PF-562271

Catalog No.S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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In DMSO USD 350 In stock
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USD 270 In stock
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Cited by 67 Publications

Purity & Quality Control

Choose Selective FAK Inhibitors

Biological Activity

Description PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
In vitro

PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. [1] PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. [2] PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrafYNHUUN3ME2wMlI4PjZizszN NY\hUpRRW0GQR1XS
SW982 MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK2TWM2OD1yLkOyPFIh|ryP M{HaVnNCVkeHUh?=
KM12 M{PBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[2TWM2OD1yLkO4OVU4KM7:TR?= NFzs[oJUSU6JRWK=
COLO-205 M4WzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13tRmlEPTB;MD60PFY2QCEQvF2= M{DqW3NCVkeHUh?=
COLO-829 M4PVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljjTWM2OD1yLke1NVc3KM7:TR?= M4GxPXNCVkeHUh?=
MG-63 NUT6U3lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLvTWM2OD1yLkiwOlM4KM7:TR?= NEDHeHZUSU6JRWK=
IGROV-1 NFjZOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DkVWlEPTB;MD64NVA{QCEQvF2= MXPTRW5ITVJ?
NCI-H650 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjyellKSzVyPUCuPFMyPTRizszN MoHHV2FPT0WU
RT-112 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7JcXlKSzVyPUCuPVg1PiEQvF2= MnXzV2FPT0WU
BCPAP MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17oWGlEPTB;MT6wNVI5QCEQvF2= MWPTRW5ITVJ?
ALL-PO MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwMEG1PFQh|ryP NVjQPHFNW0GQR1XS
KYSE-270 M4q4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwMES3NVQh|ryP NHfU[4VUSU6JRWK=
8305C MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwMEm5NFQh|ryP MWfTRW5ITVJ?
NCI-H810 Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TVN2lEPTB;MT6xNFc4PiEQvF2= MoTHV2FPT0WU
CAL-33 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnEfnRKSzVyPUGuNVI6OzhizszN NXn2[XY5W0GQR1XS
AN3-CA MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TNSmlEPTB;MT6yNVg3PyEQvF2= MYTTRW5ITVJ?
NKM-1 M4TDUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXiWWlGUUN3ME2xMlI4PTB4IN88US=> M4TCdnNCVkeHUh?=
BPH-1 NFKzc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTZSG5KSzVyPUGuNlg4PjZizszN M1m3XHNCVkeHUh?=
MES-SA MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjjVG1KSzVyPUGuN|A3QDJizszN Mn3XV2FPT0WU
CAL-62 NGnidndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnftTWM2OD1zLkOxPVA6KM7:TR?= M{LEOnNCVkeHUh?=
Detroit562 NYS2c5lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r5emlEPTB;MT6zOVIzOiEQvF2= NV20UXp1W0GQR1XS
KYSE-150 NG\lRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLUTWM2OD1zLkO1NlM3KM7:TR?= NYP5UoVQW0GQR1XS
SK-UT-1 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknYTWM2OD1zLkS0OlQ4KM7:TR?= MnK0V2FPT0WU
HUTU-80 NWLjOoxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnviTWM2OD1zLkS0PFg3KM7:TR?= M{HtOHNCVkeHUh?=
SIG-M5 NGXVW5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1WyNGlEPTB;MT60PFM5PyEQvF2= NY\YUGNIW0GQR1XS
AGS NYLWOmF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjXTWM2OD1zLkWyNVI1KM7:TR?= MoHhV2FPT0WU
ST486 NIPmRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFwNUOyO|gh|ryP NHLBcnNUSU6JRWK=
HSC-2 NGDyN3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFwNUO5OUDPxE1? NITSSZNUSU6JRWK=
LCLC-103H M1\XV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG0VppPUUN3ME2xMlU2QDF6IN88US=> MmHmV2FPT0WU
BC-1 Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjNO2tKSzVyPUGuOlE3PjRizszN MYjTRW5ITVJ?
CGTH-W-1 NWL5bIlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwNkG2O|kh|ryP MXfTRW5ITVJ?
MZ1-PC M2[5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LHOGlEPTB;MT62NlMyOiEQvF2= MWTTRW5ITVJ?
SW1710 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXVTWM2OD1zLk[yOlI5KM7:TR?= NG\3WFFUSU6JRWK=
EW-13 NYT6XGZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jETmlEPTB;MT62N|Q3PiEQvF2= NFvReZBUSU6JRWK=
TE-11 NF74Z45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTFwNkO1NlIh|ryP M4P4UXNCVkeHUh?=
BHY NYnofVhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHu5bZpKSzVyPUGuOlU3PjNizszN NUfrdmh2W0GQR1XS
ML-2 NHy4TVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFwNk[4NFIh|ryP NW\xTIV3W0GQR1XS
MEL-JUSO MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTOTWM2OD1zLkeyPFkyKM7:TR?= NVTnR|U6W0GQR1XS
U251 M{XmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LP[2lEPTB;MT63OFA{OSEQvF2= NV:2TGtOW0GQR1XS
MHH-ES-1 NGPxOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXNfZRFUUN3ME2xMlc6PTZ6IN88US=> M{e5SnNCVkeHUh?=
CAL-85-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrjTWM2OD1zLkiwOFkh|ryP MYjTRW5ITVJ?
D-336MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnoSXFWUUN3ME2xMlg2PjF2IN88US=> MmrJV2FPT0WU
VA-ES-BJ M33obmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnkTWM2OD1zLkmwN|E2KM7:TR?= MVnTRW5ITVJ?
MDA-MB-468 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFwOUGyO|Ih|ryP MlHRV2FPT0WU
MEL-HO MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlWxTWM2OD1zLkm3PVk{KM7:TR?= NVjHV|Y4W0GQR1XS
SW954 NGP6Z5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjOTWM2OD1{LkCwNVUyKM7:TR?= NUj1WnVpW0GQR1XS
LB831-BLC NFy5SllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3JN24xUUN3ME2yMlAxQTh6IN88US=> NU\NZXZWW0GQR1XS
EW-16 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnLTWM2OD1{LkCzPVg{KM7:TR?= MWfTRW5ITVJ?
NCI-H460 NWXWR5BOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonVTWM2OD1{LkC0PFM6KM7:TR?= NH\CNnRUSU6JRWK=
CHP-212 M1PLcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHW2SopKSzVyPUKuNFk2OzlizszN NFnMTIhUSU6JRWK=
MHH-NB-11 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfPcnVKSzVyPUKuNVI5OThizszN MX;TRW5ITVJ?
DU-4475 NILRWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJwMUS3OVkh|ryP MWnTRW5ITVJ?
ABC-1 MnvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELVdYFKSzVyPUKuNlUyQTZizszN NHfGV2xUSU6JRWK=
LOUCY NXPyZlhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHOTYFiUUN3ME2yMlI3OTJ6IN88US=> M3rHO3NCVkeHUh?=
LC-2-ad NWDrVHN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJwMk[5OlYh|ryP MnrVV2FPT0WU
ETK-1 NIjiNoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH23fYVKSzVyPUKuNlg1PiEQvF2= M{LJOnNCVkeHUh?=
KYSE-180 NYO2T2pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LxNGlEPTB;Mj6yPFg4PCEQvF2= NIrxR3RUSU6JRWK=
HOP-92 M{TleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJwM{C2O|Mh|ryP Mmr3V2FPT0WU
RCC10RGB MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TpT2lEPTB;Mj6zNlUxPyEQvF2= NVzhUoVJW0GQR1XS
KASUMI-1 NUfqPXJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\UZmlEPTB;Mj6zNlg5KM7:TR?= MYfTRW5ITVJ?
ACN NVLqelRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jWPWlEPTB;Mj6zOFc1PSEQvF2= NX;tXYFIW0GQR1XS
BxPC-3 Ml7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDBWWlKSzVyPUKuN|U1OzZizszN NF\WZXZUSU6JRWK=
MONO-MAC-6 M{P6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnrTolkUUN3ME2yMlQyOjR6IN88US=> NHu0fI1USU6JRWK=
CAL-39 NUDOT|NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPyeHR3UUN3ME2yMlQyPjJ6IN88US=> NWDzfVNLW0GQR1XS
CMK Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHETWM2OD1{LkSxO|k2KM7:TR?= NH;4VJpUSU6JRWK=
MFE-296 NYXnPVU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTVTWM2OD1{LkS3O|kzKM7:TR?= NGXKe4dUSU6JRWK=
DU-145 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnIc4ZuUUN3ME2yMlQ6OTF6IN88US=> MoLFV2FPT0WU
MDA-MB-231 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nENWlEPTB;Mj60PVU4OiEQvF2= NWPDNlFGW0GQR1XS
EFO-27 MnfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTxTWM2OD1{LkWxPFg5KM7:TR?= NYHBR4c1W0GQR1XS
SNU-387 M4r6RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H5cGlEPTB;Mj61NlgzKM7:TR?= NHX0N5BUSU6JRWK=
KYSE-410 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLHTWM2OD1{LkW2OVE4KM7:TR?= M2LOPHNCVkeHUh?=
NCCIT M4rHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnN[4ljUUN3ME2yMlU4OjRizszN MmqwV2FPT0WU
LXF-289 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJwNUiyO|Mh|ryP NUjhOWtjW0GQR1XS
HMV-II MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJwNUi5PVch|ryP MkjBV2FPT0WU
MOLT-4 MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPySWZuUUN3ME2yMlYxPzF{IN88US=> NV3xN4NMW0GQR1XS
KOSC-2 NGH0XIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2e2Z2lEPTB;Mj62N|g4QSEQvF2= NGPy[VhUSU6JRWK=
TUR NWq5fHR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrXTWM2OD1{Lk[1N|Y6KM7:TR?= M33RXHNCVkeHUh?=
NCI-H2087 NXzPfYw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJwN{G2OFYh|ryP M1\OO3NCVkeHUh?=
SCC-15 M1TvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\JWGFOUUN3ME2yMlc2OjV{IN88US=> MYHTRW5ITVJ?
HSC-4 NYLnfZBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTJwN{izPFkh|ryP M{HFRnNCVkeHUh?=
G-402 NWe1[Ws2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKyTWM2OD1{LkixOFQ4KM7:TR?= MUDTRW5ITVJ?
GP5d MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnqwTWM2OD1{LkizPFI4KM7:TR?= MlnvV2FPT0WU
IGR-1 NEDv[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJwOEO5PFch|ryP NWPZSJY5W0GQR1XS
SK-PN-DW NIn2NJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLK[WNUUUN3ME2yMlg3OjB2IN88US=> MlOwV2FPT0WU
OPM-2 NIWzWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJwOEm5O|gh|ryP MlvCV2FPT0WU
5637 NXfZSXA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ToXmlEPTB;Mj65NlQ{QSEQvF2= MlXQV2FPT0WU
NCI-H2030 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELuUmZKSzVyPUKuPVgxOjlizszN MkDMV2FPT0WU
SK-LU-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjoOWFKSzVyPUKuPVg{OzRizszN NYH6[YRsW0GQR1XS
EW-18 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNwMEWzNkDPxE1? MkPqV2FPT0WU
786-0 NX;LemZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPOTIJPUUN3ME2zMlA2Pzh2IN88US=> NG\hRnhUSU6JRWK=
NCI-H1963 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwMEi4NlUh|ryP NV\lcJRGW0GQR1XS
A2780 NUXGRXhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTNwMUCzOFEh|ryP NFnyUYxUSU6JRWK=
NCI-H526 M2HCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;j[ZNxUUN3ME2zMlE{QTZzIN88US=> Mn25V2FPT0WU
BHT-101 M1:1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnlb|VKSzVyPUOuNVU4QThizszN MkD5V2FPT0WU
RPMI-7951 Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrQb5pKSzVyPUOuNlAyOzdizszN NU[4O3FOW0GQR1XS
HL-60 NXm0e5FiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof6TWM2OD1|LkKxNVQh|ryP NX\1S3llW0GQR1XS
CTV-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTNwMkWzO|ch|ryP NH\HfplUSU6JRWK=
IST-SL1 NF\DSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTNwMkm0OlUh|ryP MkD5V2FPT0WU
G-401 MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNwMkm4NFgh|ryP MWTTRW5ITVJ?
OVCAR-5 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC2Wo5nUUN3ME2zMlM3OzV{IN88US=> M1PqTnNCVkeHUh?=
EW-1 M1K1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHLTWM2OD1|LkSwOVQ1KM7:TR?= NFXZc45USU6JRWK=
H4 NV3YT|l{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{OwfmlEPTB;Mz60O|U3QSEQvF2= MoDuV2FPT0WU
EM-2 NVjo[odwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXaTWM2OD1|LkS4Olc1KM7:TR?= MVrTRW5ITVJ?
RS4-11 M4eyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTCdWRKSzVyPUOuOFg4OTVizszN M{LMWHNCVkeHUh?=
NOMO-1 NVfUdJZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nVXGlEPTB;Mz60PVIxPCEQvF2= NV3lXFVNW0GQR1XS
HCT-116 NXrPPXo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm1TWM2OD1|LkWwO|EyKM7:TR?= MXfTRW5ITVJ?
CAL-120 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHGTWM2OD1|LkW3N|Uh|ryP M2TIWXNCVkeHUh?=
CAL-51 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfMTWM2OD1|LkW3OlEzKM7:TR?= MXrTRW5ITVJ?
RVH-421 NXiwTZR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PsS2lEPTB;Mz62NFMyOSEQvF2= Mkm5V2FPT0WU
NCI-H2081 NYT2TnFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TwVWlEPTB;Mz62OVI5QCEQvF2= M3PibXNCVkeHUh?=
SBC-5 NX\tU2Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDrNWNnUUN3ME2zMlY4QDh{IN88US=> Mli0V2FPT0WU
RL95-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF72epNKSzVyPUOuO|E5PjRizszN NUDWPZpJW0GQR1XS
SW872 NVWzUoFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljoTWM2OD1|Lke2PVU5KM7:TR?= MUXTRW5ITVJ?
VM-CUB-1 M1HnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HLXGlEPTB;Mz63O|UyKM7:TR?= M1PxVXNCVkeHUh?=
SUP-T1 M{C0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fvNmlEPTB;Mz63PFMzKM7:TR?= NY\EZVlsW0GQR1XS
697 NUTDZ5Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7pW2hsUUN3ME2zMlgyPjV5IN88US=> MXLTRW5ITVJ?
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SW780 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTRwN{[4OFkh|ryP MVnTRW5ITVJ?
GOTO MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPOTWM2OD12Lke5Nlk{KM7:TR?= NFX3RYhUSU6JRWK=
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RD MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfadmNHUUN3ME21MlI6PzdzIN88US=> NY\HUWs4W0GQR1XS
A2058 MlvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrNdW5KSzVyPUWuN|A1OzhizszN MX;TRW5ITVJ?
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8-MG-BA M13HSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDjTWM2OD13LkO3NFc4KM7:TR?= NXL6O|dbW0GQR1XS
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A101D MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTVwM{m2PFkh|ryP MnzlV2FPT0WU
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SF126 M1LqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT1XI5KSzVyPUWuOFE1PjVizszN M1rlPHNCVkeHUh?=
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TE-6 NUX1[Y1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnoNGZKSzVyPUWuOFQ2PjlizszN MV3TRW5ITVJ?
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HOP-62 M{\YNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTVwNU[4PFch|ryP NYLuNmtCW0GQR1XS
HCC2157 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13MTGlEPTB;NT61Olg6PiEQvF2= MonzV2FPT0WU
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TE-9 M3zZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjaPGE1UUN3ME21MlYyPzh6IN88US=> NIfYe41USU6JRWK=
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SK-MES-1 MkTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLFXmw4UUN3ME21Mlg2QDlzIN88US=> NWLRSlVHW0GQR1XS
OVCAR-3 M2e5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXofYh2UUN3ME21Mlg5OjB4IN88US=> NF\iTWdUSU6JRWK=
LB1047-RCC M1vCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3EWGhKSzVyPUWuPVAyPDhizszN NFTHSI5USU6JRWK=
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KARPAS-45 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\QXGxmUUN3ME22MlA{Pzh5IN88US=> M2fnT3NCVkeHUh?=
NCI-H1304 NWHMVHhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjOTlZXUUN3ME22MlEzPDl5IN88US=> MnL1V2FPT0WU
PC-3 M1riNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK3NGh2UUN3ME22MlE{ODd{IN88US=> M1TDdXNCVkeHUh?=
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COLO-824 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTZwMke4Olgh|ryP NYrFUVIzW0GQR1XS
COLO-680N MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWWwbIhkUUN3ME22MlM4PjN6IN88US=> M2f4VHNCVkeHUh?=
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SF295 MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\SXWFKSzVyPU[uOFQ6QCEQvF2= Mn;RV2FPT0WU
no-10 NGnHSGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTZwNEe4OEDPxE1? Mkn2V2FPT0WU
NCI-H838 NVXRU3R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nwd2lEPTB;Nj61NVcxOyEQvF2= MVTTRW5ITVJ?
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C-4-II NV31UHZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4npdmlEPTB;Nj64N|EyPyEQvF2= MkDMV2FPT0WU
23132-87 NVnIbWRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPWTWM2OD14LkmwPVAyKM7:TR?= NUmxWIYyW0GQR1XS
MEG-01 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL0VYNlUUN3ME22Mlk{PTR4IN88US=> NVW4e2hNW0GQR1XS
GI-1 M4PhUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7hN3J[UUN3ME22Mlk1OzR6IN88US=> MoDIV2FPT0WU
NCI-H2347 NITJV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSyWGRKSzVyPU[uPVQ4OTVizszN MYHTRW5ITVJ?
MS-1 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTzR4tZUUN3ME22Mlk2OTl{IN88US=> MVjTRW5ITVJ?
SK-MEL-30 M3zU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjOWZNSUUN3ME22Mlk3OzF3IN88US=> MVvTRW5ITVJ?
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HT-3 M1XkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfVXYJKSzVyPUeuNFM1QSEQvF2= MorHV2FPT0WU
NCI-H2126 M3;KNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j5eGlEPTB;Nz6wPVc6OSEQvF2= MnrWV2FPT0WU
GI-ME-N NV31U3N7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\BdGVKSzVyPUeuNVY6ODZizszN NIL1[5FUSU6JRWK=
LB771-HNC M3:2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\LcJlWUUN3ME23MlE5ODN6IN88US=> NEG5[nRUSU6JRWK=
LCLC-97TM1 NHTMdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn1dJBKSzVyPUeuNlEzPzNizszN NHn4N2VUSU6JRWK=
HO-1-N-1 MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7mdYlpUUN3ME23MlI1ODJ2IN88US=> M4L5XHNCVkeHUh?=
HCC1143 MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PLSGlEPTB;Nz6zO|g6QCEQvF2= MXPTRW5ITVJ?
HuO9 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M375V2lEPTB;Nz60PFc6PCEQvF2= NYfGZ2w6W0GQR1XS
IST-SL2 NGfZdplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXETWM2OD15LkWyNlczKM7:TR?= M{fWRXNCVkeHUh?=
MLMA MoPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrTTWM2OD15LkW0Olg6KM7:TR?= NH:zWWVUSU6JRWK=
22RV1 NGjLc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknLTWM2OD15Lk[3PVc2KM7:TR?= MXnTRW5ITVJ?
ONS-76 NXPQNWNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTdwNkm0NVYh|ryP NHvXRpdUSU6JRWK=
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HT-1080 MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXXTWM2OD15Lke4OVU2KM7:TR?= M1Ty[3NCVkeHUh?=
SF268 M1e2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XwVmlEPTB;Nz64N|U3KM7:TR?= M4SyVHNCVkeHUh?=
COLO-800 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTdwOUC2PFUh|ryP NVHGSXZsW0GQR1XS
BB30-HNC NW\TRYJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\PSW9MUUN3ME23Mlk1PTV|IN88US=> M3HBcXNCVkeHUh?=
CAKI-1 M1jlc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL2c2F{UUN3ME24MlA3PTJzIN88US=> MkHtV2FPT0WU
GCIY M2POS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPiVmFKSzVyPUiuNlM4OTNizszN NFr0SHhUSU6JRWK=
MKN28 M3Tyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;5fXRKSzVyPUiuNlQ2QThizszN MnjpV2FPT0WU
IPC-298 NWP1S3A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33wO2lEPTB;OD6yO|cxQSEQvF2= MkLMV2FPT0WU
NCI-H1650 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDiTGdKSzVyPUiuNlkyQDVizszN MonPV2FPT0WU
KP-N-YS M1;OTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHGVZNKSzVyPUiuNlk{ODhizszN NVvGRYZGW0GQR1XS
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LB2518-MEL MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3foWmlEPTB;MkCuN|k2OyEQvF2= NYrSUohEW0GQR1XS
PANC-10-05 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH61eXpKSzVyPUKwMlQ3OTNizszN NV3rSW52W0GQR1XS
MZ2-MEL NX\iPWN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTn[odtUUN3ME2yNE42QDF2IN88US=> M3;4bnNCVkeHUh?=
MFE-280 M{ixUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJzLkOxPFgh|ryP NYD1dmNWW0GQR1XS
RKO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJzLkOyNFIh|ryP NFeyN4dUSU6JRWK=
KMOE-2 M2DJVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoO0TWM2OD1{MT6zNlg5KM7:TR?= NGXxZ|BUSU6JRWK=
K5 M4XWRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnYd5lKSzVyPUKxMlM5QTNizszN NWPxWm9jW0GQR1XS
NCI-H64 Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3qzZWlEPTB;MkGuOFc2PiEQvF2= M4LOVXNCVkeHUh?=
K-562 NXe5[4NVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT6dphDUUN3ME2yNU41QTdzIN88US=> NVPGT2JXW0GQR1XS
HCE-T NGTTU4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj1TWM2OD1{MT61NFk1KM7:TR?= M17iU3NCVkeHUh?=
COLO-792 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPvS|ZKSzVyPUKxMlU5OjdizszN NFn0RXNUSU6JRWK=
PFSK-1 MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJzLk[4N|ch|ryP MontV2FPT0WU
DOK MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfLbWFKSzVyPUKxMlc3QDdizszN MYXTRW5ITVJ?
NCI-H1882 NID3PWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3XcHZKSzVyPUKxMlg2QTZizszN MX\TRW5ITVJ?
KNS-81-FD NX\FSYtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTHTWM2OD1{MT64OlMyKM7:TR?= MVjTRW5ITVJ?
OCUB-M NYTpeGM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\wVFV6UUN3ME2yNU46Pjh6IN88US=> MXTTRW5ITVJ?
NCI-H1694 NYLicG9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJzLkm4OlMh|ryP NWnybmpEW0GQR1XS
LS-513 M1LuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPzTWM2OD1{Mj6wN|Y4KM7:TR?= M3;2PXNCVkeHUh?=
NCI-H2122 NELqW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPOTWM2OD1{Mj6xOlc4KM7:TR?= NVLOR2F3W0GQR1XS
IMR-5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3vXJF3UUN3ME2yNk4zQDdizszN NEH3eoZUSU6JRWK=
SNU-C2B MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DQVWlEPTB;MkKuOlc1PiEQvF2= M{HvUXNCVkeHUh?=
A498 MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ{LkixO|ch|ryP Mkj4V2FPT0WU
NCI-H727 Ml7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1POcGlEPTB;MkKuPFg{PiEQvF2= NVy5UWVZW0GQR1XS
SW1573 M4DVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLUTWM2OD1{Mz6wOlQ3KM7:TR?= MVzTRW5ITVJ?
RO82-W-1 NETYco9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT1OpFpUUN3ME2yN{4zPTFzIN88US=> NX[2c|Q4W0GQR1XS
SKG-IIIa M3fiVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M335WmlEPTB;MkOuN|U1PiEQvF2= MW\TRW5ITVJ?
MC-CAR NIjoWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEC0fW5KSzVyPUKzMlUyQDNizszN NVO3O5ZOW0GQR1XS
NCI-H446 NHXUWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\Zd2lEPTB;MkOuOlA6OyEQvF2= MnfwV2FPT0WU
PC-14 M3Tvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ|Lk[2NlMh|ryP MlP4V2FPT0WU
TGBC1TKB NX7OPFVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJ|Lke0OlEh|ryP NHvNOmVUSU6JRWK=
EFM-19 NFWzVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESyXlVKSzVyPUK0MlE5PDRizszN M1Kwd3NCVkeHUh?=
SK-N-DZ NXjoTYJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjRV25DUUN3ME2yOE41QTd5IN88US=> M1POT3NCVkeHUh?=
NCI-H661 NWHUSFN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K5VGlEPTB;MkSuOVIyPyEQvF2= NXLvfmIyW0GQR1XS
SW1990 NV[0RY4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LjN2lEPTB;MkSuOVg5OyEQvF2= MVPTRW5ITVJ?
SW684 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzGTWM2OD1{ND63OlI1KM7:TR?= Mo\HV2FPT0WU
Ca-Ski NFy2NIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLiSoRKSzVyPUK0MlkzOzdizszN NFPsXZVUSU6JRWK=
TGW MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnkTWM2OD1{NT6yN|M4KM7:TR?= MmC5V2FPT0WU
CaR-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\5V2hKSzVyPUK1MlM2PyEQvF2= MX3TRW5ITVJ?
D-247MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[3TWM2OD1{NT60O|Q{KM7:TR?= NUXPT2FQW0GQR1XS
CCRF-CEM NEPhdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XoZ2lEPTB;MkWuO|Q2QSEQvF2= MkLCV2FPT0WU
CAPAN-1 MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHyTWM2OD1{NT63OVAyKM7:TR?= NVjyfGhLW0GQR1XS
CP50-MEL-B M1PuXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInrdGRKSzVyPUK1Mlk6ODFizszN MVfTRW5ITVJ?
FADU NYjzdlZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH0cVl6UUN3ME2yOk42OTV{IN88US=> M{L6VHNCVkeHUh?=
Daudi MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHqxeHVKSzVyPUK2MlUyPThizszN MVjTRW5ITVJ?
U-87-MG MoHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7XcnN4UUN3ME2yOk42OzB3IN88US=> MULTRW5ITVJ?
DSH1 M4fjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjLTIlYUUN3ME2yOk42PDB4IN88US=> NWe5NI41W0GQR1XS
KYSE-520 NXWzXYVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPPTWM2OD1{Nj61OVU{KM7:TR?= M1fIOnNCVkeHUh?=
HuH-7 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG3TWM2OD1{Nj65NFg3KM7:TR?= MVrTRW5ITVJ?
U-2-OS MlTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Tuc2lEPTB;MkeuNFI4OSEQvF2= NYTUSJpQW0GQR1XS
LU-99A MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\Pe4VKSzVyPUK3MlE4PTRizszN NEPhd4dUSU6JRWK=
T98G M1HldGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJ5LkG5O|Mh|ryP NIXzW5ZUSU6JRWK=
MZ7-mel NUPEb2RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTJ5LkW1OFgh|ryP MofvV2FPT0WU
SNU-C1 M1jzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHHN5VRUUN3ME2yO{43PDlzIN88US=> NXy0V5d5W0GQR1XS
MDA-MB-175-VII MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTJ5Lk[5O|Uh|ryP M37SO3NCVkeHUh?=
HuP-T3 M2rvZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnXTWM2OD1{OD6wOFk2KM7:TR?= M1K3UXNCVkeHUh?=
T-24 MlPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjQU|dGUUN3ME2yPE4yQTJ3IN88US=> NFrtV3JUSU6JRWK=
HDLM-2 NEe3S4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jiXWlEPTB;MkiuNlQ2QSEQvF2= MonrV2FPT0WU
NCI-H1651 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ns[GlEPTB;MkiuNlU6OiEQvF2= NXXuRXNGW0GQR1XS
SK-N-AS MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Dp[mlEPTB;MkiuN|E4OSEQvF2= NIWxRmFUSU6JRWK=
NY M1HER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPP[VBKSzVyPUK4MlY2PzlizszN NInvZ29USU6JRWK=
D-283MED NVm2XGQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rI[mlEPTB;MkiuPFcxQCEQvF2= NVnZSmE4W0GQR1XS
KLE M3LOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJ6Lkm5NFYh|ryP NWW2SXhvW0GQR1XS
NCI-H28 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\SbWlEPTB;MkmuNFEzKM7:TR?= MV3TRW5ITVJ?
TE-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ7LkKxOlch|ryP NUf0UlNQW0GQR1XS
SK-MEL-24 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHJZoMzUUN3ME2yPU42PDZ4IN88US=> M1vIOXNCVkeHUh?=
CAL-54 MnHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTUTWM2OD1{OT62NFQ3KM7:TR?= NHP1NXdUSU6JRWK=
A673 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon4TWM2OD1{OT63N|Ih|ryP NWPpSpdEW0GQR1XS
HEC-1 NX\IdG9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNyLkCwOVMh|ryP M{HGfnNCVkeHUh?=
LS-411N MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj5flZKSzVyPUOwMlE1PzVizszN MXPTRW5ITVJ?
SW962 NEj6OJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTUTWM2OD1|MD6yOFc4KM7:TR?= NWLTdo1ZW0GQR1XS
OVCAR-8 NUPYWGhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\hTWM2OD1|MD62O|k1KM7:TR?= NFPKUpdUSU6JRWK=
NCI-H630 M1jINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTNyLki5OVMh|ryP NG\xV5JUSU6JRWK=
D-263MG M{\DSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfSTWM2OD1|MT6wOFI1KM7:TR?= Ml;rV2FPT0WU
NCI-H596 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjl[I5ZUUN3ME2zNU4xPjJzIN88US=> NIDGe4FUSU6JRWK=
BB49-HNC NInwXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn70TWM2OD1|MT6xNVIh|ryP M1Hl[nNCVkeHUh?=
KYSE-70 MkHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNzLkOwNFgh|ryP MV3TRW5ITVJ?
LAN-6 NH;YcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTwTWM2OD1|MT60PVkzKM7:TR?= MkDDV2FPT0WU
NCI-H2228 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjW[JRKSzVyPUOxMlU3OjVizszN NWLnbYxJW0GQR1XS
SW620 M2HIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfaTWM2OD1|MT62Nlg{KM7:TR?= M{PxSHNCVkeHUh?=
KM-H2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;iO2lEPTB;M{GuO|MxPiEQvF2= MWjTRW5ITVJ?
DJM-1 M1T2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zlb2lEPTB;M{KuNVM5PiEQvF2= MVXTRW5ITVJ?
SW48 M1XqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN{LkO4NlUh|ryP MnXRV2FPT0WU
NCI-H1793 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTN{Lk[xOlMh|ryP MnLkV2FPT0WU
LU-165 NXrDe4xsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LSemlEPTB;M{OuNFA5KM7:TR?= NV\HcZdqW0GQR1XS
EHEB NWTtSoxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLTcJdSUUN3ME2zN{4xPDl2IN88US=> M3K2PXNCVkeHUh?=
NCI-H441 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPi[IxKSzVyPUOzMlIzOzVizszN MoCzV2FPT0WU
LOXIMVI M3GzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN|LkO2O|kh|ryP M4r2[HNCVkeHUh?=
MC-IXC NHfyT|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW4VJZ1UUN3ME2zN{42PjV3IN88US=> NGr5c4RUSU6JRWK=
NCI-H522 Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHFcmdXUUN3ME2zN{43PTRizszN M1jLbXNCVkeHUh?=
IA-LM NXi1ZZVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HFV2lEPTB;M{OuOlc1PiEQvF2= M1vJe3NCVkeHUh?=
NCI-H1417 NF\mTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfLUWJKSzVyPUOzMlk2QDVizszN MoPrV2FPT0WU
HCC2218 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrFRYV[UUN3ME2zOU4zOTh3IN88US=> MlPYV2FPT0WU
HC-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj0eIpKSzVyPUO1MlQxOjRizszN NWj4fFNJW0GQR1XS
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EFE-184 NEXpTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTN3Lk[4Nlkh|ryP M4\6TXNCVkeHUh?=
NCI-H1355 M{TrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGy[GpKSzVyPUO1Mlc4OThizszN M{\qS3NCVkeHUh?=
BV-173 M4niXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnxNlVKSzVyPUO1MlgzPjRizszN M{C5WXNCVkeHUh?=
NEC8 NFfEbmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3YPJpKSzVyPUO2MlQ6OjRizszN NIjvOmlUSU6JRWK=
SW1463 M{\CbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXqWZdOUUN3ME2zOk43PTZ4IN88US=> NHi3eFdUSU6JRWK=
KYSE-140 NWjiWI9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX0eYszUUN3ME2zOk44Ojl6IN88US=> MYnTRW5ITVJ?
no-11 NIjSZ5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTN4Lki1N|Yh|ryP NHHXOphUSU6JRWK=
HCC1937 NH\U[3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTN5LkCxOVQh|ryP NGDE[lZUSU6JRWK=
LNCaP-Clone-FGC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN5LkG5NFMh|ryP MoP1V2FPT0WU
KARPAS-422 M2jIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvqPY5oUUN3ME2zO{41PDNzIN88US=> Mm\RV2FPT0WU
RCM-1 NGL4PZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnGXmhsUUN3ME2zO{42OzV6IN88US=> NVjIWod5W0GQR1XS
A375 NGH3TI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7KNYlKSzVyPUO3Mlc3PDdizszN NXrmcVAxW0GQR1XS
TGBC24TKB MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH5TWM2OD1|OD6wNlM6KM7:TR?= MVPTRW5ITVJ?
MDA-MB-453 NUK4TZpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PzS2lEPTB;M{muNFIyQCEQvF2= NHLEdGJUSU6JRWK=
Capan-2 M4[zTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXVTpdrUUN3ME2zPU4xPTB7IN88US=> MXjTRW5ITVJ?
SW756 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LhXGlEPTB;M{muOVA6OSEQvF2= MUHTRW5ITVJ?
KU-19-19 M2XPfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr3ZVVKSzVyPUO5MlYzQDJizszN M2DXfnNCVkeHUh?=
NCI-H2170 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjLc4g6UUN3ME2zPU46QTd5IN88US=> NFzXWGFUSU6JRWK=
COLO-678 NX3QW2E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP2UHA4UUN3ME20NE42QTVizszN MWjTRW5ITVJ?
PF-382 MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV74R3gxUUN3ME20NE44PDh5IN88US=> Mkn3V2FPT0WU
OAW-42 M4XRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXWTWM2OD12Mj6yPVQzKM7:TR?= M{ewNnNCVkeHUh?=
LB996-RCC MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrTN29KSzVyPUSyMlgxODhizszN MkH6V2FPT0WU
SAS NY\hVYN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;PU3hNUUN3ME20N{41Ojh6IN88US=> MW\TRW5ITVJ?
MRK-nu-1 NUHMN2RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP5SnNuUUN3ME20OE44PDF2IN88US=> MYjTRW5ITVJ?
EoL-1-cell NVXlXYc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHQNm5KSzVyPUS0MlkyOzZizszN M4r5bXNCVkeHUh?=
NCI-H2342 M1PoTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTSTWM2OD12NT6xNVE4KM7:TR?= M1SxSXNCVkeHUh?=
NCI-H1703 Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PhVWlEPTB;NE[uNFU6OiEQvF2= NHfWPIVUSU6JRWK=
NCI-H187 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITad3ZKSzVyPUS2MlE5PjlizszN MUXTRW5ITVJ?
CP66-MEL MnvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXixTYd7UUN3ME20Ok4zPzh7IN88US=> MmC3V2FPT0WU
HCC1569 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLTW|lKUUN3ME20Ok42QTF5IN88US=> M1LCWXNCVkeHUh?=
BL-70 NVrmWo1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\1c4FIUUN3ME20Ok44PzN5IN88US=> MkXtV2FPT0WU
Saos-2 NWHjWnVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED3V21KSzVyPUS3MlMyOjNizszN M1XMbHNCVkeHUh?=
LC-1F MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jifWlEPTB;NEeuOlExPSEQvF2= MUDTRW5ITVJ?
KY821 NHz6blJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHVS2hFUUN3ME20O{43PDN2IN88US=> M4TURXNCVkeHUh?=
PSN1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\QPY9KUUN3ME20PE4yPDBzIN88US=> M1TSRXNCVkeHUh?=
RT4 M2T0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzNTWM2OD12OD64N|c4KM7:TR?= Mmj0V2FPT0WU
LS-1034 MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;iTWM2OD12OD64PVU1KM7:TR?= NEnEbYJUSU6JRWK=
NCI-H1395 NF;RSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrWUYdKSzVyPUS5MlA1QTJizszN NWGybVg2W0GQR1XS
EKVX Mom4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjOTHc4UUN3ME20PU43PzNzIN88US=> MmfpV2FPT0WU
IST-MES1 NGjONFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTR7Lki5OFQh|ryP NWfvTYlRW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-FAK / FAK / p-Talin / Talin ; 

PubMed: 26530902     


Dose response of PF-562271 on the phosphorylation of FAK-Y397 or Talin-S425 in PC3-mm2 cells.

p-Src / Src / p-paxillin / Paxillin / ICAM-1 ; 

PubMed: 29417941     


MDA-MB-231 cells transfected with FAK-specific siRNAs or treated for 12 h with PF-562271 at the indicated concentrations were subjected to immunoblotting with indicated antibodies.

26530902 29417941
Immunofluorescence
p-FAK; 

PubMed: 26530902     


Immunostaining of PC3-mm2 cells showed that phosphorylated FAK is localized at focal adhesions (inset).

26530902
Growth inhibition assay
Cell viability; 

PubMed: 28953264     


MTT assay showed inhibition of cell proliferation and viability in HCT116 (B) and SW480 (D) cell lines treated with resveratrol and/or different concentrations of FAK-Inhibitor (PF-562271: 0.01, 0.1, 1, and 10 µM) cultured in monolayer for 12 h. Data shown are representative of three independent sets of experiments. Values were compared with the control and statistically significant values with p < 0.05 are designated by an asterisk (*) and p < 0.01 are designated by two asterisks (**).

28953264
In vivo PF-562271 (< 33 mg/kg p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in U87MG-bearing mice. PF-562271 (50 mg/kg p.o. bid) results in 86% tumor growth inhibition in BxPc3 xenografts mice and 45% tumor growth inhibition in PC3-M xenografts mice. PF-562271 (25 mg/kg, bid) results in 2-fold greater apoptosis in treated tumors in mice bearing H125 lung xenografts. [1] PF-562271 (33 mg/kg, p.o.) inhibits extensive movement of the tumor cells over 24 hours in mice. PF-562271 (33 mg/kg, p.o.) results in altered E-cadherin dynamics in mice, which correlates with reduced E-cadherin–dependent collective cell movement. [3] PF-562271 (25 mg/kg, p.o. bid) results in 62% tumor growth inhibition in PC3M-luc-C6 subcutaneuous local implant xenograft mouse model. [4] PF-562,271 (5 mg/kg, oral) results in significant and similar increases in osteocalcin and cancellous bone parameters and a decrease in tumor growth and signs of bone healing in rats implanted with MDA-MB-231 cells in the tibia. [5]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Athymic female mice bearing BxPc3 or PC3-M xenografts.
  • Formulation: 5% Gelucire
  • Dosages: 50 mg/kg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O
For best results, use promptly after mixing.
5 mg/ml

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 507.49
Formula

C21H20F3N7O3S

CAS No. 717907-75-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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FAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID