHUh?=
NKM-1 M4LGSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPuVppKUUN3ME2xMlI4PTB4IN88US=> MofsV2FPT0WU
BPH-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrvcJFKSzVyPUGuNlg4PjZizszN MX\TRW5ITVJ?
MES-SA MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rJTmlEPTB;MT6zNFY5OiEQvF2= NV7WfFZiW0GQR1XS
CAL-62 M3\2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SzZWlEPTB;MT6zNVkxQSEQvF2= NIHld45USU6JRWK=
Detroit562 NHLibGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjZeYNKSzVyPUGuN|UzOjJizszN M3vpdnNCVkeHUh?=
KYSE-150 NEXrXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmxepRpUUN3ME2xMlM2OjN4IN88US=> MmW5V2FPT0WU
SK-UT-1 NXrK[|Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTFwNES2OFch|ryP M3qweHNCVkeHUh?=
HUTU-80 NF3NdVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jYRmlEPTB;MT60OFg5PiEQvF2= MWPTRW5ITVJ?
SIG-M5 NUDWdFk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rUfGlEPTB;MT60PFM5PyEQvF2= MVHTRW5ITVJ?
AGS MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TRVGlEPTB;MT61NlEzPCEQvF2= MVvTRW5ITVJ?
ST486 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLs[YVKSzVyPUGuOVMzPzhizszN NWO4VWhOW0GQR1XS
HSC-2 M371Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFwNUO5OUDPxE1? NHzrO4hUSU6JRWK=
LCLC-103H MkTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfHT3JKSzVyPUGuOVU5OThizszN MXzTRW5ITVJ?
BC-1 MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPZ[ZRKSzVyPUGuOlE3PjRizszN MWDTRW5ITVJ?
CGTH-W-1 NYrObmdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1G5fWlEPTB;MT62NVY4QSEQvF2= NE\RbItUSU6JRWK=
MZ1-PC Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTFwNkKzNVIh|ryP M4XDTXNCVkeHUh?=
SW1710 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTFwNkK2Nlgh|ryP NEfpZ3FUSU6JRWK=
EW-13 NVz3fXQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfUTWM2OD1zLk[zOFY3KM7:TR?= M1Lmb3NCVkeHUh?=
TE-11 MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDkSndKSzVyPUGuOlM2OjJizszN NF;DW4xUSU6JRWK=
BHY NVfyXpR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PkXWlEPTB;MT62OVY3OyEQvF2= MmrJV2FPT0WU
ML-2 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH2XpRuUUN3ME2xMlY3QDB{IN88US=> NGK4O21USU6JRWK=
MEL-JUSO MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW1OWV2UUN3ME2xMlczQDlzIN88US=> M1jDd3NCVkeHUh?=
U251 NX\aOlJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTFwN{SwN|Eh|ryP NUnKXmlWW0GQR1XS
MHH-ES-1 NILuboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHySHIxUUN3ME2xMlc6PTZ6IN88US=> MnX6V2FPT0WU
CAL-85-1 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO2WnBKSzVyPUGuPFA1QSEQvF2= NVTWbINRW0GQR1XS
D-336MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFwOEW2NVQh|ryP M3q5SnNCVkeHUh?=
VA-ES-BJ NVrO[pFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nxV2lEPTB;MT65NFMyPSEQvF2= NE\kSI1USU6JRWK=
MDA-MB-468 Ml\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDu[VY6UUN3ME2xMlkyOjd{IN88US=> MkTwV2FPT0WU
MEL-HO MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvHemtKSzVyPUGuPVc6QTNizszN MXvTRW5ITVJ?
SW954 NHn6S2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r0eWlEPTB;Mj6wNFE2OSEQvF2= NF\LRpNUSU6JRWK=
LB831-BLC NHz0TodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LpcGlEPTB;Mj6wNFk5QCEQvF2= MW\TRW5ITVJ?
EW-16 NF7lOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jpV2lEPTB;Mj6wN|k5OyEQvF2= M17yUHNCVkeHUh?=
NCI-H460 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTETWM2OD1{LkC0PFM6KM7:TR?= MWfTRW5ITVJ?
CHP-212 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET5N|NKSzVyPUKuNFk2OzlizszN Mmn5V2FPT0WU
MHH-NB-11 M4S5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu2TWM2OD1{LkGyPFE5KM7:TR?= MVrTRW5ITVJ?
DU-4475 NX\vVVVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPHZoJ6UUN3ME2yMlE1PzV7IN88US=> NEPjZ|NUSU6JRWK=
ABC-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJwMkWxPVYh|ryP MlPOV2FPT0WU
LOUCY M2jO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPZO4xKSzVyPUKuNlYyOjhizszN NXLZellHW0GQR1XS
LC-2-ad NIX2NYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXhVIdKSzVyPUKuNlY6PjZizszN MnLrV2FPT0WU
ETK-1 NWnMSGR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJwMki0OkDPxE1? NUnYWVI5W0GQR1XS
KYSE-180 NFzIO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLMTWM2OD1{LkK4PFc1KM7:TR?= NEn2SYhUSU6JRWK=
HOP-92 MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwM{C2O|Mh|ryP MUnTRW5ITVJ?
RCC10RGB MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTJwM{K1NFch|ryP NUHlSXdnW0GQR1XS
KASUMI-1 NHv2XGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fTXmlEPTB;Mj6zNlg5KM7:TR?= MlvCV2FPT0WU
ACN MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLnTWM2OD1{LkO0O|Q2KM7:TR?= M1[5OnNCVkeHUh?=
BxPC-3 NETzNHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n1c2lEPTB;Mj6zOVQ{PiEQvF2= MlPsV2FPT0WU
MONO-MAC-6 NWnjVW04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDuT4IzUUN3ME2yMlQyOjR6IN88US=> NFj6UFZUSU6JRWK=
CAL-39 M371c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJwNEG2Nlgh|ryP MUHTRW5ITVJ?
CMK MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTJwNEG3PVUh|ryP MXnTRW5ITVJ?
MFE-296 NEDXUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwNEe3PVIh|ryP NEnIfWNUSU6JRWK=
DU-145 M320R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DWUWlEPTB;Mj60PVEyQCEQvF2= M4nGPHNCVkeHUh?=
MDA-MB-231 NYrhfGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnw[ZYxUUN3ME2yMlQ6PTd{IN88US=> NWHJPIREW0GQR1XS
EFO-27 Ml2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXuUJVKSzVyPUKuOVE5QDhizszN MXfTRW5ITVJ?
SNU-387 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi2XllFUUN3ME2yMlUzQDJizszN MYrTRW5ITVJ?
KYSE-410 MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjhTWM2OD1{LkW2OVE4KM7:TR?= Mnf2V2FPT0WU
NCCIT M{CxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVKxb5MzUUN3ME2yMlU4OjRizszN MknqV2FPT0WU
LXF-289 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInQ[lZKSzVyPUKuOVgzPzNizszN M{izTnNCVkeHUh?=
HMV-II NFu4[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHFTWM2OD1{LkW4PVk4KM7:TR?= Mk\0V2FPT0WU
MOLT-4 NELQWo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzKTWM2OD1{Lk[wO|EzKM7:TR?= MXrTRW5ITVJ?
KOSC-2 MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu2RmhLUUN3ME2yMlY{QDd7IN88US=> MlPSV2FPT0WU
TUR NFnHfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPw[WhKSzVyPUKuOlU{PjlizszN MYnTRW5ITVJ?
NCI-H2087 NUL4V2NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L6TGlEPTB;Mj63NVY1PiEQvF2= MWTTRW5ITVJ?
SCC-15 NV7ib2twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwN{WyOVIh|ryP MlnDV2FPT0WU
HSC-4 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwN{izPFkh|ryP MXTTRW5ITVJ?
G-402 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDDUotxUUN3ME2yMlgyPDR5IN88US=> M4X2bXNCVkeHUh?=
GP5d M2jENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\SNWlEPTB;Mj64N|gzPyEQvF2= NYTqd3g5W0GQR1XS
IGR-1 NHLLXoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTJwOEO5PFch|ryP M4r0WHNCVkeHUh?=
SK-PN-DW NGrE[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTYUFhqUUN3ME2yMlg3OjB2IN88US=> M1HqXHNCVkeHUh?=
OPM-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjueplDUUN3ME2yMlg6QTd6IN88US=> MULTRW5ITVJ?
5637 NWXSOpRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWizNoZOUUN3ME2yMlkzPDN7IN88US=> MYHTRW5ITVJ?
NCI-H2030 M4mxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjxW3pKSzVyPUKuPVgxOjlizszN Mn3KV2FPT0WU
SK-LU-1 NWf0V2Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3Oe3BiUUN3ME2yMlk5OzN2IN88US=> NEXufWVUSU6JRWK=
EW-18 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnyVJlKSzVyPUOuNFU{OiEQvF2= NGK0UppUSU6JRWK=
