Catalog No.S7698

For research use only.

LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.

LY2584702 Chemical Structure

CAS No. 1082949-67-4

Selleck's LY2584702 has been cited by 16 publications

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

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Biological Activity

Description LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
p70S6K [1]
4 nM
In vitro

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2]

Methods Test Index PMID
Western blot p-rpS6 / rpS6 / p-RPS6KB1 / RPS6KB1 28792981
In vivo LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]

Protocol (from reference)

Animal Research:


  • Animal Models: U87MG glioblastoma and HCT116 colon carcinoma xenograft models
  • Dosages: 12.5 mg/kg BID
  • Administration: --

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 445.42


CAS No. 1082949-67-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01241461 Completed Drug: LY2584702 Cancer Eli Lilly and Company November 2010 Phase 1
NCT01115803 Terminated Drug: LY2584702|Drug: Erlotinib|Drug: Everolimus Metastases Neoplasm|Carcinoma Non-small Cell Lung|Renal Cell Carcinoma|Neuroendocrine Tumors Eli Lilly and Company March 2010 Phase 1
NCT01394003 Terminated Drug: LY2584702 Advanced Cancer Eli Lilly and Company November 2008 Phase 1

(data from, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
what is the difference between S7698 and S7704? Ie., what does the tosylate group do?

S7698 is the free base of the compound and S7704 is its tosylate salt. Chemically, salt form is more stable and has a better solubility than free base, however, it also has a higher molecular weight. Biologically, these two forms have the same activities.

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