Ledipasvir (GS5885) | HCV Protease inhibitor | 5+ Citations | In Stock

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Quality Control

Batch: Purity: 99.85%

99.85

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV
Other HCV Protease Inhibitors	Danoprevir Lomibuvir (VX-222) Asunaprevir Tizoxanide PSI-6206 (GS-331007) 2'-C-Methylcytidine Voxilaprevir Tegobuvir Herba taxilli Extract Mecarbinate

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (112.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	889.0	Formula	C₄₉H₅₄F₂N₈O₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1256388-51-8	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			SMILES	CC(C)C(C(=O)N1CC2(CC2)CC1C3=NC=C(N3)C4=CC5=C(C=C4)C6=C(C5(F)F)C=C(C=C6)C7=CC8=C(C=C7)N=C(N8)C9C1CCC(C1)N9C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	HCV
References	[1] https://pubmed.ncbi.nlm.nih.gov/24320933/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2023-08-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03903185	COMPLETED	Hepatitis C, Chronic; Hematologic Malignancy	Ain Shams University	2019-03-01	PHASE1; PHASE2
NCT04353986	UNKNOWN	HCV Infection; Beta Thalassemia Major	Ain Shams University	2018-06-11	PHASE3
NCT03402165	UNKNOWN	Hepatitis C	Sherief Abd-Elsalam	2017-01-01	PHASE4
NCT02959359	WITHDRAWN	Hepatocellular Carcinoma	Taipei Veterans General Hospital, Taiwan	2016-11	PHASE4
NCT02555943	COMPLETED	Chronic Hepatitis C Infection; HBV Coinfection; Hepatitis B Reactivation	Humanity and Health Research Centre	2015-02	PHASE2; PHASE3
NCT03261349	UNKNOWN	Indolent Lymphoma	National Taiwan University Hospital	2017-09-01	PHASE2

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Handling Instructions

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Ledipasvir (GS5885) HCV Protease inhibitor

Chemical Structure

Molecular Weight: 889.0