GlyT1 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
s4702 Sarcosine

Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

Selective
S8219 Bitopertin

Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.

Selective GlyT1, IC50: 25nM; GlyT1, IC50: 22 nM
S4218 Amoxapine

Amoxapine (CL 67772) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.

Pan GlyT1b, IC50: 1 mM