PF-562271

Catalog No.S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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In DMSO USD 350 In stock
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USD 270 In stock
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Cited by 33 Publications

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. [1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. [2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOySWduUUN3ME2wMlI4PjZizszN M2fNPXNCVkeHUh?=
SW982 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PHWmlEPTB;MD6zNlgzKM7:TR?= M{ixdnNCVkeHUh?=
KM12 NFvWWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwM{i1OVch|ryP M4DvWHNCVkeHUh?=
COLO-205 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvQTWM2OD1yLkS4OlU5KM7:TR?= M2G1V3NCVkeHUh?=
COLO-829 NHvMPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2flSmlEPTB;MD63OVE4PiEQvF2= M1XrZnNCVkeHUh?=
MG-63 M3zEZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnPOVRyUUN3ME2wMlgxPjN5IN88US=> M4TNNHNCVkeHUh?=
IGROV-1 NHW5N2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwOEGwN|gh|ryP MVTTRW5ITVJ?
NCI-H650 MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m0[mlEPTB;MD64N|E2PCEQvF2= M{LmT3NCVkeHUh?=
RT-112 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmKyTWM2OD1yLkm4OFYh|ryP MVjTRW5ITVJ?
BCPAP M4ewdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nj[GlEPTB;MT6wNVI5QCEQvF2= MVXTRW5ITVJ?
ALL-PO Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzoTWM2OD1zLkCxOVg1KM7:TR?= MWDTRW5ITVJ?
KYSE-270 NXqxZ291T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTFwMES3NVQh|ryP NI\yR3BUSU6JRWK=
8305C M1f2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DZVGlEPTB;MT6wPVkxPCEQvF2= Mn\nV2FPT0WU
NCI-H810 NYixellLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDBOnJKSzVyPUGuNVA4PzZizszN MkjUV2FPT0WU
CAL-33 NXjQeoszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHQTWM2OD1zLkGyPVM5KM7:TR?= MkLpV2FPT0WU
AN3-CA MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDMVpcxUUN3ME2xMlIyQDZ5IN88US=> NYGyc|NZW0GQR1XS
NKM-1 NH3obpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTFwMke1NFYh|ryP NFfzS4NUSU6JRWK=
BPH-1 NYnDcZExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFwMki3OlYh|ryP MX;TRW5ITVJ?
MES-SA MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnYTWM2OD1zLkOwOlgzKM7:TR?= NHWwTpVUSU6JRWK=
CAL-62 M{nGVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fYdWlEPTB;MT6zNVkxQSEQvF2= M2rodHNCVkeHUh?=
Detroit562 M{DhbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDYWnRKSzVyPUGuN|UzOjJizszN NGLyeIZUSU6JRWK=
KYSE-150 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[0VmxWUUN3ME2xMlM2OjN4IN88US=> MnmwV2FPT0WU
SK-UT-1 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTCTWM2OD1zLkS0OlQ4KM7:TR?= MYDTRW5ITVJ?
HUTU-80 M2XOVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHy3WGFKSzVyPUGuOFQ5QDZizszN NUPRTGVMW0GQR1XS
SIG-M5 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknITWM2OD1zLkS4N|g4KM7:TR?= NH\0NY9USU6JRWK=
AGS NGnDdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEntT3dKSzVyPUGuOVIyOjRizszN M3G4ZXNCVkeHUh?=
ST486 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ezUGlEPTB;MT61N|I4QCEQvF2= NVi2V2tpW0GQR1XS
HSC-2 MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFwNUO5OUDPxE1? MYnTRW5ITVJ?
LCLC-103H MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\ocoxJUUN3ME2xMlU2QDF6IN88US=> NFzuNG5USU6JRWK=
BC-1 NGLldFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfYT5h3UUN3ME2xMlYyPjZ2IN88US=> NGn1c5dUSU6JRWK=
CGTH-W-1 NWjBTWhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljNTWM2OD1zLk[xOlc6KM7:TR?= MojvV2FPT0WU
MZ1-PC MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTqbYhKSzVyPUGuOlI{OTJizszN MoXnV2FPT0WU
SW1710 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmyUlU3UUN3ME2xMlYzPjJ6IN88US=> NWqxTlcyW0GQR1XS
EW-13 NUKzRoRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfJN41yUUN3ME2xMlY{PDZ4IN88US=> MoPlV2FPT0WU
TE-11 NHu5U21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLFPGdRUUN3ME2xMlY{PTJ{IN88US=> MmCyV2FPT0WU
BHY MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwNkW2OlMh|ryP M{DLRnNCVkeHUh?=
ML-2 M3H6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwNk[4NFIh|ryP NEm0W4VUSU6JRWK=
MEL-JUSO NWLaUoJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHSU25iUUN3ME2xMlczQDlzIN88US=> M4TZSXNCVkeHUh?=
U251 NILJU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDtSFFqUUN3ME2xMlc1ODNzIN88US=> M1;xN3NCVkeHUh?=
MHH-ES-1 NXrxbFVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG0ZVJKSzVyPUGuO|k2PjhizszN Mk\yV2FPT0WU
CAL-85-1 NUDlcIR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwOEC0PUDPxE1? MWLTRW5ITVJ?
D-336MG M{\w[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3sTWM2OD1zLki1OlE1KM7:TR?= MmjvV2FPT0WU
VA-ES-BJ NIj6SYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fvWWlEPTB;MT65NFMyPSEQvF2= NFqwWopUSU6JRWK=
MDA-MB-468 M{XtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDWTWM2OD1zLkmxNlczKM7:TR?= Mn3ZV2FPT0WU
MEL-HO MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnGcXlKSzVyPUGuPVc6QTNizszN MoDQV2FPT0WU
SW954 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PLV2lEPTB;Mj6wNFE2OSEQvF2= MlTLV2FPT0WU
LB831-BLC M{nyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof4TWM2OD1{LkCwPVg5KM7:TR?= MUPTRW5ITVJ?
EW-16 Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXMXW5KSzVyPUKuNFM6QDNizszN NXrleHlWW0GQR1XS
NCI-H460 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nCNGlEPTB;Mj6wOFg{QSEQvF2= MVzTRW5ITVJ?
CHP-212 NVv0ZlU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDEd|lLUUN3ME2yMlA6PTN7IN88US=> NFjuO25USU6JRWK=
MHH-NB-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJwMUK4NVgh|ryP MnL3V2FPT0WU
DU-4475 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zwbGlEPTB;Mj6xOFc2QSEQvF2= MVvTRW5ITVJ?
ABC-1 NG\IcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH0ZmdKSzVyPUKuNlUyQTZizszN MXrTRW5ITVJ?
LOUCY NFHMSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljlTWM2OD1{LkK2NVI5KM7:TR?= NWTEZ|lVW0GQR1XS
LC-2-ad MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPENFVKSzVyPUKuNlY6PjZizszN NEL4fnJUSU6JRWK=
ETK-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\EPFd2UUN3ME2yMlI5PDZizszN M4P5OnNCVkeHUh?=
KYSE-180 MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP6UmVKSzVyPUKuNlg5PzRizszN NEH6eGFUSU6JRWK=
HOP-92 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwM{C2O|Mh|ryP NW\mRoJVW0GQR1XS
RCC10RGB MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwM{K1NFch|ryP M{fW[3NCVkeHUh?=
KASUMI-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHyZWRtUUN3ME2yMlMzQDhizszN MWfTRW5ITVJ?
ACN NHW5ZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3STpJKSzVyPUKuN|Q4PDVizszN NVzhNGUxW0GQR1XS
BxPC-3 NH;0W4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnQUoNIUUN3ME2yMlM2PDN4IN88US=> M{\pUXNCVkeHUh?=
MONO-MAC-6 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwNEGyOFgh|ryP MVPTRW5ITVJ?
CAL-39 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwNEG2Nlgh|ryP M4rIOnNCVkeHUh?=
CMK NF[3SJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XIbGlEPTB;Mj60NVc6PSEQvF2= M4PCeHNCVkeHUh?=
MFE-296 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4q1ZmlEPTB;Mj60O|c6OiEQvF2= MnzuV2FPT0WU
DU-145 NF3EOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3leZdKSzVyPUKuOFkyOThizszN NUHKTY1QW0GQR1XS
MDA-MB-231 MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHrTWM2OD1{LkS5OVczKM7:TR?= Ml\GV2FPT0WU
EFO-27 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITSToxKSzVyPUKuOVE5QDhizszN MUjTRW5ITVJ?
SNU-387 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;LUIFzUUN3ME2yMlUzQDJizszN MV\TRW5ITVJ?
KYSE-410 NGr4R|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XnUGlEPTB;Mj61OlUyPyEQvF2= NGL1SGNUSU6JRWK=
NCCIT NXP1PIxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJwNUeyOEDPxE1? MoG4V2FPT0WU
LXF-289 NXPFS5ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJwNUiyO|Mh|ryP M3ziUXNCVkeHUh?=
HMV-II M{HrfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwNUi5PVch|ryP Mk\iV2FPT0WU
MOLT-4 Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzkNIM5UUN3ME2yMlYxPzF{IN88US=> NH7FW2hUSU6JRWK=
KOSC-2 NIH5[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;FWWlEPTB;Mj62N|g4QSEQvF2= M2rYVXNCVkeHUh?=
TUR NUOyOHpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJwNkWzOlkh|ryP Mm\YV2FPT0WU
NCI-H2087 M1\CbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zmbGlEPTB;Mj63NVY1PiEQvF2= MVXTRW5ITVJ?
SCC-15 M13mVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLNPWNuUUN3ME2yMlc2OjV{IN88US=> MkezV2FPT0WU
HSC-4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHZeZl7UUN3ME2yMlc5Ozh7IN88US=> NX;XN4ZvW0GQR1XS
G-402 NILQXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJwOEG0OFch|ryP Mn3hV2FPT0WU
GP5d MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf3TWM2OD1{LkizPFI4KM7:TR?= M33ybnNCVkeHUh?=
IGR-1 Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDiWGtKSzVyPUKuPFM6QDdizszN M3zNbnNCVkeHUh?=
SK-PN-DW MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\DXmtKSzVyPUKuPFYzODRizszN NWTKcplZW0GQR1XS
OPM-2 NFPVfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwOEm5O|gh|ryP M1j6PXNCVkeHUh?=
5637 M3TZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDpNWZlUUN3ME2yMlkzPDN7IN88US=> MoDFV2FPT0WU
NCI-H2030 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv4TWM2OD1{Lkm4NFI6KM7:TR?= NFOybopUSU6JRWK=
SK-LU-1 M33TOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrrVGtFUUN3ME2yMlk5OzN2IN88US=> NVH1dolvW0GQR1XS
EW-18 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT2TWM2OD1|LkC1N|Ih|ryP NGnZbW9USU6JRWK=
786-0 NYPuRmx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\rV5JKSzVyPUOuNFU4QDRizszN M3\sN3NCVkeHUh?=
NCI-H1963 NYDY[IV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\EdYV6UUN3ME2zMlA5QDJ3IN88US=> NUHpcmpvW0GQR1XS
A2780 NV;U[3VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHJWXJHUUN3ME2zMlExOzRzIN88US=> NX:xdFB[W0GQR1XS
NCI-H526 M325TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fUPGlEPTB;Mz6xN|k3OSEQvF2= NUHaVm9UW0GQR1XS
BHT-101 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTITWM2OD1|LkG1O|k5KM7:TR?= NIrFc|NUSU6JRWK=
RPMI-7951 M{fkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTNwMkCxN|ch|ryP M1vNdXNCVkeHUh?=
HL-60 M1n2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLPeVdZUUN3ME2zMlIyOTRizszN MknLV2FPT0WU
CTV-1 NWr0XJplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrmTWM2OD1|LkK1N|c4KM7:TR?= M3;ZXHNCVkeHUh?=
