For research use only.
CAS No. 313967-18-9
FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
Selleck's FLI-06 has been cited by 9 publications
2 Customer Reviews
In the presence of FLI-06 (100 nM), wound healing assay was conducted to evaluate the cell motility after transfection. Data were from three independent experiments and were Mean ± SD. values. **P < 0.01 compared to cells transfected with vector, ##P < 0.01 compared to cells transfected with ZFR. Scale bar represents 200 μm.
Am J Cancer Res, 2017, 7(9):1804-1819. FLI-06 purchased from Selleck.
G. In the presence of FLI-06, wound healing assay was conducted to evaluate the cell motility after transfection. Scale bar represents 200 μm. H. In the presence of FLI-06, invasion assay was conducted to evaluate the cell invasiveness after transfection. Data were from three independent experiments and were Mean ± SD. **p < 0.01 compared to cells transfected with vector, ##p < 0.01 compared to cells transfected with ACTG2. Scale bar represents 100 μm.
Biochem Biophys Res Commun, 2016. FLI-06 purchased from Selleck.
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Choose Selective Notch Inhibitors
|Description||FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.|
In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER. 
|In vivo||FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos. |
|In vitro||DMSO||88 mg/mL (200.67 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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