For research use only.
CAS No. 55268-74-1
Praziquantel is an anthelmintic effective against flatworms.
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Schistosomicidal effects of PZQ, ART and OXA on 14-day-schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
PLoS Negl Trop Dis, 2015, 9(3):e00035.. Praziquantel purchased from Selleck.
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|Description||Praziquantel is an anthelmintic effective against flatworms.|
|In vitro||DMSO||63 mg/mL (201.65 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04314037||Completed||Drug: Cesol (Test)|Drug: Biltricide (Reference)||Healthy||Merck Healthcare KGaA Darmstadt Germany an affiliate of Merck KGaA Darmstadt Germany||June 17 2020||Phase 1|
|NCT03870204||Recruiting||Diagnostic Test: POC-CCA rapid urine test||Aged ≥2 Years in Schistosomiasis Affected Areas||Ina-Respond|National Institute of Health Research and Development Ministry of Health Republic of Indonesia|The National Institute of Allergy and Infectious Diseases United States||September 4 2019||--|
|NCT03437447||Completed||Drug: Cisticid|Drug: Biltricide||Healthy||Merck KGaA Darmstadt Germany||June 18 2018||Phase 1|
|NCT02194712||Completed||Other: Urine CAA detection||Schistosomiasis||Meta Roestenberg|Leiden University Medical Center||January 2015||--|
|NCT02271984||Completed||Drug: MSC2499550A|Drug: Cysticide||Healthy||Merck KGaA Darmstadt Germany||October 31 2014||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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