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p97

Other Ubiquitin Related Inhibitors

E1 Activating DUB E2 conjugating E3 Ligase SUMO
Cat.No. Product Name Information Product Use Citations Product Validations
S7285 NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).
Nat Commun, 2025, 16(1):3546
Cancers (Basel), 2025, 17(13)2109
Cell, 2024, 187(21):6055-6070.e22
Verified customer review of NMS-873
S7199 DBeQ DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.
Cell Mol Immunol, 2024, 10.1038/s41423-024-01222-1
Virol Sin, 2023, 38(4):497-507
Virol J, 2022, 19(1):90
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS (3,4-Methylenedioxy-β-nitrostyrene) is a tyrosine kinase inhibitor that inhibits Syk, Src, and p97 with IC50 values of 2.5 μM, 29.3 μM, and 1.7 μM, respectively.
Journal of Biomedical Engineering, 2021, 38(5):903-910
Phytomedicine, 2019, 61:152859
J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133
Verified customer review of MNS (3,4-Methylenedioxy-β-nitrostyrene)
S9865 CB-5339 CB-5339 is a potent p97/Valosin Containing Protein (VCP) inhibitor with an IC50 of 9 nM.
Cell Rep, 2023, 42(11):113318
S4453 NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.
S0220 ML240 ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM.
S8101 CB-5083 CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
Nat Commun, 2025, 16(1):3546
EMBO J, 2025, 10.1038/s44318-025-00517-x
Proc Natl Acad Sci U S A, 2025, 122(27):e2426218122
Verified customer review of CB-5083

Signaling Pathway Map