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Catalog No. Product Name Information Product Use Citations Product Validations
S7285 NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).
Nat Commun, 2025, 16(1):3546
Cell, 2024, 187(21):6055-6070.e22
Cell, 2024, 187(21):5967-5980.e17
S8101 CB-5083 CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
Nat Commun, 2025, 16(1):3546
Mol Cell Proteomics, 2025, 24(3):100920
Biomolecules, 2025, 15(1)76
S7199 DBeQ DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.
Cell Mol Immunol, 2024, 10.1038/s41423-024-01222-1
Virol Sin, 2023, 38(4):497-507
Virol J, 2022, 19(1):90
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
Phytomedicine, 2019, 61:152859
J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133
Toxicol Res (Camb), 2016, 5(1):188-196
S9865 CB-5339 CB-5339 is a potent p97/Valosin Containing Protein (VCP) inhibitor with an IC50 of 9 nM.
Cell Rep, 2023, 42(11):113318
S4453 NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.
S0220 ML240 ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM.
S7285 NMS-873 NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).
Nat Commun, 2025, 16(1):3546
Cell, 2024, 187(21):6055-6070.e22
Cell, 2024, 187(21):5967-5980.e17
S8101 CB-5083 CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
Nat Commun, 2025, 16(1):3546
Mol Cell Proteomics, 2025, 24(3):100920
Biomolecules, 2025, 15(1)76
S7199 DBeQ DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.
Cell Mol Immunol, 2024, 10.1038/s41423-024-01222-1
Virol Sin, 2023, 38(4):497-507
Virol J, 2022, 19(1):90
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene) MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
Phytomedicine, 2019, 61:152859
J Biomol Struct Dyn, 2019, 10.1080/07391102.2019.1640133
Toxicol Res (Camb), 2016, 5(1):188-196
S9865 CB-5339 CB-5339 is a potent p97/Valosin Containing Protein (VCP) inhibitor with an IC50 of 9 nM.
Cell Rep, 2023, 42(11):113318
S4453 NPD8733 NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration that specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family.
S0220 ML240 ML240 is an ATP-competitive inhibitor of p97 ATPase with an IC50 of 0.11 μM and a Ki of 0.22 μM.

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