5-HT4 Selective Inhibitors | Agonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2875 Prucalopride

Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.

Selective 5-HT4A, Ki: 2.5 nM; 5-HT4B, Ki: 8 nM
S4247 Prucalopride Succinate

Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.

Selective 5-HT4B, Ki: 8 nM; 5-HT4A, Ki: 2.5 nM
S3183 Amitriptyline HCl

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.

Selective 5-HT4, IC50: 7.31 nM
S1385 Mosapride Citrate

Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.