PF-562271

Catalog No.S2890

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

Cited by 33 Publications

Cancer Cell, 2019, 36(2):179-193

PubMed: 31378681 ( click the link to review the publication )

Clin Cancer Res, 2019, 25(14):4552-4566

PubMed: 30979745 ( click the link to review the publication )

J Tissue Eng Regen Med, 2019, 13(4):625-636

PubMed: 30770650 ( click the link to review the publication )

J Pharm Biomed Anal, 2019, 168:163-173

PubMed: 30807921 ( click the link to review the publication )

Mol Med Rep, 2019, 19(6):4753-4760

PubMed: 31059085 ( click the link to review the publication )

J Cell Sci, 2018, 131(10)

PubMed: 29678906 ( click the link to review the publication )

Stem Cells Int, 2018, 2018:2190657

PubMed: 30275837 ( click the link to review the publication )

Acta Pharmacol Sin, 2018, 10.1038/aps

PubMed: 29417941 ( click the link to review the publication )

Oncol Rep, 2018, 40(4):2325-2333

PubMed: 30106432 ( click the link to review the publication )

Sci Transl Med, 2017, 9(420)

PubMed: 29237758 ( click the link to review the publication )

Cell Signal, 2017, 38:1-9

PubMed: 28647573 ( click the link to review the publication )

Oncol Rep, 2017, 38(1):63-70

PubMed: 28560386 ( click the link to review the publication )

Onco Targets Ther, 2017, 10:5817-5826

PubMed: 29263678 ( click the link to review the publication )

Mol Med Rep, 2017, 16(6):8937-8943

PubMed: 28990104 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(23):5851-5863

PubMed: 27220963 ( click the link to review the publication )

Cancer Lett, 2016, 376(1):188-96

PubMed: 26996299 ( click the link to review the publication )

Breast Cancer Res, 2016, 18(1):81

PubMed: 27495308 ( click the link to review the publication )

Oral Oncology, 2016, 10.1016/j.oraloncology.2016.05.010

PubMed: ( click the link to review the publication )

J Biol Chem, 2016, 291(15):8140-9

PubMed: 26865633 ( click the link to review the publication )

Mol Pharmacol, 2016, 89(5):521-40

PubMed: 26895766 ( click the link to review the publication )

Int J Biochem Cell Biol, 2016, 71:62-71

PubMed: 26693891 ( click the link to review the publication )

Oncotarget, 2016, 7(30):48093-48106

PubMed: 27344177 ( click the link to review the publication )

Sci Rep, 2016, 6:19261

PubMed: 26763933 ( click the link to review the publication )

Nat Cell Biol, 2015, 17(11):1412-21

PubMed: 26436690 ( click the link to review the publication )
Oncogene, 2015, 34(40):5114-27

PubMed: 25639872 ( click the link to review the publication )

Cell Physiol Biochem, 2015, 37(2):515-26

PubMed: 26330161 ( click the link to review the publication )

J Biol Chem, 2015, 290(14):8677-92

PubMed: 25713079 ( click the link to review the publication )

Environ Toxicol Pharmacol, 2015, 39(1):114-24

PubMed: 25481308 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2015, 112(20):E2595-601

PubMed: 25941386 ( click the link to review the publication )

Environ Toxicol Pharm, 2014, 39(1):114-124

PubMed: 25481308 ( click the link to review the publication )

PLoS One, 2014, 9(2):e88587

PubMed: 24523919 ( click the link to review the publication )

Cancer Sci, 2013, 104(12):1618-25

PubMed: 24112719 ( click the link to review the publication )

Int J Clin Exp Pathol, 2013, 6(10):2082-91

PubMed: 24133586 ( click the link to review the publication )

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description

Targets

FAK ^[1] (Cell-free assay)	PYK2 ^[1] (Cell-free assay)	CDK2/CyclinE ^[1] (Cell-free assay)	CDK3/CyclinE ^[1] (Cell-free assay)	CDK1/CyclinB ^[1] (Cell-free assay)	View More
1.5 nM	13 nM	30 nM	47 nM	58 nM	View More

