Valsartan (CGP-48933)

For research use only.

Catalog No.S1894

3 publications

Valsartan (CGP-48933) Chemical Structure

CAS No. 137862-53-4

Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.

Selleck's Valsartan (CGP-48933) has been cited by 3 publications

1 Customer Review

  • Effect of valsartan and cardamonin on Ang II-induced phosphorylation of p38 MAPK and ERK. Representative results of Western blot.

    J Nat Med 2014 68(3), 623-9. Valsartan (CGP-48933) purchased from Selleck.

Purity & Quality Control

Choose Selective Angiotensin Receptor Inhibitors

Biological Activity

Description Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.
angiotensin II receptor [1]
In vitro

Valsartan dose-dependently inhibits the vasoconstriction induced by angiotensin II and lowers blood pressure in renin-dependent models of hypertension. Valsartan is at least as effective as ACE inhibitors, diuretics, beta-blockers and calcium antagonists. [1]

In vivo Valsartan results in improved glucose tolerance, reduced fasting blood glucose levels, and reduced serum insulin levels in mice fed a Western diet. Valsartan treatment also blocks Western diet-induced increases in serum levels of the proinflammatory cytokines interferon-gamma and monocyte chemotactic protein 1. Valsartan enhances mitochondrial function and prevents Western diet-induced decreases in glucose-stimulated insulin secretion in the pancreatic islets of mice. Valsartan treatment blocks or attenuates Western diet-induced changes in expression of several key inflammatory signals: interleukin 12p40, interleukin 12p35, tumor necrosis factor-alpha, interferon-gamma, adiponectin, platelet 12-lipoxygenase, collagen 6, inducible NO synthase, and AT1R in isolated adipocytes. [2] Valsartan significantly increases insulin-mediated 2-[3H]deoxy-d-glucose (2-[3H]DG) uptake into skeletal muscle and attenuates the increase in plasma glucose concentration after a glucose load and plasma concentrations of glucose and insulin. Valsartan treatment exaggerates the insulin-induced phosphorylation of IRS-1, the association of IRS-1 with the p85 regulatory subunit of phosphoinositide 3 kinase (PI 3-K), PI 3-K activity, and translocation of GLUT4 to the plasma membrane. Valsartan also reduces tumor necrosis factor-alpha (TNF-alpha) expression and superoxide production in skeletal muscle of KK-Ay mice. [3]


Solubility (25°C)

In vitro DMSO 87 mg/mL (199.76 mM)
Water Insoluble
Ethanol '87 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 435.52


CAS No. 137862-53-4
Storage powder
in solvent
Synonyms N/A
Smiles CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04735354 Active not recruiting Drug: sacubitril/valsartan Heart Failure Novartis Pharmaceuticals|Novartis October 27 2020 --
NCT04753112 Recruiting Drug: Sacubitril / Valsartan Oral Tablet [Entresto] Pulmonary Hypertension Germans Trias i Pujol Hospital October 29 2020 Phase 3
NCT04128891 Withdrawn Drug: Sacubitril-Valsartan Heart Failure With Preserved Ejection Fraction Flinders University February 1 2020 Phase 3
NCT04206501 Recruiting Device: Medtronic ICD with Opti Vol-Monitor Ischemic and Non-ischemic Cardiomyopathy University of Rochester|Medtronic February 5 2020 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID