For research use only.

Catalog No.S1738 Synonyms: BIBR 277

4 publications

Telmisartan  Chemical Structure

Molecular Weight(MW): 514.62

Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

Size Price Stock Quantity  
10mM (1mL in DMSO) RMB 742.58 In stock
RMB 563.16 In stock
RMB 977.63 In stock
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Selleck's Telmisartan has been cited by 4 publications

1 Customer Review

  • (B) Dose-response curves of each drug for acute G protein or barr activation derived from the CellKey assay. LOS: Losartan; EXP: EXP3174; TEL: Telmisartan.

    Sci Rep, 2015, 5:8116.. Telmisartan purchased from Selleck.

Purity & Quality Control

Choose Selective Angiotensin Receptor Inhibitors

Biological Activity

Description Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
angiotensin II receptor [1]
In vitro

Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. [1] Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. [2] Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells M1;pd2Z2dmO2aX;uJIF{e2G7 NVH6eVV1SW62YXfvcol{fCCjY4Tpeol1gSCjdDDoeY1idiCDVEGgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyCvZXHzeZJm\CCjZoTldkBwfmW{bnnnbJQhcW6ldXLheIlwdiCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE4xODJizszN MWCyOFQ3OjZ4NR?=
HepG2 cells NITMcG5HfW6ldHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGyrdnXyJJN1[WenIGDsZZNud2SrdX2gZoVz\2inaTDpcoZm[3Srb36gbY4hUGWyR{KgZ4VtdHNuIFnDOVA:OC5yMkWg{txO NUX1enVnOjJ3OE[xNlQ>
CV1 cells NYDiNZZXTnWwY4Tpc44h[XO|YYm= MlSwRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKGGocnnjZY4h\3KnZX6gcY9vc2W7IFPWNUBk\WyuczDifUBI[Wx2IITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3ME2yMlAzKM7:TR?= M3rieVIxODd7NkO2
HEK293 cells MlHvSpVv[3Srb36gZZN{[Xl? NGCycI1KdmirYnn0bY9vKG:oIHj1cYFvKE2DVFWxMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[W[2ZYKgNU42KG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVE4NjlizszN NVrCN|VlOjN{NEGwNlk>

... Click to View More Cell Line Experimental Data

Methods Test Index PMID
Western blot
p-eNOS / eNOS / p-AMPKα / AMPKα ; 

PubMed: 24827148     

HUVECs were incubated with the vehicle (DMSO) or telmisartan (0.1, 1, and 10 µM) for 2 h. A representative blot is shown. 

p-CREB / CREB / p-p38 MAPK / p38 MAPK; 

PubMed: 24827148     

HUVECs were incubated with telmisartan for 15 min to 4 h to evaluate the phosphorylation levels of p38MAPK Thr180/Tyr182 and CREB Ser133.

Cyclin D1 / CDK4 / CDK6 / CDK2 / Cylcin E / E2F2 ; 

PubMed: 28052030     

Western blot analysis of cyclin D1, Cdk4, Cdk6, Cdk2, cyclin E, and E2F2 in OE19 and SKGT-4 cells treated with 100 μM telmisartan.

24827148 28052030
In vivo Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet. [4]


Solubility (25°C)

In vitro DMSO 13 mg/mL (25.26 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 514.62


CAS No. 144701-48-4
Storage powder
in solvent
Synonyms BIBR 277
Smiles CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03705533 Completed Drug: Telmisartan|Drug: Micardis Bioequivalence Pharmtechnology LLC|Algorithme Pharma An Altasciences Company September 7 2018 Phase 1
NCT03461081 Completed Drug: telmisartan/amlodipine and atorvastatin Hypertension With Hyperlipidemia Jeil Pharmaceutical Co. Ltd. May 7 2017 Phase 1
NCT03116516 Completed Drug: Temisartan/Amlodipine+Rosuvastatin|Drug: YHP1604 Hypertension|Hyperlipidemia Yuhan Corporation April 21 2017 Phase 1
NCT02951962 Completed Drug: Twynsta 80/5mg|Drug: Crestor 20mg Hypertension|Hyperlipidemia Yuhan Corporation August 2016 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID