LY2584702 Tosylate

For research use only.

Catalog No.S7704

7 publications

LY2584702 Tosylate Chemical Structure

CAS No. 1082949-68-5

LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.

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Selleck's LY2584702 Tosylate has been cited by 7 publications

1 Customer Review

  • Samples were processed and analyzed for S6 and phospho-S6 content as described in methods.

    PLoS One, 2017, 12(1):e0169804. LY2584702 Tosylate purchased from Selleck.

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Biological Activity

Description LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
p70S6K [1]
(Cell-free assay)
4 nM
In vitro

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2]

Methods Test Index PMID
Western blot
p-rpS6 / rpS6 / p-RPS6KB1 / RPS6KB1 ; 

PubMed: 28792981     

Western blot analysis of RPS6KB1, p-RPS6KB1, rpS6 and p-rpS6 in adenocarcinoma cell line A549 and squamous cell carcinoma cell line SK-MES-1 with various LY2584702 concentrations. DMSO without any LY2584702 were expressed as a concentration of 0. β-actin was used as a loading control.

In vivo LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]


Animal Research:


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  • Animal Models: U87MG glioblastoma and HCT116 colon carcinoma xenograft models
  • Dosages: 12.5 mg/kg BID
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 7 mg/mL warmed (11.33 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 617.62


CAS No. 1082949-68-5
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F

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Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    What is the difference between S7698 and S7704? i.e, what does the tosylate group do?

  • Answer:

    S7698 is the free base of the compound and S7704 is its tosylate salt. Chemically, salt form is more stable and has a better solubility than free base, however, it also has a higher molecular weight. Biologically, these two forms have the same activities.

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID