PF-562271

Catalog No.S2890

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

Cited by 14 Publications

Nat Cell Biol, 2015, 17(11):1412-21

PubMed: 26436690 ( click the link to review the publication )

Sci Transl Med, 2017, 9(420)

PubMed: 29237758 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(23):5851-5863

PubMed: 27220963 ( click the link to review the publication )

Oncogene, 2015, 34(40):5114-27

PubMed: 25639872 ( click the link to review the publication )

Oral Oncology, 2016, 10.1016/j.oraloncology.2016.05.010

PubMed: ( click the link to review the publication )

Cancer Sci, 2013, 104(12):1618-25

PubMed: 24112719 ( click the link to review the publication )

J Biol Chem, 2015, 290(14):8677-92

PubMed: 25713079 ( click the link to review the publication )

Acta Pharmacol Sin, 2018, 10.1038/aps

PubMed: 29417941 ( click the link to review the publication )

Environ Toxicol Pharmacol, 2015, 39(1):114-24

PubMed: 25481308 ( click the link to review the publication )

Environ Toxicol Pharm, 2014, 39(1):114-124

PubMed: 25481308 ( click the link to review the publication )

PLoS One, 2014, 9(2):e88587

PubMed: 24523919 ( click the link to review the publication )

Int J Clin Exp Pathol, 2013, 6(10):2082-91

PubMed: 24133586 ( click the link to review the publication )
Oncotarget, 2016, 7(30):48093-48106

PubMed: 27344177 ( click the link to review the publication )

Sci Rep, 2016, 6:19261

PubMed: 26763933 ( click the link to review the publication )

6 Customer Reviews

Effect of matrix stiffness on the susceptibility of primary HDFs to apoptosis induced by inhibition of mechanotransduction pathways. HDFs (primary human dermal fibroblasts) were cultured on collagen-coated polyacrylamide hydrogels that recapitulated the stiffness of normal (4 kPa) or densely fibrotic (50 kPa) skin for 24 hours and treated with or without the agents indicated for an additional 48 hours. Apoptosis was assessed by annexin V staining. Data are means ± SD from three independent experiments. P value was determined by Student’s t test.

Science, 2017, 9(420), doi: 10.1126/scitranslmed.aal3765. PF-562271 purchased from Selleck.

(F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.
D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

Acta Pharmacol Sin, 2018, doi:10.1038/aps.2017.189. PF-562271 purchased from Selleck.
VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description

Targets

FAK ^[1] (Cell-free assay)	PYK2 ^[1] (Cell-free assay)	CDK2/CyclinE ^[1] (Cell-free assay)	CDK3/CyclinE ^[1] (Cell-free assay)	CDK1/CyclinB ^[1] (Cell-free assay)	View More
1.5 nM	13 nM	30 nM	47 nM	58 nM	View More

In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. ^[1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. ^[2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
MV-4-11	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXmyS5lpUUN3ME2wMlI4PjZizszN	NFP1VmZUSU6JRWK=
SW982	MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTBwM{K4NkDPxE1?	M{j1U3NCVkeHUh?=
KM12	NX72N\|Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWLhW29LUUN3ME2wMlM5PTV5IN88US=>	NVzvT3ZOW0GQR1XS
COLO-205	Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlfwTWM2OD1yLkS4OlU5KM7:TR?=	MUXTRW5ITVJ?
COLO-829	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlvPTWM2OD1yLke1NVc3KM7:TR?=	NI\YOJdUSU6JRWK=
MG-63	NHTSZm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVjJR\|UxRTBwOEC2N\|ch\|ryP	MWTTRW5ITVJ?
IGROV-1	NEf5SFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEfETVRKSzVyPUCuPFExOzhizszN	NUTCWHJWW0GQR1XS
NCI-H650	NFPreGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4C0e2lEPTB;MD64N\|E2PCEQvF2=	MnHXV2FPT0WU
RT-112	NFzwVGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTBwOUi0OkDPxE1?	NF;NSXBUSU6JRWK=
BCPAP	NH7HN\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4DQZ2lEPTB;MT6wNVI5QCEQvF2=	MljZV2FPT0WU
ALL-PO	M2L0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3zySGlEPTB;MT6wNVU5PCEQvF2=	NHjrZnVUSU6JRWK=
KYSE-270	M4i3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlHZTWM2OD1zLkC0O\|E1KM7:TR?=	NGDhNWxUSU6JRWK=
8305C	NIDEXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWDZTJJPUUN3ME2xMlA6QTB2IN88US=>	NYDpRY1bW0GQR1XS
NCI-H810	M2XBNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUS0SnprUUN3ME2xMlExPzd4IN88US=>	NGL2RXFUSU6JRWK=
CAL-33	NVnhVnltT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVTJR\|UxRTFwMUK5N\|gh\|ryP	NYfIXW1wW0GQR1XS
AN3-CA	Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MU\JR\|UxRTFwMkG4Olch\|ryP	MonhV2FPT0WU
NKM-1	NV\kV4dST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\xTXVkUUN3ME2xMlI4PTB4IN88US=>	NEjCflJUSU6JRWK=
BPH-1	NEO0WWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUPs[FBPUUN3ME2xMlI5PzZ4IN88US=>	NWnwTmVsW0GQR1XS
MES-SA	M{fvW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTFwM{C2PFIh\|ryP	NFrPUo5USU6JRWK=
CAL-62	M2jpU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU\JR\|UxRTFwM{G5NFkh\|ryP	M1;WRnNCVkeHUh?=
Detroit562	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGLEZmVKSzVyPUGuN\|UzOjJizszN	NYf4[YF7W0GQR1XS
KYSE-150	MlHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3W5PWlEPTB;MT6zOVI{PiEQvF2=	M3r0UHNCVkeHUh?=
SK-UT-1	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTQTWM2OD1zLkS0OlQ4KM7:TR?=	NEjy[HRUSU6JRWK=
HUTU-80	M1jTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M13xTGlEPTB;MT60OFg5PiEQvF2=	Mon3V2FPT0WU
SIG-M5	NWTJOIM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTSWGNvUUN3ME2xMlQ5Ozh5IN88US=>	MWXTRW5ITVJ?
AGS	NUfK[og6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkG3TWM2OD1zLkWyNVI1KM7:TR?=	NUfUfXd[W0GQR1XS
ST486	NU\idIt1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NITHSJNKSzVyPUGuOVMzPzhizszN	MlH0V2FPT0WU
HSC-2	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVPXbWlpUUN3ME2xMlU{QTVizszN	NXnONppuW0GQR1XS
LCLC-103H	NVr3eWNQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLXOoJRUUN3ME2xMlU2QDF6IN88US=>	M3ezbXNCVkeHUh?=
BC-1	NH3DenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH7vfZdKSzVyPUGuOlE3PjRizszN	NEDRdFFUSU6JRWK=
CGTH-W-1	Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3PBc2lEPTB;MT62NVY4QSEQvF2=	NI\oRXFUSU6JRWK=
MZ1-PC	M1fLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVm2boJEUUN3ME2xMlYzOzF{IN88US=>	NYfHcWFHW0GQR1XS
SW1710	Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXTJR\|UxRTFwNkK2Nlgh\|ryP	MV3TRW5ITVJ?
EW-13	NGGwOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlH0TWM2OD1zLk[zOFY3KM7:TR?=	NUjofYFLW0GQR1XS
TE-11	MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnvNTWM2OD1zLk[zOVIzKM7:TR?=	NWHHeIlDW0GQR1XS
BHY	M3\Xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUfydoU{UUN3ME2xMlY2PjZ\|IN88US=>	NEnucmdUSU6JRWK=
ML-2	MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnL0TWM2OD1zLk[2PFAzKM7:TR?=	MWXTRW5ITVJ?
MEL-JUSO	M3y2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmLmTWM2OD1zLkeyPFkyKM7:TR?=	M3rwenNCVkeHUh?=
U251	NFj1OI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{jDVmlEPTB;MT63OFA{OSEQvF2=	NVvZSm1nW0GQR1XS
MHH-ES-1	NXjXdWFnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXtb2JNUUN3ME2xMlc6PTZ6IN88US=>	M{jxTnNCVkeHUh?=
CAL-85-1	MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTFwOEC0PUDPxE1?	NF[4bVBUSU6JRWK=
D-336MG	M37ES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYXJR\|UxRTFwOEW2NVQh\|ryP	M2XlVHNCVkeHUh?=
VA-ES-BJ	M3TKeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkS2TWM2OD1zLkmwN\|E2KM7:TR?=	Mlf0V2FPT0WU
MDA-MB-468	NVfzTo84T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{TRWGlEPTB;MT65NVI4OiEQvF2=	MmXGV2FPT0WU
MEL-HO	M{PXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mln4TWM2OD1zLkm3PVk{KM7:TR?=	NFLJelVUSU6JRWK=
SW954	NYjQdlZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXzJR\|UxRTJwMECxOVEh\|ryP	MXnTRW5ITVJ?
LB831-BLC	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LGbWlEPTB;Mj6wNFk5QCEQvF2=	NW\3VppzW0GQR1XS
EW-16	MlqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4rQXWlEPTB;Mj6wN\|k5OyEQvF2=	NVvaemRsW0GQR1XS
NCI-H460	M4jlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYXJR\|UxRTJwMES4N\|kh\|ryP	MXnTRW5ITVJ?
CHP-212	MnfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjOTWM2OD1{LkC5OVM6KM7:TR?=	M1\lS3NCVkeHUh?=
MHH-NB-11	M3G4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2n6fmlEPTB;Mj6xNlgyQCEQvF2=	NHTyRmhUSU6JRWK=
DU-4475	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnzOTWM2OD1{LkG0O\|U6KM7:TR?=	NVK0Rmc{W0GQR1XS
ABC-1	NYPRcZN1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnuyTWM2OD1{LkK1NVk3KM7:TR?=	MWjTRW5ITVJ?
LOUCY	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEizTlVKSzVyPUKuNlYyOjhizszN	NULSNmlWW0GQR1XS
LC-2-ad	M3fnTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF34[lVKSzVyPUKuNlY6PjZizszN	NUOyRWJrW0GQR1XS
ETK-1	NWjiWWY6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4\jOmlEPTB;Mj6yPFQ3KM7:TR?=	NYHZbpIyW0GQR1XS
KYSE-180	NUXueWZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnOyTWM2OD1{LkK4PFc1KM7:TR?=	NYr2Znl1W0GQR1XS
HOP-92	MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{GySGlEPTB;Mj6zNFY4OyEQvF2=	MnLvV2FPT0WU
RCC10RGB	MljqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmrKTWM2OD1{LkOyOVA4KM7:TR?=	MkXwV2FPT0WU
KASUMI-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHnpdGRKSzVyPUKuN\|I5QCEQvF2=	Mnq0V2FPT0WU
ACN	MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXrJR\|UxRTJwM{S3OFUh\|ryP	NYfwV3ppW0GQR1XS
BxPC-3	NXvseVhwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHu0dVVKSzVyPUKuN\|U1OzZizszN	NXnYblY5W0GQR1XS
MONO-MAC-6	NEPwb2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1\xbGlEPTB;Mj60NVI1QCEQvF2=	NF3oeYhUSU6JRWK=
CAL-39	NYC2d2lyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml2wTWM2OD1{LkSxOlI5KM7:TR?=	MmHSV2FPT0WU
CMK	NIjZXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUnJR\|UxRTJwNEG3PVUh\|ryP	M4jodnNCVkeHUh?=
MFE-296	MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYLVcFVxUUN3ME2yMlQ4Pzl{IN88US=>	M3zHNHNCVkeHUh?=
DU-145	NI\WeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoL6TWM2OD1{LkS5NVE5KM7:TR?=	M2\BVXNCVkeHUh?=
MDA-MB-231	NF30SIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTJwNEm1O\|Ih\|ryP	MYXTRW5ITVJ?
EFO-27	NVLMVZFrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGG4folKSzVyPUKuOVE5QDhizszN	M3K2SHNCVkeHUh?=
SNU-387	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWTafIZ1UUN3ME2yMlUzQDJizszN	MnjNV2FPT0WU
KYSE-410	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYHaT493UUN3ME2yMlU3PTF5IN88US=>	MXfTRW5ITVJ?
NCCIT	NYTLUWNVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzGTVJKSzVyPUKuOVczPCEQvF2=	Mlu1V2FPT0WU
LXF-289	NFP0XZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHQTWM2OD1{LkW4Nlc{KM7:TR?=	NXrCT3o5W0GQR1XS
HMV-II	M3jp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIr6SnFKSzVyPUKuOVg6QTdizszN	M4H5OnNCVkeHUh?=
MOLT-4	NFvoT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIToflFKSzVyPUKuOlA4OTJizszN	MWTTRW5ITVJ?
KOSC-2	NYTVdmpnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LxfmlEPTB;Mj62N\|g4QSEQvF2=	NXPvPIpHW0GQR1XS
TUR	M3GwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1zoOWlEPTB;Mj62OVM3QSEQvF2=	NW\5doJkW0GQR1XS
NCI-H2087	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEDMTXFKSzVyPUKuO\|E3PDZizszN	NUDF[HRJW0GQR1XS
SCC-15	NX7LXm1PT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFX3XI9KSzVyPUKuO\|UzPTJizszN	M1q2cXNCVkeHUh?=
HSC-4	NX;6PJVpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1XGe2lEPTB;Mj63PFM5QSEQvF2=	MW\TRW5ITVJ?
G-402	NXrTe2ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHTbVBnUUN3ME2yMlgyPDR5IN88US=>	NXW5SI9WW0GQR1XS
GP5d	MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYXKXWFWUUN3ME2yMlg{QDJ5IN88US=>	MWTTRW5ITVJ?
IGR-1	M1nvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M33VfGlEPTB;Mj64N\|k5PyEQvF2=	NIC2SFRUSU6JRWK=
SK-PN-DW	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLJTWM2OD1{Lki2NlA1KM7:TR?=	NXfre2J6W0GQR1XS
OPM-2	MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1HHSGlEPTB;Mj64PVk4QCEQvF2=	NHjKNJpUSU6JRWK=
5637	NYPrZ3QxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmHtTWM2OD1{LkmyOFM6KM7:TR?=	M1q0UXNCVkeHUh?=
NCI-H2030	NXjkTVFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVfJR\|UxRTJwOUiwNlkh\|ryP	NYrLNJF7W0GQR1XS
SK-LU-1	NIniW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37UZmlEPTB;Mj65PFM{PCEQvF2=	NYH5U2t[W0GQR1XS
EW-18	NXnIbphqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NG[0RZBKSzVyPUOuNFU{OiEQvF2=	NUTBSnBFW0GQR1XS
786-0	NUDuNoxTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYjJR\|UxRTNwMEW3PFQh\|ryP	MnLEV2FPT0WU
NCI-H1963	NYTXOVNsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TxU2lEPTB;Mz6wPFgzPSEQvF2=	NES3UJpUSU6JRWK=
A2780	M1;DbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkLBTWM2OD1\|LkGwN\|QyKM7:TR?=	NGS2eWZUSU6JRWK=
NCI-H526	M{jPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LpeGlEPTB;Mz6xN\|k3OSEQvF2=	NIrBc2NUSU6JRWK=
BHT-101	NYnz[2VMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mnz3TWM2OD1\|LkG1O\|k5KM7:TR?=	MmrPV2FPT0WU
RPMI-7951	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWPnUVRjUUN3ME2zMlIxOTN5IN88US=>	NVzpO4xGW0GQR1XS
HL-60	M1nzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH;MWVhKSzVyPUOuNlEyPCEQvF2=	M1jyWnNCVkeHUh?=
CTV-1	MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYW2VFFEUUN3ME2zMlI2Ozd5IN88US=>	NF65U2VUSU6JRWK=
IST-SL1	MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkK5TWM2OD1\|LkK5OFY2KM7:TR?=	Mn64V2FPT0WU
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OVCAR-5	NF\aW\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFOybIFKSzVyPUOuN\|Y{PTJizszN	M{LlNnNCVkeHUh?=
EW-1	M1XvWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTNwNEC1OFQh\|ryP	M{nTWHNCVkeHUh?=
H4	NXq4e2R{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWLKfZFiUUN3ME2zMlQ4PTZ7IN88US=>	MV;TRW5ITVJ?
EM-2	MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2nqc2lEPTB;Mz60PFY4PCEQvF2=	NUTKNGlTW0GQR1XS
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NOMO-1	M3flWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4\teWlEPTB;Mz60PVIxPCEQvF2=	NF3KNZlUSU6JRWK=
HCT-116	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3vHZWlEPTB;Mz61NFcyOSEQvF2=	MnrxV2FPT0WU
CAL-120	MnPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEHmcW9KSzVyPUOuOVc{PSEQvF2=	MWHTRW5ITVJ?
CAL-51	NWHxcXhwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYfxXWFQUUN3ME2zMlU4PjF{IN88US=>	NX70UIxvW0GQR1XS
RVH-421	MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1rUbWlEPTB;Mz62NFMyOSEQvF2=	NEHEV3JUSU6JRWK=
NCI-H2081	NVzN[VF6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlG0TWM2OD1\|Lk[1Nlg5KM7:TR?=	MYPTRW5ITVJ?
SBC-5	NVXUdZk3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH;SdXRKSzVyPUOuOlc5QDJizszN	MVvTRW5ITVJ?
RL95-2	MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NELaVFJKSzVyPUOuO\|E5PjRizszN	MWfTRW5ITVJ?
SW872	NYi3RnlTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVLJR\|UxRTNwN{[5OVgh\|ryP	M{\4fHNCVkeHUh?=
VM-CUB-1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTNwN{e1NUDPxE1?	NYX6b2N3W0GQR1XS
SUP-T1	NULZSmdHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnK0TWM2OD1\|Lke4N\|Ih\|ryP	NIfEUYxUSU6JRWK=
697	MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVfyO5o1UUN3ME2zMlgyPjV5IN88US=>	M4fiRXNCVkeHUh?=
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TE-441-T	Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYHJR\|UxRTNwOEK5N{DPxE1?	MWPTRW5ITVJ?
A204	Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYTJR\|UxRTNwOUC5OVYh\|ryP	NX6wXWk3W0GQR1XS
HCC2998	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2ja[GlEPTB;Mz65OFg1OyEQvF2=	NIjsUXNUSU6JRWK=
SCC-4	NGHRRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHP6WHBKSzVyPUOuPVU4QDJizszN	MVPTRW5ITVJ?
ACHN	NFLTRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvMU5dNUUN3ME20MlAzOzdizszN	MoTIV2FPT0WU
NB1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHXuOGpKSzVyPUSuNFY3PDRizszN	NFjHb3lUSU6JRWK=
PANC-08-13	NUewOnluT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUfsSotSUUN3ME20MlA4PzNizszN	Moj1V2FPT0WU
A4-Fuk	NIL0T2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mlq2TWM2OD12LkC3PFYyKM7:TR?=	M2nVRXNCVkeHUh?=
NCI-H747	M3XaTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVvFdVZ{UUN3ME20MlA5Pjd2IN88US=>	NHjiN5JUSU6JRWK=
G-361	MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3voSGlEPTB;ND6wPVA3KM7:TR?=	MUDTRW5ITVJ?
NCI-H292	MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWjJR\|UxRTRwMEm0Nlkh\|ryP	MYLTRW5ITVJ?
HGC-27	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnLwTWM2OD12LkC5OVQ6KM7:TR?=	MkC2V2FPT0WU
ATN-1	NWDNboVET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXPiTHA6UUN3ME20MlExPzd5IN88US=>	NVrTPJhFW0GQR1XS
RPMI-2650	M{TBN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUHM[4w2UUN3ME20MlEzQTd3IN88US=>	NIWwVpRUSU6JRWK=
SIMA	NWPBVIl1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DWWWlEPTB;ND6xOFQh\|ryP	MkDwV2FPT0WU
CA46	MonYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYfJR\|UxRTRwMU[xNFQh\|ryP	NX\IfoJvW0GQR1XS
CHL-1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV7JR\|UxRTRwMUi5OlEh\|ryP	NWrvdG5kW0GQR1XS
TE-10	NXPGPYtDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4ftdGlEPTB;ND6yNlg5PyEQvF2=	NWS1RXh{W0GQR1XS
NCI-H1734	NETZPXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3n0WGlEPTB;ND6yOlY6PSEQvF2=	M4fjNnNCVkeHUh?=
DV-90	NWXSV2hoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmLCTWM2OD12LkK5N\|k4KM7:TR?=	MoXFV2FPT0WU
MOLT-16	MkLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XLdGlEPTB;ND6zNVAyPiEQvF2=	NEDoNWxUSU6JRWK=
HuCCT1	NF7Ic\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3zMPWlEPTB;ND6zN\|czOyEQvF2=	NXm4W5V6W0GQR1XS
A3-KAW	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDtTWM2OD12LkO1OVUzKM7:TR?=	MVrTRW5ITVJ?
HOS	M13TWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWrwcHlzUUN3ME20MlM5PTZ5IN88US=>	M1r0NnNCVkeHUh?=
KS-1	M{DMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXvUO4ptUUN3ME20MlQzPDV7IN88US=>	MX7TRW5ITVJ?
SNU-423	NFjBeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3X4UWlEPTB;ND60NlY5PSEQvF2=	M{K5SXNCVkeHUh?=
BC-3	Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHroR\|dKSzVyPUSuOFM1PzdizszN	M3PNRnNCVkeHUh?=
SCC-9	MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrhTWM2OD12LkS0Nlk6KM7:TR?=	NEHVfWdUSU6JRWK=
C8166	NIfkOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnfYTWM2OD12LkS3O\|U{KM7:TR?=	NEjpOJBUSU6JRWK=
NCI-H358	MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYfJR\|UxRTRwNEi1N\|Ih\|ryP	MUfTRW5ITVJ?
GT3TKB	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;OTWM2OD12LkS4PFIzKM7:TR?=	NWrpUlVNW0GQR1XS
NCI-SNU-1	M3ex[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXTTRohNUUN3ME20MlQ6PzBzIN88US=>	MXzTRW5ITVJ?
Ca9-22	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHzTNJZKSzVyPUSuOVU2OTZizszN	M3j4TnNCVkeHUh?=
L-363	M2XxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2ToUWlEPTB;ND61OVk6PiEQvF2=	NF\pSppUSU6JRWK=
Calu-1	MoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn:4TWM2OD12LkW4O\|A4KM7:TR?=	MkPXV2FPT0WU
OE19	NVvLPJVHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTRwNkOxOFUh\|ryP	MoXsV2FPT0WU
COR-L23	M{Dnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3:3[GlEPTB;ND62O\|I5KM7:TR?=	NGjNNI9USU6JRWK=
A431	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\iSFEyUUN3ME20MlY5OjJ6IN88US=>	MmDDV2FPT0WU
MKN1	MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml\GTWM2OD12LkewOlY2KM7:TR?=	MWLTRW5ITVJ?
SH-4	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGnONXhKSzVyPUSuO\|I3OzNizszN	MlvkV2FPT0WU
SNB75	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLWPGFNUUN3ME20Mlc1PjZizszN	MXTTRW5ITVJ?
SW780	MkfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXHvbo4{UUN3ME20Mlc3QDR7IN88US=>	NEHGdIJUSU6JRWK=
GOTO	NEn6NIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTRwN{myPVMh\|ryP	M4X6dHNCVkeHUh?=
U-266	NH\ZcI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmD1TWM2OD12Lkm0PVE6KM7:TR?=	NWjrfoN7W0GQR1XS
KURAMOCHI	MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmXYTWM2OD13LkCyPFM1KM7:TR?=	NGPhfFlUSU6JRWK=
NMC-G1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVPJR\|UxRTVwMEmxN\|kh\|ryP	M{jjdnNCVkeHUh?=
COLO-684	NV7XVndrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX3UW5VXUUN3ME21MlI2OzdzIN88US=>	NIjCfGRUSU6JRWK=
NTERA-S-cl-D1	NXPTboc2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3e3bGlEPTB;NT6yPVIyQCEQvF2=	M4rVTXNCVkeHUh?=
RD	NFzle29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVHWeI1GUUN3ME21MlI6PzdzIN88US=>	M4f1U3NCVkeHUh?=
A2058	MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkO2TWM2OD13LkOwOFM5KM7:TR?=	MVjTRW5ITVJ?
NCI-H2009	Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVf6c\|FqUUN3ME21MlMxPTN6IN88US=>	MX7TRW5ITVJ?
8-MG-BA	M37oR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX;JR\|UxRTVwM{ewO\|ch\|ryP	MV7TRW5ITVJ?
LC4-1	M{P0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYH3elhNUUN3ME21MlM6OzB\|IN88US=>	M4O4VHNCVkeHUh?=
A101D	NIXhdHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{T1VGlEPTB;NT6zPVY5QSEQvF2=	NIPrVIhUSU6JRWK=
ES8	MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\XeIgxUUN3ME21MlQyPDB7IN88US=>	NEHpT2RUSU6JRWK=
SF126	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXXUN\|hCUUN3ME21MlQyPDZ3IN88US=>	NWmze2xiW0GQR1XS
GDM-1	NI\1T3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnWwTWM2OD13LkSxO\|gyKM7:TR?=	NV\Kd2hCW0GQR1XS
TE-6	NF;BPZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYLabmlkUUN3ME21MlQ1PTZ7IN88US=>	NY\SVXZSW0GQR1XS
SR	NETSWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYrJR\|UxRTVwNUO2OFUh\|ryP	MVfTRW5ITVJ?
HOP-62	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYnMb\|VpUUN3ME21MlU3QDh5IN88US=>	MV7TRW5ITVJ?
HCC2157	NIH4eGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFPQOmVKSzVyPUWuOVY5QTZizszN	NILuUIpUSU6JRWK=
TE-15	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3r0XmlEPTB;NT61O\|c4QSEQvF2=	MnPFV2FPT0WU
BFTC-905	NF;XU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWn1SGg3UUN3ME21MlYxPDJzIN88US=>	NIT0NYxUSU6JRWK=
TE-9	NWXCWpFvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2KzV2lEPTB;NT62NVc5QCEQvF2=	MVfTRW5ITVJ?
647-V	M1rDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXnXSHlFUUN3ME21MlYzODR{IN88US=>	MVzTRW5ITVJ?
KG-1	NWr2WnRQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHW3W\|lKSzVyPUWuO\|QxODVizszN	MUfTRW5ITVJ?
KYSE-510	M4TCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoDGTWM2OD13Lke5OVgyKM7:TR?=	NVrkT4JnW0GQR1XS
SK-MES-1	NHHPOppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn;aTWM2OD13Lki1PFkyKM7:TR?=	MlLuV2FPT0WU
OVCAR-3	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYDJR\|UxRTVwOEiyNFYh\|ryP	MkPIV2FPT0WU
LB1047-RCC	NIXHNnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NG\WNo1KSzVyPUWuPVAyPDhizszN	MYXTRW5ITVJ?
HEL	M2rLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NILaZpNKSzVyPU[uNFIyQDhizszN	M4GyTHNCVkeHUh?=
KARPAS-45	NETzNpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlL0TWM2OD14LkCzO\|g4KM7:TR?=	NVK5ZWhwW0GQR1XS
NCI-H1304	NXTPV21MT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFnOeIZKSzVyPU[uNVI1QTdizszN	M1jyZnNCVkeHUh?=
PC-3	MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Moi3TWM2OD14LkGzNFczKM7:TR?=	Mkf1V2FPT0WU
Calu-3	NUP4fY9VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHnUGVHUUN3ME22MlE1Pjh7IN88US=>	MYrTRW5ITVJ?
NCI-H1648	NEPMepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{e5TmlEPTB;Nj6xOVE3KM7:TR?=	MkjoV2FPT0WU
HSC-3	NWTIWm51T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGjV[G9KSzVyPU[uNVc{QTZizszN	MoTrV2FPT0WU
COLO-824	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXnJR\|UxRTZwMke4Olgh\|ryP	NHHHTlZUSU6JRWK=
COLO-680N	NX;GNWQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HHemlEPTB;Nj6zO\|Y{QCEQvF2=	NWnHenhPW0GQR1XS
SK-NEP-1	MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIPjeW5KSzVyPU[uOFA{PiEQvF2=	MnvTV2FPT0WU
SCC-25	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX61TmRzUUN3ME22MlQzPDl\|IN88US=>	MULTRW5ITVJ?
SF295	M1XObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NITDWIJKSzVyPU[uOFQ6QCEQvF2=	MYXTRW5ITVJ?
no-10	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;6TWM2OD14LkS3PFQh\|ryP	NUC1fnNmW0GQR1XS
NCI-H838	NHPqXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFnaSmJKSzVyPU[uOVE4ODNizszN	Mn3HV2FPT0WU
M059J	NWXyZWZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3PQdmlEPTB;Nj61OVYzPSEQvF2=	MnnTV2FPT0WU
Calu-6	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmnWTWM2OD14Lk[1OFM2KM7:TR?=	MlHFV2FPT0WU
TE-12	NGO4fIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTZwN{KzO\|ch\|ryP	NETtZ2dUSU6JRWK=
639-V	NF3IepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYPESIRFUUN3ME22Mlc2OTJ5IN88US=>	NGC3[\|JUSU6JRWK=
ESS-1	NUHObVdbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX3QTXVmUUN3ME22Mlc3ODd{IN88US=>	Mn7SV2FPT0WU
C-4-II	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWjVbml{UUN3ME22Mlg{OTF5IN88US=>	MmPEV2FPT0WU
23132-87	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmPlTWM2OD14LkmwPVAyKM7:TR?=	M2Cw[3NCVkeHUh?=
MEG-01	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX[4ZlJZUUN3ME22Mlk{PTR4IN88US=>	MXTTRW5ITVJ?
GI-1	NFH0d\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEXRUWlKSzVyPU[uPVQ{PDhizszN	Mki1V2FPT0WU
NCI-H2347	MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{HSSWlEPTB;Nj65OFcyPSEQvF2=	MmXHV2FPT0WU
MS-1	M3jlbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX[0SllNUUN3ME22Mlk2OTl{IN88US=>	M4nqT3NCVkeHUh?=
SK-MEL-30	NH7ISm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTZwOU[zNVUh\|ryP	NIWyUYxUSU6JRWK=
YKG-1	M3fl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3zpVWlEPTB;Nz6wNlY4QCEQvF2=	M2D1XHNCVkeHUh?=
HT-3	M1L1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYnnb3VsUUN3ME23MlA{PDlizszN	MU\TRW5ITVJ?
NCI-H2126	NVrCTmtWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEHvbI5KSzVyPUeuNFk4QTFizszN	NILZRVRUSU6JRWK=
GI-ME-N	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUPJR\|UxRTdwMU[5NFYh\|ryP	NWLxS2xKW0GQR1XS
LB771-HNC	NGPIeoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTdwMUiwN\|gh\|ryP	MXrTRW5ITVJ?
LCLC-97TM1	M2r4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVXvTHYzUUN3ME23MlIyOjd\|IN88US=>	NHrlUYRUSU6JRWK=
HO-1-N-1	NI\le2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWfxT49KUUN3ME23MlI1ODJ2IN88US=>	NW\pcHpHW0GQR1XS
HCC1143	NX;wNoJDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4LzN2lEPTB;Nz6zO\|g6QCEQvF2=	Mm\5V2FPT0WU
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IST-SL2	NWnw[m8zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NU\0VIEyUUN3ME23MlUzOjd{IN88US=>	NYnGeJQ3W0GQR1XS
MLMA	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M33JeGlEPTB;Nz61OFY5QSEQvF2=	M3jC[XNCVkeHUh?=
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ONS-76	M13h[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{HlXGlEPTB;Nz62PVQyPiEQvF2=	MXLTRW5ITVJ?
ECC12	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVraeZY1UUN3ME23MlczQTBzIN88US=>	MYLTRW5ITVJ?
HT-1080	NGP6RWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX7nV4MxUUN3ME23Mlc5PTV3IN88US=>	MYDTRW5ITVJ?
SF268	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFfwTlVKSzVyPUeuPFM2PiEQvF2=	MXvTRW5ITVJ?
COLO-800	NHzab49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYq4fodHUUN3ME23MlkxPjh3IN88US=>	NHTwcGxUSU6JRWK=
BB30-HNC	MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXTJR\|UxRTdwOUS1OVMh\|ryP	NETFc5dUSU6JRWK=
CAKI-1	Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWDnS3E3UUN3ME24MlA3PTJzIN88US=>	MoH1V2FPT0WU
GCIY	MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHGTWM2OD16LkKzO\|E{KM7:TR?=	NFLtWJRUSU6JRWK=
MKN28	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUKyT3l6UUN3ME24MlI1PTl6IN88US=>	MlH5V2FPT0WU
IPC-298	Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2ThcGlEPTB;OD6yO\|cxQSEQvF2=	NYrTcoVDW0GQR1XS
NCI-H1650	NHjteJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHjrVGNKSzVyPUiuNlkyQDVizszN	NHPWOGdUSU6JRWK=
KP-N-YS	MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4rvTGlEPTB;OD6yPVMxQCEQvF2=	M1H3cXNCVkeHUh?=
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SK-HEP-1	NYPrNlA1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmnKTWM2OD16LkO1O\|I{KM7:TR?=	MUHTRW5ITVJ?
PANC-03-27	MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MornTWM2OD16LkO2PVIh\|ryP	NFrJZplUSU6JRWK=
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RERF-LC-MS	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2nOSWlEPTB;OD60PFU6PSEQvF2=	M4ThdHNCVkeHUh?=
C-33-A	MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUnJR\|UxRThwNkG1Nlkh\|ryP	MULTRW5ITVJ?
PA-1	NF7QNJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWXOOVVbUUN3ME24MlY3Pjl2IN88US=>	MkO5V2FPT0WU
TE-5	MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NY\RTHNWUUN3ME24MlcxOjl4IN88US=>	NUnzOmJ6W0GQR1XS
MHH-PREB-1	NYHyTpNLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\0TWdKSzVyPUiuO\|MyODdizszN	NHS0UlVUSU6JRWK=
C3A	Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWTvVJFyUUN3ME24Mlc3PTZzIN88US=>	MWfTRW5ITVJ?
SK-OV-3	Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRThwN{m3O\|Ih\|ryP	MYrTRW5ITVJ?
AM-38	M33VUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHSZ3F7UUN3ME24MlgxPDN7IN88US=>	NVm5WWQzW0GQR1XS
LoVo	MlH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHuTWM2OD16Lkm1OVY3KM7:TR?=	Mkm1V2FPT0WU
MKN45	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Moj2TWM2OD16Lkm2NFY{KM7:TR?=	MWHTRW5ITVJ?
NH-12	NEfNfXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml;vTWM2OD17LkCyOVQzKM7:TR?=	M3jTSXNCVkeHUh?=
CAMA-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkTwTWM2OD17LkC2NFEzKM7:TR?=	M2nLT3NCVkeHUh?=
HT-29	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGjPT3BKSzVyPUmuNVI{PzNizszN	NFG0VoVUSU6JRWK=
DMS-273	Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIqwUWdKSzVyPUmuNVI2KM7:TR?=	NHPydo5USU6JRWK=
NCI-H719	M2LCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoKzTWM2OD17LkG4N\|kyKM7:TR?=	M13xenNCVkeHUh?=
SF539	NU\pV2p6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjpTWM2OD17LkKxNFk5KM7:TR?=	MnPuV2FPT0WU
Daoy	NXrUeld{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{XnNWlEPTB;OT6yOFE1OyEQvF2=	M2DHNXNCVkeHUh?=
HCC70	NE[1[4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn[3TWM2OD17LkK3N\|A6KM7:TR?=	MkLnV2FPT0WU
MFH-ino	M4P6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTlwMkmwNFch\|ryP	MYHTRW5ITVJ?
UACC-62	NW\veFJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmHoTWM2OD17LkO3Nlk4KM7:TR?=	MoLFV2FPT0WU
C2BBe1	M3G4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nQcmlEPTB;OT6zPVY2OiEQvF2=	NF[2PGpUSU6JRWK=
KNS-42	Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVXmbYxVUUN3ME25MlQ{PDB5IN88US=>	NGn3WJFUSU6JRWK=
SK-LMS-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVvLVXpuUUN3ME25Mlc2PTN3IN88US=>	MVTTRW5ITVJ?
SK-CO-1	NXPjN3dVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3jxZ2lEPTB;OT63OlI{PSEQvF2=	NXLpbFZ[W0GQR1XS
SN12C	NWPtVYtCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NU[4cGc6UUN3ME25Mlc3QDB4IN88US=>	NHGzc2ZUSU6JRWK=
HTC-C3	NHnYe\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEmxTWRKSzVyPUmuO\|c6QDRizszN	MY\TRW5ITVJ?
OVCAR-4	M3faWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWXJR\|UxRTlwOES4Nlgh\|ryP	M1G3cnNCVkeHUh?=
CHP-126	M4DrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTlwOUOyPUDPxE1?	NXfTSmRwW0GQR1XS
NCI-H716	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTyeY9KSzVyPUmuPVM{OjJizszN	Mk\rV2FPT0WU
U-698-M	MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjac4hKSzVyPUmuPVk4KM7:TR?=	M2PUV3NCVkeHUh?=
EFO-21	M1;zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnPSTWM2OD1zMD6wNFk{KM7:TR?=	NYXBVYtVW0GQR1XS
RXF393	NWnvVXprT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXHReINjUUN3ME2xNE4yOzl{IN88US=>	NHPNfXRUSU6JRWK=
ChaGo-K-1	NH;OUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVHJR\|UxRTFyLkG3O\|Yh\|ryP	MnzaV2FPT0WU
SJRH30	M1\1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlznTWM2OD1zMD6xPFQ1KM7:TR?=	MmqxV2FPT0WU
LU-65	NWi2[WloT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXLJR\|UxRTFyLkK5OFMh\|ryP	NFrCO21USU6JRWK=
OS-RC-2	NVHEVZhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnTiTWM2OD1zMD6zNlI4KM7:TR?=	NGHHVYVUSU6JRWK=
YT	NHjBfmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XXPWlEPTB;MUCuOFAxOSEQvF2=	MWrTRW5ITVJ?
COLO-679	MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEfyV5JKSzVyPUGwMlQzQDVizszN	NY\RfWk{W0GQR1XS
CAS-1	MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX\JR\|UxRTFyLkS2NFgh\|ryP	NXrRVIppW0GQR1XS
NCI-H2052	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTFyLkWxNFUh\|ryP	NXTPNZpCW0GQR1XS
NCI-H2452	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nSZWlEPTB;MUCuOlE5OSEQvF2=	M3\kbXNCVkeHUh?=
SW13	MoSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1X4cGlEPTB;MUCuOlM4PCEQvF2=	MYrTRW5ITVJ?
HuP-T4	M1jM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVuyVphOUUN3ME2xNE44ODZ6IN88US=>	NETlXZRUSU6JRWK=
UMC-11	MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTFyLkmzO\|Mh\|ryP	MnK4V2FPT0WU
EGI-1	NHjxN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFjOemxKSzVyPUGwMlk1PTVizszN	MXLTRW5ITVJ?
JiyoyeP-2003	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NELrZZJKSzVyPUGxMlA5QTJizszN	Ml\QV2FPT0WU
J-RT3-T3-5	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M37ie2lEPTB;MUGuNVIxQSEQvF2=	MlPTV2FPT0WU
DoTc2-4510	M1\t[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTFzLkGzPFkh\|ryP	NYLoU4hLW0GQR1XS
HLE	NHzZfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LZSGlEPTB;MUGuNlEyQSEQvF2=	MmjOV2FPT0WU
SW626	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX3JR\|UxRTFzLkK4PFkh\|ryP	NYSxRot6W0GQR1XS
COR-L105	M1fkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYfv[Zc5UUN3ME2xNU4{OjN5IN88US=>	M4HWd3NCVkeHUh?=
ES6	NVnOVXdQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn\PTWM2OD1zMT61O\|Yh\|ryP	MmeyV2FPT0WU
SNU-449	NEDDNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHrNVmlKSzVyPUGxMlYxPzJizszN	NUXVb4gyW0GQR1XS
GR-ST	NHf1OHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHWzcHBKSzVyPUGxMlYyQDFizszN	MVvTRW5ITVJ?
BL-41	NGDSSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTFzLkexO\|Mh\|ryP	NVLrelBiW0GQR1XS
GB-1	NH\k[lJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYjjS4MyUUN3ME2xNU44PjF7IN88US=>	MWrTRW5ITVJ?
COLO-320-HSR	NGPlUYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWqwcmU6UUN3ME2xNU45PTF7IN88US=>	NYm4fFZbW0GQR1XS
L-540	MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTFzLki5PUDPxE1?	M1nVc3NCVkeHUh?=
NCI-H69	M4LrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTF{LkCxN\|kh\|ryP	NY[2ZYVzW0GQR1XS
769-P	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mk\JTWM2OD1zMj6wNVkh\|ryP	MlrJV2FPT0WU
A172	NGXaTWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIPWZ\|FKSzVyPUGyMlEzODdizszN	MX\TRW5ITVJ?
CAL-27	MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoWwTWM2OD1zMj6xN\|Y6KM7:TR?=	NXzZ[\|ZqW0GQR1XS
NCI-H1437	NXTOSWM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3e4XmlEPTB;MUKuNVQ1PyEQvF2=	MlXiV2FPT0WU
REH	NHG1fW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{X1dmlEPTB;MUKuNVU4OyEQvF2=	MkTHV2FPT0WU
KINGS-1	MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{fNWWlEPTB;MUKuN\|QzOSEQvF2=	MXjTRW5ITVJ?
NCI-H1792	Mln3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfOZW9YUUN3ME2xNk4{QDVzIN88US=>	MWrTRW5ITVJ?
SK-MM-2	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDwTWM2OD1zMj60NFg4KM7:TR?=	M2mzNnNCVkeHUh?=
8505C	MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHztfFJKSzVyPUGyMlYyOiEQvF2=	NIm0VIVUSU6JRWK=
HAL-01	NWm2c\|dsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2H2U2lEPTB;MUKuOlE4PCEQvF2=	MlGzV2FPT0WU
NCI-H2141	NVzqUVlPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF60PIdKSzVyPUGyMlY2QCEQvF2=	MYTTRW5ITVJ?
HCC1806	NV\zVJZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4e2fGlEPTB;MUKuOlk2OiEQvF2=	M{LS[HNCVkeHUh?=
LU-134-A	M3PFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{j1[WlEPTB;MUKuPVMh\|ryP	NEDUN5hUSU6JRWK=
HT	MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV;tZ4dwUUN3ME2xNk46PDN5IN88US=>	NXjmToQ{W0GQR1XS
OE33	MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX\JR\|UxRTF{Lkm0OVYh\|ryP	M1vzWXNCVkeHUh?=
ES4	M3XY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPyUGxKSzVyPUGyMlk1QDdizszN	MoHmV2FPT0WU
SW948	Mn;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1HzeGlEPTB;MUOuNFE{KM7:TR?=	MWHTRW5ITVJ?
LB2241-RCC	M13JdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml[5TWM2OD1zMz6xOFY6KM7:TR?=	NVO4UFVYW0GQR1XS
CCF-STTG1	M4HIc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF23ZnJKSzVyPUGzMlQxOzlizszN	NUHnO21FW0GQR1XS
RPMI-8402	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NY\iNGpFUUN3ME2xN{42ODNzIN88US=>	MULTRW5ITVJ?
DEL	NIHBO\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHjYUIVKSzVyPUGzMlU2ODNizszN	MV7TRW5ITVJ?
NB5	M3fNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFHjV\|FKSzVyPUGzMlU2ODNizszN	NXj5UHRSW0GQR1XS
NUGC-3	NU\0TnJnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF;QTZhKSzVyPUGzMlc1PTNizszN	MXvTRW5ITVJ?
CAL-72	NH7LUIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NITXN\|hKSzVyPUG0MlE6ODZizszN	NV7Zd5FCW0GQR1XS
VMRC-RCZ	Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVnUSWRKUUN3ME2xOE4zOzZizszN	M1qzdHNCVkeHUh?=
YAPC	NY\oUIh[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWTUe4pIUUN3ME2xOE4zPDB5IN88US=>	MYfTRW5ITVJ?
ES5	NXTpVpA5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrBOpNKSzVyPUG0MlI2QTlizszN	NGDxXpZUSU6JRWK=
CAL-12T	M{j6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFHVO4tKSzVyPUG0MlQ{OzZizszN	NWH3TWNpW0GQR1XS
GAMG	NEnx[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MY\JR\|UxRTF2LkW1O\|ch\|ryP	NWixXW9NW0GQR1XS
BT-20	Mke3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1f5fGlEPTB;MUSuPVM5PCEQvF2=	MUHTRW5ITVJ?
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LS-123	M4Pud2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIG2WolKSzVyPUG1MlAyPjVizszN	Mni2V2FPT0WU
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NY	NV7yUXZyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWnXdlg5UUN3ME2yPE43PTd7IN88US=>	MYnTRW5ITVJ?
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EHEB	NYTzZmJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGjyTZZKSzVyPUOzMlA1QTRizszN	M4HZW3NCVkeHUh?=
NCI-H441	NVe5R4hYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTN\|LkKyN\|Uh\|ryP	NIfu[\|hUSU6JRWK=
LOXIMVI	M4LJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYDvNlRUUUN3ME2zN{4{Pjd7IN88US=>	MW\TRW5ITVJ?
MC-IXC	NFy2[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXzYSopqUUN3ME2zN{42PjV3IN88US=>	MlLFV2FPT0WU
NCI-H522	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTN\|Lk[1OEDPxE1?	NXnxSmNYW0GQR1XS
IA-LM	M3i3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M13TcWlEPTB;M{OuOlc1PiEQvF2=	MULTRW5ITVJ?
NCI-H1417	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{G4T2lEPTB;M{OuPVU5PSEQvF2=	MVLTRW5ITVJ?
HCC2218	NV\ndGJzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4TmNGlEPTB;M{WuNlE5PSEQvF2=	M4L0ZXNCVkeHUh?=
HC-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1K5cmlEPTB;M{WuOFAzPCEQvF2=	NIHn[WJUSU6JRWK=
HH	NEPUfYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XZTmlEPTB;M{WuOFE1OSEQvF2=	M4jTNHNCVkeHUh?=
EFE-184	NX\5fohDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3PXO2lEPTB;M{WuOlgzQSEQvF2=	NGPaTHFUSU6JRWK=
NCI-H1355	NES4RVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH\qT\|ZKSzVyPUO1Mlc4OThizszN	M3f2[nNCVkeHUh?=
BV-173	M4TqTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHXwOIJKSzVyPUO1MlgzPjRizszN	MVjTRW5ITVJ?
NEC8	M1z1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTN4LkS5NlQh\|ryP	NE\aSYhUSU6JRWK=
SW1463	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{LjRmlEPTB;M{[uOlU3PiEQvF2=	NHvB[mpUSU6JRWK=
KYSE-140	MoH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTN4LkeyPVgh\|ryP	NVrsTpRRW0GQR1XS
no-11	NFjK[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVrRcJptUUN3ME2zOk45PTN4IN88US=>	NGrmc41USU6JRWK=
HCC1937	NYjafGNkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWfJR\|UxRTN5LkCxOVQh\|ryP	MWTTRW5ITVJ?
LNCaP-Clone-FGC	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2\jRmlEPTB;M{euNVkxOyEQvF2=	NHn1fnRUSU6JRWK=
KARPAS-422	NXm0WHc4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DQUWlEPTB;M{euOFQ{OSEQvF2=	M3H3VnNCVkeHUh?=
RCM-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHLXU2pKSzVyPUO3MlU{PThizszN	M3zjRnNCVkeHUh?=
A375	M2jufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTN5Lke2OFch\|ryP	MkPkV2FPT0WU
TGBC24TKB	M1\nb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX\KNG1JUUN3ME2zPE4xOjN7IN88US=>	M4fydHNCVkeHUh?=
MDA-MB-453	MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\rcJM{UUN3ME2zPU4xOjF6IN88US=>	NWHhTng{W0GQR1XS
Capan-2	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYfJR\|UxRTN7LkC1NFkh\|ryP	MYXTRW5ITVJ?
SW756	NHjlWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1;Be2lEPTB;M{muOVA6OSEQvF2=	Ml65V2FPT0WU
KU-19-19	NHPNWGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXrPZBKSzVyPUO5MlYzQDJizszN	NWX1TIdoW0GQR1XS
NCI-H2170	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIPmfGNKSzVyPUO5Mlk6PzdizszN	MlXTV2FPT0WU
COLO-678	NEe2SYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHKxS2RKSzVyPUSwMlU6PSEQvF2=	NGO1PFFUSU6JRWK=
PF-382	NHXEfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{G1OGlEPTB;NECuO\|Q5PyEQvF2=	NGjRdIVUSU6JRWK=
OAW-42	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVrJR\|UxRTR{LkK5OFIh\|ryP	M3;pU3NCVkeHUh?=
LB996-RCC	Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3vEZWlEPTB;NEKuPFAxQCEQvF2=	MV3TRW5ITVJ?
SAS	NV3scZJZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDJXGZHUUN3ME20N{41Ojh6IN88US=>	NX\mO2hWW0GQR1XS
MRK-nu-1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NILZTYVKSzVyPUS0Mlc1OTRizszN	NV7VVopjW0GQR1XS
EoL-1-cell	NIjGPZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{HDRWlEPTB;NESuPVE{PiEQvF2=	M1TRUHNCVkeHUh?=
NCI-H2342	NH;jWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGL1W4VKSzVyPUS1MlEyOTdizszN	NGX3WHhUSU6JRWK=
NCI-H1703	NGn0SnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXmyW5J5UUN3ME20Ok4xPTl{IN88US=>	MW\TRW5ITVJ?
NCI-H187	MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVPFTldoUUN3ME20Ok4yQDZ7IN88US=>	MVLTRW5ITVJ?
CP66-MEL	MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXWTWM2OD12Nj6yO\|g6KM7:TR?=	MknCV2FPT0WU
HCC1569	NGTRN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnK1TWM2OD12Nj61PVE4KM7:TR?=	NEHydHhUSU6JRWK=
BL-70	M1TQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEXUO3BKSzVyPUS2Mlc4OzdizszN	NXHyenpVW0GQR1XS
Saos-2	M3rVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jDWmlEPTB;NEeuN\|EzOyEQvF2=	Mm\tV2FPT0WU
LC-1F	NFHWXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVL1THVvUUN3ME20O{43OTB3IN88US=>	MV3TRW5ITVJ?
KY821	NU\nZmpQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHoWoxnUUN3ME20O{43PDN2IN88US=>	MYHTRW5ITVJ?
PSN1	M{HKS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2TaTWlEPTB;NEiuNVQxOSEQvF2=	NGrMbmxUSU6JRWK=
RT4	NH3sSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4CzUmlEPTB;NEiuPFM4PyEQvF2=	M2HqfHNCVkeHUh?=
LS-1034	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{D1cWlEPTB;NEiuPFk2PCEQvF2=	M4flPXNCVkeHUh?=
NCI-H1395	NWL0N4hGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXXJR\|UxRTR7LkC0PVIh\|ryP	MojzV2FPT0WU
EKVX	M1PGfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYfmUJhSUUN3ME20PU43PzNzIN88US=>	M2\Cc3NCVkeHUh?=
IST-MES1	MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV7JR\|UxRTR7Lki5OFQh\|ryP	M1\xWHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo

PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. ^[1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. ^[3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. ^[4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. ^[5]

Protocol

Animal Research:^[1]	+ Expand Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts. Formulation: 5% Gelucire Dosages: 50 mg/kg Administration: Oral gavage (Only for Reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	100 mg/mL warmed (197.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download PF-562271 SDF

Molecular Weight	507.49
Formula	C₂₁H₂₀F₃N₇O₃S
CAS No.	717907-75-0
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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C1=C0/X	C1:	LOG(C1):
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C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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FAK Signaling Pathway Map

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Defactinib (VS-6063, PF-04554878) ^New

Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
PF-00562271 Besylate

PF-00562271 Besylate is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
PF-573228

PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.
PF-562271 HCl

PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Ibrutinib (PCI-32765)

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
Dasatinib

Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.
Saracatinib (AZD0530)

Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Phase 2/3.

Features:The 1st Src inhibitor to show inhibition of the Src pathway in human tumor tissue.

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PF-562271

Cited by 14 Publications

6 Customer Reviews

Purity & Quality Control

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Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download PF-562271 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

FAK Signaling Pathway Map

Related FAK Products0

Choose Your Country or Region

By Signaling Pathways

By product type

PF-562271

Cited by 14 Publications

6 Customer Reviews

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download PF-562271 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

FAK Signaling Pathway Map

Related FAK Products0

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)