IACS-010759 (IACS-10759)

Catalog No.S8731

IACS-010759 (IACS-10759) Chemical Structure

Molecular Weight(MW): 562.56

IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I.

Size Price Stock Quantity  
USD 157 In stock
USD 507 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Biological Activity

Description IACS-010759 (IACS-10759) is a potent and selective oxidative phosphorylation inhibitor (IC50 < 10 nM) that blocks cellular respiration through inhibition of complex I.
Targets
oxidative phosphorylation [2]
()
In vitro

IACS-010759 significantly reduced viability measured by CTG assay in all cell lines tested (Notch mutant: Pf382, 1301, Jurkat, MOLT-4, P12-Ichikawa and Notch wt: T-ALL1). Treatment of T-ALL with IACS-010759 had effectively inhibited FA-stimulated mitochondrial respiration indicated by decreased oxygen consumption rates (OCR). However, the cells maintain an ability to generate energy via glycolysis, indicated by high extracellular acidification rate (ECAR) in both, control and IACS-treated groups[1]. In CLL cells, IACS-010759 causes minimal cell death, inhibits oxygen consumption rate (OCR) and increases glycolysis. It also decreases intracellular ribonucleotide triphosphate pools in CLL[2]. In sensitive AML cells IACS-010759 induces AMPK activation leading to mTOR suppression which results in cell growth inhibition in AML cells. AMPK and mTOR could be putative biomarkers of anti-leukemia activity of the novel OxPhosi IACS-010759[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Z-138 M1\leXBzd2yrZnXyZZRqd25iYYPzZZk> MVe3NkBp NUnyV45rUUGFUz2wNVA4PTliaX7obYJqfGWmIITo[UBxem:uaX\ldoF1cW:wIH;mJHouOTN6IHnuJIEh\G:|ZXTldIVv\GWwdDDtZY5v\XJiYYSgcoFvd22xbHHyJINwdmOnboTyZZRqd26| NWHwOVl6OzFyNki0OFA>
Maver-1 NV\1PHdIWHKxbHnm[ZJifGmxbjDhd5NigQ>? NEXVXJY4OiCq NVnScoplUUGFUz2wNVA4PTliaX7obYJqfGWmIITo[UBxem:uaX\ldoF1cW:wIH;mJG1ifmW{LUGgbY4h[SCmb4Pl[IVx\W6mZX70JI1idm6ncjDheEBv[W6xbX;sZZIh[2:wY3XueJJifGmxboO= NVfjWm93OzFyNki0OFA>
H1975 NFHSb|ZRem:uaX\ldoF1cW:wIHHzd4F6 NEDzdFgzKGSjeYO= MknZbIF{KGyrbXn0[YQh\W[oZXP0JI9vKGOnbHygdJJwdGmoZYLheIlwdg>? MlmyN|A3OjV|Mkm=
CLL cells MlXOSpVv[3Srb36gZZN{[Xl? NITLNYMyODBibl2= M3HVXVI1KGh? M3jsbIlvcGmkaYTzJG9EWiCjbnSgbY5kemWjc3XzJIdtgWOxbInzbZMhcW5iQ1zMJINmdGy| MX[yPVg3OTh2Nx?=

... Click to View More Cell Line Experimental Data

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: CLL cells
  • Concentrations: 30 nM, 100 nM, 300 nM, 1 μM, and 3 μM
  • Incubation Time: 24 or 48 h
  • Method:

    CLL cells are treated with IACS-010759 for 24 or 48 h and were then stained with acridine orange and analyzed by flow cytometry.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 27 mg/mL (47.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 562.56
Formula

C25H25F3N6O4S

CAS No. 1570496-34-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03291938 Recruiting Malignant Neoplasm of Breast|Malignant Neoplasms of Bone and Articular Cartilage|Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Mesothelial and Soft Tissue|Malignant Neoplasms of Respiratory and Intrathoracic Organs|Malignant Neoplasms of Thyroid and Other Endocrine Glands|Malignant Neoplasms of Urinary Tract|Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic M.D. Anderson Cancer Center November 13 2017 Phase 1
NCT03291938 Recruiting Malignant Neoplasm of Breast|Malignant Neoplasms of Bone and Articular Cartilage|Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Mesothelial and Soft Tissue|Malignant Neoplasms of Respiratory and Intrathoracic Organs|Malignant Neoplasms of Thyroid and Other Endocrine Glands|Malignant Neoplasms of Urinary Tract|Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic M.D. Anderson Cancer Center November 13 2017 Phase 1
NCT02882321 Recruiting Acute Myeloid Leukemia M.D. Anderson Cancer Center|The Leukemia and Lymphoma Society September 29 2016 Phase 1
NCT02882321 Recruiting Acute Myeloid Leukemia M.D. Anderson Cancer Center|The Leukemia and Lymphoma Society September 29 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Others Products0

Tags: buy IACS-010759 (IACS-10759) | IACS-010759 (IACS-10759) supplier | purchase IACS-010759 (IACS-10759) | IACS-010759 (IACS-10759) cost | IACS-010759 (IACS-10759) manufacturer | order IACS-010759 (IACS-10759) | IACS-010759 (IACS-10759) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID