PF-562271

Catalog No.S2890

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

6 Customer Reviews

Effect of matrix stiffness on the susceptibility of primary HDFs to apoptosis induced by inhibition of mechanotransduction pathways. HDFs (primary human dermal fibroblasts) were cultured on collagen-coated polyacrylamide hydrogels that recapitulated the stiffness of normal (4 kPa) or densely fibrotic (50 kPa) skin for 24 hours and treated with or without the agents indicated for an additional 48 hours. Apoptosis was assessed by annexin V staining. Data are means ± SD from three independent experiments. P value was determined by Student’s t test.

Science, 2017, 9(420), doi: 10.1126/scitranslmed.aal3765. PF-562271 purchased from Selleck.

(F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.
D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

Acta Pharmacol Sin, 2018, doi:10.1038/aps.2017.189. PF-562271 purchased from Selleck.
VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description

Targets

FAK ^[1] (Cell-free assay)	PYK2 ^[1] (Cell-free assay)	CDK2/CyclinE ^[1] (Cell-free assay)	CDK3/CyclinE ^[1] (Cell-free assay)	CDK1/CyclinB ^[1] (Cell-free assay)	View More
1.5 nM	13 nM	30 nM	47 nM	58 nM	View More

In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. ^[1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. ^[2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
MV-4-11	M3T6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTBwMke2OkDPxE1?	MoX0V2FPT0WU
SW982	M3qwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTBwM{K4NkDPxE1?	Mk\aV2FPT0WU
KM12	NY\rbXV5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWP1Z2N1UUN3ME2wMlM5PTV5IN88US=>	MkXEV2FPT0WU
COLO-205	M3H5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHny[GhKSzVyPUCuOFg3PThizszN	MVHTRW5ITVJ?
COLO-829	MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHHsW\|dKSzVyPUCuO\|UyPzZizszN	NXS3SmNbW0GQR1XS
MG-63	NEXkNFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYDJR\|UxRTBwOEC2N\|ch\|ryP	M3ywVHNCVkeHUh?=
IGROV-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVjJR\|UxRTBwOEGwN\|gh\|ryP	NH:3SnlUSU6JRWK=
NCI-H650	MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEDWdGdKSzVyPUCuPFMyPTRizszN	NGXDUG9USU6JRWK=
RT-112	MnHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnTTTWM2OD1yLkm4OFYh\|ryP	NYj1[2M2W0GQR1XS
BCPAP	M2raSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVfJR\|UxRTFwMEGyPFgh\|ryP	M3vzVnNCVkeHUh?=
ALL-PO	MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mk\STWM2OD1zLkCxOVg1KM7:TR?=	MUDTRW5ITVJ?
KYSE-270	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3PSWWlEPTB;MT6wOFcyPCEQvF2=	MmTaV2FPT0WU
8305C	MmK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTFwMEm5NFQh\|ryP	M3\qcnNCVkeHUh?=
NCI-H810	M3G2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXrLeW5QUUN3ME2xMlExPzd4IN88US=>	MVvTRW5ITVJ?
CAL-33	NFnGOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTFwMUK5N\|gh\|ryP	NYjzXYNlW0GQR1XS
AN3-CA	NV3lW4NbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVvFXXpUUUN3ME2xMlIyQDZ5IN88US=>	MVzTRW5ITVJ?
NKM-1	Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWnJR\|UxRTFwMke1NFYh\|ryP	NVLte2tHW0GQR1XS
BPH-1	MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIjsXJRKSzVyPUGuNlg4PjZizszN	MVPTRW5ITVJ?
MES-SA	NELtW\|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTFwM{C2PFIh\|ryP	M1HafnNCVkeHUh?=
CAL-62	M1rwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkfOTWM2OD1zLkOxPVA6KM7:TR?=	NHvjTFNUSU6JRWK=
Detroit562	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4[zcmlEPTB;MT6zOVIzOiEQvF2=	M3XNNXNCVkeHUh?=
KYSE-150	NIXVdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH30T4pKSzVyPUGuN\|UzOzZizszN	NXPkV4t5W0GQR1XS
SK-UT-1	NV3kd4ttT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{nRdWlEPTB;MT60OFY1PyEQvF2=	M2\SenNCVkeHUh?=
HUTU-80	M2rF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoXPTWM2OD1zLkS0PFg3KM7:TR?=	NUGwfYMzW0GQR1XS
SIG-M5	M37IPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIKwNm5KSzVyPUGuOFg{QDdizszN	M3PLZnNCVkeHUh?=
AGS	M{LpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYXJR\|UxRTFwNUKxNlQh\|ryP	M3naVXNCVkeHUh?=
ST486	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHPacWlKSzVyPUGuOVMzPzhizszN	MkHiV2FPT0WU
HSC-2	NInHUWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4r6RWlEPTB;MT61N\|k2KM7:TR?=	M{XaXnNCVkeHUh?=
LCLC-103H	NVT3O4V[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF[3fnpKSzVyPUGuOVU5OThizszN	MVXTRW5ITVJ?
BC-1	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHPJVXFKSzVyPUGuOlE3PjRizszN	M1\vOnNCVkeHUh?=
CGTH-W-1	M2TFN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnHoTWM2OD1zLk[xOlc6KM7:TR?=	NF;U[pJUSU6JRWK=
MZ1-PC	M2G2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3PFe2lEPTB;MT62NlMyOiEQvF2=	MoXCV2FPT0WU
SW1710	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2f0RmlEPTB;MT62NlYzQCEQvF2=	MkjzV2FPT0WU
EW-13	M4HwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUnPcIZ7UUN3ME2xMlY{PDZ4IN88US=>	MlTCV2FPT0WU
TE-11	Mmj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTFwNkO1NlIh\|ryP	NHnQbVJUSU6JRWK=
BHY	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2ntc2lEPTB;MT62OVY3OyEQvF2=	NY\LOGtzW0GQR1XS
ML-2	NVLYVmJQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUPJR\|UxRTFwNk[4NFIh\|ryP	M3HnSnNCVkeHUh?=
MEL-JUSO	NXrMemgzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXqOY9pUUN3ME2xMlczQDlzIN88US=>	NHTFWIFUSU6JRWK=
U251	M2HYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3jvOGlEPTB;MT63OFA{OSEQvF2=	MmPxV2FPT0WU
MHH-ES-1	M2rLfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVrJR\|UxRTFwN{m1Olgh\|ryP	NHv1WVVUSU6JRWK=
CAL-85-1	NUf0VGZbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTFwOEC0PUDPxE1?	MUnTRW5ITVJ?
D-336MG	NFr6WHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF20Z2FKSzVyPUGuPFU3OTRizszN	MXPTRW5ITVJ?
VA-ES-BJ	M1PtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2PZSmlEPTB;MT65NFMyPSEQvF2=	NGq0S29USU6JRWK=
MDA-MB-468	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Moq1TWM2OD1zLkmxNlczKM7:TR?=	MXXTRW5ITVJ?
MEL-HO	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHHaSZdKSzVyPUGuPVc6QTNizszN	M3W4PHNCVkeHUh?=
