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mGluR2 Selective Agonists | Modulators

  • NMDA receptor
  • AMPA receptor
  • mGluR2
  • mGluR3
  • mGluR4
  • mGluR5
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S6618 JNJ-42153605 JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM. Selective mGlu2 receptor, EC50: 17 nM
S6001 pomaglumetad (LY404039) LY404039 is a potent agonist of recombinant human mGlu2/mGlu3 receptors with Ki of 149 nM/92 nM, shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. Phase 3. Pan Recombinant human mGlu2, Ki: 149 nM; Rat neurons expressing native mGlu2/3, Ki: 88 nM