OX1 receptor Selective Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1545 SB408124

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

Selective OX1 (membrane), Ki: 27 nM; OX1 (whole cell), Ki: 57 nM
S7585 SB-334867

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

Selective
S2160 Almorexant HCl

Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

Pan OX1 receptor, IC50: 6.6 nM