786-0 NGf0SpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS0d|NKSzVyPUOuNFU4QDRizszN MorxV2FPT0WU
NCI-H1963 NFjNc4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SyOWlEPTB;Mz6wPFgzPSEQvF2= MmfWV2FPT0WU
A2780 NIXXe4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTzTWM2OD1|LkGwN|QyKM7:TR?= MnjKV2FPT0WU
NCI-H526 MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3idlNKSzVyPUOuNVM6PjFizszN M4LnVHNCVkeHUh?=
BHT-101 M1T5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTNwMUW3PVgh|ryP M3:wd3NCVkeHUh?=
RPMI-7951 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1joZWlEPTB;Mz6yNFE{PyEQvF2= MXPTRW5ITVJ?
HL-60 Mn;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HQXGlEPTB;Mz6yNVE1KM7:TR?= MVXTRW5ITVJ?
CTV-1 NYPLbJBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX64WnUxUUN3ME2zMlI2Ozd5IN88US=> NYLLdIF5W0GQR1XS
IST-SL1 NWTJUmJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTNwMkm0OlUh|ryP M4T6V3NCVkeHUh?=
G-401 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNwMkm4NFgh|ryP Mn7vV2FPT0WU
OVCAR-5 NYflN3V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[zTWM2OD1|LkO2N|UzKM7:TR?= NUfwWVd1W0GQR1XS
EW-1 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTNwNEC1OFQh|ryP NHixdZdUSU6JRWK=
H4 NGDFNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjvRYQ4UUN3ME2zMlQ4PTZ7IN88US=> MlvpV2FPT0WU
EM-2 M{PKZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHBTWM2OD1|LkS4Olc1KM7:TR?= M2f6VnNCVkeHUh?=
RS4-11 MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTNwNEi3NVUh|ryP MmDoV2FPT0WU
NOMO-1 NHjS[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXyTI5rUUN3ME2zMlQ6OjB2IN88US=> M3jSXHNCVkeHUh?=
HCT-116 NVrRN|lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfPV2JKSzVyPUOuOVA4OTFizszN MV;TRW5ITVJ?
CAL-120 M133N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTNwNUezOUDPxE1? NYfnUlVrW0GQR1XS
CAL-51 NHLLPG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PaNmlEPTB;Mz61O|YyOiEQvF2= MmDaV2FPT0WU
RVH-421 M2nY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XYc2lEPTB;Mz62NFMyOSEQvF2= MmS0V2FPT0WU
NCI-H2081 M2f4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTNwNkWyPFgh|ryP MmXvV2FPT0WU
SBC-5 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\PVIRKSzVyPUOuOlc5QDJizszN MnTaV2FPT0WU
RL95-2 NULYSWhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNwN{G4OlQh|ryP NE\HXmJUSU6JRWK=
SW872 M1;NfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrVWWRKSzVyPUOuO|Y6PThizszN MoK5V2FPT0WU
VM-CUB-1 NEXPXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO2SWx4UUN3ME2zMlc4PTFizszN NYnXN4RWW0GQR1XS
SUP-T1 NFnodY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTNwN{izNkDPxE1? MUPTRW5ITVJ?
697 NFXoO2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[4XohKSzVyPUOuPFE3PTdizszN NX3FWGUzW0GQR1XS
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HT-1376 NVvSSpViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvyc4M4UUN3ME2xPU4zODJ7IN88US=> M4nHWXNCVkeHUh?=
SK-MEL-2 NHSwcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHUUY5jUUN3ME2xPU4zOTV3IN88US=> MXnTRW5ITVJ?
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NOS-1 NGjld2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17iOmlEPTB;MkCuNVU4PyEQvF2= MYXTRW5ITVJ?
EW-7 M3jnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX6we4xDUUN3ME2yNE4yPjJ6IN88US=> M4OzOHNCVkeHUh?=
Raji M3uyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\JTWM2OD1{MD6yOVY5KM7:TR?= NV7Te4xKW0GQR1XS
LB2518-MEL M12zVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXRPI1rUUN3ME2yNE4{QTV|IN88US=> NXrJSJRKW0GQR1XS
PANC-10-05 NVPsWWZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK1ToJWUUN3ME2yNE41PjF|IN88US=> Ml\IV2FPT0WU
MZ2-MEL M3\tPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLhWFB1UUN3ME2yNE42QDF2IN88US=> M{TQUXNCVkeHUh?=
MFE-280 NVjV[3ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;MPJFKSzVyPUKxMlMyQDhizszN MYjTRW5ITVJ?
RKO NEm2VHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJzLkOyNFIh|ryP NHHSc5VUSU6JRWK=
KMOE-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrQWFlTUUN3ME2yNU4{Ojh6IN88US=> MUTTRW5ITVJ?
K5 NVv5dnJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDDfZlJUUN3ME2yNU4{QDl|IN88US=> Mk\EV2FPT0WU
NCI-H64 M1XtdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJzLkS3OVYh|ryP MULTRW5ITVJ?
K-562 NWHIXVNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfMXGZPUUN3ME2yNU41QTdzIN88US=> M2XnW3NCVkeHUh?=
HCE-T Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTJzLkWwPVQh|ryP MV7TRW5ITVJ?
COLO-792 NUnicY1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7NVllGUUN3ME2yNU42QDJ5IN88US=> NHr5cXBUSU6JRWK=
PFSK-1 NFOzfJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi5ZWxKSzVyPUKxMlY5OzdizszN M1vI[HNCVkeHUh?=
DOK MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nwcGlEPTB;MkGuO|Y5PyEQvF2= NU\iTHpWW0GQR1XS
NCI-H1882 NXHXenYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPnZXdWUUN3ME2yNU45PTl4IN88US=> MYDTRW5ITVJ?
KNS-81-FD NEDVWWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zWZmlEPTB;MkGuPFY{OSEQvF2= MnLrV2FPT0WU
OCUB-M NEPYTWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rxXGlEPTB;MkGuPVY5QCEQvF2= M13NenNCVkeHUh?=
NCI-H1694 M2PKZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XRTGlEPTB;MkGuPVg3OyEQvF2= NEK5cI9USU6JRWK=
LS-513 M1HY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTPSFlnUUN3ME2yNk4xOzZ5IN88US=> NUDGWGdIW0GQR1XS
NCI-H2122 NGDDUpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ{LkG2O|ch|ryP NUn6NlZtW0GQR1XS
IMR-5 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PoUWlEPTB;MkKuNlg4KM7:TR?= NEHrSlVUSU6JRWK=
SNU-C2B NVPaXGJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\Bd4pKSzVyPUKyMlY4PDZizszN MUDTRW5ITVJ?
A498 NET3TlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\sTWM2OD1{Mj64NVc4KM7:TR?= MlzVV2FPT0WU
NCI-H727 Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJ{Lki4N|Yh|ryP MYnTRW5ITVJ?
SW1573 NWrnfZRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjWTWM2OD1{Mz6wOlQ3KM7:TR?= NWX3T2RXW0GQR1XS
RO82-W-1 MoHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ|LkK1NVEh|ryP M3fSZ3NCVkeHUh?=
SKG-IIIa MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS0[GdKSzVyPUKzMlM2PDZizszN MofMV2FPT0WU
MC-CAR MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fuTGlEPTB;MkOuOVE5OyEQvF2= M4fGVXNCVkeHUh?=
NCI-H446 NVTYdWxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJ|Lk[wPVMh|ryP MYjTRW5ITVJ?
PC-14 NXnJN5F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[ydW1KSzVyPUKzMlY3OjNizszN MULTRW5ITVJ?
TGBC1TKB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorzTWM2OD1{Mz63OFYyKM7:TR?= MmXZV2FPT0WU
EFM-19 NX7RblZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT4UXdKSzVyPUK0MlE5PDRizszN NVfPSYFwW0GQR1XS
SK-N-DZ NYXKVpV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX63XlhOUUN3ME2yOE41QTd5IN88US=> NXzpNlRxW0GQR1XS
NCI-H661 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzxTWdKSzVyPUK0MlUzOTdizszN NU[z[5ZSW0GQR1XS
SW1990 M1PoVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\mTJRKSzVyPUK0MlU5QDNizszN MoPwV2FPT0WU
SW684 MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLkOGo1UUN3ME2yOE44PjJ2IN88US=> MVLTRW5ITVJ?
Ca-Ski M2rqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJ2LkmyN|ch|ryP NVXt[Jg{W0GQR1XS
TGW NF35TFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTCNHV3UUN3ME2yOU4zOzN5IN88US=> Mn\tV2FPT0WU
CaR-1 NInOT25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ3LkO1O{DPxE1? NWDic4tIW0GQR1XS
D-247MG NYnDOmZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJ3LkS3OFMh|ryP MniwV2FPT0WU
CCRF-CEM NF3M[5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrKOHNpUUN3ME2yOU44PDV7IN88US=> MU\TRW5ITVJ?
CAPAN-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\zUGlEPTB;MkWuO|UxOSEQvF2= M1ThXHNCVkeHUh?=
CP50-MEL-B NXLqbGFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\6fWlEPTB;MkWuPVkxOSEQvF2= M1z6O3NCVkeHUh?=
FADU M{TGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHy4OFFKSzVyPUK2MlUyPTJizszN MmfoV2FPT0WU
Daudi NXXidVV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2G3XWlEPTB;Mk[uOVE2QCEQvF2= MVzTRW5ITVJ?
U-87-MG NFe1eYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL1TWM2OD1{Nj61N|A2KM7:TR?= MWXTRW5ITVJ?
DSH1 NUXUOI1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmizTWM2OD1{Nj61OFA3KM7:TR?= NV;RUJZQW0GQR1XS
KYSE-520 NFrKbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nYOmlEPTB;Mk[uOVU2OyEQvF2= Ml7tV2FPT0WU
HuH-7 NFGzN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W3TmlEPTB;Mk[uPVA5PiEQvF2= M3uwUnNCVkeHUh?=
U-2-OS MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nhVmlEPTB;MkeuNFI4OSEQvF2= M4e2OXNCVkeHUh?=
LU-99A Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPsTWM2OD1{Nz6xO|U1KM7:TR?= NGHX[2FUSU6JRWK=
T98G NFvO[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ5LkG5O|Mh|ryP M3PRcnNCVkeHUh?=
MZ7-mel NV\wco9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJ5LkW1OFgh|ryP NFjQTWFUSU6JRWK=
SNU-C1 M3PKXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL0U2ZKSzVyPUK3MlY1QTFizszN MY\TRW5ITVJ?
MDA-MB-175-VII M3eyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPqTWM2OD1{Nz62PVc2KM7:TR?= NHjYVHRUSU6JRWK=
HuP-T3 NH3I[YFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PW[mlEPTB;MkiuNFQ6PSEQvF2= NVu4UoRrW0GQR1XS
T-24 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojlTWM2OD1{OD6xPVI2KM7:TR?= MX\TRW5ITVJ?
HDLM-2 M3m2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3COYhKSzVyPUK4MlI1PTlizszN MlvxV2FPT0WU
NCI-H1651 NYX3ZmZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJ6LkK1PVIh|ryP NWDzbIpRW0GQR1XS
SK-N-AS M3znN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;BTWM2OD1{OD6zNVcyKM7:TR?= M4To[3NCVkeHUh?=
NY MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWzNHFKSzVyPUK4MlY2PzlizszN M{LxeXNCVkeHUh?=
D-283MED NV;tVZlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETnfItKSzVyPUK4Mlg4ODhizszN NIGzfFlUSU6JRWK=
KLE MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\GTWM2OD1{OD65PVA3KM7:TR?= M2LxSXNCVkeHUh?=
NCI-H28 NEL4U5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT4dZFKSzVyPUK5MlAyOiEQvF2= NIXtWnBUSU6JRWK=
TE-1 NVmxOHV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TLcGlEPTB;MkmuNlE3PyEQvF2= NVnlS2VXW0GQR1XS
SK-MEL-24 MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XtWmlEPTB;MkmuOVQ3PiEQvF2= MU\TRW5ITVJ?
CAL-54 NYXXZ4NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;pXGlEPTB;MkmuOlA1PiEQvF2= MX7TRW5ITVJ?
A673 NIn0XIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\USWVKSzVyPUK5Mlc{OiEQvF2= NILDbIxUSU6JRWK=
HEC-1 NVzDdI81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNyLkCwOVMh|ryP NGr5[G9USU6JRWK=
LS-411N M1LEcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfrTWM2OD1|MD6xOFc2KM7:TR?= Mn;uV2FPT0WU
SW962 NVXUUYpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTFTWM2OD1|MD6yOFc4KM7:TR?= Mnz5V2FPT0WU
OVCAR-8 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTNyLk[3PVQh|ryP M2ewVHNCVkeHUh?=
NCI-H630 NVu0UGkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHuTWM2OD1|MD64PVU{KM7:TR?= NWHiU5B[W0GQR1XS
D-263MG MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLNTWM2OD1|MT6wOFI1KM7:TR?= MUTTRW5ITVJ?
NCI-H596 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzDTWM2OD1|MT6wOlIyKM7:TR?= NFq1OmhUSU6JRWK=
BB49-HNC NGO3NVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTNzLkGxNkDPxE1? MY\TRW5ITVJ?
KYSE-70 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fRV2lEPTB;M{GuN|AxQCEQvF2= MX7TRW5ITVJ?
