For research use only.
CAS No. 137862-53-4
Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.
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|Description||Valsartan (CGP-48933) is a selective angiotensin II receptor antagonist, used to treat high blood pressure and congestive heart failure.|
Valsartan dose-dependently inhibits the vasoconstriction induced by angiotensin II and lowers blood pressure in renin-dependent models of hypertension. Valsartan is at least as effective as ACE inhibitors, diuretics, beta-blockers and calcium antagonists. 
|In vivo||Valsartan results in improved glucose tolerance, reduced fasting blood glucose levels, and reduced serum insulin levels in mice fed a Western diet. Valsartan treatment also blocks Western diet-induced increases in serum levels of the proinflammatory cytokines interferon-gamma and monocyte chemotactic protein 1. Valsartan enhances mitochondrial function and prevents Western diet-induced decreases in glucose-stimulated insulin secretion in the pancreatic islets of mice. Valsartan treatment blocks or attenuates Western diet-induced changes in expression of several key inflammatory signals: interleukin 12p40, interleukin 12p35, tumor necrosis factor-alpha, interferon-gamma, adiponectin, platelet 12-lipoxygenase, collagen 6, inducible NO synthase, and AT1R in isolated adipocytes.  Valsartan significantly increases insulin-mediated 2-[3H]deoxy-d-glucose (2-[3H]DG) uptake into skeletal muscle and attenuates the increase in plasma glucose concentration after a glucose load and plasma concentrations of glucose and insulin. Valsartan treatment exaggerates the insulin-induced phosphorylation of IRS-1, the association of IRS-1 with the p85 regulatory subunit of phosphoinositide 3 kinase (PI 3-K), PI 3-K activity, and translocation of GLUT4 to the plasma membrane. Valsartan also reduces tumor necrosis factor-alpha (TNF-alpha) expression and superoxide production in skeletal muscle of KK-Ay mice. |
|In vitro||DMSO||87 mg/mL (199.76 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04735354||Active not recruiting||Drug: sacubitril/valsartan||Heart Failure||Novartis Pharmaceuticals|Novartis||October 27 2020||--|
|NCT04753112||Recruiting||Drug: Sacubitril / Valsartan Oral Tablet [Entresto]||Pulmonary Hypertension||Germans Trias i Pujol Hospital||October 29 2020||Phase 3|
|NCT04128891||Withdrawn||Drug: Sacubitril-Valsartan||Heart Failure With Preserved Ejection Fraction||Flinders University||February 1 2020||Phase 3|
|NCT04206501||Recruiting||Device: Medtronic ICD with Opti Vol-Monitor||Ischemic and Non-ischemic Cardiomyopathy||University of Rochester|Medtronic||February 5 2020||Not Applicable|
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