In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. ^[1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. ^[2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
MV-4-11	MlrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYOySWduUUN3ME2wMlI4PjZizszN	M2fNPXNCVkeHUh?=
SW982	MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{PHWmlEPTB;MD6zNlgzKM7:TR?=	M{ixdnNCVkeHUh?=
KM12	NFvWWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTBwM{i1OVch\|ryP	M4DvWHNCVkeHUh?=
COLO-205	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnvQTWM2OD1yLkS4OlU5KM7:TR?=	M2G1V3NCVkeHUh?=
COLO-829	NHvMPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2flSmlEPTB;MD63OVE4PiEQvF2=	M1XrZnNCVkeHUh?=
MG-63	M3zEZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVnPOVRyUUN3ME2wMlgxPjN5IN88US=>	M4TNNHNCVkeHUh?=
IGROV-1	NHW5N2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTBwOEGwN\|gh\|ryP	MVTTRW5ITVJ?
NCI-H650	MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1m0[mlEPTB;MD64N\|E2PCEQvF2=	M{LmT3NCVkeHUh?=
RT-112	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmKyTWM2OD1yLkm4OFYh\|ryP	MVjTRW5ITVJ?
BCPAP	M4ewdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1nj[GlEPTB;MT6wNVI5QCEQvF2=	MVXTRW5ITVJ?
ALL-PO	Ml\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnzoTWM2OD1zLkCxOVg1KM7:TR?=	MWDTRW5ITVJ?
KYSE-270	NXqxZ291T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUPJR\|UxRTFwMES3NVQh\|ryP	NI\yR3BUSU6JRWK=
8305C	M1f2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2DZVGlEPTB;MT6wPVkxPCEQvF2=	Mn\nV2FPT0WU
NCI-H810	NYixellLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEDBOnJKSzVyPUGuNVA4PzZizszN	MkjUV2FPT0WU
CAL-33	NXjQeoszT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoHQTWM2OD1zLkGyPVM5KM7:TR?=	MkLpV2FPT0WU
AN3-CA	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUDMVpcxUUN3ME2xMlIyQDZ5IN88US=>	NYGyc\|NZW0GQR1XS
NKM-1	NH3obpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTFwMke1NFYh\|ryP	NFfzS4NUSU6JRWK=
BPH-1	NYnDcZExT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWnJR\|UxRTFwMki3OlYh\|ryP	MX;TRW5ITVJ?
MES-SA	MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlnYTWM2OD1zLkOwOlgzKM7:TR?=	NHWwTpVUSU6JRWK=
CAL-62	M{nGVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fYdWlEPTB;MT6zNVkxQSEQvF2=	M2rodHNCVkeHUh?=
Detroit562	M{DhbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEDYWnRKSzVyPUGuN\|UzOjJizszN	NGLyeIZUSU6JRWK=
KYSE-150	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NY[0VmxWUUN3ME2xMlM2OjN4IN88US=>	MnmwV2FPT0WU
SK-UT-1	MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnTCTWM2OD1zLkS0OlQ4KM7:TR?=	MYDTRW5ITVJ?
HUTU-80	M2XOVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHy3WGFKSzVyPUGuOFQ5QDZizszN	NUPRTGVMW0GQR1XS
SIG-M5	Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MknITWM2OD1zLkS4N\|g4KM7:TR?=	NH\0NY9USU6JRWK=
AGS	NGnDdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEntT3dKSzVyPUGuOVIyOjRizszN	M3G4ZXNCVkeHUh?=
ST486	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3ezUGlEPTB;MT61N\|I4QCEQvF2=	NVi2V2tpW0GQR1XS
HSC-2	MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUHJR\|UxRTFwNUO5OUDPxE1?	MYnTRW5ITVJ?
LCLC-103H	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\ocoxJUUN3ME2xMlU2QDF6IN88US=>	NFzuNG5USU6JRWK=
BC-1	NGLldFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWfYT5h3UUN3ME2xMlYyPjZ2IN88US=>	NGn1c5dUSU6JRWK=
CGTH-W-1	NWjBTWhZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MljNTWM2OD1zLk[xOlc6KM7:TR?=	MojvV2FPT0WU
MZ1-PC	MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHTqbYhKSzVyPUGuOlI{OTJizszN	MoXnV2FPT0WU
SW1710	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYmyUlU3UUN3ME2xMlYzPjJ6IN88US=>	NWqxTlcyW0GQR1XS
EW-13	NUKzRoRkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUfJN41yUUN3ME2xMlY{PDZ4IN88US=>	MoPlV2FPT0WU
TE-11	NHu5U21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXLFPGdRUUN3ME2xMlY{PTJ{IN88US=>	MmCyV2FPT0WU
BHY	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTFwNkW2OlMh\|ryP	M{DLRnNCVkeHUh?=
ML-2	M3H6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXHJR\|UxRTFwNk[4NFIh\|ryP	NEm0W4VUSU6JRWK=
MEL-JUSO	NWLaUoJlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHSU25iUUN3ME2xMlczQDlzIN88US=>	M4TZSXNCVkeHUh?=
U251	NILJU\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYDtSFFqUUN3ME2xMlc1ODNzIN88US=>	M1;xN3NCVkeHUh?=
MHH-ES-1	NXrxbFVQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIG0ZVJKSzVyPUGuO\|k2PjhizszN	Mk\yV2FPT0WU
CAL-85-1	NUDlcIR5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV7JR\|UxRTFwOEC0PUDPxE1?	MWLTRW5ITVJ?
D-336MG	M{\w[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml3sTWM2OD1zLki1OlE1KM7:TR?=	MmjvV2FPT0WU
VA-ES-BJ	NIj6SYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4fvWWlEPTB;MT65NFMyPSEQvF2=	NFqwWopUSU6JRWK=
MDA-MB-468	M{XtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoDWTWM2OD1zLkmxNlczKM7:TR?=	Mn3ZV2FPT0WU
MEL-HO	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGnGcXlKSzVyPUGuPVc6QTNizszN	MoDQV2FPT0WU
SW954	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1PLV2lEPTB;Mj6wNFE2OSEQvF2=	MlTLV2FPT0WU
LB831-BLC	M{nyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mof4TWM2OD1{LkCwPVg5KM7:TR?=	MUPTRW5ITVJ?
EW-16	Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXMXW5KSzVyPUKuNFM6QDNizszN	NXrleHlWW0GQR1XS
NCI-H460	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2nCNGlEPTB;Mj6wOFg{QSEQvF2=	MVzTRW5ITVJ?
CHP-212	NVv0ZlU5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDEd\|lLUUN3ME2yMlA6PTN7IN88US=>	NFjuO25USU6JRWK=
MHH-NB-11	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTJwMUK4NVgh\|ryP	MnL3V2FPT0WU
DU-4475	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zwbGlEPTB;Mj6xOFc2QSEQvF2=	MVvTRW5ITVJ?
ABC-1	NG\IcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFH0ZmdKSzVyPUKuNlUyQTZizszN	MXrTRW5ITVJ?
LOUCY	NFHMSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MljlTWM2OD1{LkK2NVI5KM7:TR?=	NWTEZ\|lVW0GQR1XS
LC-2-ad	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEPENFVKSzVyPUKuNlY6PjZizszN	NEL4fnJUSU6JRWK=
ETK-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NW\EPFd2UUN3ME2yMlI5PDZizszN	M4P5OnNCVkeHUh?=
KYSE-180	MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHP6UmVKSzVyPUKuNlg5PzRizszN	NEH6eGFUSU6JRWK=
HOP-92	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTJwM{C2O\|Mh\|ryP	NW\mRoJVW0GQR1XS
RCC10RGB	MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUXJR\|UxRTJwM{K1NFch\|ryP	M{fW[3NCVkeHUh?=
KASUMI-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWHyZWRtUUN3ME2yMlMzQDhizszN	MWfTRW5ITVJ?
ACN	NHW5ZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH3STpJKSzVyPUKuN\|Q4PDVizszN	NVzhNGUxW0GQR1XS
BxPC-3	NH;0W4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWnQUoNIUUN3ME2yMlM2PDN4IN88US=>	M{\pUXNCVkeHUh?=
MONO-MAC-6	MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXLJR\|UxRTJwNEGyOFgh\|ryP	MVPTRW5ITVJ?
CAL-39	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVfJR\|UxRTJwNEG2Nlgh\|ryP	M4rIOnNCVkeHUh?=
CMK	NF[3SJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{XIbGlEPTB;Mj60NVc6PSEQvF2=	M4PCeHNCVkeHUh?=
MFE-296	MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4q1ZmlEPTB;Mj60O\|c6OiEQvF2=	MnzuV2FPT0WU
DU-145	NF3EOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH3leZdKSzVyPUKuOFkyOThizszN	NUHKTY1QW0GQR1XS
MDA-MB-231	MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlHrTWM2OD1{LkS5OVczKM7:TR?=	Ml\GV2FPT0WU
EFO-27	Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NITSToxKSzVyPUKuOVE5QDhizszN	MUjTRW5ITVJ?
SNU-387	MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV;LUIFzUUN3ME2yMlUzQDJizszN	MV\TRW5ITVJ?
KYSE-410	NGr4R\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{XnUGlEPTB;Mj61OlUyPyEQvF2=	NGL1SGNUSU6JRWK=
NCCIT	NXP1PIxKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV;JR\|UxRTJwNUeyOEDPxE1?	MoG4V2FPT0WU
LXF-289	NXPFS5ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTJwNUiyO\|Mh\|ryP	M3ziUXNCVkeHUh?=
HMV-II	M{HrfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWPJR\|UxRTJwNUi5PVch\|ryP	Mk\iV2FPT0WU
MOLT-4	Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXzkNIM5UUN3ME2yMlYxPzF{IN88US=>	NH7FW2hUSU6JRWK=
KOSC-2	NIH5[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1;FWWlEPTB;Mj62N\|g4QSEQvF2=	M2rYVXNCVkeHUh?=
TUR	NUOyOHpwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWnJR\|UxRTJwNkWzOlkh\|ryP	Mm\YV2FPT0WU
NCI-H2087	M1\CbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3zmbGlEPTB;Mj63NVY1PiEQvF2=	MVXTRW5ITVJ?
SCC-15	M13mVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXLNPWNuUUN3ME2yMlc2OjV{IN88US=>	MkezV2FPT0WU
HSC-4	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWHZeZl7UUN3ME2yMlc5Ozh7IN88US=>	NX;XN4ZvW0GQR1XS
G-402	NILQXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTJwOEG0OFch\|ryP	Mn3hV2FPT0WU
GP5d	MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mkf3TWM2OD1{LkizPFI4KM7:TR?=	M33ybnNCVkeHUh?=
IGR-1	Mk[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGDiWGtKSzVyPUKuPFM6QDdizszN	M3zNbnNCVkeHUh?=
SK-PN-DW	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NG\DXmtKSzVyPUKuPFYzODRizszN	NWTKcplZW0GQR1XS
OPM-2	NFPVfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWfJR\|UxRTJwOEm5O\|gh\|ryP	M1j6PXNCVkeHUh?=
5637	M3TZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWDpNWZlUUN3ME2yMlkzPDN7IN88US=>	MoDFV2FPT0WU
NCI-H2030	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mlv4TWM2OD1{Lkm4NFI6KM7:TR?=	NFOybopUSU6JRWK=
SK-LU-1	M33TOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYrrVGtFUUN3ME2yMlk5OzN2IN88US=>	NVH1dolvW0GQR1XS
EW-18	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkT2TWM2OD1\|LkC1N\|Ih\|ryP	NGnZbW9USU6JRWK=
786-0	NYPuRmx1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\rV5JKSzVyPUOuNFU4QDRizszN	M3\sN3NCVkeHUh?=
NCI-H1963	NYDY[IV{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NU\EdYV6UUN3ME2zMlA5QDJ3IN88US=>	NUHpcmpvW0GQR1XS
A2780	NV;U[3VRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUHJWXJHUUN3ME2zMlExOzRzIN88US=>	NX:xdFB[W0GQR1XS
NCI-H526	M325TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3fUPGlEPTB;Mz6xN\|k3OSEQvF2=	NUHaVm9UW0GQR1XS
BHT-101	Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmTITWM2OD1\|LkG1O\|k5KM7:TR?=	NIrFc\|NUSU6JRWK=
RPMI-7951	M{fkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTNwMkCxN\|ch\|ryP	M1vNdXNCVkeHUh?=
HL-60	M1n2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLPeVdZUUN3ME2zMlIyOTRizszN	MknLV2FPT0WU
CTV-1	NWr0XJplT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnrmTWM2OD1\|LkK1N\|c4KM7:TR?=	M3;ZXHNCVkeHUh?=
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NCI-H747	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mof0TWM2OD12LkC4Olc1KM7:TR?=	MnLOV2FPT0WU
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NCI-H2126	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkGzTWM2OD15LkC5O\|kyKM7:TR?=	MlvWV2FPT0WU
GI-ME-N	NYj5OFlCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEnyN2pKSzVyPUeuNVY6ODZizszN	NHT1O2pUSU6JRWK=
LB771-HNC	M2LZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXjRXldrUUN3ME23MlE5ODN6IN88US=>	M{fmcHNCVkeHUh?=
LCLC-97TM1	NYLLOohGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUHtUnA2UUN3ME23MlIyOjd\|IN88US=>	NGfIeGNUSU6JRWK=
HO-1-N-1	M1;jOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{jmS2lEPTB;Nz6yOFAzPCEQvF2=	MoTRV2FPT0WU
HCC1143	M{jMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mki0TWM2OD15LkO3PFk5KM7:TR?=	NYfLVIdsW0GQR1XS
HuO9	M4jIc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TrNmlEPTB;Nz60PFc6PCEQvF2=	Mo\lV2FPT0WU
IST-SL2	NInSPZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF\LfZRKSzVyPUeuOVIzPzJizszN	MX7TRW5ITVJ?
MLMA	NVPRUJYzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TINmlEPTB;Nz61OFY5QSEQvF2=	M2i1N3NCVkeHUh?=
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ONS-76	NUO1UVhoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2i5VWlEPTB;Nz62PVQyPiEQvF2=	MWnTRW5ITVJ?
ECC12	NFG3fJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGnzPVZKSzVyPUeuO\|I6ODFizszN	M2CxTHNCVkeHUh?=
HT-1080	M36zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTdwN{i1OVUh\|ryP	MmrOV2FPT0WU
SF268	MnPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTdwOEO1OkDPxE1?	NYPo[plPW0GQR1XS
COLO-800	M1m1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NY[ySnUzUUN3ME23MlkxPjh3IN88US=>	MnHsV2FPT0WU
BB30-HNC	NFLsW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYrJR\|UxRTdwOUS1OVMh\|ryP	NWXM[5FKW0GQR1XS
CAKI-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUewTmtuUUN3ME24MlA3PTJzIN88US=>	NXizNHVZW0GQR1XS
GCIY	NX\oOXM1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DiSGlEPTB;OD6yN\|cyOyEQvF2=	MkKyV2FPT0WU
MKN28	M1TaO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nTRWlEPTB;OD6yOFU6QCEQvF2=	NXO5SYx3W0GQR1XS
IPC-298	MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjZeFlKSzVyPUiuNlc4ODlizszN	MmTGV2FPT0WU
NCI-H1650	NHnib5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlG1TWM2OD16LkK5NVg2KM7:TR?=	MWPTRW5ITVJ?
KP-N-YS	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEf5SGRKSzVyPUiuNlk{ODhizszN	M{KzdnNCVkeHUh?=
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SK-HEP-1	M{TsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{n0XWlEPTB;OD6zOVczOyEQvF2=	NXjmcolOW0GQR1XS
PANC-03-27	MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWPNOVBUUUN3ME24MlM3QTJizszN	MXPTRW5ITVJ?
KP-4	MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NILuS\|dKSzVyPUiuOFE5PTNizszN	NYHtXYNXW0GQR1XS
RERF-LC-MS	NILlUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2HOemlEPTB;OD60PFU6PSEQvF2=	NHfNNVZUSU6JRWK=
C-33-A	NHjiW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWLJR\|UxRThwNkG1Nlkh\|ryP	NETjeFlUSU6JRWK=
PA-1	NFK5bG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfPcXJCUUN3ME24MlY3Pjl2IN88US=>	MUDTRW5ITVJ?
TE-5	NEHhZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1nr[mlEPTB;OD63NFI6PiEQvF2=	M4WwOHNCVkeHUh?=
MHH-PREB-1	MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRThwN{OxNFch\|ryP	NX30fJpCW0GQR1XS
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SK-OV-3	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlT4TWM2OD16Lke5O\|czKM7:TR?=	Ml;RV2FPT0WU
AM-38	NUjYU243T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGDhW5FKSzVyPUiuPFA1OzlizszN	MXfTRW5ITVJ?
LoVo	NHX2bXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYHJR\|UxRThwOUW1OlYh\|ryP	NX;6N2xIW0GQR1XS
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NH-12	M1PQemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkDhTWM2OD17LkCyOVQzKM7:TR?=	MnjkV2FPT0WU
CAMA-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnv3TWM2OD17LkC2NFEzKM7:TR?=	MYfTRW5ITVJ?
HT-29	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTlwMUKzO\|Mh\|ryP	NVr6cHN5W0GQR1XS
DMS-273	NX;OUoppT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXnEO4hLUUN3ME25MlEzPSEQvF2=	NUDPZ2hUW0GQR1XS
NCI-H719	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkSzTWM2OD17LkG4N\|kyKM7:TR?=	NY\ZVGMyW0GQR1XS
SF539	NIjRSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvvbYpKSzVyPUmuNlExQThizszN	NITmWXNUSU6JRWK=
Daoy	NEe2OlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml;1TWM2OD17LkK0NVQ{KM7:TR?=	M3r1T3NCVkeHUh?=
HCC70	NYDNR2F7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHHnUVBKSzVyPUmuNlc{ODlizszN	MUDTRW5ITVJ?
MFH-ino	NWLrfJR[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\pTGNKSzVyPUmuNlkxODdizszN	NUH5TYRoW0GQR1XS
UACC-62	NEX4NGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NY\ENZVrUUN3ME25MlM4Ojl5IN88US=>	NXHoRm1qW0GQR1XS
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KNS-42	NXXyPJFTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\QTWM2OD17LkSzOFA4KM7:TR?=	MWDTRW5ITVJ?
SK-LMS-1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWXJR\|UxRTlwN{W1N\|Uh\|ryP	M3fMPHNCVkeHUh?=
SK-CO-1	MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV:yeohqUUN3ME25Mlc3OjN3IN88US=>	MmjXV2FPT0WU
SN12C	NXvJWYJqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIqwVXNKSzVyPUmuO\|Y5ODZizszN	MnnxV2FPT0WU
HTC-C3	MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MorXTWM2OD17Lke3PVg1KM7:TR?=	NEjUcWlUSU6JRWK=
OVCAR-4	MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFvvOplKSzVyPUmuPFQ5OjhizszN	NUfRTHIxW0GQR1XS
CHP-126	M2HFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkfDTWM2OD17LkmzNlkh\|ryP	NFqyS4tUSU6JRWK=
NCI-H716	M{jBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXTkR3V3UUN3ME25Mlk{OzJ{IN88US=>	NY\Sc\|ZGW0GQR1XS
U-698-M	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHvCc5FKSzVyPUmuPVk4KM7:TR?=	MVjTRW5ITVJ?
EFO-21	MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MljITWM2OD1zMD6wNFk{KM7:TR?=	MXrTRW5ITVJ?
RXF393	Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWrjWXdUUUN3ME2xNE4yOzl{IN88US=>	MWHTRW5ITVJ?
ChaGo-K-1	NYjmTW9QT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{\L[WlEPTB;MUCuNVc4PiEQvF2=	NWT5WJJTW0GQR1XS
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LU-65	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH\iOplKSzVyPUGwMlI6PDNizszN	MoTLV2FPT0WU
OS-RC-2	NIPXSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2TITGlEPTB;MUCuN\|IzPyEQvF2=	MWXTRW5ITVJ?
YT	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmTBTWM2OD1zMD60NFAyKM7:TR?=	M1r2T3NCVkeHUh?=
COLO-679	NXO3fHp7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmfHTWM2OD1zMD60Nlg2KM7:TR?=	NVnpRYc1W0GQR1XS
CAS-1	MmHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DjeGlEPTB;MUCuOFYxQCEQvF2=	MYDTRW5ITVJ?
NCI-H2052	NGDaNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mmr3TWM2OD1zMD61NVA2KM7:TR?=	MYDTRW5ITVJ?
NCI-H2452	M2fZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEf5ZZpKSzVyPUGwMlYyQDFizszN	MoL5V2FPT0WU
SW13	NGD6c\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTFyLk[zO\|Qh\|ryP	NYTicnhiW0GQR1XS
HuP-T4	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXzJR\|UxRTFyLkewOlgh\|ryP	MV;TRW5ITVJ?
UMC-11	MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXLjdpoxUUN3ME2xNE46Ozd\|IN88US=>	M33FTXNCVkeHUh?=
EGI-1	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWLyZodvUUN3ME2xNE46PDV3IN88US=>	M37DcnNCVkeHUh?=
JiyoyeP-2003	NX;0Z4dnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXy5bGpyUUN3ME2xNU4xQDl{IN88US=>	NEe4e\|hUSU6JRWK=
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DoTc2-4510	M2PoeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUXJR\|UxRTFzLkGzPFkh\|ryP	NEXCRVhUSU6JRWK=
HLE	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIr2U3RKSzVyPUGxMlIyOTlizszN	NFrmXWVUSU6JRWK=
SW626	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTFzLkK4PFkh\|ryP	MWnTRW5ITVJ?
COR-L105	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{LGfWlEPTB;MUGuN\|I{PyEQvF2=	NW\2bpZuW0GQR1XS
ES6	NYPtS257T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1rhUWlEPTB;MUGuOVc3KM7:TR?=	NFvl[GNUSU6JRWK=
SNU-449	NUPJXGx6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml;OTWM2OD1zMT62NFczKM7:TR?=	MW\TRW5ITVJ?
GR-ST	MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUmyZo5yUUN3ME2xNU43OThzIN88US=>	M2TYenNCVkeHUh?=
BL-41	NEm4SG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm\yTWM2OD1zMT63NVc{KM7:TR?=	MYXTRW5ITVJ?
GB-1	MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3;HN2lEPTB;MUGuO\|YyQSEQvF2=	MXPTRW5ITVJ?
COLO-320-HSR	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUH6PYo{UUN3ME2xNU45PTF7IN88US=>	NVz1OYo2W0GQR1XS
L-540	MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEHRVWtKSzVyPUGxMlg6QSEQvF2=	MULTRW5ITVJ?
NCI-H69	M1HRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXHJR\|UxRTF{LkCxN\|kh\|ryP	Mn\oV2FPT0WU
769-P	M{[xO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIf6dldKSzVyPUGyMlAyQSEQvF2=	NGnQOG1USU6JRWK=
A172	NXrNTI13T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVjwcJZuUUN3ME2xNk4yOjB5IN88US=>	NYLERoxDW0GQR1XS
CAL-27	M1;Odmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUfJR\|UxRTF{LkGzOlkh\|ryP	NGrDZYFUSU6JRWK=
NCI-H1437	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFzS[FBKSzVyPUGyMlE1PDdizszN	NH\KT\|NUSU6JRWK=
REH	NVK4d2JLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWTJR\|UxRTF{LkG1O\|Mh\|ryP	MYHTRW5ITVJ?
KINGS-1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGX0elVKSzVyPUGyMlM1OjFizszN	NEPzXZZUSU6JRWK=
NCI-H1792	NWjBUJNkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1jCV2lEPTB;MUKuN\|g2OSEQvF2=	NWjOUY1QW0GQR1XS
SK-MM-2	M3[0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlHnTWM2OD1zMj60NFg4KM7:TR?=	MljjV2FPT0WU
8505C	M2\ueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml21TWM2OD1zMj62NVIh\|ryP	MVjTRW5ITVJ?
HAL-01	NWrrW4xsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEXXTndKSzVyPUGyMlYyPzRizszN	MmnaV2FPT0WU
NCI-H2141	NIj4ZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHzsO4lKSzVyPUGyMlY2QCEQvF2=	NFS1RnJUSU6JRWK=
HCC1806	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWfJR\|UxRTF{Lk[5OVIh\|ryP	M{H0OnNCVkeHUh?=
LU-134-A	M3jpXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX3uXld[UUN3ME2xNk46OyEQvF2=	NIKzXWZUSU6JRWK=
HT	M{PheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{HjO2lEPTB;MUKuPVQ{PyEQvF2=	MoS4V2FPT0WU
OE33	NEHqUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUjJR\|UxRTF{Lkm0OVYh\|ryP	M2nBdnNCVkeHUh?=
ES4	NWnkUYZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYrv[JR{UUN3ME2xNk46PDh5IN88US=>	NIjYdFZUSU6JRWK=
SW948	NXjIN4xkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4rXdmlEPTB;MUOuNFE{KM7:TR?=	M1\nd3NCVkeHUh?=
LB2241-RCC	Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTF\|LkG0Olkh\|ryP	M4fCT3NCVkeHUh?=
CCF-STTG1	NVW0PWExT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\J[5BKSzVyPUGzMlQxOzlizszN	MYDTRW5ITVJ?
RPMI-8402	MoWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLWTWM2OD1zMz61NFMyKM7:TR?=	MkjGV2FPT0WU
DEL	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\ITWM2OD1zMz61OVA{KM7:TR?=	NVzGT3lLW0GQR1XS
NB5	NHe0SoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTF\|LkW1NFMh\|ryP	MkWxV2FPT0WU
NUGC-3	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkPBTWM2OD1zMz63OFU{KM7:TR?=	M2TxfnNCVkeHUh?=
CAL-72	M2X3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlniTWM2OD1zND6xPVA3KM7:TR?=	NVrp[IpNW0GQR1XS
VMRC-RCZ	NGn2PIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3v2UGlEPTB;MUSuNlM3KM7:TR?=	MnTRV2FPT0WU
YAPC	M2XGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYfNbI1LUUN3ME2xOE4zPDB5IN88US=>	MoXWV2FPT0WU
ES5	NVHJO4V[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkXrTWM2OD1zND6yOVk6KM7:TR?=	NWe2fohKW0GQR1XS
CAL-12T	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUfJR\|UxRTF2LkSzN\|Yh\|ryP	M2i5PXNCVkeHUh?=
GAMG	MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHK5NXdKSzVyPUG0MlU2PzdizszN	NViwdllSW0GQR1XS
BT-20	NInPW5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmjxTWM2OD1zND65N\|g1KM7:TR?=	M3S4eHNCVkeHUh?=
KALS-1	NETTc5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHTk[mNKSzVyPUG1MlAyPThizszN	M2DwTHNCVkeHUh?=
LS-123	M{f4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVvNO2RzUUN3ME2xOU4xOTZ3IN88US=>	NFvXW4NUSU6JRWK=
LK-2	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MojxTWM2OD1zNT6wPFYzKM7:TR?=	M3XwVXNCVkeHUh?=
NCI-H1770	MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml[zTWM2OD1zNT6yPFY5KM7:TR?=	MnnpV2FPT0WU
MIA-PaCa-2	MkGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYW0[3JLUUN3ME2xOU41OTZ\|IN88US=>	NXT2c4ptW0GQR1XS
DB	MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{ntTGlEPTB;MUWuOlk1OSEQvF2=	MnfQV2FPT0WU
Becker	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1rJOmlEPTB;MUWuPFkzPiEQvF2=	NFrhWXVUSU6JRWK=
HT-144	Mn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmrJTWM2OD1zNT65OFk4KM7:TR?=	NWTrTZlGW0GQR1XS
NCI-H2405	M334N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGrEb3BKSzVyPUG2MlIzOThizszN	M{e5PXNCVkeHUh?=
TK10	M1PuZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmfxTWM2OD1zNj6zO\|QzKM7:TR?=	MnLlV2FPT0WU
THP-1	Ml;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\zWGlEPTB;MU[uOFY3PSEQvF2=	M3zSWXNCVkeHUh?=
LB373-MEL-D	NHH1TodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUKweVl6UUN3ME2xOk43OTN6IN88US=>	NFHsSWNUSU6JRWK=
SJSA-1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnvXTWM2OD1zNj65NlE6KM7:TR?=	M{PuRnNCVkeHUh?=
EB2	Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4G4bGlEPTB;MUeuO\|QzPiEQvF2=	MUXTRW5ITVJ?
MN-60	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlzWTWM2OD1zNz63PVM3KM7:TR?=	M1P2UHNCVkeHUh?=
A253	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLTXopTUUN3ME2xO{45OjVizszN	MU\TRW5ITVJ?
CESS	NVLIOoVIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYfJR\|UxRTF5LkmzNlYh\|ryP	NIHYeXRUSU6JRWK=
EW-11	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXTueIs{UUN3ME2xO{46QTV6IN88US=>	M2TsUXNCVkeHUh?=
TE-8	MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWnC[JBuUUN3ME2xPE4xPjZ7IN88US=>	NULDWY5UW0GQR1XS
UACC-257	NILJ[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIiz[VZKSzVyPUG4MlIxPjJizszN	NGDUSIhUSU6JRWK=
NCI-H226	Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWLOPWhQUUN3ME2xPE45Ojl7IN88US=>	NFvndYJUSU6JRWK=
NCI-H748	NWrjSoE2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3:ycWlEPTB;MUiuPFU5PSEQvF2=	MmD6V2FPT0WU
NCI-H1299	M4DqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVrMTmpCUUN3ME2xPE45QTF6IN88US=>	NXflUo9HW0GQR1XS
IST-MEL1	NFvEV4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYnyWJBIUUN3ME2xPU4yPzV2IN88US=>	MlvkV2FPT0WU
HCC1187	M1PNR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3z4bGlEPTB;MUmuNVc6PiEQvF2=	M3fucHNCVkeHUh?=
HT-1376	Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX;JR\|UxRTF7LkKwNlkh\|ryP	MVHTRW5ITVJ?
SK-MEL-2	M4[2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoexTWM2OD1zOT6yNVU2KM7:TR?=	MmjlV2FPT0WU
U031	MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{TCT2lEPTB;MUmuNlIyQSEQvF2=	Mn\jV2FPT0WU
NCI-H524	NGn3T4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTF7LkW3NlUh\|ryP	NUOxW3c3W0GQR1XS
KU812	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVrJR\|UxRTF7LkW5OFQh\|ryP	Mn7aV2FPT0WU
NB10	NHW1c29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4TDdWlEPTB;MUmuOlI3QCEQvF2=	MWrTRW5ITVJ?
NOS-1	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;VOW9DUUN3ME2yNE4yPTd5IN88US=>	NVXjTIcxW0GQR1XS
EW-7	NWr1eZYyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4e2WmlEPTB;MkCuNVYzQCEQvF2=	MnLjV2FPT0WU
Raji	Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXjJR\|UxRTJyLkK1Olgh\|ryP	MofIV2FPT0WU
LB2518-MEL	NG\6bIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nGfmlEPTB;MkCuN\|k2OyEQvF2=	M4jSfnNCVkeHUh?=
PANC-10-05	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTJyLkS2NVMh\|ryP	NXXHT3BkW0GQR1XS
MZ2-MEL	M3nVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nkZWlEPTB;MkCuOVgyPCEQvF2=	MnfGV2FPT0WU
MFE-280	NFPVXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4r1N2lEPTB;MkGuN\|E5QCEQvF2=	NVnH[\|JOW0GQR1XS
RKO	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnXRTWM2OD1{MT6zNlAzKM7:TR?=	MYDTRW5ITVJ?
KMOE-2	M17RT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnW3TWM2OD1{MT6zNlg5KM7:TR?=	NYXvSVY2W0GQR1XS
K5	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYH2NZRZUUN3ME2yNU4{QDl\|IN88US=>	NH3zV\|dUSU6JRWK=
NCI-H64	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3zXemlEPTB;MkGuOFc2PiEQvF2=	M3nwXHNCVkeHUh?=
K-562	NEnSWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkTDTWM2OD1{MT60PVcyKM7:TR?=	MnfIV2FPT0WU
HCE-T	NFHrRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTJzLkWwPVQh\|ryP	NE\QbHRUSU6JRWK=
COLO-792	MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjpTWM2OD1{MT61PFI4KM7:TR?=	MWXTRW5ITVJ?
PFSK-1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXjJR\|UxRTJzLk[4N\|ch\|ryP	NVHzUll3W0GQR1XS
DOK	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGrrcmlKSzVyPUKxMlc3QDdizszN	MkHHV2FPT0WU
NCI-H1882	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mm\4TWM2OD1{MT64OVk3KM7:TR?=	NFLZeWFUSU6JRWK=
KNS-81-FD	NWnOWXVFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn3FTWM2OD1{MT64OlMyKM7:TR?=	MVrTRW5ITVJ?
OCUB-M	NXPDUGlIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFvTfYpKSzVyPUKxMlk3QDhizszN	NInTZYVUSU6JRWK=
NCI-H1694	NHK2XlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTJzLkm4OlMh\|ryP	M1zVRXNCVkeHUh?=
LS-513	M4PEZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NI[4cWZKSzVyPUKyMlA{PjdizszN	M1j4SXNCVkeHUh?=
NCI-H2122	NWi0N5Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFLYfmpKSzVyPUKyMlE3PzdizszN	M3jsWnNCVkeHUh?=
IMR-5	NIfPZ2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTJ{LkK4O{DPxE1?	M2TuPHNCVkeHUh?=
SNU-C2B	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NETURmhKSzVyPUKyMlY4PDZizszN	M4Hre3NCVkeHUh?=
A498	MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYTJR\|UxRTJ{LkixO\|ch\|ryP	M3G3UnNCVkeHUh?=
NCI-H727	NH\NVFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTJ{Lki4N\|Yh\|ryP	MoW4V2FPT0WU
SW1573	MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2j5UWlEPTB;MkOuNFY1PiEQvF2=	MnnmV2FPT0WU
RO82-W-1	NXzIZotKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\EXnpEUUN3ME2yN{4zPTFzIN88US=>	M3nNSHNCVkeHUh?=
SKG-IIIa	NGXITo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXvJR\|UxRTJ\|LkO1OFYh\|ryP	NXXReFBqW0GQR1XS
MC-CAR	NWrGbXRCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYLzWYpZUUN3ME2yN{42OTh\|IN88US=>	MYHTRW5ITVJ?
NCI-H446	M1Oyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2XwWmlEPTB;MkOuOlA6OyEQvF2=	NH30SVhUSU6JRWK=
PC-14	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MofmTWM2OD1{Mz62OlI{KM7:TR?=	MWDTRW5ITVJ?
TGBC1TKB	NI\nXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MojHTWM2OD1{Mz63OFYyKM7:TR?=	MVzTRW5ITVJ?
EFM-19	NV\IdGQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LZWGlEPTB;MkSuNVg1PCEQvF2=	MlXHV2FPT0WU
SK-N-DZ	NF24dJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NID0bYZKSzVyPUK0MlQ6PzdizszN	MlrWV2FPT0WU
NCI-H661	M4f6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYjSNpcyUUN3ME2yOE42OjF5IN88US=>	MmS3V2FPT0WU
SW1990	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MW\JR\|UxRTJ2LkW4PFMh\|ryP	NIXJbHpUSU6JRWK=
SW684	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTJ2Lke2NlQh\|ryP	NXHkO45KW0GQR1XS
Ca-Ski	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXT3NWx[UUN3ME2yOE46OjN5IN88US=>	M3rnNHNCVkeHUh?=
TGW	NHft[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlLpTWM2OD1{NT6yN\|M4KM7:TR?=	MVXTRW5ITVJ?
CaR-1	NFnBSlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLBTWM2OD1{NT6zOVch\|ryP	M1LCe3NCVkeHUh?=
D-247MG	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHOTWM2OD1{NT60O\|Q{KM7:TR?=	NFvJWpRUSU6JRWK=
CCRF-CEM	M{H6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{DXU2lEPTB;MkWuO\|Q2QSEQvF2=	MWPTRW5ITVJ?
CAPAN-1	NGTWe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTJ3Lke1NFEh\|ryP	NWPrcYhsW0GQR1XS
CP50-MEL-B	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NInhe5VKSzVyPUK1Mlk6ODFizszN	NUPoRWdJW0GQR1XS
FADU	Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGT2SnNKSzVyPUK2MlUyPTJizszN	NXnEZVJkW0GQR1XS
Daudi	NE\6cG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEXjeI9KSzVyPUK2MlUyPThizszN	NIHaPI5USU6JRWK=
U-87-MG	M{DBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1jpeGlEPTB;Mk[uOVMxPSEQvF2=	M4D1UXNCVkeHUh?=
DSH1	MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVy0N4NUUUN3ME2yOk42PDB4IN88US=>	NGD1T5hUSU6JRWK=
KYSE-520	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYjJR\|UxRTJ4LkW1OVMh\|ryP	MVnTRW5ITVJ?
HuH-7	MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DON2lEPTB;Mk[uPVA5PiEQvF2=	NF:zbHdUSU6JRWK=
U-2-OS	MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmrzTWM2OD1{Nz6wNlcyKM7:TR?=	M1fme3NCVkeHUh?=
LU-99A	M2fiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2j0WmlEPTB;MkeuNVc2PCEQvF2=	M4q5d3NCVkeHUh?=
T98G	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTJ5LkG5O\|Mh\|ryP	MoiwV2FPT0WU
MZ7-mel	NGPXdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHPLZVVKSzVyPUK3MlU2PDhizszN	MnrSV2FPT0WU
SNU-C1	NWi1bXlWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1T3TWlEPTB;MkeuOlQ6OSEQvF2=	NXnERYRiW0GQR1XS
MDA-MB-175-VII	M2fQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{jad2lEPTB;MkeuOlk4PSEQvF2=	NXzJN49MW0GQR1XS
HuP-T3	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUf0dXNyUUN3ME2yPE4xPDl3IN88US=>	NYDxV5J7W0GQR1XS
T-24	MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlL6TWM2OD1{OD6xPVI2KM7:TR?=	MY\TRW5ITVJ?
HDLM-2	MonhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEPwZ3JKSzVyPUK4MlI1PTlizszN	NFjJ[olUSU6JRWK=
NCI-H1651	M13sdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkDMTWM2OD1{OD6yOVkzKM7:TR?=	MmjsV2FPT0WU
SK-N-AS	NH7tSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHrHU4VKSzVyPUK4MlMyPzFizszN	NWTCZok{W0GQR1XS
NY	M1q1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXfZRnNoUUN3ME2yPE43PTd7IN88US=>	MXTTRW5ITVJ?
D-283MED	NHTUTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2DydmlEPTB;MkiuPFcxQCEQvF2=	NWXSWIZ4W0GQR1XS
KLE	M2PWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUnWUY1{UUN3ME2yPE46QTB4IN88US=>	MlPqV2FPT0WU
NCI-H28	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MofWTWM2OD1{OT6wNVIh\|ryP	NILCVVdUSU6JRWK=
TE-1	NHe2cJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWDJR\|UxRTJ7LkKxOlch\|ryP	NFjRO5JUSU6JRWK=
SK-MEL-24	NFrvPYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mki4TWM2OD1{OT61OFY3KM7:TR?=	MV7TRW5ITVJ?
CAL-54	NHWxO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXlTWM2OD1{OT62NFQ3KM7:TR?=	NHfvU4JUSU6JRWK=
A673	NHvEdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmW2TWM2OD1{OT63N\|Ih\|ryP	MoTIV2FPT0WU
HEC-1	M3fuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1T3SGlEPTB;M{CuNFA2OyEQvF2=	NVzIXmF7W0GQR1XS
LS-411N	M{jCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NU\nW2w5UUN3ME2zNE4yPDd3IN88US=>	NIr2Z29USU6JRWK=
SW962	NYmxc29jT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfvdJhSUUN3ME2zNE4zPDd5IN88US=>	NHTIe2pUSU6JRWK=
OVCAR-8	M2Dm[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1XIVmlEPTB;M{CuOlc6PCEQvF2=	NXvqPFFKW0GQR1XS
NCI-H630	M1G4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUTHbWhwUUN3ME2zNE45QTV\|IN88US=>	NUXWU5dGW0GQR1XS
D-263MG	NWLrdpBbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrLXWpuUUN3ME2zNU4xPDJ2IN88US=>	MYDTRW5ITVJ?
NCI-H596	MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{XQeWlEPTB;M{GuNFYzOSEQvF2=	M{DY[nNCVkeHUh?=
BB49-HNC	M3nPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF3JNolKSzVyPUOxMlEyOiEQvF2=	Mn2yV2FPT0WU
KYSE-70	NF3KTHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGLUdXFKSzVyPUOxMlMxODhizszN	MVzTRW5ITVJ?
LAN-6	M{H4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYfsepI3UUN3ME2zNU41QTl{IN88US=>	NUHSTpFIW0GQR1XS
NCI-H2228	M3O3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlTITWM2OD1\|MT61OlI2KM7:TR?=	M{nuTHNCVkeHUh?=
SW620	NWD5V3JWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFj5c5lKSzVyPUOxMlYzQDNizszN	M2C5c3NCVkeHUh?=
KM-H2	NWnTeVVpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUDJR\|UxRTNzLkezNFYh\|ryP	M4PtSnNCVkeHUh?=
DJM-1	NFPnNoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVHKZnh1UUN3ME2zNk4yOzh4IN88US=>	NG[5fIJUSU6JRWK=
SW48	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTN{LkO4NlUh\|ryP	NV\TWJBWW0GQR1XS
NCI-H1793	M1Tzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3exPGlEPTB;M{KuOlE3OyEQvF2=	NX;hcFhmW0GQR1XS
LU-165	M{TNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnLMTWM2OD1\|Mz6wNFgh\|ryP	MUPTRW5ITVJ?
EHEB	NEnS[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXsTWM2OD1\|Mz6wOFk1KM7:TR?=	NInKPYpUSU6JRWK=
NCI-H441	NVP4eoRQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HOT2lEPTB;M{OuNlI{PSEQvF2=	MV7TRW5ITVJ?
LOXIMVI	NWW2NmZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mlu2TWM2OD1\|Mz6zOlc6KM7:TR?=	MYPTRW5ITVJ?
MC-IXC	M3PtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX\JR\|UxRTN\|LkW2OVUh\|ryP	M1v4fnNCVkeHUh?=
NCI-H522	NUO3[GpmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVvvZ3Y2UUN3ME2zN{43PTRizszN	NVjDTHE4W0GQR1XS
IA-LM	MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MneyTWM2OD1\|Mz62O\|Q3KM7:TR?=	M{jqOHNCVkeHUh?=
NCI-H1417	NGG5PGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml:zTWM2OD1\|Mz65OVg2KM7:TR?=	M1i2OXNCVkeHUh?=
HCC2218	M1X0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoPnTWM2OD1\|NT6yNVg2KM7:TR?=	NI\tV\|BUSU6JRWK=
HC-1	NH7o[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTN3LkSwNlQh\|ryP	M2e3RXNCVkeHUh?=
HH	NX;l[3hnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVX4UmVmUUN3ME2zOU41OTRzIN88US=>	NEXWSVBUSU6JRWK=
EFE-184	NYDJTYVWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFixelNKSzVyPUO1MlY5OjlizszN	MnqzV2FPT0WU
NCI-H1355	M2T1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2DNWGlEPTB;M{WuO\|cyQCEQvF2=	NFP3R2hUSU6JRWK=
BV-173	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGrVPG9KSzVyPUO1MlgzPjRizszN	NWLPNlB[W0GQR1XS
NEC8	NEniV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4\YeGlEPTB;M{[uOFkzPCEQvF2=	NUXvTYt4W0GQR1XS
SW1463	M1;KXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXG3OWpZUUN3ME2zOk43PTZ4IN88US=>	NV:zblhqW0GQR1XS
KYSE-140	NInaVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3zzWGlEPTB;M{[uO\|I6QCEQvF2=	NH\1TGhUSU6JRWK=
no-11	M3zuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUTJR\|UxRTN4Lki1N\|Yh\|ryP	NFrFXo1USU6JRWK=
HCC1937	NFHzSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXXoT4NMUUN3ME2zO{4xOTV2IN88US=>	MXzTRW5ITVJ?
LNCaP-Clone-FGC	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX;JR\|UxRTN5LkG5NFMh\|ryP	NFXOUGxUSU6JRWK=
KARPAS-422	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml3VTWM2OD1\|Nz60OFMyKM7:TR?=	NY\ISnFMW0GQR1XS
RCM-1	M1frV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYrJR\|UxRTN5LkWzOVgh\|ryP	NWnwPVFkW0GQR1XS
A375	MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1vO[GlEPTB;M{euO\|Y1PyEQvF2=	NYL2cphuW0GQR1XS
TGBC24TKB	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYrJR\|UxRTN6LkCyN\|kh\|ryP	MnvXV2FPT0WU
MDA-MB-453	M4CzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NG\SS29KSzVyPUO5MlAzOThizszN	MWnTRW5ITVJ?
Capan-2	MlzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4PkTWlEPTB;M{muNFUxQSEQvF2=	NWT0fYVPW0GQR1XS
SW756	M3\QTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWTJR\|UxRTN7LkWwPVEh\|ryP	NX[wdWRCW0GQR1XS
KU-19-19	NH\JTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4\OV2lEPTB;M{muOlI5OiEQvF2=	MXfTRW5ITVJ?
NCI-H2170	M1z5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX25TllzUUN3ME2zPU46QTd5IN88US=>	MUPTRW5ITVJ?
COLO-678	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGO1OY5KSzVyPUSwMlU6PSEQvF2=	MmHWV2FPT0WU
PF-382	NX;zcYVyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHnyZ\|FKSzVyPUSwMlc1QDdizszN	MY\TRW5ITVJ?
OAW-42	NEXpRWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NILvO4lKSzVyPUSyMlI6PDJizszN	MYnTRW5ITVJ?
LB996-RCC	NVXFO4Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3TndGlEPTB;NEKuPFAxQCEQvF2=	M1\McnNCVkeHUh?=
SAS	NEm0RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVjJR\|UxRTR\|LkSyPFgh\|ryP	M{mxfnNCVkeHUh?=
MRK-nu-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NITobJJKSzVyPUS0Mlc1OTRizszN	MnnIV2FPT0WU
EoL-1-cell	MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXPJR\|UxRTR2LkmxN\|Yh\|ryP	NYXETphnW0GQR1XS
NCI-H2342	NWjhVHpiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlS3TWM2OD12NT6xNVE4KM7:TR?=	Mn24V2FPT0WU
NCI-H1703	MlKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4LkPWlEPTB;NE[uNFU6OiEQvF2=	MWfTRW5ITVJ?
NCI-H187	Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmXXTWM2OD12Nj6xPFY6KM7:TR?=	NGjKfFVUSU6JRWK=
CP66-MEL	MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYPIVZpMUUN3ME20Ok4zPzh7IN88US=>	NF24UIpUSU6JRWK=
HCC1569	MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1rWPWlEPTB;NE[uOVkyPyEQvF2=	MUXTRW5ITVJ?
BL-70	NWH4bGZKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTR4Lke3N\|ch\|ryP	MWTTRW5ITVJ?
Saos-2	M17Mdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTR5LkOxNlMh\|ryP	MmPwV2FPT0WU
LC-1F	NV7mWYt2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4LpbWlEPTB;NEeuOlExPSEQvF2=	MWHTRW5ITVJ?
KY821	M{XNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTR5Lk[0N\|Qh\|ryP	NYLk[YZCW0GQR1XS
PSN1	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1;5emlEPTB;NEiuNVQxOSEQvF2=	MmfjV2FPT0WU
RT4	NHPTXG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYTJR\|UxRTR6LkizO\|ch\|ryP	NXHKVGdDW0GQR1XS
LS-1034	NFj1RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX\aTZFPUUN3ME20PE45QTV2IN88US=>	NXiwfWdXW0GQR1XS
NCI-H1395	NEjVd4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4rLR2lEPTB;NEmuNFQ6OiEQvF2=	NYDhTHhuW0GQR1XS
EKVX	M3ezTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2nvfmlEPTB;NEmuOlc{OSEQvF2=	NIjWeWFUSU6JRWK=
IST-MES1	M1S5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH;LPYZKSzVyPUS5Mlg6PDRizszN	NYrKRVcxW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-FAK / FAK / p-Talin / Talin ; PubMed: 26530902 Cancer Res Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells. p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; PubMed: 29417941 Acta Pharmacol Sin MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.	26530902 29417941
Immunofluorescence	p-FAK; PubMed: 26530902 Cancer Res Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).	26530902
Growth inhibition assay	Cell viability; PubMed: 28953264 Nutrients MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk () and p < 0.01 are designated by two asterisks (*).	28953264

In vivo

PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. ^[1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. ^[3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. ^[4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. ^[5]

Protocol

Animal Research:^[1]	+ Expand Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts. Formulation: 5% Gelucire Dosages: 50 mg/kg Administration: Oral gavage (Only for Reference)

References

+ Expand

Solubility (25°C)

In vitro	DMSO	100 mg/mL warmed (197.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O For best results, use promptly after mixing.	5 mg/ml

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download PF-562271 SDF

Molecular Weight	507.49
Formula	C₂₁H₂₀F₃N₇O₃S
CAS No.	717907-75-0
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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FAK Signaling Pathway Map

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PF-00562271 Besylate

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PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Ibrutinib (PCI-32765)

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.
Dasatinib

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Saracatinib (AZD0530)

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Features:The 1st Src inhibitor to show inhibition of the Src pathway in human tumor tissue.

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PF-562271

Cited by 33 Publications

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Chemical Information Download PF-562271 SDF

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Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

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Related FAK Products

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PF-562271

Cited by 33 Publications

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download PF-562271 SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

FAK Signaling Pathway Map

Related FAK Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)