For research use only.
CAS No. 55268-74-1
Praziquantel is an anthelmintic effective against flatworms.
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Schistosomicidal effects of PZQ, ART and OXA on 14-day-schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
PLoS Negl Trop Dis, 2015, 9(3):e00035.. Praziquantel purchased from Selleck.
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Choose Selective Anti-infection Inhibitors
|Description||Praziquantel is an anthelmintic effective against flatworms.|
|In vitro||DMSO||63 mg/mL (201.65 mM)|
|Ethanol||63 mg/mL (201.65 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04635553||Recruiting||Drug: Praziquantel 600 milligram||Schistosomiasis||Institut de Recherche pour le Developpement||August 11 2020||--|
|NCT04314037||Completed||Drug: Cesol (Test)|Drug: Biltricide (Reference)||Healthy||Merck Healthcare KGaA Darmstadt Germany an affiliate of Merck KGaA Darmstadt Germany||June 17 2020||Phase 1|
|NCT03870204||Active not recruiting||Diagnostic Test: POC-CCA rapid urine test||Aged ≥2 Years in Schistosomiasis Affected Areas||Ina-Respond|National Institute of Health Research and Development Ministry of Health Republic of Indonesia|The National Institute of Allergy and Infectious Diseases United States||September 4 2019||--|
|NCT03437447||Completed||Drug: Cisticid|Drug: Biltricide||Healthy||Merck KGaA Darmstadt Germany||June 18 2018||Phase 1|
|NCT02194712||Completed||Other: Urine CAA detection||Schistosomiasis||Meta Roestenberg|Leiden University Medical Center||January 2015||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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