Molecular Weight(MW): 283.37
Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.
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C, G0s2-null MEFs were transfected with HRAS and the following day treated with either 40 mmol/L of ATGL inhibitor atglistatin or DMSO (Vehicle) every 2 days. Left, representative plates. Right, the average of biologic triplicate determinations. Error bars, SD. The experiment was repeated twice with similar results.
Cancer Res, 2016, 76(5):1204-13.. Atglistatin purchased from Selleck.
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Choose Selective Lipase Inhibitors
|Description||Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.|
Atglistatin inhibits lipolysis in cell and organ cultures by targeting ATGL with no cytotoxicity up to a concentration of 50 μM. 
|In vivo||In vivo, Atglistatin (i.p.) results in Dose and time-dependent inhibition of lipolysis. Oral treatment of Atglistatin causes a dose-dependent decrease in FA and glycerol of up to 50% and 62%, respectively, and also causes a strong reduction in plasma TG levels (43%). In addition, Atglistatin shows a distinct tissue distribution and primarily accumulates in liver and adipose tissue. |
Determination of lipase activity:For determination of lipase activity, lysates are incubated with a substrate containing radiolabeled [9,10-3H(N)]-triolein. Subsequently, FA are extracted and quantitated by liquid scintilation counting. Data are presented as mean ?S.D. of triplicate determinations and representative for at least three independent experiments.
|In vitro||DMSO||56 mg/mL (197.62 mM)|
|Ethanol||4 mg/mL (14.11 mM)|
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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