Catalog No.S7698

LY2584702 Chemical Structure

Molecular Weight(MW): 445.42

LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.

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Cited by 6 Publications

5 Customer Reviews

  • Murine DCs were pretreated with PBS or kinase inhibitors (10 μmol/l) wortmanni LY2584702 2 h prior to nicotine (10−7 mol/l) 12~15 h stimulation. MR expression was determined via western blot analyses (C, F). β-actin was used as an internal control.

    Oncotarget, 2016, 7(25):38451-38466. LY2584702 purchased from Selleck.

    (A) Flow cytometry for TNF-α and IL-12 p40 intracellular expression and ELISA assays for IL-12p70 and IL-23 in supernatants of untreated or treated cells after 24 h. Results were expressed as pictograms per milliliter (± SD) from four independent experiments, each performed in triplicate. *p < 0.05 versus IFN-γ, **p < 0.01 versus IFN-γ.

    J Immunol, 2016, 197(9):3545-3553. LY2584702 purchased from Selleck.

  • Peripheral blood monocytes were mock or HCMV infected, or treated with GMCSF or M-CSF for 30 min. Levels of p-S6K (T389), and S6K were detected by immunoblotting from whole cell lysates. Membranes were then reprobed for β-actin as a loading control. Data are representative of 3-6 independent blood donors.

    Antiviral Res, 2018, 158:13-24. LY2584702 purchased from Selleck.

    Pre-warmed human neutrophil suspensions (37°C, 5 million cells/ml in HBSS containing 1.6 mM CaCl2) were incubated with PF-4708671, LY2584702 or vehicle (DMSO) for 5 minutes, then stimulated with 100 nM thapsigargin for 10 minutes. B) Samples were processed and analyzed for S6 and phospho-S6 content as described in methods. Data are from one experiment, representative of three.

    PLoS One, 2017, 12(1):e0169804. LY2584702 purchased from Selleck.

  • Western blot analysis of RPS6KB1, p-RPS6KB1, rpS6 and p-rpS6 in adenocarcinoma cell line A549 and squamous cell carcinoma cell line SK-MES-1 with various LY2584702 concentrations. DMSO without any LY2584702 were expressed as a concentration of 0. β-actin was used as a loading control.

    PLoS One, 2017, 12(8):e0182891. LY2584702 purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
p70S6K [1]
4 nM
In vitro

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2]

In vivo LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]


Animal Research:


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  • Animal Models: U87MG glioblastoma and HCT116 colon carcinoma xenograft models
  • Formulation: --
  • Dosages: 12.5 mg/kg BID
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 1 mg/mL warmed (2.24 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 445.42


CAS No. 1082949-67-4
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    what is the difference between S7698 and S7704? Ie., what does the tosylate group do?

  • Answer:

    S7698 is the free base of the compound and S7704 is its tosylate salt. Chemically, salt form is more stable and has a better solubility than free base, however, it also has a higher molecular weight. Biologically, these two forms have the same activities.

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID