Riociguat (BAY 63-2521)

Catalog No.S8135

For research use only.

Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.

Riociguat (BAY 63-2521) Chemical Structure

CAS No. 625115-55-1

Selleck's Riociguat (BAY 63-2521) has been cited by 7 Publications

Purity & Quality Control

Choose Selective Guanylate Cyclase Inhibitors

Biological Activity

Description Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.
guanylate cyclase [1]
In vitro

BAY 63-2521 stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism. [1] Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes. [2] [3]

In vivo In chronic treatment of hypoxic mice and MCT-injected rats, Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature. [1]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Chronic hypoxic mice, and monocrotaline (MCT)-injected rats
  • Dosages: 10 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 422.42


CAS No. 625115-55-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04813926 Recruiting Drug: Riociguat (Adempas BAY63-2521) Pulmonary Arterial Hypertension Bayer|Xcenda LLC July 16 2021 --
NCT04780932 Recruiting Drug: Macitentan 10mg|Drug: Placebo Thromboembolic Pulmonary Hypertension|Chronic Disease|Inoperable Disease Assistance Publique - Hôpitaux de Paris|Janssen LP June 14 2021 Phase 2|Phase 3
NCT03389321 Completed Drug: Riociguat (Adempas)|Drug: Macitentan (Opsumit) Healthy Subjects Actelion January 9 2018 Phase 1
NCT02562235 Active not recruiting Drug: Riociguat (Adempas BAY63-2521) Hypertension Pulmonary Bayer|Merck Sharp & Dohme LLC October 29 2015 Phase 3

(data from, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Riociguat (BAY 63-2521) | Riociguat (BAY 63-2521) ic50 | Riociguat (BAY 63-2521) price | Riociguat (BAY 63-2521) cost | Riociguat (BAY 63-2521) solubility dmso | Riociguat (BAY 63-2521) purchase | Riociguat (BAY 63-2521) manufacturer | Riociguat (BAY 63-2521) research buy | Riociguat (BAY 63-2521) order | Riociguat (BAY 63-2521) mouse | Riociguat (BAY 63-2521) chemical structure | Riociguat (BAY 63-2521) mw | Riociguat (BAY 63-2521) molecular weight | Riociguat (BAY 63-2521) datasheet | Riociguat (BAY 63-2521) supplier | Riociguat (BAY 63-2521) in vitro | Riociguat (BAY 63-2521) cell line | Riociguat (BAY 63-2521) concentration | Riociguat (BAY 63-2521) nmr