For research use only.

Catalog No.S3667

Imipenem Chemical Structure

CAS No. 74431-23-5

Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections.

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Biological Activity

Description Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections.
AmpC β-lactamase [1]
In vitro

Imipenem, a β-lactam antibiotic, binds to penicillin binding protein 2 with the highest affinity and produces rounded cells. The binding of imipenem causes cells to lyse quickly and thereby to release less free endotoxin[1].

In vivo Imipenem has a very short half-life[1]. Imipenem has antimycobacterial activity both in a mouse model and in humans at high risk for failure of treatment for MDR (multiple-drug-resistant) tuberculosis[2].


Animal Research:[1]
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  • Animal Models: BALB/c mice
  • Dosages: 50, 75, and 100 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro Water 63 mg/mL (198.51 mM)
DMSO 1 mg/mL (3.15 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 317.36


CAS No. 74431-23-5
Storage powder
in solvent
Synonyms N/A
Smiles CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04493151 Not yet recruiting Drug: Imipenem Cilastatin and Relebactam Sepsis Joseph L. Kuti PharmD|Merck Sharp & Dohme Corp.|Hartford Hospital September 1 2020 Phase 1
NCT04147221 Recruiting Drug: Imipenem-relebactam Sepsis Hartford Hospital|Merck Sharp & Dohme Corp. February 10 2020 Phase 1
NCT03969901 Recruiting Drug: IMI/REL|Drug: Active Control Suspected or Documented Gram-negative Bacterial Infection Merck Sharp & Dohme Corp. October 8 2019 Phase 2|Phase 3
NCT03858387 Recruiting Drug: Meropenem|Drug: Imipenem Critical Illness|Bacterial Infections Prince of Songkla University September 1 2018 --
NCT02897466 Unknown status Other: Direct Antimicrobial Susceptibility Testing Ventilator-associated Pneumonia Assistance Publique - Hôpitaux de Paris December 11 2017 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID