PD-1/PD-L1 Inhibitor 3

For research use only.

Catalog No.S8158

3 publications

PD-1/PD-L1 Inhibitor 3 Chemical Structure

CAS No. 1629654-95-0

PD-1/PD-L1 Inhibitor 3(Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3)is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM

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Biological Activity

Description PD-1/PD-L1 Inhibitor 3(Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3)is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
PD-1/PD-L1 interaction [1]
(Cell-free assay)
5.6 nM
In vitro

PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity[1].


Solubility (25°C)

In vitro Water 100 mg/mL (53.99 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1852.17


CAS No. 1629654-95-0
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Could you tell me what the difference is between these products (S7911, S7912, S8158), and do you have any recommendations about which one to select?

  • Answer:

    The products are of high purity and can be used for both cell culture and mouse study. S7911 and S7912 are small-molecule inhibitors that have different IC50s, while S8158 is a macrocyclic inhibitor.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID