Taste Receptor

Inhibitory Selectivity

Isoform-specific Inhibitors

Taste Receptor Products

Catalog No. Information Product Use Citations Product Validations
S4022

Probenecid

Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.
S9006

Perillartine

Perillartine (Perilla sugar, Peryllartine) is a sweetener. Perillartine can activation of the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner.
S1273New

Amarogentin

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.
Catalog No. Information Product Use Citations Product Validations
S4022

Probenecid

Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. Probenecid is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker.
Catalog No. Information Product Use Citations Product Validations
S9006

Perillartine

Perillartine (Perilla sugar, Peryllartine) is a sweetener. Perillartine can activation of the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner.
Catalog No. Information Product Use Citations Product Validations
S1273New

Amarogentin

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.