p97

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p97 Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S0220 ML240 ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM.
S4453 NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133
Phytomedicine, 2019, 61:152859
Toxicol Res (Camb), 2016, 5(1):188-196
S7199 DBeQ DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.
Virol J, 2022, 19(1):90
Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x
J Virol, 2020, JVI.01570-20
S7285 NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).
PLoS One, 2022, 17(4):e0266478
Sci Transl Med, 2021, 13(587)eabg1168
Cell Chem Biol, 2021, S2451-9456(21)00356-1
S8101 CB-5083 CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
Cell Rep, 2022, 39(2):110664
Cell Death Dis, 2022, 13(3):203
PLoS One, 2022, 17(4):e0266478
S0220 ML240 ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM.
S4453 NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133
Phytomedicine, 2019, 61:152859
Toxicol Res (Camb), 2016, 5(1):188-196
S7199 DBeQ DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.
Virol J, 2022, 19(1):90
Nat Chem Biol, 2021, 10.1038/s41589-020-00726-x
J Virol, 2020, JVI.01570-20
S7285 NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).
PLoS One, 2022, 17(4):e0266478
Sci Transl Med, 2021, 13(587)eabg1168
Cell Chem Biol, 2021, S2451-9456(21)00356-1
S8101 CB-5083 CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
Cell Rep, 2022, 39(2):110664
Cell Death Dis, 2022, 13(3):203
PLoS One, 2022, 17(4):e0266478
Tags: p97 inhibitor|p97 agonist|p97 activator|p97 inducer|p97 antagonist|p97 signaling pathway|p97 assay kit