IMR-1

Catalog No.S8280

For research use only.

IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.

IMR-1 Chemical Structure

CAS No. 310456-65-6

Selleck's IMR-1 has been cited by 5 Publications

Purity & Quality Control

Choose Selective Notch Inhibitors

Biological Activity

Description IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 26 μM.
Targets
Notch [1]
(Cell-free assay)
26 μM

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: OE33 and 786-0 cells
  • Concentrations: 5, 10, 15, 25 μM
  • Incubation Time: --
  • Method:

    ChIP assay on the HES1 promoter using the indicated antibodies following treatment of OE33 and 786-0 cells with DAPT (15 μM), IMR-1 (25 μM), or vehicle (DMSO) using GAPDH as loading control.

Animal Research:

[1]

  • Animal Models: xenograft model(mouse)
  • Dosages: 15 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 353.41
Formula

C15H15NO5S2

CAS No. 310456-65-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCOC(=O)COC1=C(C=C(C=C1)C=C2C(=O)NC(=S)S2)OC

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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