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Guanylate Cyclase

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Cat.No. Product Name Information Product Use Citations Product Validations
S8135 Riociguat Riociguat is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.
Biomed Pharmacother, 2025, 190:118425
J Immunother Cancer, 2024, 12(11)e009805
J Exp Med, 2023, 220(2)e20211422
S9796 ODQ ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.
J Ethnopharmacol, 2023, 300:115705
S9693 Vericiguat Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.
S8128 BAY 41-2272 BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
E4805 Methylene Blue trihydrate Methylene blue trihydrate (C.I. Basic Blue 9 trihydrate) acts as an inhibitor of soluble guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS). Methylene blue trihydrate exhibits antimalarial, antidepressant, and anxiolytic activity effects. Methylene Blue trihydrate has potential applications in treating methemoglobinemia, neurodegenerative disorders, and ifosfamide-induced encephalopathy.
S7958 Lificiguat (YC-1) Lificiguat (YC-1) is a nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
J Transl Med, 2024, 22(1):248
J Transl Med, 2024, 22(1):1003
Hepatol Commun, 2024, 8(1)e0350
S4535 Methylene Blue Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
Cell Res, 2023, 10.1038/s41422-023-00846-8
bioRxiv, 2020, 2020/9/20.4.7.30734
S5229 Isosorbide dinitrate Isosorbide Dinitrate (ISDN, Sorbide nitrate, Sorbidnitrate, Isordil, Nitrosorbide) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).