Mixed Lineage Kinase

Inhibitory Selectivity

Mixed Lineage Kinase Products

Catalog No. Information Product Use Citations Product Validations
S7343

URMC-099

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.

S8251

Necrosulfonamide

Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).

Catalog No. Information Product Use Citations Product Validations
S7343

URMC-099

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.

S8251

Necrosulfonamide

Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).

Tags: MLK Inhibitors | MLKL Review