LAN-6 NI\1Z4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zxdWlEPTB;M{GuOFk6OiEQvF2= MXHTRW5ITVJ?
NCI-H2228 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnYWGlpUUN3ME2zNU42PjJ3IN88US=> NYnqPI94W0GQR1XS
SW620 NFi5SVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTNzLk[yPFMh|ryP M4DITHNCVkeHUh?=
KM-H2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;LVFJSUUN3ME2zNU44OzB4IN88US=> MVPTRW5ITVJ?
DJM-1 NVn5Z4pzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLRTWM2OD1|Mj6xN|g3KM7:TR?= MlLqV2FPT0WU
SW48 M3\ofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fa[2lEPTB;M{KuN|gzPSEQvF2= M3TvRXNCVkeHUh?=
NCI-H1793 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN{Lk[xOlMh|ryP NF7sNnRUSU6JRWK=
LU-165 M3\hZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq5PGdrUUN3ME2zN{4xODhizszN NYXqO2RUW0GQR1XS
EHEB NV;zT|BVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHuTWM2OD1|Mz6wOFk1KM7:TR?= NED0TGhUSU6JRWK=
NCI-H441 M2jYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTN|LkKyN|Uh|ryP MlPRV2FPT0WU
LOXIMVI NHPGeWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTXTWM2OD1|Mz6zOlc6KM7:TR?= NVPQdXViW0GQR1XS
MC-IXC M4LJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN|LkW2OVUh|ryP NISxbWxUSU6JRWK=
NCI-H522 M1PKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7OR41KSzVyPUOzMlY2PCEQvF2= MnnyV2FPT0WU
IA-LM NWXie|RJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorITWM2OD1|Mz62O|Q3KM7:TR?= MmfXV2FPT0WU
NCI-H1417 NEHvWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTxeXVZUUN3ME2zN{46PTh3IN88US=> NWfISYNVW0GQR1XS
HCC2218 NES1[|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS4NZpKSzVyPUO1MlIyQDVizszN M{W3PXNCVkeHUh?=
HC-1 M2fpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[ybmlKSzVyPUO1MlQxOjRizszN MkfRV2FPT0WU
HH NV6xVI1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m4TGlEPTB;M{WuOFE1OSEQvF2= M3nyVHNCVkeHUh?=
EFE-184 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHVVndtUUN3ME2zOU43QDJ7IN88US=> MWrTRW5ITVJ?
NCI-H1355 NVuzOWFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTN3Lke3NVgh|ryP NHKxXmFUSU6JRWK=
BV-173 M2L2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfxdXBHUUN3ME2zOU45OjZ2IN88US=> M4XOb3NCVkeHUh?=
NEC8 Mnv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTN4LkS5NlQh|ryP MV;TRW5ITVJ?
SW1463 NVTzU|VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTN4Lk[1OlYh|ryP NX21XVJDW0GQR1XS
KYSE-140 M2DLbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfSW4lWUUN3ME2zOk44Ojl6IN88US=> NVvwV5NkW0GQR1XS
no-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnWcJBKSzVyPUO2Mlg2OzZizszN M3LJPHNCVkeHUh?=
HCC1937 NHj2XGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTN5LkCxOVQh|ryP M1izVHNCVkeHUh?=
LNCaP-Clone-FGC NYHGT293T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTN5LkG5NFMh|ryP NXW4TWcyW0GQR1XS
KARPAS-422 NXGxVZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrhXWJKSzVyPUO3MlQ1OzFizszN M2fnXnNCVkeHUh?=
RCM-1 Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DhbWlEPTB;M{euOVM2QCEQvF2= MV\TRW5ITVJ?
A375 NIDab5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN5Lke2OFch|ryP M2HCOnNCVkeHUh?=
TGBC24TKB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XMOmlEPTB;M{iuNFI{QSEQvF2= MYTTRW5ITVJ?
MDA-MB-453 NWDmeIt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnjN2Y5UUN3ME2zPU4xOjF6IN88US=> NH7rcJRUSU6JRWK=
Capan-2 NFS4TmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\RTWM2OD1|OT6wOVA6KM7:TR?= MlexV2FPT0WU
SW756 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TJO2lEPTB;M{muOVA6OSEQvF2= MWDTRW5ITVJ?
KU-19-19 NVfPdI5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzONY9KSzVyPUO5MlYzQDJizszN MUDTRW5ITVJ?
NCI-H2170 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\Id2tPUUN3ME2zPU46QTd5IN88US=> NE[4bYZUSU6JRWK=
