Guanylate Cyclase

Guanylate Cyclase Products

  • All (8)
  • Guanylate Cyclase Inhibitors (4)
  • Guanylate Cyclase Activator (1)
  • Guanylate Cyclase Agonists (3)
  • New Guanylate Cyclase Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7958 Lificiguat (YC-1) Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
Hepatol Commun, 2024, 8(1)e0350
Bioact Mater, 2023, 19:690-702
J Neuroinflammation, 2023, 20(1):82
S8135 Riociguat Riociguat is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.
J Exp Med, 2023, 220(2)e20211422
Open Biol, 2022, 12(8):220058
Hepatology, 2021, 10.1002/hep.31987
S4535 Methylene Blue Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
Cell Res, 2023, 10.1038/s41422-023-00846-8
bioRxiv, 2020, 2020/9/20.4.7.30734
S9796 ODQ ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.
J Ethnopharmacol, 2023, 300:115705
S9693 Vericiguat Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.
S8128 BAY 41-2272 BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
D4009New Indusatumab vedotin Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate (ADC) composed of an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody and a anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE).
S5229 Isosorbide dinitrate Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).
S7958 Lificiguat (YC-1) Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
Hepatol Commun, 2024, 8(1)e0350
Bioact Mater, 2023, 19:690-702
J Neuroinflammation, 2023, 20(1):82
S4535 Methylene Blue Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
Cell Res, 2023, 10.1038/s41422-023-00846-8
bioRxiv, 2020, 2020/9/20.4.7.30734
S9796 ODQ ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.
J Ethnopharmacol, 2023, 300:115705
D4009New Indusatumab vedotin Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate (ADC) composed of an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody and a anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE).
S5229 Isosorbide dinitrate Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).
S8135 Riociguat Riociguat is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.
J Exp Med, 2023, 220(2)e20211422
Open Biol, 2022, 12(8):220058
Hepatology, 2021, 10.1002/hep.31987
S9693 Vericiguat Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.
S8128 BAY 41-2272 BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
D4009New Indusatumab vedotin Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate (ADC) composed of an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody and a anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE).

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Tags: Guanylate Cyclase inhibitor|Guanylate Cyclase agonist|Guanylate Cyclase activator|Guanylate Cyclase inducer|Guanylate Cyclase antagonist|Guanylate Cyclase signaling pathway|Guanylate Cyclase assay kit