Guanylate Cyclase

Inhibitory Selectivity

Guanylate Cyclase Products

All (5) Guanylate Cyclase Inhibitors (2) Guanylate Cyclase Activators (1)

Catalog No.	Information	Product Use Citations
S7958	Lificiguat(YC-1) YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).	Sci Rep, 2020, 7;10(1):7714 Biomed Pharmacother, 2020, 123:109742 ACS Nano, 2019, 13(2):2176-2189
S4535	Methylene Blue Methylene Blue is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.	bioRxiv, 2020, 2020/9/20.4.7.30734
S5229	Isosorbide dinitrate Isosorbide Dinitrate (ISDN) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).
S8128	BAY 41-2272 BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
S8135	Riociguat (BAY 63-2521) Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.	Cell Rep, 2019, 27(6):1769-1780 Oncogene, 2019, 38(22):4397-4411 Endocr Relat Cancer, 2019, 26(2):251-264

Catalog No.

Information

Product Use Citations

Product Validations

S7958

Lificiguat(YC-1)

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).

Sci Rep, 2020, 7;10(1):7714

Biomed Pharmacother, 2020, 123:109742

ACS Nano, 2019, 13(2):2176-2189

S4535

Methylene Blue

Methylene Blue is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.

bioRxiv, 2020, 2020/9/20.4.7.30734

Catalog No.	Information	Product Use Citations	Product Validations
S5229	Isosorbide dinitrate Isosorbide Dinitrate (ISDN) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).

Catalog No.

Information

Product Use Citations

Product Validations

S5229

Isosorbide Dinitrate (ISDN) is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide Dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. Isosorbide Dinitrate can converte to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A).

Catalog No.	Information	Product Use Citations	Product Validations
S8128	BAY 41-2272 BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
S8135	Riociguat (BAY 63-2521) Riociguat (BAY 63-2521) is an oral soluble guanylate cyclase (GC) stimulator, used in the treatment of ipulmonary hypertension.	Cell Rep, 2019, 27(6):1769-1780 Oncogene, 2019, 38(22):4397-4411 Endocr Relat Cancer, 2019, 26(2):251-264

Catalog No.

Information

Product Use Citations

Product Validations

S8128