SW954	M2\SfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX;JR\|UxRTJwMECxOVEh\|ryP	MkftV2FPT0WU
LB831-BLC	MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlfnTWM2OD1{LkCwPVg5KM7:TR?=	MlHJV2FPT0WU
EW-16	NY\sVlU3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHLkNmxKSzVyPUKuNFM6QDNizszN	M332WXNCVkeHUh?=
NCI-H460	NFfxdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmrkTWM2OD1{LkC0PFM6KM7:TR?=	NH3yNWRUSU6JRWK=
CHP-212	NGHR[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn;NTWM2OD1{LkC5OVM6KM7:TR?=	M{mwSHNCVkeHUh?=
MHH-NB-11	M2jwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF63OpdKSzVyPUKuNVI5OThizszN	NF20WnJUSU6JRWK=
DU-4475	NYDj[m1yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1fIXWlEPTB;Mj6xOFc2QSEQvF2=	NUHESIJ5W0GQR1XS
ABC-1	NIS0PGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYHJR\|UxRTJwMkWxPVYh\|ryP	NXvFUXM5W0GQR1XS
LOUCY	M2PKdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXHJR\|UxRTJwMk[xNlgh\|ryP	MljRV2FPT0WU
LC-2-ad	M4PEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mli4TWM2OD1{LkK2PVY3KM7:TR?=	M2L1SHNCVkeHUh?=
ETK-1	NVP3SI5ST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnTWTWM2OD1{LkK4OFYh\|ryP	MWrTRW5ITVJ?
KYSE-180	Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVjJR\|UxRTJwMki4O\|Qh\|ryP	M2r3NHNCVkeHUh?=
HOP-92	MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1LXTWlEPTB;Mj6zNFY4OyEQvF2=	NV\XZ4s2W0GQR1XS
RCC10RGB	NYTidohrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEnIcnpKSzVyPUKuN\|I2ODdizszN	MkfBV2FPT0WU
KASUMI-1	MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUXqVVdYUUN3ME2yMlMzQDhizszN	MnfSV2FPT0WU
ACN	NHixWG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWjJR\|UxRTJwM{S3OFUh\|ryP	M4nIUXNCVkeHUh?=
BxPC-3	NWHSfoFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1PlN2lEPTB;Mj6zOVQ{PiEQvF2=	NWq4[5ZJW0GQR1XS
MONO-MAC-6	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTJwNEGyOFgh\|ryP	MmThV2FPT0WU
CAL-39	NFnOZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGXrPZVKSzVyPUKuOFE3OjhizszN	NVPiepJEW0GQR1XS
CMK	Mnj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVPxe4toUUN3ME2yMlQyPzl3IN88US=>	MoXkV2FPT0WU
MFE-296	M1rFbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWTJR\|UxRTJwNEe3PVIh\|ryP	NGPIXWZUSU6JRWK=
DU-145	M2m1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHlVoJUUUN3ME2yMlQ6OTF6IN88US=>	MlvWV2FPT0WU
MDA-MB-231	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjpfmVKSzVyPUKuOFk2PzJizszN	Mm[yV2FPT0WU
EFO-27	NU\XeZBLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3q5SGlEPTB;Mj61NVg5QCEQvF2=	NUnQd2NWW0GQR1XS
SNU-387	Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTJwNUK4NkDPxE1?	NES1XGpUSU6JRWK=
KYSE-410	NIHM[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWXUV2ZZUUN3ME2yMlU3PTF5IN88US=>	NGWxSmxUSU6JRWK=
NCCIT	M2jRSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIS3WHJKSzVyPUKuOVczPCEQvF2=	MX;TRW5ITVJ?
LXF-289	M4L0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX;MWY81UUN3ME2yMlU5Ojd\|IN88US=>	NF;CXFBUSU6JRWK=
HMV-II	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYP2OWNSUUN3ME2yMlU5QTl5IN88US=>	MkXHV2FPT0WU
MOLT-4	M1vtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTJwNkC3NVIh\|ryP	MmjyV2FPT0WU
KOSC-2	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;SXZVtUUN3ME2yMlY{QDd7IN88US=>	NH7nNJdUSU6JRWK=
TUR	NU\DVIxvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTJwNkWzOlkh\|ryP	MXjTRW5ITVJ?
NCI-H2087	Mk\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1nsb2lEPTB;Mj63NVY1PiEQvF2=	M17O[3NCVkeHUh?=
SCC-15	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVPFdnlrUUN3ME2yMlc2OjV{IN88US=>	MnPUV2FPT0WU
HSC-4	M1fWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTJwN{izPFkh\|ryP	M3HRNXNCVkeHUh?=
G-402	M3zuc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYjNdGh1UUN3ME2yMlgyPDR5IN88US=>	M{m4fHNCVkeHUh?=
GP5d	Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGizOoNKSzVyPUKuPFM5OjdizszN	MYDTRW5ITVJ?
IGR-1	MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3sbZYxUUN3ME2yMlg{QTh5IN88US=>	M4XSVnNCVkeHUh?=
SK-PN-DW	NE\SPZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVvJR\|UxRTJwOE[yNFQh\|ryP	M3[zXnNCVkeHUh?=
OPM-2	NVToWZlGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUTwcVNVUUN3ME2yMlg6QTd6IN88US=>	NH31N41USU6JRWK=
5637	M3j5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHHlSYlKSzVyPUKuPVI1OzlizszN	MUjTRW5ITVJ?
NCI-H2030	Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mnr3TWM2OD1{Lkm4NFI6KM7:TR?=	M1zpWHNCVkeHUh?=
SK-LU-1	NISyNWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXjQb4ZIUUN3ME2yMlk5OzN2IN88US=>	NIWxPYhUSU6JRWK=
EW-18	NHzw[\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIXofGFKSzVyPUOuNFU{OiEQvF2=	MUfTRW5ITVJ?
786-0	NFjVU5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHfiNHFKSzVyPUOuNFU4QDRizszN	Ml3ZV2FPT0WU
NCI-H1963	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\JfW5KSzVyPUOuNFg5OjVizszN	MXvTRW5ITVJ?
A2780	MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml[wTWM2OD1\|LkGwN\|QyKM7:TR?=	MXnTRW5ITVJ?
NCI-H526	MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPGWXVKSzVyPUOuNVM6PjFizszN	MXLTRW5ITVJ?
BHT-101	M3\yVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTNwMUW3PVgh\|ryP	NEi1cVZUSU6JRWK=
RPMI-7951	NGrsT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn7qTWM2OD1\|LkKwNVM4KM7:TR?=	NUCxOZllW0GQR1XS
HL-60	M3i0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4SzZmlEPTB;Mz6yNVE1KM7:TR?=	NH;SWWpUSU6JRWK=
CTV-1	M2j1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIHHNJBKSzVyPUOuNlU{PzdizszN	NVm0VGVvW0GQR1XS
IST-SL1	NV;qcGtST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUDuXG9ZUUN3ME2zMlI6PDZ3IN88US=>	M4rDZXNCVkeHUh?=
G-401	NUjtd3c2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWDzRoVrUUN3ME2zMlI6QDB6IN88US=>	NHvzfGNUSU6JRWK=
OVCAR-5	NUnBR2FuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWnJR\|UxRTNwM{[zOVIh\|ryP	NH7VPGdUSU6JRWK=
EW-1	M1T5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHfqO3lKSzVyPUOuOFA2PDRizszN	MV;TRW5ITVJ?
H4	Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVPJR\|UxRTNwNEe1Olkh\|ryP	MXLTRW5ITVJ?
EM-2	MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHnJNZZKSzVyPUOuOFg3PzRizszN	Mm[zV2FPT0WU
