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Daclatasvir (BMS-790052)
Catalog No.S1482 Synonyms: EBP883
For research use only.
Daclatasvir (BMS-790052, EBP883) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.
CAS No. 1009119-64-5
Selleck's Daclatasvir (BMS-790052) has been cited by 48 publications
Purity & Quality Control
Choose Selective HCV Protease Inhibitors
Related Compound Libraries
Other HCV Protease Products
Biological Activity
| Description | Daclatasvir (BMS-790052, EBP883) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Features | First-in-class, highly selective inhibitor of hepatitis C virus (HCV) NS5A with picomolar EC50 values. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Targets |
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| In vitro |
BMS-790052 is one of the most potent inhibitors of HCV replication reported so far. The mean EC50 valuses of BMS-790052 are 50 and 9 pM for HCV genotype 1a and 1b replicons, respectively. BMS-790052 displays a therapeutic index (CC50/EC50) of at least 105 and is inactive towards a panel of 10 RNA and DNA viruses, with EC50 higher than 10 μM. This confirms BMS-790052's specificity for HCV. [1] In Huh7 cells harboring the HCV genotype 1b replicons, BMS-790052 blocks both transient and stable HCV genome replication, with EC50 values raging from 1-15 pM. BMS-790052 (100 pM or 1 nM) has been shown to alter the subcellular localization and biochemical fractionation of NS5A. [2] BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with EC50 of 7-13 pM. Residue 30 of NS5A is an important site for BMS-790052-mediated resistance in the hybrid replicons. [3] |
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| Cell Data |
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Protocol (from reference)
| Kinase Assay:[4] |
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| Cell Research:[1] |
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| References |
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Solubility (25°C)
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In vitro |
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Chemical Information
| Molecular Weight | 738.88 | ||
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| Formula | C40H50N8O6 |
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| CAS No. | 1009119-64-5 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC | ||
In vivo Formulation Calculator (Clear solution)
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT04852614 | Recruiting | Diagnostic Test: Pharmacokinetic test | Hepatitis C Virus Infection | Ain Shams University | December 1 2020 | -- |
| NCT04773756 | Completed | Drug: Sofosbuvir 400 MG/ Daclatasvir 60mg | Covid19 | Alexandria University | November 1 2020 | Phase 4 |
| NCT03208322 | Unknown status | Other: Non-Interventional | Hepatitis C | Bristol-Myers Squibb | November 30 2018 | -- |
| NCT03487848 | Terminated | Drug: Daclatasvir|Drug: Sofosbuvir | Hepatitis C|Chronic Hepatitis | Bristol-Myers Squibb | June 25 2018 | Phase 2 |
| NCT03500562 | Terminated | -- | Chronic Hepatitis C | Bristol-Myers Squibb | May 8 2018 | -- |
(data from https://clinicaltrials.gov, updated on 2022-01-17)
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