Home MAPK MNK MNK2 Inhibitors

MNK2 Inhibitors

  • MNK1
  • MNK2
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance. Pan MNK2, IC50: 1 nM
S6888 SEL201 SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8  nM and 5.4 nM, respectively. Pan MNK2, IC50: 5.4 nM
S6658 ETC-206 (AUM 001) ETC-206 (AUM 001, ETC-1907206) is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively. Pan MNK2, IC50: 86 nM