Telmisartan
For research use only.
Catalog No.S1738 Synonyms: BIBR 277
4 publications

CAS No. 144701-48-4
Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
Selleck's Telmisartan has been cited by 4 publications
Purity & Quality Control
Choose Selective Angiotensin Receptor Inhibitors
Biological Activity
Description | Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. | |||||||||||||||||||||||||||||||||||||
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Targets |
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In vitro |
Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. [1] Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. [2] Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. [3] |
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Cell Data |
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Assay |
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In vivo | Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet. [4] |
Protocol
Solubility (25°C)
In vitro | DMSO | 13 mg/mL (25.26 mM) |
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Water | Insoluble | |
Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 514.62 |
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Formula | C33H30N4O2 |
CAS No. | 144701-48-4 |
Storage |
powder in solvent |
Synonyms | BIBR 277 |
Smiles | CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C |
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) | ||||||||||
Dosage | mg/kg | Average weight of animals | g | Dosing volume per animal | ul | Number of animals | ||||
Step 2: Enter the in vivo formulation () | ||||||||||
% DMSO % % Tween 80 % ddH2O | ||||||||||
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: : mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL,)
Method for preparing in vivo formulation:Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80,mix and clarify, next add μL ddH2O,mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Bio Calculators
Molarity Calculator
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Dilution Calculator
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Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
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NCT03705533 | Completed | Drug: Telmisartan|Drug: Micardis | Bioequivalence | Pharmtechnology LLC|Algorithme Pharma An Altasciences Company | September 7 2018 | Phase 1 |
NCT03461081 | Completed | Drug: telmisartan/amlodipine and atorvastatin | Hypertension With Hyperlipidemia | Jeil Pharmaceutical Co. Ltd. | May 7 2017 | Phase 1 |
NCT03116516 | Completed | Drug: Temisartan/Amlodipine+Rosuvastatin|Drug: YHP1604 | Hypertension|Hyperlipidemia | Yuhan Corporation | April 21 2017 | Phase 1 |
NCT02951962 | Completed | Drug: Twynsta 80/5mg|Drug: Crestor 20mg | Hypertension|Hyperlipidemia | Yuhan Corporation | August 2016 | Phase 1 |
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