IST-SL1 NWnwfnh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nMcWlEPTB;Mz6yPVQ3PSEQvF2= NU\nNlNYW0GQR1XS
G-401 Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNwMkm4NFgh|ryP NGnzV2lUSU6JRWK=
OVCAR-5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDlOVlKSzVyPUOuN|Y{PTJizszN NUniSIFuW0GQR1XS
EW-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNwNEC1OFQh|ryP MUTTRW5ITVJ?
H4 NF\HN|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTIPJRYUUN3ME2zMlQ4PTZ7IN88US=> NHOzTHFUSU6JRWK=
EM-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nhTGlEPTB;Mz60PFY4PCEQvF2= NFvXSW9USU6JRWK=
RS4-11 NWOxOmFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHPT4ZKSzVyPUOuOFg4OTVizszN NIjtRpZUSU6JRWK=
NOMO-1 M3n4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTNwNEmyNFQh|ryP M4LJbnNCVkeHUh?=
HCT-116 M3TJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfDZohKSzVyPUOuOVA4OTFizszN M2jpXnNCVkeHUh?=
CAL-120 NXn3do5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXZfVNKSzVyPUOuOVc{PSEQvF2= NGDKdJVUSU6JRWK=
CAL-51 NX\IW3ZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTNwNUe2NVIh|ryP Mkj5V2FPT0WU
RVH-421 NELYZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX4fI9KSzVyPUOuOlA{OTFizszN M{HGbHNCVkeHUh?=
NCI-H2081 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTVTWM2OD1|Lk[1Nlg5KM7:TR?= NX32XIR{W0GQR1XS
SBC-5 MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTNwNke4PFIh|ryP MkXhV2FPT0WU
RL95-2 M1TBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTNwN{G4OlQh|ryP MYLTRW5ITVJ?
SW872 MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNwN{[5OVgh|ryP NHvz[m5USU6JRWK=
VM-CUB-1 M3L0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLQTWM2OD1|Lke3OVEh|ryP NUO2ToNlW0GQR1XS
SUP-T1 M{jUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHjXZBKSzVyPUOuO|g{OiEQvF2= MVzTRW5ITVJ?
697 NX\PelJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTNwOEG2OVch|ryP MmSwV2FPT0WU
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KU812 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTF7LkW5OFQh|ryP Mn7aV2FPT0WU
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LB2518-MEL NG\6bIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nGfmlEPTB;MkCuN|k2OyEQvF2= M4jSfnNCVkeHUh?=
PANC-10-05 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJyLkS2NVMh|ryP NXXHT3BkW0GQR1XS
MZ2-MEL M3nVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nkZWlEPTB;MkCuOVgyPCEQvF2= MnfGV2FPT0WU
MFE-280 NFPVXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r1N2lEPTB;MkGuN|E5QCEQvF2= NVnH[|JOW0GQR1XS
RKO MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXRTWM2OD1{MT6zNlAzKM7:TR?= MYDTRW5ITVJ?
KMOE-2 M17RT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW3TWM2OD1{MT6zNlg5KM7:TR?= NYXvSVY2W0GQR1XS
K5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH2NZRZUUN3ME2yNU4{QDl|IN88US=> NH3zV|dUSU6JRWK=
NCI-H64 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zXemlEPTB;MkGuOFc2PiEQvF2= M3nwXHNCVkeHUh?=
K-562 NEnSWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTDTWM2OD1{MT60PVcyKM7:TR?= MnfIV2FPT0WU
HCE-T NFHrRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJzLkWwPVQh|ryP NE\QbHRUSU6JRWK=
COLO-792 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjpTWM2OD1{MT61PFI4KM7:TR?= MWXTRW5ITVJ?
PFSK-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJzLk[4N|ch|ryP NVHzUll3W0GQR1XS
DOK MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrrcmlKSzVyPUKxMlc3QDdizszN MkHHV2FPT0WU
NCI-H1882 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\4TWM2OD1{MT64OVk3KM7:TR?= NFLZeWFUSU6JRWK=
KNS-81-FD NWnOWXVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3FTWM2OD1{MT64OlMyKM7:TR?= MVrTRW5ITVJ?
OCUB-M NXPDUGlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvTfYpKSzVyPUKxMlk3QDhizszN NInTZYVUSU6JRWK=
NCI-H1694 NHK2XlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJzLkm4OlMh|ryP M1zVRXNCVkeHUh?=
LS-513 M4PEZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[4cWZKSzVyPUKyMlA{PjdizszN M1j4SXNCVkeHUh?=
NCI-H2122 NWi0N5Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLYfmpKSzVyPUKyMlE3PzdizszN M3jsWnNCVkeHUh?=
IMR-5 NIfPZ2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJ{LkK4O{DPxE1? M2TuPHNCVkeHUh?=
SNU-C2B MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETURmhKSzVyPUKyMlY4PDZizszN M4Hre3NCVkeHUh?=
A498 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ{LkixO|ch|ryP M3G3UnNCVkeHUh?=
NCI-H727 NH\NVFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJ{Lki4N|Yh|ryP MoW4V2FPT0WU
SW1573 MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j5UWlEPTB;MkOuNFY1PiEQvF2= MnnmV2FPT0WU
RO82-W-1 NXzIZotKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\EXnpEUUN3ME2yN{4zPTFzIN88US=> M3nNSHNCVkeHUh?=
SKG-IIIa NGXITo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ|LkO1OFYh|ryP NXXReFBqW0GQR1XS
MC-CAR NWrGbXRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLzWYpZUUN3ME2yN{42OTh|IN88US=> MYHTRW5ITVJ?
NCI-H446 M1Oyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XwWmlEPTB;MkOuOlA6OyEQvF2= NH30SVhUSU6JRWK=
PC-14 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofmTWM2OD1{Mz62OlI{KM7:TR?= MWDTRW5ITVJ?
TGBC1TKB NI\nXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojHTWM2OD1{Mz63OFYyKM7:TR?= MVzTRW5ITVJ?
EFM-19 NV\IdGQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LZWGlEPTB;MkSuNVg1PCEQvF2= MlXHV2FPT0WU
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NCI-H661 M4f6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjSNpcyUUN3ME2yOE42OjF5IN88US=> MmS3V2FPT0WU
SW1990 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJ2LkW4PFMh|ryP NIXJbHpUSU6JRWK=
SW684 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJ2Lke2NlQh|ryP NXHkO45KW0GQR1XS
Ca-Ski MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT3NWx[UUN3ME2yOE46OjN5IN88US=> M3rnNHNCVkeHUh?=
TGW NHft[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLpTWM2OD1{NT6yN|M4KM7:TR?= MVXTRW5ITVJ?
CaR-1 NFnBSlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLBTWM2OD1{NT6zOVch|ryP M1LCe3NCVkeHUh?=
D-247MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHOTWM2OD1{NT60O|Q{KM7:TR?= NFvJWpRUSU6JRWK=
CCRF-CEM M{H6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DXU2lEPTB;MkWuO|Q2QSEQvF2= MWPTRW5ITVJ?
CAPAN-1 NGTWe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ3Lke1NFEh|ryP NWPrcYhsW0GQR1XS
CP50-MEL-B MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInhe5VKSzVyPUK1Mlk6ODFizszN NUPoRWdJW0GQR1XS
FADU Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT2SnNKSzVyPUK2MlUyPTJizszN NXnEZVJkW0GQR1XS
Daudi NE\6cG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXjeI9KSzVyPUK2MlUyPThizszN NIHaPI5USU6JRWK=
U-87-MG M{DBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jpeGlEPTB;Mk[uOVMxPSEQvF2= M4D1UXNCVkeHUh?=
DSH1 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy0N4NUUUN3ME2yOk42PDB4IN88US=> NGD1T5hUSU6JRWK=
KYSE-520 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ4LkW1OVMh|ryP MVnTRW5ITVJ?
HuH-7 MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DON2lEPTB;Mk[uPVA5PiEQvF2= NF:zbHdUSU6JRWK=
U-2-OS MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrzTWM2OD1{Nz6wNlcyKM7:TR?= M1fme3NCVkeHUh?=
LU-99A M2fiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2j0WmlEPTB;MkeuNVc2PCEQvF2= M4q5d3NCVkeHUh?=
T98G MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJ5LkG5O|Mh|ryP MoiwV2FPT0WU
MZ7-mel NGPXdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPLZVVKSzVyPUK3MlU2PDhizszN MnrSV2FPT0WU
SNU-C1 NWi1bXlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T3TWlEPTB;MkeuOlQ6OSEQvF2= NXnERYRiW0GQR1XS
MDA-MB-175-VII M2fQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jad2lEPTB;MkeuOlk4PSEQvF2= NXzJN49MW0GQR1XS
HuP-T3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf0dXNyUUN3ME2yPE4xPDl3IN88US=> NYDxV5J7W0GQR1XS
T-24 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL6TWM2OD1{OD6xPVI2KM7:TR?= MY\TRW5ITVJ?
HDLM-2 MonhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPwZ3JKSzVyPUK4MlI1PTlizszN NFjJ[olUSU6JRWK=
NCI-H1651 M13sdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDMTWM2OD1{OD6yOVkzKM7:TR?= MmjsV2FPT0WU
SK-N-AS NH7tSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrHU4VKSzVyPUK4MlMyPzFizszN NWTCZok{W0GQR1XS
NY M1q1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfZRnNoUUN3ME2yPE43PTd7IN88US=> MXTTRW5ITVJ?
D-283MED NHTUTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DydmlEPTB;MkiuPFcxQCEQvF2= NWXSWIZ4W0GQR1XS
KLE M2PWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnWUY1{UUN3ME2yPE46QTB4IN88US=> MlPqV2FPT0WU
NCI-H28 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofWTWM2OD1{OT6wNVIh|ryP NILCVVdUSU6JRWK=
TE-1 NHe2cJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJ7LkKxOlch|ryP NFjRO5JUSU6JRWK=
SK-MEL-24 NFrvPYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki4TWM2OD1{OT61OFY3KM7:TR?= MV7TRW5ITVJ?
CAL-54 NHWxO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXlTWM2OD1{OT62NFQ3KM7:TR?= NHfvU4JUSU6JRWK=
A673 NHvEdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW2TWM2OD1{OT63N|Ih|ryP MoTIV2FPT0WU
HEC-1 M3fuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T3SGlEPTB;M{CuNFA2OyEQvF2= NVzIXmF7W0GQR1XS
LS-411N M{jCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\nW2w5UUN3ME2zNE4yPDd3IN88US=> NIr2Z29USU6JRWK=
SW962 NYmxc29jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfvdJhSUUN3ME2zNE4zPDd5IN88US=> NHTIe2pUSU6JRWK=
OVCAR-8 M2Dm[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XIVmlEPTB;M{CuOlc6PCEQvF2= NXvqPFFKW0GQR1XS
NCI-H630 M1G4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTHbWhwUUN3ME2zNE45QTV|IN88US=> NUXWU5dGW0GQR1XS
D-263MG NWLrdpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrLXWpuUUN3ME2zNU4xPDJ2IN88US=> MYDTRW5ITVJ?
NCI-H596 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XQeWlEPTB;M{GuNFYzOSEQvF2= M{DY[nNCVkeHUh?=
BB49-HNC M3nPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3JNolKSzVyPUOxMlEyOiEQvF2= Mn2yV2FPT0WU
KYSE-70 NF3KTHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLUdXFKSzVyPUOxMlMxODhizszN MVzTRW5ITVJ?
LAN-6 M{H4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfsepI3UUN3ME2zNU41QTl{IN88US=> NUHSTpFIW0GQR1XS
NCI-H2228 M3O3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTITWM2OD1|MT61OlI2KM7:TR?= M{nuTHNCVkeHUh?=
SW620 NWD5V3JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj5c5lKSzVyPUOxMlYzQDNizszN M2C5c3NCVkeHUh?=
KM-H2 NWnTeVVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNzLkezNFYh|ryP M4PtSnNCVkeHUh?=
