MNK
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S7421 | CGP 57380 | <1 mg/mL | 48 mg/mL | <1 mg/mL |
| S8275 | eFT-508 (eFT508) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
- MNK Inhibitors (2)
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S7421 |
CGP 57380CGP 57380 is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. |
PC-3 cells were seeded in 6-well plates. On the next day, cells were treated with the indicated concentrations of 3-AWA, LY294002, CGP57380 or Rapamycin alone and or combination for 12 h. The cells were then subjected to preparation of whole-cell lysates for detection of the indicated proteins using western blotting. The western blots are the representative of three similar experiments.
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| S8275 |
eFT-508 (eFT508)eFT-508 (eFT508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. |
