OX1 receptor Selective Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1545 SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

Selective OX1 (membrane), Ki: 27 nM; OX1 (whole cell), Ki: 57 nM
S7585 SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

Selective
S2160 Almorexant HCl

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

Pan OX1 receptor, IC50: 6.6 nM