IACS-010759 (IACS-10759)

For research use only.

Catalog No.S8731

3 publications

IACS-010759 (IACS-10759) Chemical Structure

CAS No. 1570496-34-2

IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 289 In stock
USD 157 In stock
USD 507 In stock
USD 1170 In stock
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Selleck's IACS-010759 (IACS-10759) has been cited by 3 publications

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Biological Activity

Description IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I.
oxidative phosphorylation [2]
10 nM
In vitro

IACS-010759 significantly reduced viability measured by CTG assay in all cell lines tested (Notch mutant: Pf382, 1301, Jurkat, MOLT-4, P12-Ichikawa and Notch wt: T-ALL1). Treatment of T-ALL with IACS-010759 had effectively inhibited FA-stimulated mitochondrial respiration indicated by decreased oxygen consumption rates (OCR). However, the cells maintain an ability to generate energy via glycolysis, indicated by high extracellular acidification rate (ECAR) in both, control and IACS-treated groups[1]. In CLL cells, IACS-010759 causes minimal cell death, inhibits oxygen consumption rate (OCR) and increases glycolysis. It also decreases intracellular ribonucleotide triphosphate pools in CLL[2]. In sensitive AML cells IACS-010759 induces AMPK activation leading to mTOR suppression which results in cell growth inhibition in AML cells. AMPK and mTOR could be putative biomarkers of anti-leukemia activity of the novel OxPhosi IACS-010759[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Z-138 M1T5eHBzd2yrZnXyZZRqd25iYYPzZZk> MkLiO|IhcA>? NHO3VVVKSUOVLUCxNFc2QSCrbnjpZol1\WRidHjlJJBzd2yrZnXyZZRqd25ib3[gXk0yOzhiaX6gZUBld3OnZHXw[Y5l\W62IH3hco5meiCjdDDuZY5wdW:uYYKgZ49v[2WwdILheIlwdnN? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTB4OES0NEc,OzFyNki0OFA9N2F-
Maver-1 M{fYVnBzd2yrZnXyZZRqd25iYYPzZZk> MUi3NkBp NX3VN2c3UUGFUz2wNVA4PTliaX7obYJqfGWmIITo[UBxem:uaX\ldoF1cW:wIH;mJG1ifmW{LUGgbY4h[SCmb4Pl[IVx\W6mZX70JI1idm6ncjDheEBv[W6xbX;sZZIh[2:wY3XueJJifGmxboO= NEWwV3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUC2PFQ1OCd-M{GwOlg1PDB:L3G+
H1975 M{XYdXBzd2yrZnXyZZRqd25iYYPzZZk> Mln1NkBl[Xm| M1nVc4hieyCuaX3peIVlKGWoZnXjeEBwdiClZXzsJJBzd2yrZnXyZZRqd25? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZ{NUOyPUc,OzB4MkWzNlk9N2F-
CLL cells M3HO[mZ2dmO2aX;uJIF{e2G7 NVHRVJVLOTByIH7N Mn;NNlQhcA>? NWnIUlJHcW6qaXLpeJMhV0OUIHHu[EBqdmO{ZXHz[ZMh\2y7Y3;sfZNqeyCrbjDDUGwh[2WubIO= NHTQV2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi2NVg1Pyd-Mkm4OlE5PDd:L3G+

... Click to View More Cell Line Experimental Data


Cell Research:


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  • Cell lines: CLL cells
  • Concentrations: 30 nM, 100 nM, 300 nM, 1 μM, and 3 μM
  • Incubation Time: 24 or 48 h
  • Method:

    CLL cells are treated with IACS-010759 for 24 or 48 h and were then stained with acridine orange and analyzed by flow cytometry.

    (Only for Reference)

Solubility (25°C)

In vitro DMSO 27 mg/mL (47.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 562.56


CAS No. 1570496-34-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1=NC(=NN1CC2=CC(=CC=C2)N3CCC(CC3)S(=O)(=O)C)C4=NC(=NO4)C5=CC=C(C=C5)OC(F)(F)F

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID