For research use only.

Catalog No.S1738 Synonyms: BIBR 277

4 publications

Telmisartan  Chemical Structure

CAS No. 144701-48-4

Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

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10mM (1mL in DMSO) USD 90 In stock
USD 70 In stock
USD 120 In stock
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Selleck's Telmisartan has been cited by 4 publications

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  • (B) Dose-response curves of each drug for acute G protein or barr activation derived from the CellKey assay. LOS: Losartan; EXP: EXP3174; TEL: Telmisartan.

    Sci Rep, 2015, 5:8116.. Telmisartan purchased from Selleck.

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Choose Selective Angiotensin Receptor Inhibitors

Biological Activity

Description Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
angiotensin II receptor [1]
In vitro

Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. [1] Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. [2] Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells MljWSpVv[3Srb36gZZN{[Xl? MnHaRY51[WexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBCXDFicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNJVyClZXzsd{Bu\WG|dYLl[EBi\nSncjDveoVzdmmpaISgbY5kfWKjdHnvckBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6wNFIh|ryP NVr4[GNjOjR2NkK2OlU>
HepG2 cells NWLGd|M6TnWwY4Tpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKGyrdnXyJJN1[WenIGDsZZNud2SrdX2gZoVz\2inaTDpcoZm[3Srb36gbY4hUGWyR{KgZ4VtdHNuIFnDOVA:OC5yMkWg{txO MWmyNlU5PjF{NB?=
CV1 cells NXy0copoTnWwY4Tpc44h[XO|YYm= NHXLeZpC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR3YyKGOnbHzzJIJ6KEejbESgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVIvODJizszN NI\mWm8zODB5OU[zOi=>
HEK293 cells MW\GeY5kfGmxbjDhd5NigQ>? NGjNPXNKdmirYnn0bY9vKG:oIHj1cYFvKE2DVFWxMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[W[2ZYKgNU42KG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVE4NjlizszN MVWyN|I1OTB{OR?=

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Methods Test Index PMID
Western blot
p-eNOS / eNOS / p-AMPKα / AMPKα ; 

PubMed: 24827148     

HUVECs were incubated with the vehicle (DMSO) or telmisartan (0.1, 1, and 10 µM) for 2 h. A representative blot is shown. 

p-CREB / CREB / p-p38 MAPK / p38 MAPK; 

PubMed: 24827148     

HUVECs were incubated with telmisartan for 15 min to 4 h to evaluate the phosphorylation levels of p38MAPK Thr180/Tyr182 and CREB Ser133.

Cyclin D1 / CDK4 / CDK6 / CDK2 / Cylcin E / E2F2 ; 

PubMed: 28052030     

Western blot analysis of cyclin D1, Cdk4, Cdk6, Cdk2, cyclin E, and E2F2 in OE19 and SKGT-4 cells treated with 100 μM telmisartan.

24827148 28052030
In vivo Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet. [4]


Solubility (25°C)

In vitro DMSO 13 mg/mL warmed (25.26 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 514.62


CAS No. 144701-48-4
Storage powder
in solvent
Synonyms BIBR 277
Smiles CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04736329 Not yet recruiting Drug: Telmisartan Heart Failure With Reduced Ejection Fraction|Renal Insufficiency Cairo University February 2021 Not Applicable
NCT03705533 Completed Drug: Telmisartan|Drug: Micardis Bioequivalence Pharmtechnology LLC|Algorithme Pharma An Altasciences Company September 7 2018 Phase 1
NCT03461081 Completed Drug: telmisartan/amlodipine and atorvastatin Hypertension With Hyperlipidemia Jeil Pharmaceutical Co. Ltd. May 7 2017 Phase 1
NCT02170246 Completed Drug: Telmisartan Acute HIV Infection|HIV Infections Yale University|National Institute of Neurological Disorders and Stroke (NINDS)|South East Asia Research Collaboration with Hawaii|University of California San Francisco|Walter Reed Army Institute of Research (WRAIR)|University of Hawaii|National Institute of Mental Health (NIMH) January 28 2015 Phase 1
NCT01578772 Completed Drug: Telmisartan Endothelial Dysfunction University of California Los Angeles|The Campbell Foundation August 2012 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID