PF-562271

Catalog No.S2890

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

Cited by 14 Publications

Nat Cell Biol, 2015, 17(11):1412-21

PubMed: 26436690 ( click the link to review the publication )

Sci Transl Med, 2017, 9(420)

PubMed: 29237758 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(23):5851-5863

PubMed: 27220963 ( click the link to review the publication )

Oncogene, 2015, 34(40):5114-27

PubMed: 25639872 ( click the link to review the publication )

Oral Oncology, 2016, 10.1016/j.oraloncology.2016.05.010

PubMed: ( click the link to review the publication )

Cancer Sci, 2013, 104(12):1618-25

PubMed: 24112719 ( click the link to review the publication )

J Biol Chem, 2015, 290(14):8677-92

PubMed: 25713079 ( click the link to review the publication )

Acta Pharmacol Sin, 2018, 10.1038/aps

PubMed: 29417941 ( click the link to review the publication )

Environ Toxicol Pharmacol, 2015, 39(1):114-24

PubMed: 25481308 ( click the link to review the publication )

Environ Toxicol Pharm, 2014, 39(1):114-124

PubMed: 25481308 ( click the link to review the publication )

PLoS One, 2014, 9(2):e88587

PubMed: 24523919 ( click the link to review the publication )

Int J Clin Exp Pathol, 2013, 6(10):2082-91

PubMed: 24133586 ( click the link to review the publication )
Oncotarget, 2016, 7(30):48093-48106

PubMed: 27344177 ( click the link to review the publication )

Sci Rep, 2016, 6:19261

PubMed: 26763933 ( click the link to review the publication )

6 Customer Reviews

Effect of matrix stiffness on the susceptibility of primary HDFs to apoptosis induced by inhibition of mechanotransduction pathways. HDFs (primary human dermal fibroblasts) were cultured on collagen-coated polyacrylamide hydrogels that recapitulated the stiffness of normal (4 kPa) or densely fibrotic (50 kPa) skin for 24 hours and treated with or without the agents indicated for an additional 48 hours. Apoptosis was assessed by annexin V staining. Data are means ± SD from three independent experiments. P value was determined by Student’s t test.

Science, 2017, 9(420), doi: 10.1126/scitranslmed.aal3765. PF-562271 purchased from Selleck.

(F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.
D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

Acta Pharmacol Sin, 2018, doi:10.1038/aps.2017.189. PF-562271 purchased from Selleck.
VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description

Targets

FAK ^[1] (Cell-free assay)	PYK2 ^[1] (Cell-free assay)	CDK2/CyclinE ^[1] (Cell-free assay)	CDK3/CyclinE ^[1] (Cell-free assay)	CDK1/CyclinB ^[1] (Cell-free assay)	View More
1.5 nM	13 nM	30 nM	47 nM	58 nM	View More

In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. ^[1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. ^[2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
MV-4-11	NIDhfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXXJR\|UxRTBwMke2OkDPxE1?	NVTzT4lxW0GQR1XS
SW982	NYXjemdlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfLTWM2OD1yLkOyPFIh\|ryP	NYG5emVCW0GQR1XS
KM12	NVziTZVXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTBwM{i1OVch\|ryP	M3:0SXNCVkeHUh?=
COLO-205	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nI[2lEPTB;MD60PFY2QCEQvF2=	M{HnOHNCVkeHUh?=
COLO-829	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIPYb29KSzVyPUCuO\|UyPzZizszN	NIOxUoZUSU6JRWK=
MG-63	NWf3eWFZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHvCZlNKSzVyPUCuPFA3OzdizszN	NXrYcZpVW0GQR1XS
IGROV-1	M{LjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NET6Z2tKSzVyPUCuPFExOzhizszN	MnHXV2FPT0WU
NCI-H650	M3XKOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHqwWJNKSzVyPUCuPFMyPTRizszN	M2D2OHNCVkeHUh?=
RT-112	M{HLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGP1c5VKSzVyPUCuPVg1PiEQvF2=	MVTTRW5ITVJ?
BCPAP	Ml24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVi4SHlHUUN3ME2xMlAyOjh6IN88US=>	NEfIZ4RUSU6JRWK=
ALL-PO	M4XXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnnYTWM2OD1zLkCxOVg1KM7:TR?=	NH3BOmFUSU6JRWK=
KYSE-270	NH[5dJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFHaNWtKSzVyPUGuNFQ4OTRizszN	M4TzR3NCVkeHUh?=
8305C	NFLqdXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoO5TWM2OD1zLkC5PVA1KM7:TR?=	NYDrN5BiW0GQR1XS
NCI-H810	NWTHXG5ST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUXTS4ZmUUN3ME2xMlExPzd4IN88US=>	MUTTRW5ITVJ?
CAL-33	NVTxSoFET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHnUcoFKSzVyPUGuNVI6OzhizszN	MnXiV2FPT0WU
AN3-CA	MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTFwMkG4Olch\|ryP	NEjLbFNUSU6JRWK=
NKM-1	M13yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{jucWlEPTB;MT6yO\|UxPiEQvF2=	NETKU4NUSU6JRWK=
BPH-1	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTFwMki3OlYh\|ryP	MV7TRW5ITVJ?
MES-SA	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mni5TWM2OD1zLkOwOlgzKM7:TR?=	MVzTRW5ITVJ?
CAL-62	NFXxN\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M33uPGlEPTB;MT6zNVkxQSEQvF2=	NXXzXnc1W0GQR1XS
Detroit562	NV:1R\|dNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHP4UHFKSzVyPUGuN\|UzOjJizszN	MVPTRW5ITVJ?
KYSE-150	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NW[z[nFFUUN3ME2xMlM2OjN4IN88US=>	NIr3[YFUSU6JRWK=
SK-UT-1	M4TUUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NETtOYRKSzVyPUGuOFQ3PDdizszN	MmnVV2FPT0WU
HUTU-80	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M13pT2lEPTB;MT60OFg5PiEQvF2=	NWThZlY3W0GQR1XS
SIG-M5	Ml2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MU\JR\|UxRTFwNEizPFch\|ryP	MlrjV2FPT0WU
AGS	M2Hqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorWTWM2OD1zLkWyNVI1KM7:TR?=	M4rtZ3NCVkeHUh?=
ST486	MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYDtO3lSUUN3ME2xMlU{Ojd6IN88US=>	MXnTRW5ITVJ?
HSC-2	M37MNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIrOV2FKSzVyPUGuOVM6PSEQvF2=	NWnTenljW0GQR1XS
LCLC-103H	MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUDJR\|UxRTFwNUW4NVgh\|ryP	MmnyV2FPT0WU
BC-1	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTFwNkG2OlQh\|ryP	M1vleXNCVkeHUh?=
CGTH-W-1	M3XSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTFwNkG2O\|kh\|ryP	MX;TRW5ITVJ?
MZ1-PC	NVuxfnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfhTWM2OD1zLk[yN\|EzKM7:TR?=	NFvPelBUSU6JRWK=
SW1710	NYrVZ3FtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTFwNkK2Nlgh\|ryP	NFLmUnZUSU6JRWK=
EW-13	M1[0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTFwNkO0OlYh\|ryP	M3PXNHNCVkeHUh?=
TE-11	NIjjZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXPJR\|UxRTFwNkO1NlIh\|ryP	MonzV2FPT0WU
BHY	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWTIW3ZbUUN3ME2xMlY2PjZ\|IN88US=>	NIHlfINUSU6JRWK=
ML-2	NVnqUGxpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYSxXnhnUUN3ME2xMlY3QDB{IN88US=>	M3LBbHNCVkeHUh?=
MEL-JUSO	MoLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NW\idHQyUUN3ME2xMlczQDlzIN88US=>	NX;XOVduW0GQR1XS
U251	NXj5fHl{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjRTWM2OD1zLke0NFMyKM7:TR?=	NGfrOpBUSU6JRWK=
MHH-ES-1	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4P3UWlEPTB;MT63PVU3QCEQvF2=	M2W5VnNCVkeHUh?=
CAL-85-1	MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYj2bm9VUUN3ME2xMlgxPDlizszN	MYrTRW5ITVJ?
D-336MG	Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3TiOGlEPTB;MT64OVYyPCEQvF2=	M3jjbHNCVkeHUh?=
VA-ES-BJ	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnuxTWM2OD1zLkmwN\|E2KM7:TR?=	NWLBZ2dqW0GQR1XS
MDA-MB-468	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnmwTWM2OD1zLkmxNlczKM7:TR?=	M{D5dXNCVkeHUh?=
MEL-HO	NHjhSYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{TCeGlEPTB;MT65O\|k6OyEQvF2=	NH7mWo5USU6JRWK=
SW954	NIjGemxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV7G[Wo1UUN3ME2yMlAxOTVzIN88US=>	M{[1WHNCVkeHUh?=
LB831-BLC	M1HQNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfkZ4dKSzVyPUKuNFA6QDhizszN	NFvhU\|dUSU6JRWK=
EW-16	Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYfJR\|UxRTJwMEO5PFMh\|ryP	NX:3fWpKW0GQR1XS
NCI-H460	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUTJR\|UxRTJwMES4N\|kh\|ryP	NYj4PIFiW0GQR1XS
CHP-212	NGLoVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUXJR\|UxRTJwMEm1N\|kh\|ryP	NHL0fpZUSU6JRWK=
MHH-NB-11	NED1cm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUXMPWFbUUN3ME2yMlEzQDF6IN88US=>	NWfLfmZiW0GQR1XS
DU-4475	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVrQfmJMUUN3ME2yMlE1PzV7IN88US=>	M{LtUnNCVkeHUh?=
ABC-1	M2X0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoHUTWM2OD1{LkK1NVk3KM7:TR?=	MnTtV2FPT0WU
LOUCY	NF\vNYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2XCS2lEPTB;Mj6yOlEzQCEQvF2=	M2HCeXNCVkeHUh?=
LC-2-ad	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NY\COGJuUUN3ME2yMlI3QTZ4IN88US=>	NYHUOoJwW0GQR1XS
ETK-1	NV;vdoV3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2rrV2lEPTB;Mj6yPFQ3KM7:TR?=	M1TTO3NCVkeHUh?=
KYSE-180	M1q5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoW0TWM2OD1{LkK4PFc1KM7:TR?=	M1LyUXNCVkeHUh?=
HOP-92	NIDOcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWj5fVNvUUN3ME2yMlMxPjd\|IN88US=>	MXjTRW5ITVJ?
RCC10RGB	MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTJwM{K1NFch\|ryP	NYSzWmJPW0GQR1XS
KASUMI-1	NUnQbo9tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnnsTWM2OD1{LkOyPFgh\|ryP	MmGwV2FPT0WU
ACN	NGju[XJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4XZOWlEPTB;Mj6zOFc1PSEQvF2=	NIPT[\|lUSU6JRWK=
BxPC-3	M1f1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH;ENFVKSzVyPUKuN\|U1OzZizszN	MmG0V2FPT0WU
MONO-MAC-6	NI\TOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGn4eWpKSzVyPUKuOFEzPDhizszN	MX\TRW5ITVJ?
CAL-39	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlvwTWM2OD1{LkSxOlI5KM7:TR?=	NWXDfY9lW0GQR1XS
CMK	NVqxco1[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmXWTWM2OD1{LkSxO\|k2KM7:TR?=	MkDmV2FPT0WU
MFE-296	NX7QcmZqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\hOo5KSzVyPUKuOFc4QTJizszN	MX;TRW5ITVJ?
DU-145	M1L5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo\ETWM2OD1{LkS5NVE5KM7:TR?=	NF7hfIhUSU6JRWK=
MDA-MB-231	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn25TWM2OD1{LkS5OVczKM7:TR?=	M1zLWnNCVkeHUh?=
EFO-27	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTJwNUG4PFgh\|ryP	MVXTRW5ITVJ?
SNU-387	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTjWW9KSzVyPUKuOVI5OiEQvF2=	NEHJOo1USU6JRWK=
KYSE-410	NV\CZY1yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MU\JR\|UxRTJwNU[1NVch\|ryP	M1HweXNCVkeHUh?=
NCCIT	NXTiUHZHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPObXJKSzVyPUKuOVczPCEQvF2=	NUjlc2lyW0GQR1XS
LXF-289	NGjw[YdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVTJR\|UxRTJwNUiyO\|Mh\|ryP	NHnBSGFUSU6JRWK=
HMV-II	NX7Yb\|NlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkjyTWM2OD1{LkW4PVk4KM7:TR?=	MYrTRW5ITVJ?
MOLT-4	MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm\ETWM2OD1{Lk[wO\|EzKM7:TR?=	MojwV2FPT0WU
KOSC-2	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXHJR\|UxRTJwNkO4O\|kh\|ryP	MUfTRW5ITVJ?
TUR	NGm0cFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M33CXGlEPTB;Mj62OVM3QSEQvF2=	M2SzeXNCVkeHUh?=
NCI-H2087	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnHGTWM2OD1{LkexOlQ3KM7:TR?=	MkHoV2FPT0WU
SCC-15	NHzFOnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml\0TWM2OD1{Lke1NlUzKM7:TR?=	MYrTRW5ITVJ?
HSC-4	NIjLNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFnnSZBKSzVyPUKuO\|g{QDlizszN	Mm\ZV2FPT0WU
G-402	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV7VbYMzUUN3ME2yMlgyPDR5IN88US=>	MlLQV2FPT0WU
GP5d	MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4\mRmlEPTB;Mj64N\|gzPyEQvF2=	NGDPXIVUSU6JRWK=
IGR-1	Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH3PfmtKSzVyPUKuPFM6QDdizszN	Mni3V2FPT0WU
SK-PN-DW	M1Lmb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkPDTWM2OD1{Lki2NlA1KM7:TR?=	Mn[1V2FPT0WU
OPM-2	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVnJR\|UxRTJwOEm5O\|gh\|ryP	Ml31V2FPT0WU
5637	M{PvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnn4TWM2OD1{LkmyOFM6KM7:TR?=	MkDQV2FPT0WU
NCI-H2030	MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrHTWM2OD1{Lkm4NFI6KM7:TR?=	NGnzXJBUSU6JRWK=
SK-LU-1	MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTJwOUizN\|Qh\|ryP	MVfTRW5ITVJ?
EW-18	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmTWTWM2OD1\|LkC1N\|Ih\|ryP	M1zkTHNCVkeHUh?=
786-0	NF2ybINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXfJR\|UxRTNwMEW3PFQh\|ryP	M37DenNCVkeHUh?=
NCI-H1963	M1jaXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIL5bI1KSzVyPUOuNFg5OjVizszN	MWXTRW5ITVJ?
A2780	NWHabXJJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NU[0ZpR6UUN3ME2zMlExOzRzIN88US=>	M1zPSHNCVkeHUh?=
NCI-H526	MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NETufG5KSzVyPUOuNVM6PjFizszN	NHPoSZVUSU6JRWK=
BHT-101	Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MU\JR\|UxRTNwMUW3PVgh\|ryP	MoS1V2FPT0WU
RPMI-7951	NVPFdIJRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIr3N3VKSzVyPUOuNlAyOzdizszN	NVq2VVdtW0GQR1XS
HL-60	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWjtdGpHUUN3ME2zMlIyOTRizszN	NVjmSHU{W0GQR1XS
CTV-1	MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInyPVZKSzVyPUOuNlU{PzdizszN	M4r2Z3NCVkeHUh?=
IST-SL1	NFXBXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXjMZ\|hWUUN3ME2zMlI6PDZ3IN88US=>	MonUV2FPT0WU
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OVCAR-5	NUDpO2M5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV;4TpNnUUN3ME2zMlM3OzV{IN88US=>	NF7rd2VUSU6JRWK=
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HCT-116	NFrCfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3zCZ2lEPTB;Mz61NFcyOSEQvF2=	NEi1XFdUSU6JRWK=
CAL-120	MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIradZhKSzVyPUOuOVc{PSEQvF2=	NWTTfHN4W0GQR1XS
CAL-51	NEO5TYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV;wNo9qUUN3ME2zMlU4PjF{IN88US=>	Ml\JV2FPT0WU
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NCI-H2081	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX3JR\|UxRTNwNkWyPFgh\|ryP	Mn25V2FPT0WU
SBC-5	MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nBNGlEPTB;Mz62O\|g5OiEQvF2=	MX\TRW5ITVJ?
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NCI-H2009	Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnL5TWM2OD13LkOwOVM5KM7:TR?=	NX23bJpIW0GQR1XS
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NCI-H1304	NHvT[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XuR2lEPTB;Nj6xNlQ6PyEQvF2=	MnrUV2FPT0WU
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no-10	NFTjSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkXnTWM2OD14LkS3PFQh\|ryP	MXnTRW5ITVJ?
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GI-1	MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLRUZhKSzVyPU[uPVQ{PDhizszN	NWHzW2NuW0GQR1XS
NCI-H2347	NF:1XWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MknpTWM2OD14Lkm0O\|E2KM7:TR?=	NIDOVI9USU6JRWK=
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NCI-H2126	M{DyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkfLTWM2OD15LkC5O\|kyKM7:TR?=	MVTTRW5ITVJ?
GI-ME-N	M2\iTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1nST2lEPTB;Nz6xOlkxPiEQvF2=	NF7aXXJUSU6JRWK=
LB771-HNC	NFnsNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTdwMUiwN\|gh\|ryP	MmrNV2FPT0WU
LCLC-97TM1	M2C5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlPVTWM2OD15LkKxNlc{KM7:TR?=	NV3yRnFQW0GQR1XS
HO-1-N-1	MnHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUfTXpluUUN3ME23MlI1ODJ2IN88US=>	M3;FXHNCVkeHUh?=
HCC1143	NGD6ZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVvJR\|UxRTdwM{e4PVgh\|ryP	MYTTRW5ITVJ?
HuO9	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHf5bpdKSzVyPUeuOFg4QTRizszN	NULrd4hnW0GQR1XS
IST-SL2	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGHOT4dKSzVyPUeuOVIzPzJizszN	M33xfHNCVkeHUh?=
MLMA	NYrv[5htT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXzJR\|UxRTdwNUS2PFkh\|ryP	MkTsV2FPT0WU
22RV1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTdwNke5O\|Uh\|ryP	M3:yWXNCVkeHUh?=
ONS-76	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHrB[I9KSzVyPUeuOlk1OTZizszN	NILPco5USU6JRWK=
ECC12	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoPXTWM2OD15LkeyPVAyKM7:TR?=	MnfBV2FPT0WU
HT-1080	M13sbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXnjdmR7UUN3ME23Mlc5PTV3IN88US=>	MVfTRW5ITVJ?
SF268	NWnERpVXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXjzUpFmUUN3ME23Mlg{PTZizszN	MkXzV2FPT0WU
COLO-800	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWHiOpVMUUN3ME23MlkxPjh3IN88US=>	M1qwdHNCVkeHUh?=
BB30-HNC	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnzITWM2OD15Lkm0OVU{KM7:TR?=	NUO1XJg1W0GQR1XS
CAKI-1	MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIq2XHNKSzVyPUiuNFY2OjFizszN	NF;6[HVUSU6JRWK=
GCIY	NH3XWGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF3iNGdKSzVyPUiuNlM4OTNizszN	NFG0R2hUSU6JRWK=
MKN28	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NInSWVRKSzVyPUiuNlQ2QThizszN	M1\5cnNCVkeHUh?=
IPC-298	MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2KzZ2lEPTB;OD6yO\|cxQSEQvF2=	MUDTRW5ITVJ?
NCI-H1650	MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEKyUo1KSzVyPUiuNlkyQDVizszN	MmnYV2FPT0WU
KP-N-YS	NX25RXNjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYPJR\|UxRThwMkmzNFgh\|ryP	NFroeINUSU6JRWK=
J82	NGrL[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Moi0TWM2OD16LkO0NVI1KM7:TR?=	NFSwbZNUSU6JRWK=
SK-HEP-1	M1ruRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkPCTWM2OD16LkO1O\|I{KM7:TR?=	M{Xr[HNCVkeHUh?=
PANC-03-27	M3Xqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3TPfGlEPTB;OD6zOlkzKM7:TR?=	M{P1OHNCVkeHUh?=
KP-4	NULKd4l{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnS0TWM2OD16LkSxPFU{KM7:TR?=	M{THcXNCVkeHUh?=
RERF-LC-MS	MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRThwNEi1PVUh\|ryP	NUD1ToRlW0GQR1XS
C-33-A	M4TZSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWXJR\|UxRThwNkG1Nlkh\|ryP	NFezNIhUSU6JRWK=
PA-1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3XhfGlEPTB;OD62OlY6PCEQvF2=	MVjTRW5ITVJ?
TE-5	MknQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH3z[mJKSzVyPUiuO\|AzQTZizszN	MUXTRW5ITVJ?
MHH-PREB-1	NUC1WWo5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXTJR\|UxRThwN{OxNFch\|ryP	NGXIVoNUSU6JRWK=
C3A	M1PF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2DZ[WlEPTB;OD63OlU3OSEQvF2=	NWi2Tol3W0GQR1XS
SK-OV-3	MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRThwN{m3O\|Ih\|ryP	M2XpeXNCVkeHUh?=
AM-38	NGLtNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2fLV2lEPTB;OD64NFQ{QSEQvF2=	M37Z[3NCVkeHUh?=
LoVo	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVzIToRjUUN3ME24Mlk2PTZ4IN88US=>	M4raV3NCVkeHUh?=
MKN45	M1HiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorzTWM2OD16Lkm2NFY{KM7:TR?=	MmrVV2FPT0WU
NH-12	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\y[FRKSzVyPUmuNFI2PDJizszN	NGXLfHJUSU6JRWK=
CAMA-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHzvd3hKSzVyPUmuNFYxOTJizszN	MXrTRW5ITVJ?
HT-29	NFHacIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEXIfllKSzVyPUmuNVI{PzNizszN	MnjtV2FPT0WU
DMS-273	M{LOR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHMXnNKSzVyPUmuNVI2KM7:TR?=	MWHTRW5ITVJ?
NCI-H719	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{XER2lEPTB;OT6xPFM6OSEQvF2=	NHTmT\|NUSU6JRWK=
SF539	NE\yZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUThWnhwUUN3ME25MlIyODl6IN88US=>	NVzqXYtIW0GQR1XS
Daoy	NW\ybo45T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX\JR\|UxRTlwMkSxOFMh\|ryP	MVPTRW5ITVJ?
HCC70	NUfSZoFkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3PMfGlEPTB;OT6yO\|MxQSEQvF2=	MojLV2FPT0WU
MFH-ino	NWPmb4UyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmLuTWM2OD17LkK5NFA4KM7:TR?=	MVjTRW5ITVJ?
UACC-62	M374Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3;RWmlEPTB;OT6zO\|I6PyEQvF2=	Mnn3V2FPT0WU
C2BBe1	NH;6WYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGPkV3NKSzVyPUmuN\|k3PTJizszN	MWjTRW5ITVJ?
KNS-42	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DhXGlEPTB;OT60N\|QxPyEQvF2=	MVLTRW5ITVJ?
SK-LMS-1	M3\lc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo\VTWM2OD17Lke1OVM2KM7:TR?=	M{fEcXNCVkeHUh?=
SK-CO-1	MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3jtTGlEPTB;OT63OlI{PSEQvF2=	MmXpV2FPT0WU
SN12C	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NULjc4ZFUUN3ME25Mlc3QDB4IN88US=>	MYDTRW5ITVJ?
HTC-C3	MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3f1XmlEPTB;OT63O\|k5PCEQvF2=	NES5dnhUSU6JRWK=
OVCAR-4	NXj2PVdST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH\5UY1KSzVyPUmuPFQ5OjhizszN	M2HhWXNCVkeHUh?=
CHP-126	M{PqSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTlwOUOyPUDPxE1?	MoPQV2FPT0WU
NCI-H716	MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1L3dGlEPTB;OT65N\|MzOiEQvF2=	NHfuNllUSU6JRWK=
U-698-M	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX3EW\|lmUUN3ME25Mlk6PyEQvF2=	NGLYU5lUSU6JRWK=
EFO-21	NEHLOIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTFyLkCwPVMh\|ryP	MkLDV2FPT0WU
RXF393	M3\3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LLXmlEPTB;MUCuNVM6OiEQvF2=	M3;BPHNCVkeHUh?=
ChaGo-K-1	MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkThTWM2OD1zMD6xO\|c3KM7:TR?=	MlH4V2FPT0WU
SJRH30	NVW3XGFXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XTfGlEPTB;MUCuNVg1PCEQvF2=	NYPi[HdFW0GQR1XS
LU-65	M2\sSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUnKXYttUUN3ME2xNE4zQTR\|IN88US=>	NFTMfHZUSU6JRWK=
OS-RC-2	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVL6U4RUUUN3ME2xNE4{OjJ5IN88US=>	NVH4S41bW0GQR1XS
YT	M{fRS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkSyTWM2OD1zMD60NFAyKM7:TR?=	M2XOXHNCVkeHUh?=
COLO-679	NYLVdIhKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH3iSFdKSzVyPUGwMlQzQDVizszN	M{\NWnNCVkeHUh?=
CAS-1	NHPHboRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1vsTmlEPTB;MUCuOFYxQCEQvF2=	M1rJ[HNCVkeHUh?=
NCI-H2052	Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYjwflBZUUN3ME2xNE42OTB3IN88US=>	M3TiN3NCVkeHUh?=
NCI-H2452	MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm\jTWM2OD1zMD62NVgyKM7:TR?=	M3K0cXNCVkeHUh?=
SW13	M1TnZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfqc3lKSzVyPUGwMlY{PzRizszN	NFq2WWNUSU6JRWK=
HuP-T4	NWW2U2dzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEfJd5lKSzVyPUGwMlcxPjhizszN	M4e3[3NCVkeHUh?=
UMC-11	MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NETnboFKSzVyPUGwMlk{PzNizszN	NY[1UII4W0GQR1XS
EGI-1	MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DHTmlEPTB;MUCuPVQ2PSEQvF2=	NWXQ[\|FKW0GQR1XS
JiyoyeP-2003	NHrFbWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2m5T2lEPTB;MUGuNFg6OiEQvF2=	M{nh[XNCVkeHUh?=
J-RT3-T3-5	NVq0bJRYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4jkZ2lEPTB;MUGuNVIxQSEQvF2=	NVzQTWFtW0GQR1XS
DoTc2-4510	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{Ln[GlEPTB;MUGuNVM5QSEQvF2=	MnjLV2FPT0WU
HLE	Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFrjR\|hKSzVyPUGxMlIyOTlizszN	MlnpV2FPT0WU
SW626	MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTFzLkK4PFkh\|ryP	Mm\GV2FPT0WU
COR-L105	NYfmVph[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHHveY1KSzVyPUGxMlMzOzdizszN	NF;HfYtUSU6JRWK=
ES6	MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWexRnRjUUN3ME2xNU42PzZizszN	NGTB[ZpUSU6JRWK=
SNU-449	NXmybZpJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUHKN49CUUN3ME2xNU43ODd{IN88US=>	MVnTRW5ITVJ?
GR-ST	MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3myc2lEPTB;MUGuOlE5OSEQvF2=	NWq3NYliW0GQR1XS
BL-41	MlvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2PxZmlEPTB;MUGuO\|E4OyEQvF2=	MmnWV2FPT0WU
GB-1	NF;pXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXUTndKSzVyPUGxMlc3OTlizszN	NIHDcGJUSU6JRWK=
COLO-320-HSR	NXKyZ\|hCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml3aTWM2OD1zMT64OVE6KM7:TR?=	NULWUXB5W0GQR1XS
L-540	MlvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn7WTWM2OD1zMT64PVkh\|ryP	NXfoTW17W0GQR1XS
NCI-H69	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTYZYdKSzVyPUGyMlAyOzlizszN	M4TTPXNCVkeHUh?=
769-P	Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWnJVW9vUUN3ME2xNk4xOTlizszN	NYn5RlBYW0GQR1XS
A172	M1;wcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3HBXWlEPTB;MUKuNVIxPyEQvF2=	MYfTRW5ITVJ?
CAL-27	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;rfZdwUUN3ME2xNk4yOzZ7IN88US=>	M3\IU3NCVkeHUh?=
NCI-H1437	Mnq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmrQTWM2OD1zMj6xOFQ4KM7:TR?=	NVTkdpJtW0GQR1XS
REH	MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MY\JR\|UxRTF{LkG1O\|Mh\|ryP	NFjxTFNUSU6JRWK=
KINGS-1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEXZfmZKSzVyPUGyMlM1OjFizszN	NGHW[XZUSU6JRWK=
NCI-H1792	M1LZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWOySpY{UUN3ME2xNk4{QDVzIN88US=>	M33ZZXNCVkeHUh?=
SK-MM-2	NEXJNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mk\JTWM2OD1zMj60NFg4KM7:TR?=	NVXMcVhJW0GQR1XS
8505C	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXnSSFFYUUN3ME2xNk43OTJizszN	MX3TRW5ITVJ?
HAL-01	M3[3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX7JR\|UxRTF{Lk[xO\|Qh\|ryP	MnfEV2FPT0WU
NCI-H2141	NI\zZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIPUVppKSzVyPUGyMlY2QCEQvF2=	NGX1NmxUSU6JRWK=
HCC1806	M3HmWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkfxTWM2OD1zMj62PVUzKM7:TR?=	M37pWnNCVkeHUh?=
LU-134-A	NFXqXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnSxTWM2OD1zMj65N{DPxE1?	MULTRW5ITVJ?
HT	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUXsdWJ2UUN3ME2xNk46PDN5IN88US=>	MnPoV2FPT0WU
OE33	NFHQcJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1ewUWlEPTB;MUKuPVQ2PiEQvF2=	M{jicXNCVkeHUh?=
ES4	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTF{Lkm0PFch\|ryP	NHm2eHJUSU6JRWK=
SW948	NWTZcVRFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2LGfmlEPTB;MUOuNFE{KM7:TR?=	NXW0clVzW0GQR1XS
LB2241-RCC	NXy4WpBRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjyTWM2OD1zMz6xOFY6KM7:TR?=	M3LGOXNCVkeHUh?=
CCF-STTG1	NXjLd2VpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIHCfXJKSzVyPUGzMlQxOzlizszN	MkPXV2FPT0WU
RPMI-8402	NEC5b2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX3JR\|UxRTF\|LkWwN\|Eh\|ryP	MWTTRW5ITVJ?
DEL	NYDmdpVFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{mwbWlEPTB;MUOuOVUxOyEQvF2=	NVHS[XlVW0GQR1XS
NB5	NHfFSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2\SVmlEPTB;MUOuOVUxOyEQvF2=	NEfhdpdUSU6JRWK=
NUGC-3	M4DaVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFTUW\|ZKSzVyPUGzMlc1PTNizszN	NV3QXWNsW0GQR1XS
CAL-72	M1PKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYC1RmVHUUN3ME2xOE4yQTB4IN88US=>	MoTXV2FPT0WU
VMRC-RCZ	NFLzN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYXqSVh3UUN3ME2xOE4zOzZizszN	MY\TRW5ITVJ?
YAPC	M2DiSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXSxZ5p7UUN3ME2xOE4zPDB5IN88US=>	M{HYfXNCVkeHUh?=
ES5	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4HINGlEPTB;MUSuNlU6QSEQvF2=	MkDhV2FPT0WU
CAL-12T	M4mxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIG3fnhKSzVyPUG0MlQ{OzZizszN	Mn2zV2FPT0WU
GAMG	M13HZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUTOeoZSUUN3ME2xOE42PTd5IN88US=>	M{P6UXNCVkeHUh?=
BT-20	NEOyOXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHPHSnNKSzVyPUG0Mlk{QDRizszN	NXnRPYwzW0GQR1XS
KALS-1	NWGx[3ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHf5V3dKSzVyPUG1MlAyPThizszN	MULTRW5ITVJ?
LS-123	M1XsWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFz4N2FKSzVyPUG1MlAyPjVizszN	MVHTRW5ITVJ?
LK-2	M2\2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIq5elBKSzVyPUG1MlA5PjJizszN	MWjTRW5ITVJ?
NCI-H1770	M4mzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYLJR\|UxRTF3LkK4Olgh\|ryP	M3LI[HNCVkeHUh?=
MIA-PaCa-2	MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVvJR\|UxRTF3LkSxOlMh\|ryP	NE\sfYVUSU6JRWK=
DB	M{\yWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWDp[HRuUUN3ME2xOU43QTRzIN88US=>	MkGxV2FPT0WU
Becker	M4PpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M132UGlEPTB;MUWuPFkzPiEQvF2=	M3XOWXNCVkeHUh?=
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NCI-H727	MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NW\CSlgxUUN3ME2yNk45QDN4IN88US=>	NUXYOnVIW0GQR1XS
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RO82-W-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTJ\|LkK1NVEh\|ryP	M4jNenNCVkeHUh?=
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NCI-H446	NULOcI8yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1zvV2lEPTB;MkOuOlA6OyEQvF2=	NXjWOHFOW0GQR1XS
PC-14	NF34eGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWTse5kzUUN3ME2yN{43PjJ\|IN88US=>	NGjTPYNUSU6JRWK=
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EFM-19	NFj3dYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3LybmlEPTB;MkSuNVg1PCEQvF2=	M4\yPXNCVkeHUh?=
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CAPAN-1	MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYLBXphLUUN3ME2yOU44PTBzIN88US=>	M4fFN3NCVkeHUh?=
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KYSE-520	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mo[5TWM2OD1{Nj61OVU{KM7:TR?=	M1vrT3NCVkeHUh?=
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HDLM-2	MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mnj1TWM2OD1{OD6yOFU6KM7:TR?=	NGm2NGNUSU6JRWK=
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NCI-H28	MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXvJR\|UxRTJ7LkCxNkDPxE1?	M4DESXNCVkeHUh?=
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LOXIMVI	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{ixdmlEPTB;M{OuN\|Y4QSEQvF2=	MkT0V2FPT0WU
MC-IXC	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGXpOJJKSzVyPUOzMlU3PTVizszN	MWPTRW5ITVJ?
NCI-H522	Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MortTWM2OD1\|Mz62OVQh\|ryP	Mo[zV2FPT0WU
IA-LM	Ml;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmHQTWM2OD1\|Mz62O\|Q3KM7:TR?=	MW\TRW5ITVJ?
NCI-H1417	NXrqdndIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXP4fnk3UUN3ME2zN{46PTh3IN88US=>	MXfTRW5ITVJ?
HCC2218	NFzpUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmrTTWM2OD1\|NT6yNVg2KM7:TR?=	NIfXWFJUSU6JRWK=
HC-1	NHz0R2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTN3LkSwNlQh\|ryP	M2TVO3NCVkeHUh?=
HH	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjWcVVKSzVyPUO1MlQyPDFizszN	NFq0UYVUSU6JRWK=
EFE-184	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWnJR\|UxRTN3Lk[4Nlkh\|ryP	NXrZ[GJQW0GQR1XS
NCI-H1355	NHrw[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYDJR\|UxRTN3Lke3NVgh\|ryP	M4SyfXNCVkeHUh?=
BV-173	NVrtVnpUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkT1TWM2OD1\|NT64NlY1KM7:TR?=	Mmf5V2FPT0WU
NEC8	M1XWfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGr1TpZKSzVyPUO2MlQ6OjRizszN	NIT5Z4NUSU6JRWK=
SW1463	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX3wOVRHUUN3ME2zOk43PTZ4IN88US=>	M{XV[HNCVkeHUh?=
KYSE-140	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NG\3U4ZKSzVyPUO2MlczQThizszN	NFHO[ZBUSU6JRWK=
no-11	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1XzeGlEPTB;M{[uPFU{PiEQvF2=	MYLTRW5ITVJ?
HCC1937	Mk\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUnPfWNZUUN3ME2zO{4xOTV2IN88US=>	NWmydFZlW0GQR1XS
LNCaP-Clone-FGC	M2L6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLNUI5KSzVyPUO3MlE6ODNizszN	MWTTRW5ITVJ?
KARPAS-422	Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\YTWM2OD1\|Nz60OFMyKM7:TR?=	MofSV2FPT0WU
RCM-1	NXTMTlhsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1\JVmlEPTB;M{euOVM2QCEQvF2=	NV;pe2x5W0GQR1XS
A375	NWjReGU3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmLFTWM2OD1\|Nz63OlQ4KM7:TR?=	NID5[m1USU6JRWK=
TGBC24TKB	MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTN6LkCyN\|kh\|ryP	M1u1b3NCVkeHUh?=
MDA-MB-453	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4H4SWlEPTB;M{muNFIyQCEQvF2=	NEXKfYFUSU6JRWK=
Capan-2	M1\HfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFL2PVNKSzVyPUO5MlA2ODlizszN	MW\TRW5ITVJ?
SW756	NWfUN5dWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MonzTWM2OD1\|OT61NFkyKM7:TR?=	MnrmV2FPT0WU
KU-19-19	MoCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXz4R5dGUUN3ME2zPU43Ojh{IN88US=>	MnHXV2FPT0WU
NCI-H2170	NVTGfIhJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlfUTWM2OD1\|OT65PVc4KM7:TR?=	MYLTRW5ITVJ?
COLO-678	NUXJVphqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV;JR\|UxRTRyLkW5OUDPxE1?	Mk\3V2FPT0WU
PF-382	M2qxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXjJR\|UxRTRyLke0PFch\|ryP	M1;TSnNCVkeHUh?=
OAW-42	M3L2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTR{LkK5OFIh\|ryP	MUfTRW5ITVJ?
LB996-RCC	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoXjTWM2OD12Mj64NFA5KM7:TR?=	MWTTRW5ITVJ?
SAS	NIntOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHfyNmdKSzVyPUSzMlQzQDhizszN	M4PZS3NCVkeHUh?=
MRK-nu-1	NYO1cWxGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVLJR\|UxRTR2Lke0NVQh\|ryP	NU[0PYR6W0GQR1XS
EoL-1-cell	M2DBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHP3d3JKSzVyPUS0MlkyOzZizszN	MXLTRW5ITVJ?
NCI-H2342	M1Owb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnToTWM2OD12NT6xNVE4KM7:TR?=	MU\TRW5ITVJ?
NCI-H1703	M1vwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH\6fJFKSzVyPUS2MlA2QTJizszN	NH;TcohUSU6JRWK=
NCI-H187	MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRTR4LkG4Olkh\|ryP	MUXTRW5ITVJ?
CP66-MEL	M1L0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTR4LkK3PFkh\|ryP	NIXCN\|RUSU6JRWK=
HCC1569	NXHTco1LT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3S0WWlEPTB;NE[uOVkyPyEQvF2=	MkmyV2FPT0WU
BL-70	MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXfJR\|UxRTR4Lke3N\|ch\|ryP	NEPjd\|VUSU6JRWK=
Saos-2	NIGxS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH;1clFKSzVyPUS3MlMyOjNizszN	NF\CZYNUSU6JRWK=
LC-1F	NILiR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1;Ub2lEPTB;NEeuOlExPSEQvF2=	NImxUXpUSU6JRWK=
KY821	MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUnDRZVoUUN3ME20O{43PDN2IN88US=>	NGjRNZpUSU6JRWK=
PSN1	NYDkOJl{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofvTWM2OD12OD6xOFAyKM7:TR?=	MV;TRW5ITVJ?
RT4	NGTKS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXPzZnVpUUN3ME20PE45Ozd5IN88US=>	MVXTRW5ITVJ?
LS-1034	NIjwdlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYHGdIRzUUN3ME20PE45QTV2IN88US=>	MUXTRW5ITVJ?
NCI-H1395	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MojtTWM2OD12OT6wOFkzKM7:TR?=	M{DPbHNCVkeHUh?=
EKVX	NF76d4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkTzTWM2OD12OT62O\|MyKM7:TR?=	NYfEdJNkW0GQR1XS
IST-MES1	MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTR7Lki5OFQh\|ryP	M3qxS3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo

PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. ^[1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. ^[3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. ^[4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. ^[5]

Protocol

Animal Research:^[1]	+ Expand Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts. Formulation: 5% Gelucire Dosages: 50 mg/kg Administration: Oral gavage (Only for Reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	100 mg/mL warmed (197.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download PF-562271 SDF

Molecular Weight	507.49
Formula	C₂₁H₂₀F₃N₇O₃S
CAS No.	717907-75-0
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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FAK Signaling Pathway Map

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Defactinib (VS-6063, PF-04554878) ^New

Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
PF-00562271 Besylate

PF-00562271 Besylate is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
PF-573228

PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.
PF-562271 HCl

PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Ibrutinib (PCI-32765)

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
Dasatinib

Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.
Saracatinib (AZD0530)

Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Phase 2/3.

Features:The 1st Src inhibitor to show inhibition of the Src pathway in human tumor tissue.

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PF-562271

Cited by 14 Publications

6 Customer Reviews

Purity & Quality Control

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Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download PF-562271 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

FAK Signaling Pathway Map

Related FAK Products0

Choose Your Country or Region

By Signaling Pathways

By product type

PF-562271

Cited by 14 Publications

6 Customer Reviews

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download PF-562271 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

FAK Signaling Pathway Map

Related FAK Products0

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)