COLO-678 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\3WWlEPTB;NECuOVk2KM7:TR?= NFy0eJFUSU6JRWK=
PF-382 M3XIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\5O3NVUUN3ME20NE44PDh5IN88US=> MUHTRW5ITVJ?
OAW-42 M{frU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTR{LkK5OFIh|ryP NWDXbI9oW0GQR1XS
LB996-RCC NILaZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXycXRKSzVyPUSyMlgxODhizszN NGHyc25USU6JRWK=
SAS NHnIcZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13SWmlEPTB;NEOuOFI5QCEQvF2= NYXDPYVXW0GQR1XS
MRK-nu-1 NITtdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33OdGlEPTB;NESuO|QyPCEQvF2= MXzTRW5ITVJ?
EoL-1-cell MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnNfmhKSzVyPUS0MlkyOzZizszN MVrTRW5ITVJ?
NCI-H2342 M3XueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTR3LkGxNVch|ryP NELvOXRUSU6JRWK=
NCI-H1703 NWTPUlhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnCUoF4UUN3ME20Ok4xPTl{IN88US=> NUHlZVc{W0GQR1XS
NCI-H187 MnXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DHZmlEPTB;NE[uNVg3QSEQvF2= MYLTRW5ITVJ?
CP66-MEL NX[1dHRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17pemlEPTB;NE[uNlc5QSEQvF2= NXfZSHpPW0GQR1XS
HCC1569 MoPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\0d2VRUUN3ME20Ok42QTF5IN88US=> M3jKdnNCVkeHUh?=
BL-70 NIe0OINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnJVlhKSzVyPUS2Mlc4OzdizszN M2rxdXNCVkeHUh?=
Saos-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX6N2hjUUN3ME20O{4{OTJ|IN88US=> Mmn1V2FPT0WU
LC-1F Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTR5Lk[xNFUh|ryP NHvEXnRUSU6JRWK=
KY821 NHrQZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfKOmozUUN3ME20O{43PDN2IN88US=> NECzWlVUSU6JRWK=
PSN1 NUn6dYkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXruRlUxUUN3ME20PE4yPDBzIN88US=> NH3TTZhUSU6JRWK=
RT4 M1jocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR6LkizO|ch|ryP NFfVU29USU6JRWK=
LS-1034 M2Xxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXyRXUxUUN3ME20PE45QTV2IN88US=> MULTRW5ITVJ?
NCI-H1395 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v4RWlEPTB;NEmuNFQ6OiEQvF2= M1rqSHNCVkeHUh?=
EKVX NGHicpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rNPGlEPTB;NEmuOlc{OSEQvF2= M334OnNCVkeHUh?=
IST-MES1 MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\NeppjUUN3ME20PU45QTR2IN88US=> NHW3c5dUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-FAK / FAK / p-Talin / Talin ; 

PubMed: 26530902     


Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells.

p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; 

PubMed: 29417941     


MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.

26530902 29417941
Immunofluorescence
p-FAK; 

PubMed: 26530902     


Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).

26530902
Growth inhibition assay
Cell viability; 

PubMed: 28953264     


MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk (*) and p < 0.01 are designated by two asterisks (**).

28953264
In vivo PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. [1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. [3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. [4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. [5]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts.
  • Dosages: 50 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
For best results, use promptly after mixing.
5 mg/ml

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 507.49
Formula

C21H20F3N7O3S

CAS No. 717907-75-0
Storage powder
in solvent
Synonyms N/A
Smiles CN(C1=C(CNC2=C(C=NC(=N2)NC3=CC=C4NC(=O)CC4=C3)C(F)(F)F)C=CC=N1)[S](C)(=O)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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FAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID