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Dinitolmide Parasite inhibitor

Name: Dinitolmide
Brand: Selleck Chemicals
SKU: S4141
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4141

Dinitolmide (Zoalene) is a broad-spectrum anticoccidial drug.

Chemical Structure

Molecular Weight: 225.16

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S414101 DMSO]45 mg/mL]false]Ethanol]1 mg/mL]false]Water]Insoluble]false Purity: 99.7%

99.7

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Chemical Information, Storage & Stability

Molecular Weight	225.16	Formula	C₈H₇N₃O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	148-01-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Zoalene			Smiles	CC1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])C(=O)N

Solubility

In vitro
Batch:

DMSO : 45 mg/mL (199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.250mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 45 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.450mg/ml (2.00mM)	Taking the 1 mL working solution as an example, add 50 μL of 9 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Dinitolmide is a drug used for the prevention and treatment of coccidiosis in poultry. For prophylactic purposes the drug is used as an additive to poultry feeds at a level of between 40 and 250 p.p.m. and is sometimes used in conjunction with anti-blackhead drugs and antibiotics. Several spectrophotometric methods have been proposed for the determination of dinitolmide. ^[1]
In vivo	Overall mean recoveries greater than 85% are obtained with Zoalene and its 2 monoamino metabolites in breast, thigh, and liver tissues fortified with 0.25-2.00 ppm. ^[2]
References	[1] http://pubs.rsc.org/en/content/articlepdf/1969/an/an9699401159 [2] https://pubmed.ncbi.nlm.nih.gov/3949706/

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Handling Instructions

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