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Technical Data
| Formula | C16H16ClNO2S.H2SO4 |
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| Molecular Weight | 419.9 | CAS No. | 120202-66-6 | |
| Solubility (25°C)* | In vitro | DMSO | 83 mg/mL (197.66 mM) | |
| Ethanol | 46 mg/mL (109.54 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Clopidogrel (SR-25990C) Bisulfate is an oral, thienopyridine class antiplatelet agent. | |
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| In vitro | Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3] | |
| In vivo | Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5] |
Protocol (from reference)
References
Customer Product Validation
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, , Cell, 2018, 172(3):564-577.e13
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Data from [Data independently produced by , , Mol Carcinog, 2018, 57(12):1690-1697]
Selleck's Clopidogrel (SR-25990C) Bisulfate has been cited by 9 publications
| Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability [ Cell Mol Life Sci, 2024, 81(1):116] | PubMed: 38438808 |
| Clopidogrel Administration Impairs Post-Stroke Learning and Memory Recovery in Mice [ Int J Mol Sci, 2023, 24(14)11706] | PubMed: 37511466 |
| P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition [ Mol Ther, 2022, S1525-0016(22)00420-8] | PubMed: 35791881 |
| XJ-8, a natural compound isolated from Sanguis draxonis, inhibits platelet function and thrombosis by targeting MAP3K3 [ J Thromb Haemost, 2021, 10.1111/jth.15593] | PubMed: 34780114 |
| Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures [ Cell Rep, 2020, 33(5):108346] | PubMed: 33147450 |
| Towards the Therapeutic Use of TSP-1 (Thrombospondin-1)/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent [ Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120314571] | PubMed: 33232198 |
| P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine. [ J Neuroinflammation, 2019, 16(1):217] | PubMed: 31722730 |
| FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway [Toeda Y Mol Carcinog, 2018, 57(12):1690-1697] | PubMed: 30129678 |
| Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease. [Pagan JD, et al. Cell, 2017, S0092-8674(17)31431-9] | PubMed: 29275858 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.