GlyT

Inhibitory Selectivity
Solubility

Catalog No.	Product Name	Solubility(25°C)
Catalog No.	Product Name	Water	DMSO	Alcohol
S4218	Amoxapine	<1 mg/mL	3 mg/mL	<1 mg/mL
S8219	Bitopertin	<1 mg/mL	100 mg/mL	100 mg/mL
S4702	Sarcosine	17 mg/mL	<1 mg/mL	<1 mg/mL

GlyT Inhibitors (3)

Catalog No.	Information	Product Use Citations	Product Validations
S4218	Amoxapine Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
S8219	Bitopertin Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
S4702	Sarcosine Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.

Catalog No.

Information

Product Use Citations

Product Validations

S4218

Amoxapine

Amoxapine is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.

S8219

Bitopertin

Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.

S4702