DJM-1 NFPnNoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHKZnh1UUN3ME2zNk4yOzh4IN88US=> NG[5fIJUSU6JRWK=
SW48 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTN{LkO4NlUh|ryP NV\TWJBWW0GQR1XS
NCI-H1793 M1Tzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3exPGlEPTB;M{KuOlE3OyEQvF2= NX;hcFhmW0GQR1XS
LU-165 M{TNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLMTWM2OD1|Mz6wNFgh|ryP MUPTRW5ITVJ?
EHEB NEnS[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXsTWM2OD1|Mz6wOFk1KM7:TR?= NInKPYpUSU6JRWK=
NCI-H441 NVP4eoRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HOT2lEPTB;M{OuNlI{PSEQvF2= MV7TRW5ITVJ?
LOXIMVI NWW2NmZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu2TWM2OD1|Mz6zOlc6KM7:TR?= MYPTRW5ITVJ?
MC-IXC M3PtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTN|LkW2OVUh|ryP M1v4fnNCVkeHUh?=
NCI-H522 NUO3[GpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvvZ3Y2UUN3ME2zN{43PTRizszN NVjDTHE4W0GQR1XS
IA-LM MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MneyTWM2OD1|Mz62O|Q3KM7:TR?= M{jqOHNCVkeHUh?=
NCI-H1417 NGG5PGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:zTWM2OD1|Mz65OVg2KM7:TR?= M1i2OXNCVkeHUh?=
HCC2218 M1X0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPnTWM2OD1|NT6yNVg2KM7:TR?= NI\tV|BUSU6JRWK=
HC-1 NH7o[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTN3LkSwNlQh|ryP M2e3RXNCVkeHUh?=
HH NX;l[3hnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX4UmVmUUN3ME2zOU41OTRzIN88US=> NEXWSVBUSU6JRWK=
EFE-184 NYDJTYVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFixelNKSzVyPUO1MlY5OjlizszN MnqzV2FPT0WU
NCI-H1355 M2T1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DNWGlEPTB;M{WuO|cyQCEQvF2= NFP3R2hUSU6JRWK=
BV-173 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrVPG9KSzVyPUO1MlgzPjRizszN NWLPNlB[W0GQR1XS
NEC8 NEniV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\YeGlEPTB;M{[uOFkzPCEQvF2= NUXvTYt4W0GQR1XS
SW1463 M1;KXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG3OWpZUUN3ME2zOk43PTZ4IN88US=> NV:zblhqW0GQR1XS
KYSE-140 NInaVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zzWGlEPTB;M{[uO|I6QCEQvF2= NH\1TGhUSU6JRWK=
no-11 M3zuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN4Lki1N|Yh|ryP NFrFXo1USU6JRWK=
HCC1937 NFHzSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXoT4NMUUN3ME2zO{4xOTV2IN88US=> MXzTRW5ITVJ?
LNCaP-Clone-FGC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTN5LkG5NFMh|ryP NFXOUGxUSU6JRWK=
KARPAS-422 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3VTWM2OD1|Nz60OFMyKM7:TR?= NY\ISnFMW0GQR1XS
RCM-1 M1frV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN5LkWzOVgh|ryP NWnwPVFkW0GQR1XS
A375 MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vO[GlEPTB;M{euO|Y1PyEQvF2= NYL2cphuW0GQR1XS
TGBC24TKB MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTN6LkCyN|kh|ryP MnvXV2FPT0WU
MDA-MB-453 M4CzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\SS29KSzVyPUO5MlAzOThizszN MWnTRW5ITVJ?
Capan-2 MlzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PkTWlEPTB;M{muNFUxQSEQvF2= NWT0fYVPW0GQR1XS
SW756 M3\QTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTN7LkWwPVEh|ryP NX[wdWRCW0GQR1XS
KU-19-19 NH\JTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\OV2lEPTB;M{muOlI5OiEQvF2= MXfTRW5ITVJ?
NCI-H2170 M1z5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX25TllzUUN3ME2zPU46QTd5IN88US=> MUPTRW5ITVJ?
COLO-678 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO1OY5KSzVyPUSwMlU6PSEQvF2= MmHWV2FPT0WU
PF-382 NX;zcYVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnyZ|FKSzVyPUSwMlc1QDdizszN MY\TRW5ITVJ?
OAW-42 NEXpRWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILvO4lKSzVyPUSyMlI6PDJizszN MYnTRW5ITVJ?
LB996-RCC NVXFO4Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TndGlEPTB;NEKuPFAxQCEQvF2= M1\McnNCVkeHUh?=
SAS NEm0RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTR|LkSyPFgh|ryP M{mxfnNCVkeHUh?=
MRK-nu-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITobJJKSzVyPUS0Mlc1OTRizszN MnnIV2FPT0WU
EoL-1-cell MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTR2LkmxN|Yh|ryP NYXETphnW0GQR1XS
NCI-H2342 NWjhVHpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS3TWM2OD12NT6xNVE4KM7:TR?= Mn24V2FPT0WU
NCI-H1703 MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LkPWlEPTB;NE[uNFU6OiEQvF2= MWfTRW5ITVJ?
NCI-H187 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXXTWM2OD12Nj6xPFY6KM7:TR?= NGjKfFVUSU6JRWK=
CP66-MEL MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPIVZpMUUN3ME20Ok4zPzh7IN88US=> NF24UIpUSU6JRWK=
HCC1569 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rWPWlEPTB;NE[uOVkyPyEQvF2= MUXTRW5ITVJ?
BL-70 NWH4bGZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTR4Lke3N|ch|ryP MWTTRW5ITVJ?
Saos-2 M17Mdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTR5LkOxNlMh|ryP MmPwV2FPT0WU
LC-1F NV7mWYt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LpbWlEPTB;NEeuOlExPSEQvF2= MWHTRW5ITVJ?
KY821 M{XNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTR5Lk[0N|Qh|ryP NYLk[YZCW0GQR1XS
PSN1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;5emlEPTB;NEiuNVQxOSEQvF2= MmfjV2FPT0WU
RT4 NHPTXG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTR6LkizO|ch|ryP NXHKVGdDW0GQR1XS
LS-1034 NFj1RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\aTZFPUUN3ME20PE45QTV2IN88US=> NXiwfWdXW0GQR1XS
NCI-H1395 NEjVd4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rLR2lEPTB;NEmuNFQ6OiEQvF2= NYDhTHhuW0GQR1XS
EKVX M3ezTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nvfmlEPTB;NEmuOlc{OSEQvF2= NIjWeWFUSU6JRWK=
IST-MES1 M1S5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;LPYZKSzVyPUS5Mlg6PDRizszN NYrKRVcxW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-FAK / FAK / p-Talin / Talin ; 

PubMed: 26530902     


Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells.

p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; 

PubMed: 29417941     


MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.

26530902 29417941
Immunofluorescence
p-FAK; 

PubMed: 26530902     


Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).

26530902
Growth inhibition assay
Cell viability; 

PubMed: 28953264     


MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk (*) and p < 0.01 are designated by two asterisks (**).

28953264
In vivo PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. [1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. [3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. [4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. [5]

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts.
  • Formulation: 5% Gelucire
  • Dosages: 50 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
For best results, use promptly after mixing.
5 mg/ml

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 507.49
Formula

C21H20F3N7O3S

CAS No. 717907-75-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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FAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID