FLI-06
Catalog No.S7399
Molecular Weight(MW): 438.52
FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
1 Customer Review
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G. In the presence of FLI-06, wound healing assay was conducted to evaluate the cell motility after transfection. Scale bar represents 200 μm. H. In the presence of FLI-06, invasion assay was conducted to evaluate the cell invasiveness after transfection. Data were from three independent experiments and were Mean ± SD. **p < 0.01 compared to cells transfected with vector, ##p < 0.01 compared to cells transfected with ACTG2. Scale bar represents 100 μm.
Biochem Biophys Res Commun, 2016. FLI-06 purchased from Selleck.
Purity & Quality Control
Choose Selective Gamma-secretase Inhibitors
Biological Activity
| Description | FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. | ||||||||||||||||
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| Targets |
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| In vitro |
In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER. [1] |
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| Cell Data |
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| In vivo | FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos. [1] |
Protocol
| Animal Research: |
+ Expand
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Solubility (25°C)
| In vitro | DMSO | 88 mg/mL (200.67 mM) |
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| Ethanol | 8 mg/mL (18.24 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 438.52 |
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| Formula | C25H30N2O5 |
| CAS No. | 313967-18-9 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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