RS4-11	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYOxSI5LUUN3ME2zMlQ5PzF3IN88US=>	NEPCT2ZUSU6JRWK=
NOMO-1	MnHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHXqR4VKSzVyPUOuOFkzODRizszN	NYDXSZpMW0GQR1XS
HCT-116	NUDEU4dMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1LSUGlEPTB;Mz61NFcyOSEQvF2=	MUXTRW5ITVJ?
CAL-120	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVfTW\|lMUUN3ME2zMlU4OzVizszN	NXPzVoFyW0GQR1XS
CAL-51	M1fxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TXWmlEPTB;Mz61O\|YyOiEQvF2=	NYC0e4MzW0GQR1XS
RVH-421	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTNwNkCzNVEh\|ryP	MlnCV2FPT0WU
NCI-H2081	MoP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4ezUWlEPTB;Mz62OVI5QCEQvF2=	NVm3e5pKW0GQR1XS
SBC-5	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUfvXmc5UUN3ME2zMlY4QDh{IN88US=>	M{PKZnNCVkeHUh?=
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SW872	M2Pw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHZUVBKSzVyPUOuO\|Y6PThizszN	NHfBdmZUSU6JRWK=
VM-CUB-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYq3XIQxUUN3ME2zMlc4PTFizszN	NHX6c4pUSU6JRWK=
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697	MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTNwOEG2OVch\|ryP	NF\CS4pUSU6JRWK=
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TE-441-T	MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXnJd\|h3UUN3ME2zMlgzQTNizszN	NFnaU4xUSU6JRWK=
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HCC2998	M{\nW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWnoUVRSUUN3ME2zMlk1QDR\|IN88US=>	MlrnV2FPT0WU
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PANC-08-13	MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV;KS2tNUUN3ME20MlA4PzNizszN	MnL1V2FPT0WU
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NCI-H747	NV3Zb3JjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\afXE3UUN3ME20MlA5Pjd2IN88US=>	MUDTRW5ITVJ?
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NCI-H292	Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M336dmlEPTB;ND6wPVQzQSEQvF2=	NFiw[mJUSU6JRWK=
HGC-27	NGrhXJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF7WNnZKSzVyPUSuNFk2PDlizszN	NUT5b3hzW0GQR1XS
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SIMA	MnjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmT5TWM2OD12LkG0OEDPxE1?	MXzTRW5ITVJ?
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NCI-H1734	Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlnmTWM2OD12LkK2Olk2KM7:TR?=	NEn2dWFUSU6JRWK=
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HOS	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmPTTWM2OD12LkO4OVY4KM7:TR?=	M{ftenNCVkeHUh?=
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NCI-SNU-1	NFTWelFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTRwNEm3NFEh\|ryP	NU\CflI5W0GQR1XS
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Calu-1	Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4n1fGlEPTB;ND61PFcxPyEQvF2=	M4\NNXNCVkeHUh?=
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COR-L23	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{fLSWlEPTB;ND62O\|I5KM7:TR?=	M{C0OnNCVkeHUh?=
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GOTO	M3XM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIntOYNKSzVyPUSuO\|kzQTNizszN	MWDTRW5ITVJ?
U-266	MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{fxcGlEPTB;ND65OFkyQSEQvF2=	NETIV4pUSU6JRWK=
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RD	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LzZ2lEPTB;NT6yPVc4OSEQvF2=	NXrGWWtEW0GQR1XS
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NCI-H2009	M3\6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlPVTWM2OD13LkOwOVM5KM7:TR?=	MUjTRW5ITVJ?
8-MG-BA	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmfwTWM2OD13LkO3NFc4KM7:TR?=	M3rCTnNCVkeHUh?=
LC4-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoW3TWM2OD13LkO5N\|A{KM7:TR?=	M3:2OHNCVkeHUh?=
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SF126	MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2e2R2lEPTB;NT60NVQ3PSEQvF2=	NHnHPGNUSU6JRWK=
GDM-1	Mn;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\TTWM2OD13LkSxO\|gyKM7:TR?=	NED3Sm5USU6JRWK=
TE-6	NInhfHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTVwNES1Olkh\|ryP	NF63fWFUSU6JRWK=
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KYSE-510	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2LORWlEPTB;NT63PVU5OSEQvF2=	MX7TRW5ITVJ?
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OVCAR-3	M37KeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4qwSWlEPTB;NT64PFIxPiEQvF2=	MWnTRW5ITVJ?
LB1047-RCC	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGLocFZKSzVyPUWuPVAyPDhizszN	Mki0V2FPT0WU
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NCI-H1304	NIPxfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYCwT3d7UUN3ME22MlEzPDl5IN88US=>	M3i3RXNCVkeHUh?=
PC-3	NHn3ZWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVq2Z49FUUN3ME22MlE{ODd{IN88US=>	NELGdJZUSU6JRWK=
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HSC-3	NVv4UlhUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HBcGlEPTB;Nj6xO\|M6PiEQvF2=	NFnXVI5USU6JRWK=
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SK-NEP-1	NV\pfnhyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGnPdYdKSzVyPU[uOFA{PiEQvF2=	MWDTRW5ITVJ?
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no-10	NH;2PJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTZwNEe4OEDPxE1?	NGXjdmxUSU6JRWK=
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TE-12	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M17sZmlEPTB;Nj63NlM4PyEQvF2=	MnexV2FPT0WU
639-V	M1vqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTZwN{WxNlch\|ryP	M1LlOHNCVkeHUh?=
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C-4-II	NIO1VYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXnJR\|UxRTZwOEOxNVch\|ryP	NY\iOoZoW0GQR1XS
23132-87	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXX1[WNqUUN3ME22MlkxQTBzIN88US=>	M{CxSnNCVkeHUh?=
MEG-01	NFzGNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUW1UJV{UUN3ME22Mlk{PTR4IN88US=>	NYfOToJMW0GQR1XS
GI-1	NUPCOmdXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2HZO2lEPTB;Nj65OFM1QCEQvF2=	NGLFS4VUSU6JRWK=
NCI-H2347	M{T4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTZwOUS3NVUh\|ryP	MmPFV2FPT0WU
MS-1	NHLmOGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX7Ib2VYUUN3ME22Mlk2OTl{IN88US=>	Mlm3V2FPT0WU
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HT-3	MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXHBW4dXUUN3ME23MlA{PDlizszN	M33TVnNCVkeHUh?=
NCI-H2126	NHjsblZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXnWSplPUUN3ME23MlA6PzlzIN88US=>	M3iwWXNCVkeHUh?=
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LB771-HNC	MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm[yTWM2OD15LkG4NFM5KM7:TR?=	MVTTRW5ITVJ?
LCLC-97TM1	M1LzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3;IfGlEPTB;Nz6yNVI4OyEQvF2=	NEPNVI9USU6JRWK=
HO-1-N-1	MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3vRXmlEPTB;Nz6yOFAzPCEQvF2=	NILVOHZUSU6JRWK=
HCC1143	NVTKO2x{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTdwM{e4PVgh\|ryP	MoXNV2FPT0WU
HuO9	Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGf3bY1KSzVyPUeuOFg4QTRizszN	M3rYSHNCVkeHUh?=
IST-SL2	MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWXJR\|UxRTdwNUKyO\|Ih\|ryP	NHGxeIJUSU6JRWK=
MLMA	NGG3O5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTdwNUS2PFkh\|ryP	MoDnV2FPT0WU
22RV1	NXrTR3BET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1zVS2lEPTB;Nz62O\|k4PSEQvF2=	MmPUV2FPT0WU
ONS-76	M3nYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV7TcYs2UUN3ME23MlY6PDF4IN88US=>	M{fYcnNCVkeHUh?=
ECC12	MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEDRdIpKSzVyPUeuO\|I6ODFizszN	Mlq4V2FPT0WU
HT-1080	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV;JR\|UxRTdwN{i1OVUh\|ryP	NHzpR\|NUSU6JRWK=
SF268	NV\KZlJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkK3TWM2OD15LkizOVYh\|ryP	MYLTRW5ITVJ?
COLO-800	NH7mSIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1j1U2lEPTB;Nz65NFY5PSEQvF2=	MXfTRW5ITVJ?
BB30-HNC	MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF\Ze2JKSzVyPUeuPVQ2PTNizszN	MlTvV2FPT0WU
CAKI-1	NX7ndGdWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4j4PWlEPTB;OD6wOlUzOSEQvF2=	NGr2TlNUSU6JRWK=
GCIY	NVrXTnQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2Pzc2lEPTB;OD6yN\|cyOyEQvF2=	NGnaeZdUSU6JRWK=
MKN28	NVjTSGozT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnvWTWM2OD16LkK0OVk5KM7:TR?=	NYKxcnptW0GQR1XS
IPC-298	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTucHVKSzVyPUiuNlc4ODlizszN	NVXTRWh1W0GQR1XS
NCI-H1650	NEnOSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXm5RlRbUUN3ME24MlI6OTh3IN88US=>	NF61clRUSU6JRWK=
KP-N-YS	NVLiOpBKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUG0eI1KUUN3ME24MlI6OzB6IN88US=>	NVO1WYc4W0GQR1XS
J82	NH\GXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3TpT2lEPTB;OD6zOFEzPCEQvF2=	MYXTRW5ITVJ?
SK-HEP-1	NVHxNZpGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn3aTWM2OD16LkO1O\|I{KM7:TR?=	MnjsV2FPT0WU
PANC-03-27	MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jKNWlEPTB;OD6zOlkzKM7:TR?=	NYXhcmFbW0GQR1XS
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RERF-LC-MS	NHjrbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmH4TWM2OD16LkS4OVk2KM7:TR?=	Mlq4V2FPT0WU
C-33-A	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFXSOWlKSzVyPUiuOlE2OjlizszN	MoL0V2FPT0WU
PA-1	NXHoR29{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnfKTWM2OD16Lk[2Olk1KM7:TR?=	NGjVe4dUSU6JRWK=
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MHH-PREB-1	M{X2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmHnTWM2OD16LkezNVA4KM7:TR?=	MlzDV2FPT0WU
C3A	MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWL2ZXo5UUN3ME24Mlc3PTZzIN88US=>	MUDTRW5ITVJ?
SK-OV-3	M1TGUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPoS4xKSzVyPUiuO\|k4PzJizszN	MVTTRW5ITVJ?
AM-38	NXfmWJF7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXLJR\|UxRThwOEC0N\|kh\|ryP	M172[nNCVkeHUh?=
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MKN45	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXjJR\|UxRThwOU[wOlMh\|ryP	MmjsV2FPT0WU
NH-12	M2Dwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoPjTWM2OD17LkCyOVQzKM7:TR?=	M{THWHNCVkeHUh?=
CAMA-1	M2TNUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV3JR\|UxRTlwME[wNVIh\|ryP	M2PwTXNCVkeHUh?=
HT-29	NFrz[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXPod4FJUUN3ME25MlEzOzd\|IN88US=>	M4TGSXNCVkeHUh?=
DMS-273	MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRTlwMUK1JO69VQ>?	NWrtUZVTW0GQR1XS
NCI-H719	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnVTWM2OD17LkG4N\|kyKM7:TR?=	NHLzWYtUSU6JRWK=
SF539	MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYDGSI86UUN3ME25MlIyODl6IN88US=>	M1y0e3NCVkeHUh?=
Daoy	NXLBNGVMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LZe2lEPTB;OT6yOFE1OyEQvF2=	MULTRW5ITVJ?
HCC70	NXXnXFU6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfYOoVUUUN3ME25MlI4OzB7IN88US=>	M2D3dHNCVkeHUh?=
MFH-ino	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVHJR\|UxRTlwMkmwNFch\|ryP	NV7ucWtHW0GQR1XS
UACC-62	Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF3HdY5KSzVyPUmuN\|czQTdizszN	M2LtbnNCVkeHUh?=
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KNS-42	MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{nNbGlEPTB;OT60N\|QxPyEQvF2=	M{L3dnNCVkeHUh?=
SK-LMS-1	MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnfxTWM2OD17Lke1OVM2KM7:TR?=	NGXofWZUSU6JRWK=
SK-CO-1	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoLtTWM2OD17Lke2NlM2KM7:TR?=	NGTOV3hUSU6JRWK=
SN12C	NX:zbmtFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTlwN{[4NFYh\|ryP	NHHKZ3ZUSU6JRWK=
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OVCAR-4	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEDHVWdKSzVyPUmuPFQ5OjhizszN	MljNV2FPT0WU
CHP-126	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NW[xbZU{UUN3ME25Mlk{OjlizszN	NFjxfItUSU6JRWK=
NCI-H716	Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\aT4VDUUN3ME25Mlk{OzJ{IN88US=>	NFPVXHhUSU6JRWK=
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ChaGo-K-1	NH\5RWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXjYcW9IUUN3ME2xNE4yPzd4IN88US=>	MnHKV2FPT0WU
SJRH30	Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHX5O3pKSzVyPUGwMlE5PDRizszN	NFzQbmtUSU6JRWK=
LU-65	NIfUUXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYjJR\|UxRTFyLkK5OFMh\|ryP	MWXTRW5ITVJ?
OS-RC-2	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MljHTWM2OD1zMD6zNlI4KM7:TR?=	MmfSV2FPT0WU
YT	NUnLSo1mT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfPTWM2OD1zMD60NFAyKM7:TR?=	M{jTbHNCVkeHUh?=
COLO-679	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV7JR\|UxRTFyLkSyPFUh\|ryP	MYXTRW5ITVJ?
CAS-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVTzOGdlUUN3ME2xNE41PjB6IN88US=>	MVrTRW5ITVJ?
NCI-H2052	M1[5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmPMTWM2OD1zMD61NVA2KM7:TR?=	MV3TRW5ITVJ?
NCI-H2452	NWfrR3BJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIn6T4ZKSzVyPUGwMlYyQDFizszN	M{XJOnNCVkeHUh?=
SW13	Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkHFTWM2OD1zMD62N\|c1KM7:TR?=	M3HZVnNCVkeHUh?=
HuP-T4	M1;nfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXjU[ZVWUUN3ME2xNE44ODZ6IN88US=>	MknuV2FPT0WU
UMC-11	M2DSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWPJR\|UxRTFyLkmzO\|Mh\|ryP	MVXTRW5ITVJ?
EGI-1	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFnTfHZKSzVyPUGwMlk1PTVizszN	MWfTRW5ITVJ?
JiyoyeP-2003	NGXaN3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\wd2dKSzVyPUGxMlA5QTJizszN	MojRV2FPT0WU
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DoTc2-4510	MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkXUTWM2OD1zMT6xN\|g6KM7:TR?=	NGXac41USU6JRWK=
HLE	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3W3c2lEPTB;MUGuNlEyQSEQvF2=	NX;tfYw2W0GQR1XS
SW626	M{P6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4TsbGlEPTB;MUGuNlg5QSEQvF2=	NHX3cW5USU6JRWK=
COR-L105	M2LHVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFHGSohKSzVyPUGxMlMzOzdizszN	MYrTRW5ITVJ?
ES6	NFHtSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXfreld{UUN3ME2xNU42PzZizszN	NXTFWYpOW0GQR1XS
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GR-ST	M{\p[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2KyfmlEPTB;MUGuOlE5OSEQvF2=	M3;5WHNCVkeHUh?=
BL-41	MkTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTFzLkexO\|Mh\|ryP	MXXTRW5ITVJ?
GB-1	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWHJR\|UxRTFzLke2NVkh\|ryP	MWTTRW5ITVJ?
COLO-320-HSR	MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1PUSmlEPTB;MUGuPFUyQSEQvF2=	M4jjWnNCVkeHUh?=
L-540	NYfuVnhwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mk\RTWM2OD1zMT64PVkh\|ryP	Mmq0V2FPT0WU
NCI-H69	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXzJR\|UxRTF{LkCxN\|kh\|ryP	NFjBRoFUSU6JRWK=
769-P	M4TWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NES3ZlFKSzVyPUGyMlAyQSEQvF2=	M4DXVHNCVkeHUh?=
A172	Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkKzTWM2OD1zMj6xNlA4KM7:TR?=	M{\CeXNCVkeHUh?=
CAL-27	NEXYZpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGXETHNKSzVyPUGyMlE{PjlizszN	MXTTRW5ITVJ?
NCI-H1437	M1y0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnvBTWM2OD1zMj6xOFQ4KM7:TR?=	MVjTRW5ITVJ?
REH	MoDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkDRTWM2OD1zMj6xOVc{KM7:TR?=	MYTTRW5ITVJ?
KINGS-1	NF\jVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13KZ2lEPTB;MUKuN\|QzOSEQvF2=	MlTjV2FPT0WU
NCI-H1792	NUjlb\|ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWDNOmZPUUN3ME2xNk4{QDVzIN88US=>	NFXYbZpUSU6JRWK=
SK-MM-2	MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{nabmlEPTB;MUKuOFA5PyEQvF2=	MWXTRW5ITVJ?
8505C	MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjj[ItKSzVyPUGyMlYyOiEQvF2=	MlHRV2FPT0WU
HAL-01	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmexTWM2OD1zMj62NVc1KM7:TR?=	NITMV21USU6JRWK=
NCI-H2141	NFe3U2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFLLS3lKSzVyPUGyMlY2QCEQvF2=	M{P3NXNCVkeHUh?=
HCC1806	M2OyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV\JR\|UxRTF{Lk[5OVIh\|ryP	NHr4cpZUSU6JRWK=
LU-134-A	NHnaOWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkC1TWM2OD1zMj65N{DPxE1?	NGXpe4ZUSU6JRWK=
HT	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnvjTWM2OD1zMj65OFM4KM7:TR?=	NVy0fmx6W0GQR1XS
OE33	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWTnZWZRUUN3ME2xNk46PDV4IN88US=>	NWPkPYd6W0GQR1XS
ES4	NYjFOW4zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGHR[mlKSzVyPUGyMlk1QDdizszN	MofCV2FPT0WU
SW948	Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnXlTWM2OD1zMz6wNVMh\|ryP	MVrTRW5ITVJ?
LB2241-RCC	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoLDTWM2OD1zMz6xOFY6KM7:TR?=	NYPEb5U5W0GQR1XS
CCF-STTG1	NUfBfZdVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFuyc4ZKSzVyPUGzMlQxOzlizszN	NF\OVmpUSU6JRWK=
RPMI-8402	NYTQc3hmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTF\|LkWwN\|Eh\|ryP	MUPTRW5ITVJ?
DEL	NED5ZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NG\PcFRKSzVyPUGzMlU2ODNizszN	NYXYfmRwW0GQR1XS
NB5	NUHFZYhMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\FUId5UUN3ME2xN{42PTB\|IN88US=>	NWrmZXBbW0GQR1XS
NUGC-3	NHL5UZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlvWTWM2OD1zMz63OFU{KM7:TR?=	MlLDV2FPT0WU
CAL-72	NIjqPGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXMTWM2OD1zND6xPVA3KM7:TR?=	MlvXV2FPT0WU
VMRC-RCZ	NYXNXGZzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;ITWM2OD1zND6yN\|Yh\|ryP	NVT5OJViW0GQR1XS
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CAL-12T	MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4Pne2lEPTB;MUSuOFM{PiEQvF2=	NGPqe25USU6JRWK=
GAMG	NWexcml5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTF2LkW1O\|ch\|ryP	M3nCbnNCVkeHUh?=
BT-20	MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3rmVmlEPTB;MUSuPVM5PCEQvF2=	NEfJTlRUSU6JRWK=
KALS-1	NEXSU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn\rTWM2OD1zNT6wNVU5KM7:TR?=	MlO3V2FPT0WU
LS-123	NUS2V\|FQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1L0XGlEPTB;MUWuNFE3PSEQvF2=	MXPTRW5ITVJ?
LK-2	M3Tpemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUDhZWJFUUN3ME2xOU4xQDZ{IN88US=>	MV3TRW5ITVJ?
NCI-H1770	NWSyT\|Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\mVYt1UUN3ME2xOU4zQDZ6IN88US=>	Ml;4V2FPT0WU
MIA-PaCa-2	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVPzSZA4UUN3ME2xOU41OTZ\|IN88US=>	MkDRV2FPT0WU
DB	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH\GRmFKSzVyPUG1MlY6PDFizszN	MX7TRW5ITVJ?
Becker	MkjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnENllKSzVyPUG1Mlg6OjZizszN	MVTTRW5ITVJ?
HT-144	NGLSSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXLJR\|UxRTF3Lkm0PVch\|ryP	MmHaV2FPT0WU
NCI-H2405	NYnzTnBbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVjBSW9QUUN3ME2xOk4zOjF6IN88US=>	MYPTRW5ITVJ?
TK10	NELtc\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnoU5FFUUN3ME2xOk4{PzR{IN88US=>	M1u4cXNCVkeHUh?=
THP-1	MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTF4LkS2OlUh\|ryP	NFHGRoRUSU6JRWK=
LB373-MEL-D	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWrJR\|UxRTF4Lk[xN\|gh\|ryP	MUjTRW5ITVJ?
SJSA-1	NGPTdHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn60TWM2OD1zNj65NlE6KM7:TR?=	NXrVV5hqW0GQR1XS
EB2	NHnDWGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXrmWJBWUUN3ME2xO{44PDJ4IN88US=>	MmLQV2FPT0WU
MN-60	Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnyTWM2OD1zNz63PVM3KM7:TR?=	MWjTRW5ITVJ?
A253	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3K1d2lEPTB;MUeuPFI2KM7:TR?=	M3\4d3NCVkeHUh?=
CESS	NVe4fFVJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTF5LkmzNlYh\|ryP	MXPTRW5ITVJ?
EW-11	Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEjrXXNKSzVyPUG3Mlk6PThizszN	NX3LU5kyW0GQR1XS
TE-8	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkDBTWM2OD1zOD6wOlY6KM7:TR?=	MUDTRW5ITVJ?
UACC-257	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoHTTWM2OD1zOD6yNFYzKM7:TR?=	MnW4V2FPT0WU
NCI-H226	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYP6bZBkUUN3ME2xPE45Ojl7IN88US=>	NYTqSmhuW0GQR1XS
NCI-H748	NEjjTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3T0UWlEPTB;MUiuPFU5PSEQvF2=	Mnz0V2FPT0WU
NCI-H1299	NFz1NW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXjJR\|UxRTF6Lki5NVgh\|ryP	NGXLT3VUSU6JRWK=
IST-MEL1	NGnQZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHEdG1KSzVyPUG5MlE4PTRizszN	NITz[YxUSU6JRWK=
HCC1187	M4GwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1XZUmlEPTB;MUmuNVc6PiEQvF2=	MlPoV2FPT0WU
HT-1376	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmC2TWM2OD1zOT6yNFI6KM7:TR?=	M3H1THNCVkeHUh?=
SK-MEL-2	NHHZN4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXrpS491UUN3ME2xPU4zOTV3IN88US=>	M3rKSHNCVkeHUh?=
U031	NWS2eo06T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH7WfXJKSzVyPUG5MlIzOTlizszN	M17TRXNCVkeHUh?=
NCI-H524	MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXzERlRLUUN3ME2xPU42PzJ3IN88US=>	NHftVFFUSU6JRWK=
KU812	NXXqN3BOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIDOT5ZKSzVyPUG5MlU6PDRizszN	MkmxV2FPT0WU
NB10	NYXySJNFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1XofWlEPTB;MUmuOlI3QCEQvF2=	MYfTRW5ITVJ?
NOS-1	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWWzNnkxUUN3ME2yNE4yPTd5IN88US=>	MmX0V2FPT0WU
EW-7	NFvDRYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHvCV49KSzVyPUKwMlE3OjhizszN	NHH5VIlUSU6JRWK=
Raji	NF\RXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\OWpFKSzVyPUKwMlI2PjhizszN	NV;JWHZVW0GQR1XS
LB2518-MEL	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1[3N2lEPTB;MkCuN\|k2OyEQvF2=	MlPlV2FPT0WU
PANC-10-05	NFv4T\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3PUVmlEPTB;MkCuOFYyOyEQvF2=	MmnpV2FPT0WU
MZ2-MEL	MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlnsTWM2OD1{MD61PFE1KM7:TR?=	NXrWdVhlW0GQR1XS
MFE-280	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTJzLkOxPFgh\|ryP	MljUV2FPT0WU
RKO	MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInQXoxKSzVyPUKxMlMzODJizszN	MmfRV2FPT0WU
KMOE-2	M1;tOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXnWPYw{UUN3ME2yNU4{Ojh6IN88US=>	NYfJWYRXW0GQR1XS
K5	M17Lb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrzVoFKSzVyPUKxMlM5QTNizszN	NGTNXZVUSU6JRWK=
NCI-H64	NYrwVVliT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTJzLkS3OVYh\|ryP	M2i5UHNCVkeHUh?=
K-562	NWmyVFVbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NG\RbZFKSzVyPUKxMlQ6PzFizszN	M1rqPHNCVkeHUh?=
HCE-T	NHH1cIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXaPXhKSzVyPUKxMlUxQTRizszN	M17yZXNCVkeHUh?=
COLO-792	NVXGeIJwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUnJR\|UxRTJzLkW4Nlch\|ryP	NX7E[FRuW0GQR1XS
PFSK-1	M1TD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVPJR\|UxRTJzLk[4N\|ch\|ryP	M3TmV3NCVkeHUh?=
DOK	NULQSWJWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGLQ[lFKSzVyPUKxMlc3QDdizszN	M2HFcnNCVkeHUh?=
NCI-H1882	M3fJU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mk[xTWM2OD1{MT64OVk3KM7:TR?=	NXHSV5I{W0GQR1XS
KNS-81-FD	MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3v0[mlEPTB;MkGuPFY{OSEQvF2=	MYDTRW5ITVJ?
OCUB-M	NHmyeZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NITVXplKSzVyPUKxMlk3QDhizszN	NVTzVZM4W0GQR1XS
NCI-H1694	M{DWfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlH5TWM2OD1{MT65PFY{KM7:TR?=	M1\hUXNCVkeHUh?=
LS-513	Ml:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTJ{LkCzOlch\|ryP	MWTTRW5ITVJ?
NCI-H2122	NHTIOGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTJ{LkG2O\|ch\|ryP	M3nz[nNCVkeHUh?=
IMR-5	NGK2dFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXyTWM2OD1{Mj6yPFch\|ryP	NFrHUmhUSU6JRWK=
SNU-C2B	M1;PZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTJ{Lk[3OFYh\|ryP	M2OyXHNCVkeHUh?=
A498	M1K2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MontTWM2OD1{Mj64NVc4KM7:TR?=	NV25cIt{W0GQR1XS
NCI-H727	NH23eGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnfYTWM2OD1{Mj64PFM3KM7:TR?=	Mk\hV2FPT0WU
SW1573	M1rQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUi3THJLUUN3ME2yN{4xPjR4IN88US=>	MnLEV2FPT0WU
RO82-W-1	NGnkN5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXzJR\|UxRTJ\|LkK1NVEh\|ryP	NYHHeI1KW0GQR1XS
SKG-IIIa	NH3HXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUfpcY54UUN3ME2yN{4{PTR4IN88US=>	M2LQOXNCVkeHUh?=
MC-CAR	M4DXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXjJR\|UxRTJ\|LkWxPFMh\|ryP	NHniNHVUSU6JRWK=
NCI-H446	M3nk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1fH[GlEPTB;MkOuOlA6OyEQvF2=	M1LBfnNCVkeHUh?=
PC-14	NVzKVXhpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTJ\|Lk[2NlMh\|ryP	NUfTcINxW0GQR1XS
TGBC1TKB	NFPzPGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFfXc4hKSzVyPUKzMlc1PjFizszN	NID3VWRUSU6JRWK=
EFM-19	NFvP[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NG\BdpZKSzVyPUK0MlE5PDRizszN	MXTTRW5ITVJ?
SK-N-DZ	NWPa[YJDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XYc2lEPTB;MkSuOFk4PyEQvF2=	NWPWfXpJW0GQR1XS
NCI-H661	M{exRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnTjTWM2OD1{ND61NlE4KM7:TR?=	NWDOd3F2W0GQR1XS
SW1990	Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV3JR\|UxRTJ2LkW4PFMh\|ryP	MUTTRW5ITVJ?
SW684	M1rrUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYDmSHNsUUN3ME2yOE44PjJ2IN88US=>	MVrTRW5ITVJ?
Ca-Ski	NVLmO3BQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTJ2LkmyN\|ch\|ryP	MonIV2FPT0WU
TGW	NYrFXFZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrXeHl3UUN3ME2yOU4zOzN5IN88US=>	NWTYTGp5W0GQR1XS
CaR-1	MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2ThcmlEPTB;MkWuN\|U4KM7:TR?=	NXLjfpNwW0GQR1XS
D-247MG	NXzNV45YT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoPqTWM2OD1{NT60O\|Q{KM7:TR?=	MYDTRW5ITVJ?
CCRF-CEM	MoHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWHwbJhDUUN3ME2yOU44PDV7IN88US=>	NGTjSVJUSU6JRWK=
CAPAN-1	NULrc\|VtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTJ3Lke1NFEh\|ryP	M{\WRXNCVkeHUh?=
CP50-MEL-B	NXfldlRXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXPJR\|UxRTJ3Lkm5NFEh\|ryP	NUTYXXY6W0GQR1XS
FADU	Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnfZTWM2OD1{Nj61NVUzKM7:TR?=	NEO5epZUSU6JRWK=
Daudi	MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFe0dVRKSzVyPUK2MlUyPThizszN	MmX4V2FPT0WU
U-87-MG	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLoOpdXUUN3ME2yOk42OzB3IN88US=>	NFTpc\|JUSU6JRWK=
DSH1	M3vxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV7mUnVlUUN3ME2yOk42PDB4IN88US=>	NHzaRXdUSU6JRWK=
KYSE-520	M1vtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXjFeW45UUN3ME2yOk42PTV\|IN88US=>	M2rWdnNCVkeHUh?=
HuH-7	NELHNopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkjRTWM2OD1{Nj65NFg3KM7:TR?=	MnjFV2FPT0WU
U-2-OS	M1zH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4PofGlEPTB;MkeuNFI4OSEQvF2=	MlTKV2FPT0WU
LU-99A	M2W0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYTJSox5UUN3ME2yO{4yPzV2IN88US=>	NFPUO\|FUSU6JRWK=
T98G	MkTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFv0OIpKSzVyPUK3MlE6PzNizszN	Mmq3V2FPT0WU
MZ7-mel	MkL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnfzTWM2OD1{Nz61OVQ5KM7:TR?=	NGPqWZhUSU6JRWK=
SNU-C1	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1;6bGlEPTB;MkeuOlQ6OSEQvF2=	NUnFUZQ{W0GQR1XS
MDA-MB-175-VII	M2HRdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTJ5Lk[5O\|Uh\|ryP	NVrlWmh4W0GQR1XS
HuP-T3	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGPyW\|lKSzVyPUK4MlA1QTVizszN	MWnTRW5ITVJ?
T-24	NW\iclB3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTJ6LkG5NlUh\|ryP	NFj4Z2ZUSU6JRWK=
HDLM-2	NH:3[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUfJR\|UxRTJ6LkK0OVkh\|ryP	MnzYV2FPT0WU
NCI-H1651	NHXNToJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTJ6LkK1PVIh\|ryP	NHTjc3dUSU6JRWK=
SK-N-AS	M4LucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF7DbI9KSzVyPUK4MlMyPzFizszN	MWjTRW5ITVJ?
NY	MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2SyUWlEPTB;MkiuOlU4QSEQvF2=	M3fXWnNCVkeHUh?=
D-283MED	Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm\ITWM2OD1{OD64O\|A5KM7:TR?=	MVXTRW5ITVJ?
KLE	NWi1e4dLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4Sx[WlEPTB;MkiuPVkxPiEQvF2=	MW\TRW5ITVJ?
NCI-H28	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlPDTWM2OD1{OT6wNVIh\|ryP	NH\KW\|dUSU6JRWK=
TE-1	MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml\UTWM2OD1{OT6yNVY4KM7:TR?=	NEnHSIxUSU6JRWK=
SK-MEL-24	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnf6TWM2OD1{OT61OFY3KM7:TR?=	NVTGNIMxW0GQR1XS
CAL-54	M1ziW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPkPHRKSzVyPUK5MlYxPDZizszN	M1ixTXNCVkeHUh?=
A673	NHTVfHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV;BVJFLUUN3ME2yPU44OzJizszN	MVnTRW5ITVJ?
HEC-1	M17JdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWnJR\|UxRTNyLkCwOVMh\|ryP	M3vreXNCVkeHUh?=
LS-411N	Mlj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTNyLkG0O\|Uh\|ryP	MlS1V2FPT0WU
SW962	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGrUbGlKSzVyPUOwMlI1PzdizszN	NGDTeIdUSU6JRWK=
OVCAR-8	NVrMNXVGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUW2PZZWUUN3ME2zNE43Pzl2IN88US=>	NXTsfGVpW0GQR1XS
NCI-H630	M4jOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MknvTWM2OD1\|MD64PVU{KM7:TR?=	MWXTRW5ITVJ?
D-263MG	NFXmWVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHK0XpRKSzVyPUOxMlA1OjRizszN	NUHyb\|J6W0GQR1XS
NCI-H596	MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTuTWM2OD1\|MT6wOlIyKM7:TR?=	MmDoV2FPT0WU
BB49-HNC	NF;CXJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlPoTWM2OD1\|MT6xNVIh\|ryP	MojPV2FPT0WU
KYSE-70	MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPaPYNKSzVyPUOxMlMxODhizszN	M3rMPXNCVkeHUh?=
LAN-6	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{naZWlEPTB;M{GuOFk6OiEQvF2=	M1KzeHNCVkeHUh?=
NCI-H2228	NYXzUnR4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mk\ITWM2OD1\|MT61OlI2KM7:TR?=	NGTKR5FUSU6JRWK=
SW620	NVXtSI4zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWDJR\|UxRTNzLk[yPFMh\|ryP	NIPy[\|lUSU6JRWK=
KM-H2	NULvfVE6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYnJR\|UxRTNzLkezNFYh\|ryP	MVvTRW5ITVJ?
DJM-1	M2\2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYHJR\|UxRTN{LkGzPFYh\|ryP	MXXTRW5ITVJ?
SW48	MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWDPb4k1UUN3ME2zNk4{QDJ3IN88US=>	NGfic21USU6JRWK=
NCI-H1793	NWi3WmFoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX\JR\|UxRTN{Lk[xOlMh\|ryP	MXTTRW5ITVJ?
LU-165	M3PaO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV6zVXA1UUN3ME2zN{4xODhizszN	NYj3NnZEW0GQR1XS
EHEB	NIS1WJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXLUfmY5UUN3ME2zN{4xPDl2IN88US=>	NE\XSXJUSU6JRWK=
NCI-H441	M4XSemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fTXWlEPTB;M{OuNlI{PSEQvF2=	NGrWZW5USU6JRWK=
LOXIMVI	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zkZWlEPTB;M{OuN\|Y4QSEQvF2=	M1fWNXNCVkeHUh?=
MC-IXC	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWXJR\|UxRTN\|LkW2OVUh\|ryP	MXfTRW5ITVJ?
NCI-H522	NFjYUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4TqNWlEPTB;M{OuOlU1KM7:TR?=	MYfTRW5ITVJ?
IA-LM	MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV;6T5B7UUN3ME2zN{43PzR4IN88US=>	MVzTRW5ITVJ?
NCI-H1417	M{L2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NE\XWYlKSzVyPUOzMlk2QDVizszN	MUPTRW5ITVJ?
HCC2218	NVjGZ4hkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWHJR\|UxRTN3LkKxPFUh\|ryP	M3ryd3NCVkeHUh?=
HC-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnnwTWM2OD1\|NT60NFI1KM7:TR?=	NWiwZZp4W0GQR1XS
HH	NGWwZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVjJR\|UxRTN3LkSxOFEh\|ryP	MXrTRW5ITVJ?
EFE-184	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{T3ZmlEPTB;M{WuOlgzQSEQvF2=	MVjTRW5ITVJ?
NCI-H1355	NXzt[3ptT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1vnWmlEPTB;M{WuO\|cyQCEQvF2=	Mmm0V2FPT0WU
BV-173	M3TZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH7DeFFKSzVyPUO1MlgzPjRizszN	NFvONGNUSU6JRWK=
NEC8	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlrxTWM2OD1\|Nj60PVI1KM7:TR?=	M{XjTHNCVkeHUh?=
SW1463	M1fRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{\yXGlEPTB;M{[uOlU3PiEQvF2=	MXjTRW5ITVJ?
KYSE-140	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHjPcXNKSzVyPUO2MlczQThizszN	NU\Td5dZW0GQR1XS
no-11	NGT6[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYHJR\|UxRTN4Lki1N\|Yh\|ryP	NWmxfGdUW0GQR1XS
HCC1937	Mn\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHoZWRmUUN3ME2zO{4xOTV2IN88US=>	NYG4d5NiW0GQR1XS
LNCaP-Clone-FGC	NXjR[nRST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH7x[\|BKSzVyPUO3MlE6ODNizszN	M{H6ZnNCVkeHUh?=
KARPAS-422	NXK4RolHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4HHU2lEPTB;M{euOFQ{OSEQvF2=	MkLVV2FPT0WU
RCM-1	M2j3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn3JTWM2OD1\|Nz61N\|U5KM7:TR?=	Mki3V2FPT0WU
A375	M2rQTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mne1TWM2OD1\|Nz63OlQ4KM7:TR?=	MlHTV2FPT0WU
TGBC24TKB	NGjHSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF\IcWtKSzVyPUO4MlAzOzlizszN	NVraUm9iW0GQR1XS
MDA-MB-453	M3;Fc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFvMTpRKSzVyPUO5MlAzOThizszN	Mnj0V2FPT0WU
Capan-2	NYLYZXpLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2rZZWlEPTB;M{muNFUxQSEQvF2=	M2rybnNCVkeHUh?=
SW756	MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHXTWM2OD1\|OT61NFkyKM7:TR?=	MlP0V2FPT0WU
KU-19-19	NV[4[WVNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnO5TWM2OD1\|OT62NlgzKM7:TR?=	MUnTRW5ITVJ?
NCI-H2170	NIO4XVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTN7Lkm5O\|ch\|ryP	MmjFV2FPT0WU
COLO-678	NVnqVW5ET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\5SXZxUUN3ME20NE42QTVizszN	NIX2eG9USU6JRWK=
PF-382	NUHr[JJNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmL5TWM2OD12MD63OFg4KM7:TR?=	MXrTRW5ITVJ?
OAW-42	M2TrUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYixWW92UUN3ME20Nk4zQTR{IN88US=>	NYPMN5p5W0GQR1XS
LB996-RCC	NXO3XVR[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1r5PWlEPTB;NEKuPFAxQCEQvF2=	M4nRXXNCVkeHUh?=
SAS	NWTM[4p5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV7BZlV[UUN3ME20N{41Ojh6IN88US=>	NV3md\|NoW0GQR1XS
MRK-nu-1	NIXodXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTR2Lke0NVQh\|ryP	NHPMNm5USU6JRWK=
EoL-1-cell	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkPzTWM2OD12ND65NVM3KM7:TR?=	NWj0cWxsW0GQR1XS
NCI-H2342	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4e2bWlEPTB;NEWuNVEyPyEQvF2=	MkfIV2FPT0WU
NCI-H1703	NGD0OHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M17kTWlEPTB;NE[uNFU6OiEQvF2=	MlH1V2FPT0WU
NCI-H187	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NW\HS3BjUUN3ME20Ok4yQDZ7IN88US=>	M2\wR3NCVkeHUh?=
CP66-MEL	MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYLJR\|UxRTR4LkK3PFkh\|ryP	NYLRU5ppW0GQR1XS
HCC1569	Ml76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEHsUmZKSzVyPUS2MlU6OTdizszN	M{fDU3NCVkeHUh?=
BL-70	M2LHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUHkcnVrUUN3ME20Ok44PzN5IN88US=>	M2H0[XNCVkeHUh?=
Saos-2	NF20O45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NITFcpZKSzVyPUS3MlMyOjNizszN	NU\adHdnW0GQR1XS
LC-1F	NHfGcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlrUTWM2OD12Nz62NVA2KM7:TR?=	MUfTRW5ITVJ?
KY821	NYS4bG1[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFrIdHNKSzVyPUS3MlY1OzRizszN	MYfTRW5ITVJ?
PSN1	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEjkO4VKSzVyPUS4MlE1ODFizszN	Mnn4V2FPT0WU
RT4	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYfmOWU1UUN3ME20PE45Ozd5IN88US=>	NYC5TVEyW0GQR1XS
LS-1034	M3LzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVrMT2V[UUN3ME20PE45QTV2IN88US=>	M1fic3NCVkeHUh?=
NCI-H1395	NHyzZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFrhSHdKSzVyPUS5MlA1QTJizszN	NGrsUGRUSU6JRWK=
EKVX	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF7WPFFKSzVyPUS5MlY4OzFizszN	Mn[5V2FPT0WU
IST-MES1	M{HCU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWTJR\|UxRTR7Lki5OFQh\|ryP	MUTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo

PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. ^[1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. ^[3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. ^[4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. ^[5]

Protocol

Animal Research:^[1]	+ Expand Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts. Formulation: 5% Gelucire Dosages: 50 mg/kg Administration: Oral gavage (Only for Reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	100 mg/mL warmed (197.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download PF-562271 SDF

Molecular Weight	507.49
Formula	C₂₁H₂₀F₃N₇O₃S
CAS No.	717907-75-0
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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FAK Signaling Pathway Map

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PF-562271 HCl

PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
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Features:The 1st Src inhibitor to show inhibition of the Src pathway in human tumor tissue.

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PF-562271