|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
|Pan||Chk2, IC50: <10 nM|
PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2. Phase 1.
|Pan||Chk2, Ki: 47 nM|
CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.
|Pan||Chk2, IC50: 697.4 nM|
|S2735||MK-8776 (SCH 900776)||
SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 500-fold selectivity against Chk2. Phase 2.
|Pan||Chk2, IC50: 1.5 μM|
There are no products matching the selection yet, if you have any question please do not hesitate to contact us.