Home Immunology & Inflammation PD-1/PD-L1 inhibitor PD-1/PD-L1 Inhibitor 3

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PD-1/PD-L1 Inhibitor 3 PD-1/PD-L1 inhibitor

Cat.No.S8158

PD-1/PD-L1 Inhibitor 3（Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3）is a Macrocyclic inhibitor of PD-1/PD-L1 interaction with IC50 of 5.6 nM
PD-1/PD-L1 Inhibitor 3 PD-1/PD-L1 inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 1852.17

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Chemical Information, Storage & Stability

Molecular Weight 1852.17 Formula

C89H126N24O18S

 Storage (From the date of receipt)
CAS No. 1629654-95-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCCCC1C(=O)NC(C(=O)NC(CSCC(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)N(CC(=O)NC(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N1C)CCCC)C)CC3=CNC4=CC=CC=C43)CO)CC5=CNC6=CC=CC=C65)C)CC(C)C)CC7=CN=CN7)CC(=O)N)C)C)CC8=CC=CC=C8)C(=O)NCC(=O)N)CCCNC(=N)N

Solubility

In vitro
Batch:

Water : 100 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
PD-1/PD-L1 interaction [1]
(Cell-free assay)
5.6 nM
In vitro

PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80. It has highly efficacious binding to PD-L1 and promotes enhanced T cell functional activity[1].
References

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Frequently Asked Questions

Question 1:
Could you tell me what the difference is between these products (S7911, S7912, S8158), and do you have any recommendations about which one to select?

Answer:
They are of high purity and can be used for both cell culture and mouse study. S7911 and S7912 are small-molecule inhibitors that have different IC50s, while S8158 is a macrocyclic inhibitor.