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LY2584702

Name: LY2584702
Brand: Selleck Chemicals
SKU: S7698
Rating: 5 (24 reviews)

Catalog No.S7698 Purity:99.02%

LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.

LY2584702 Chemical Structure

CAS No. 1082949-67-4

Purity & Quality Control

Batch: Purity: 99.02%

99.02

LY2584702 Related Products

Related Targets	p70 S6K p70 S6K1 RSK1 RSK2 RSK3 RSK4	Click to Expand
Related Products	PF-4708671 BI-D1870 LY2584702 Tosylate LJI308 LJH685	Click to Expand
Related Compound Libraries	Kinase Inhibitor Library PI3K/Akt Inhibitor Library Apoptosis Compound Library Cell Cycle compound library NF-κB Signaling Compound Library	Click to Expand

Signaling Pathway

S6 Kinase Signaling Pathway

Biological Activity

Description

LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.

Targets

p70S6K ^[1]

4 nM

In vitro
In vitro	In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. ^[1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor or with the mTOR inhibitor. ^[2]
Cell Research	Cell lines	Neuronal cells
	Concentrations	250 nM
	Incubation Time	24 h
	Method	Cells were treated with indicated concentration of drug for 24 h.
Experimental Result Images	Methods	Biomarkers	Images	PMID
Experimental Result Images	Western blot	p-rpS6 / rpS6 / p-RPS6KB1 / RPS6KB1		28792981

In Vivo
In vivo	LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. ^[1]
Animal Research	Animal Models	U87MG glioblastoma and HCT116 colon carcinoma xenograft models
	Dosages	12.5 mg/kg BID
	Administration	--

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT01241461	Completed	Cancer	Eli Lilly and Company	November 2010	Phase 1
NCT01115803	Terminated	Metastases Neoplasm\|Carcinoma Non-small Cell Lung\|Renal Cell Carcinoma\|Neuroendocrine Tumors	Eli Lilly and Company	March 2010	Phase 1
NCT01394003	Terminated	Advanced Cancer	Eli Lilly and Company	November 2008	Phase 1

References

Chemical Information & Solubility

Molecular Weight	445.42	Formula	C₂₁H₁₉F₄N₇
CAS No.	1082949-67-4	SDF	Download LY2584702 SDF
Smiles	CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 4.44 mg/mL ( (9.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo Batch: Add solvents to the product individually and in order.				In vivo Formulation Calculator
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.500mg/ml (3.37mM)
	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.370mg/ml (0.83mM)

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

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Frequently Asked Questions

Question 1:
what is the difference between S7698 and S7704? Ie., what does the tosylate group do?

Answer:
S7698 is the free base of the compound and S7704 is its tosylate salt. Chemically, salt form is more stable and has a better solubility than free base, however, it also has a higher molecular weight. Biologically, these two forms have the same activities.

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